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Huiting Zhang et al.
Bioorganic & medicinal chemistry, 15(18), 6089-6095 (2007-07-07)
Molecular imprinted polymers (MIPs) binding with phenoxyacetic acid (PA) as a dummy template molecule were synthesized via thermal initiation in aqueous medium. The retention behaviors of benzoic acid (BA), PA, 2-methyl-4-chlorophenoxyacetic acid (MCPA), 4-chlorophenoxyacetic acid (4-CPA), and 2,4-dichlorophenoxyacetic acid (2,4-D)
Orapin Chienthavorn et al.
Journal of chromatography. A, 1152(1-2), 268-273 (2007-01-11)
Phase transfer catalytic methylation was applied to directly derivatise chlorophenoxy acid herbicides in superheated water extracts from sand and soil samples. The extractions were carried out at 120 degrees C statically for 5 min and then dynamically for 10 min
Ming-Kung Yeh et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 27(1), 49-54 (2011-01-15)
Dynamic liquid-liquid-liquid microextraction coupled with ion-pair liquid chromatography (IP-LC) and photodiode array detection was developed and used for the extraction and analysis of chlorinated phenoxyacetic acids (CPAs) and chlorophenols (CPs) from water samples. An organic extraction solvent mixture was chosen
Giuseppe Fracchiolla et al.
ChemMedChem, 2(5), 641-654 (2007-03-16)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that govern lipid and glucose homeostasis, and play a central role in cardiovascular disease, obesity, and diabetes. Thus, there is significant interest in developing new and specific agonists for these receptors. Herein
Guan-Sheng Jiao et al.
Bioorganic & medicinal chemistry letters, 22(6), 2242-2246 (2012-02-22)
Four core structures capable of providing sub-nanomolar inhibitors of anthrax lethal factor (LF) were evaluated by comparing the potential for toxicity, physicochemical properties, in vitro ADME profiles, and relative efficacy in a rat lethal toxin (LT) model of LF intoxication.
Bin Ni et al.
Journal of chromatographic science, 48(5), 353-357 (2010-06-03)
A simple and sensitive high-performance liquid chromatographic method was developed for quantification of the metabolin of meclofenoxate, chlorophenoxyacetic acid, in human plasma. Ibuprofen was used as an internal standard. The present method used protein precipitation for extraction of chlorophenoxyacetic acid
Maria G Margariti et al.
Therapeutic drug monitoring, 29(2), 150-163 (2007-04-10)
Extensive use of synthetic pesticides for agricultural and nonagricultural purposes began in the past 50 years. As a result of their wide and extensive application, exposure to hazardous pesticides is a concern to the general population and occupationally exposed persons.
Charles Timchalk
Toxicology, 200(1), 1-19 (2004-05-26)
Phenoxyacetic acids including 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxyacetic acid (MCPA) are widely utilized organic acid herbicides that have undergone extensive toxicity and pharmacokinetic analyses. The dog is particularly susceptible to the toxicity of phenoxyacetic acids and related organic acids relative
M Shanthi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 67(2), 479-482 (2006-10-20)
The effects of substituents and solvents have been studied through the absorption spectra of nearly 19 para- and ortho-substituted phenoxyacetic acids in the range of 200-400 nm. The effects of substituent on the absorption spectra of compounds under present investigation
Ricardo Pérez-Pastén et al.
The Journal of pharmacy and pharmacology, 58(10), 1343-1349 (2006-10-13)
The phenoxyacetic acid derivatives 1-6 [2-methoxy-4-(2-propenyl)phenoxyacetic acid (1); 2-methoxy-5-nitro-4-(2-propenyl)phenoxyacetic acid (2); methyl 2-methoxy-4-(2-propenyl)phenoxyacetate (3); ethyl 2-methoxy-4-(2-propenyl)phenoxyacetate (4); methyl 2-methoxy-5-nitro-4-(2-propenyl)phenoxyacetate (5); ethyl 2-methoxy-5-nitro-4-(2-propenyl)phenoxyacetate (6)] related to alpha-asarone have been reported previously as hypolipidaemic agents in diet-induced hyperlipidaemic mice. We have aimed
Amjid Iqbal et al.
Molecules (Basel, Switzerland), 12(2), 245-254 (2007-09-12)
A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc
Katarzyna Ignatowicz
Journal of hazardous materials, 169(1-3), 953-957 (2009-05-19)
This paper presents research on phenoxyacid pesticides removal using sorption methods on activated carbons. It was noted, that physico-chemical properties of adsorbent and adsorbate as well as parameters of the process have influence on adsorption of pesticides, derivatives of phenoxyacetic
Jochem Louisse et al.
Toxicological sciences : an official journal of the Society of Toxicology, 118(2), 470-484 (2010-09-14)
At present, regulatory assessment of systemic toxicity is almost solely carried out using animal models. The European Commission's REACH legislation stimulates the use of animal-free approaches to obtain information on the toxicity of chemicals. In vitro toxicity tests provide in
M Shahar Yar et al.
Journal of enzyme inhibition and medicinal chemistry, 24(3), 876-882 (2008-10-28)
Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between 2-{4-[3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} acetic acid and substituted acid hydrazides and were tested for their in vitro cytotoxicity and antiviral activity. None of the compounds showed any specific antiviral activity
Kazuhito Itoh et al.
FEMS microbiology ecology, 84(1), 124-132 (2012-11-22)
Sixty-nine fungal strains were isolated countrywide from 10 Vietnamese soils, in areas both with and without a history of exposure to Agent Orange, and their degrading activities on the phenoxy acid herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), as
Discovery of carboranes as inducers of 20S proteasome activity.
Hyun Seung Ban et al.
ChemMedChem, 5(8), 1236-1241 (2010-05-13)
Mohamed Ashraf Ali et al.
Bioorganic & medicinal chemistry, 15(5), 1896-1902 (2007-01-26)
A series of 2-{4-[1-amino (thioxo) methyl-5-(substituted phenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methoxyphenoxy}acetic acid and 2-{4-[1-carbamoyl-5-(substituted phenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methoxyphenoxy}acetic acid were synthesized and the in vitro activity of the synthesized compounds against Mycobacterium tuberculosis H37Rv (MTB) and INH-resistant M. tuberculosis (INHR-MTB) was studied. Among the synthesized compounds, compound
Chung-Chiang Chen et al.
Journal of chromatography. A, 1104(1-2), 33-39 (2005-12-20)
A simple liquid-liquid-liquid microextraction with automated movement of the acceptor and the donor phase (LLLME/AMADP) technique is described for the quantitative determination of five phenoxyacetic acids in water using a disposable and ready to use hollow fiber. The target compounds
Tim Luker et al.
Bioorganic & medicinal chemistry letters, 21(12), 3616-3621 (2011-05-20)
A novel series of biaryl phenoxyacetic acids was discovered as potent, selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2). A hit compound 4 was discovered from high throughput screening. Modulation of multiple aryl substituents
Sanne A B Hermsen et al.
Reproductive toxicology (Elmsford, N.Y.), 32(2), 245-252 (2011-05-31)
The zebrafish embryotoxicity test (ZET) is an alternative test to predict embryotoxicity of substances based on morphological assessment. Implementing transcriptomics may increase sensitivity and objectivity of the test system. We applied the category approach to compare effects of compounds from
Masanori Morimoto et al.
Journal of agricultural and food chemistry, 55(3), 700-705 (2007-02-01)
A series of aurones were prepared from various phenols via phenoxy acetic acids and coumaranones and evaluated for insect antifeedant activity against the common cutworm (Spodoptera litura). The naturally occurring aurone was most active at an ED50 of 0.12 micromol/cm2.
Karen A Evans et al.
Bioorganic & medicinal chemistry letters, 21(8), 2345-2350 (2011-03-19)
A series of phenoxyacetic acids as subtype selective and potent hPPARδ partial agonists is described. Many analogues were readily accessible via a single solution-phase synthetic route which resulted in the rapid identification of key structure-activity relationships (SAR), and the discovery
N Sundaraganesan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 70(2), 430-438 (2008-02-20)
In this work, we will report a combined experimental and theoretical study on molecular and vibrational structure of o-chlorophenoxy acetic acid (OCPAA) and p-chlorophenoxy acetic acids (PCPAA). The FT-IR and Fourier transform-Raman spectra of both the compounds was recorded in
Osamu Kimura et al.
Toxicology letters, 189(2), 102-109 (2009-05-26)
The uptake mechanism of phenoxyacetic acid (PA) and its chlorine derivatives, 4-chlorophenoxyacetic acid (4-CPA), 2,4-dichlorophenoxyacetic acid (2,4-D), and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), was investigated using Caco-2 cells. The cells were incubated with PA, 4-CPA, 2,4-D or 2,4,5-T at pH 6.0 and
David A Sandham et al.
Bioorganic & medicinal chemistry letters, 17(15), 4347-4350 (2007-05-29)
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
Jochem Louisse et al.
Toxicology and applied pharmacology, 245(2), 236-243 (2010-03-17)
Embryotoxicity of glycol ethers is caused by their alkoxyacetic acid metabolites, but the mechanism underlying the embryotoxicity of these acid metabolites is so far not known. The present study investigates a possible mechanism underlying the embryotoxicity of glycol ether alkoxyacetic
In memoriam professor Corwin Hansch: birth pangs of QSAR before 1961.
Toshio Fujita
Journal of computer-aided molecular design, 25(6), 509-517 (2011-06-23)
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