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Makiko Kawaguchi et al.
The American journal of pathology, 185(6), 1610-1623 (2015-04-07)
Hepatocyte growth factor activator inhibitor type 1 (HAI-1; official symbol SPINT1) is a membrane-associated serine proteinase inhibitor abundantly expressed in epithelial tissues. Genetically engineered mouse models demonstrated that HAI-1 is critical for epidermal function, possibly through direct and indirect regulation
Xi Zhang et al.
ACS nano, 9(3), 2659-2667 (2015-02-20)
Reversibly switchable fluorescent proteins (RSFPs) can be effectively used for super-resolution optical fluctuation imaging (SOFI) based on the switching and fluctuation of single molecules. Several properties of RSFPs strongly influence the quality of SOFI images. These properties include (i) the
S Chometton et al.
Journal of chemical neuroanatomy, 61-62, 72-82 (2014-08-16)
Neurons producing melanin-concentrating hormone (MCH) or hypocretin/orexin (Hcrt) have been implicated in the sleep/wake cycle and feeding behavior. Sleep and feeding habits vary greatly among mammalian species, depending in part of the prey/predatory status of animals. However, the distribution of
Hourinaz Behesti et al.
Developmental biology, 333(2), 360-372 (2009-07-07)
Tbx2 is a T-box transcription factor gene that is dynamically expressed in the presumptive retina during optic vesicle invagination. Several findings implicate Tbx2 in cell cycle regulation, including its overexpression in tumours and regulation of proliferation during heart development. We
Min Jung Park et al.
PloS one, 9(10), e109527-e109527 (2014-10-10)
Rett syndrome (RTT) is an autism spectrum disorder (ASD) caused by mutations in the X-linked MECP2 gene that encodes methyl-CpG binding protein 2 (MeCP2). Symptoms range in severity and include psychomotor disabilities, seizures, ataxia, and intellectual disability. Symptom onset is
M Sousa et al.
Zygote (Cambridge, England), 23(1), 145-157 (2013-09-03)
Human oocyte dysmorphisms attain a large proportion of retrieved oocytes from assisted reproductive technology (ART) treatment cycles. Extracytoplasmic defects involve abnormal morphology of the zona pellucida (ZP), perivitelline space and first polar body. The aim of the present study was
Tadashi Okubo et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 244(7), 874-887 (2015-05-23)
The pharyngeal arches (PAs) generate cranial organs including the tongue. The taste placodes, formed in particular locations on the embryonic tongue surface, differentiate into taste buds harbored in distinct gustatory papillae. The developing tongue also has a complex supply of
Leon H Chew et al.
Autophagy, 11(6), 891-905 (2015-05-23)
The Atg1 complex, which contains 5 major subunits: Atg1, Atg13, Atg17, Atg29, and Atg31, regulates the induction of autophagy and autophagosome formation. To gain a better understanding of the overall architecture and assembly mechanism of this essential autophagy regulatory complex
Ting Meng et al.
PloS one, 9(9), e108723-e108723 (2014-09-30)
The exacerbation of IgA nephropathy (IgAN) is related to respiratory tract infection with hemolytic streptococcus (HS), but the mechanism is unknown. In this study we investigated the role of chemokine ligand 20 (CCL20) in response to the effect of T
Walter H Reinhart et al.
Microvascular research, 98, 102-107 (2015-02-11)
Plasma sodium concentration is normally held within a narrow range. It may however vary greatly under pathophysiological conditions. Changes in osmolality lead to either swelling or shrinkage of red blood cells (RBCs). Here we investigated the influence of suspension osmolality
Yunjun Lu et al.
Journal of agricultural and food chemistry, 63(43), 9513-9519 (2015-09-30)
Phytohemagglutin (PHA), purified from red kidney beans (Phaseolus vulgaris) by Affi-Gel blue affinity chromatography, was subjected to ultrahigh-pressure (UHP) treatment (150, 250, 350, and 450 MPa). The purified PHA lost its hemagglutination activity after 450 MPa treatment and showed less
Michael R McAllaster et al.
Molecular biology of the cell, 26(17), 3013-3029 (2015-07-03)
Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single flagellum that is nucleated at the posterior of the cell
Ahmed I Mahmoud et al.
Nature protocols, 9(2), 305-311 (2014-01-18)
Although amphibian and fish models of heart regeneration have existed for decades, a mammalian equivalent has long remained elusive. Our discovery of a brief postnatal window for heart regeneration in neonatal mice has led to the establishment of surgical models
Harriet P Lo et al.
The Journal of cell biology, 210(5), 833-849 (2015-09-02)
Dysfunction of caveolae is involved in human muscle disease, although the underlying molecular mechanisms remain unclear. In this paper, we have functionally characterized mouse and zebrafish models of caveolae-associated muscle disease. Using electron tomography, we quantitatively defined the unique three-dimensional
Carole Kebbi-Beghdadi et al.
Microbes and infection, 17(11-12), 749-754 (2015-10-02)
Recent large scale studies questioning the presence of intracellular bacteria of the Chlamydiales order in ticks and fleas revealed that arthropods, similarly to mammals, reptiles, birds or fishes, can be colonized by Chlamydia-related bacteria with a predominant representation of the
Nadine S Feichtmeier et al.
Environmental science and pollution research international, 22(11), 8549-8558 (2015-01-07)
Within the last years, nanogold has become more and more important in nanotechnology, for example, as catalyst or in medical applications. Its rising production, application, and disposal inevitably lead to an increased emission of gold nanoparticles (Au-NPs) in the environment.
Lucy Coughlin et al.
Investigative ophthalmology & visual science, 56(3), 1437-1446 (2015-02-07)
Decreased ATP correlates with intraocular pressure exposure in the optic nerves of mice with glaucoma. To understand what underlies this energy deficit, we examined mitochondria in the myelinated optic nerve axons of the DBA/2J mouse, a model of glaucoma secondary
Aparna Shinde et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(2), 77-84 (2014-12-20)
Cell-penetrating peptides (CPPs) are known as efficient transporters of molecular cargo across cellular membranes. Their properties make them ideal candidates for in vivo applications. However, challenges in the development of effective CPPs still exist: CPPs are often fast degraded by
Renu Singh et al.
Analytica chimica acta, 853, 588-595 (2014-12-04)
Reusability of a biosensor has recently received considerable attention, and it is closely related with the effective desorption of probe molecules. We present a novel mechanical desorption technique to reuse biosensors by using periodic jets of carbon dioxide (CO2) aerosols
Benjamin L Farah et al.
PloS one, 9(6), e98155-e98155 (2014-06-21)
Autophagy recently has been shown to be involved in normal hepatic function and in pathological conditions such as non-alcoholic fatty liver disease. Adrenergic signalling also is an important regulator of hepatic metabolism and function. However, currently little is known about
Xiaoli Chen et al.
PloS one, 9(10), e108418-e108418 (2014-10-02)
The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro. We have previously shown that these neurospheres originate from
Jun Negishi et al.
Journal of tissue engineering and regenerative medicine, 9(11), E144-E151 (2012-12-13)
Many types of decellularized tissues have been studied and some have been commercially used in clinics. In this study, small-diameter vascular grafts were made using HHP to decellularize porcine radial arteries. One decellularization method, high hydrostatic pressure (HHP), has been
Xiaoying Lei et al.
Scientific reports, 5, 7824-7824 (2015-01-17)
The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection
P D'Incecco et al.
Journal of dairy science, 98(8), 5164-5172 (2015-06-09)
Clostridium tyrobutyricum is the main spoilage agent of late blowing defect (LBD) in Grana Padano and Parmigiano-Reggiano cheeses; LBD is characterized by openings and holes and is sometimes accompanied by cracks and an undesirable flavor. Even a very few spores
Masashi Fujihara et al.
Investigative ophthalmology & visual science, 55(11), 7285-7295 (2014-10-16)
Mice typically produce apolipoprotein B (apoB)-48 and not apoB100. Apolipoprotein B100 accumulates in Bruch's membrane prior to basal deposit and drusen formation during the onset of AMD, raising the possibility that they are a trigger for these Bruch's membrane alterations.
Long M G Bui et al.
Microbes and infection, 17(1), 77-82 (2014-10-07)
Staphylococcus aureus is extremely versatile. It has a capacity to persist within its host by switching to the alternative lifestyles of biofilm or Small Colony Variants (SCV). The induction of this switch has been presumed to be in response to
Yu Zhang et al.
Molecular neurobiology, 50(2), 647-654 (2014-01-15)
Neural stem cells (NSCs) can be isolated from nervous tissues or derived from embryonic stem cells. However, their procurement for clinical applications is limited, and there is a need for alternative types of cell that have NSCs properties. In the
Shivika Sharma et al.
Biotechnology progress, 31(3), 715-723 (2015-03-05)
Gallic acid (3, 4, 5- trihydroxybenzoic acid) is an important antioxidant, anti-inflammatory, and radical scavenging agent. In the present study, a purified thermo-tolerant extra-cellular lipase of Bacillus licheniformis SCD11501 was successfully immobilized by adsorption on Celite 545 gel matrix followed
Ling-Chao Meng et al.
Chinese medical journal, 128(21), 2902-2905 (2015-11-03)
Mutations of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis, which occurs worldwide. To date, more and more mutations in the TTR gene have been reported. Some variations in the clinical presentation are often observed in
X Zhao et al.
International journal of molecular medicine, 35(3), 684-692 (2015-01-13)
Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein
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