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Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Chun-Xia Zhao et al.
Biotechnology and bioengineering, 112(5), 957-964 (2014-11-27)
Antimicrobial peptides, as a new class of antibiotics, have generated tremendous interest as potential alternatives to classical antibiotics. However, the large-scale production of antimicrobial peptides remains a significant challenge. This paper reports a simple and low-cost chromatography-free platform technology for
Esther See et al.
International journal of pharmaceutics, 473(1-2), 528-535 (2014-08-01)
To facilitate the development of a liposomal formulation for cancer therapy, the physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were characterized. Nano-liposomes were prepared by thin-film hydration in conjugation with active drug loading using ammonium sulphate and post-insertion
Peng Liu et al.
Chinese journal of natural medicines, 13(6), 471-480 (2015-06-16)
A method coupling ultra-performance liquid chromatography (UPLC) with quadrupole time-of-flight mass spectrometer (Qtof MS) using the electrospray ionization (ESI) source was developed for the identification of the major saponins from Panax notoginseng powder (PNP). Ten different PNP samples were analyzed
Tomeu Viver et al.
Systematic and applied microbiology, 38(4), 266-275 (2015-03-11)
The culturable fraction of aerobic, heterotrophic and extremely halophilic microbiota retrieved from sediment and brine samples of eight sampling sites in the Mediterranean, Canary Islands and Chile was studied by means of a tandem approach combining large-scale cultivation, MALDI-TOF MS
Sohail Mohammad et al.
Therapie, 70(4), 329-335 (2015-02-14)
A two way, randomized cross-over bioequivalence study was conducted to analyse the rate and extent of absorption of atorvastatin after a single dose of 80 mg atorvastatin as atorvastatin calcium tablets. The study was carried out using healthy male volunteers
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Qiangwei Wang et al.
Aquatic toxicology (Amsterdam, Netherlands), 160, 163-171 (2015-02-01)
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our objective was to investigate whether long-term exposure to low concentrations of TDCPP can
Zhuoyang Fan et al.
PloS one, 10(4), e0120129-e0120129 (2015-04-02)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)-a significant problem in the administration of PTX to cancer patients. To increase the
A Marechal et al.
Journal of chromatography. A, 1406, 109-117 (2015-06-27)
A composite 30-cm capillary was prepared. The head of the capillary was a 1.5-cm original and miniaturized aptamer-based monolithic affinity support that was in-line coupled to the end of the capillary used for capillary electrophoresis (CE) with laser induced fluorescence
Thomas P Forbes et al.
Analytical chemistry, 86(15), 7788-7797 (2014-06-27)
We demonstrate the coupling of desorption electro-flow focusing ionization (DEFFI) with in-source collision induced dissociation (CID) for the mass spectrometric (MS) detection and imaging of explosive device components, including both inorganic and organic explosives and energetic materials. We utilize in-source
Keith G Davies et al.
The Journal of experimental biology, 218(Pt 5), 778-785 (2015-01-27)
Ambient exposure to a short synthetic peptide has enhanced fecundity (number of offspring) in invertebrates and vertebrates, ostensibly by disinhibiting reproduction. In separate experiments, nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) were exposed via their aqueous environment to a
Christian Atsriku et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(5), 428-441 (2014-12-09)
1. The disposition of tanzisertib [(1S,4R)-4-(9-((S)tetrahydrofuran-3-yl)-8-(2,4,6-trifluorophenylamino)-9H-purin-2-ylamino) cyclohexanol], a potent, orally active c-Jun amino-terminal kinase inhibitor intended for treatment of fibrotic diseases was studied in rats, dogs and humans following a single oral dose of [(14)C]tanzisertib (Independent Investigational Review Board Inc.
T Alvarez-Segura et al.
Journal of chromatography. A, 1409, 79-88 (2015-07-29)
Getting useful chemical information from samples containing many compounds is still a challenge to analysts in liquid chromatography. The highest complexity corresponds to samples for which there is no prior knowledge about their chemical composition. Computer-based methodologies are currently considered
Alexandra A Astafieva et al.
Plant science : an international journal of experimental plant biology, 238, 323-329 (2015-08-11)
Two novel homologous peptides named ToHyp1 and ToHyp2 that show no similarity to any known proteins were isolated from Taraxacum officinale Wigg. flowers by multidimensional liquid chromatography. Amino acid and mass spectrometry analyses demonstrated that the peptides have unusual structure:
Yan-xu Chang et al.
Journal of pharmaceutical and biomedical analysis, 117, 1-10 (2015-09-05)
A rapid, sensitive and selective high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of four phenolic acids (neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and ferulic acid) and seven alkaloids (berberine, epiberberine, coptisine
Jie Ye et al.
PloS one, 10(7), e0130885-e0130885 (2015-07-03)
Tomato (Solanum lycopersicum) serves as a research model for fruit development; however, while it is an important dietary source of antioxidant nutrients, the transcriptional regulation of genes that determine nutrient levels remains poorly understood. Here, the transcriptomes of fruit at
Maria Peiris-Pagès et al.
Aging, 7(10), 816-838 (2015-11-06)
Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and
Natalija Topic Popovic et al.
Ecotoxicology and environmental safety, 120, 235-242 (2015-06-21)
A two-season investigation of the wastewater treatment plant (WWTP) effluent, of related waters, sludge and fish across a wide area and 11 stations, with emphasis on Aeromonas spp. was conducted. Aeromonas veronii was the prevailing aeromonad isolated by MALDI TOF
Brian Wiggins et al.
Journal of pharmaceutical sciences, 104(4), 1362-1372 (2015-01-30)
Two US FDA-approved antibody-drug conjugates (ADCs; Kadcyla(®) and Adcetris(®) ) have accelerated clinical interest in the potential of targeted cancer therapeutics as the next generation of oncology drugs that are designed to increase efficacy while reducing overall toxicity. Thiol conjugates
Arturo Roca-Rivada et al.
Scientific reports, 5, 12214-12214 (2015-07-23)
In the context of obesity, strong evidences support a distinctive pathological contribution of adipose tissue depending on its anatomical site of accumulation. Therefore, subcutaneous adipose tissue (SAT) has been lately considered metabolically benign compared to visceral fat (VAT), whose location
Nadine Pinder et al.
Clinical chemistry and laboratory medicine, 53(8), 1259-1264 (2015-01-08)
Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physostigmine and its metabolite eseroline, however
Navneeta Bansal et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 97-103 (2014-05-31)
To address the shortcomings of urine cytology and cystoscopy for screening and grading of urinary bladder cancer (BC) we applied a serum-based proteomics approach as a surrogate tactic for rapid BC probing. This study was performed on 90 sera samples
Dinesh Chandra Khara et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(9), 1793-1798 (2014-04-23)
4-Aminophthalimide (AP) is an extensively used molecule both for fundamental studies and applications primarily due to its highly solvent-sensitive fluorescence properties. The fluorescence spectrum of AP in aqueous media was recently shown to be dependent on the excitation wavelength. A
C Esteve et al.
Talanta, 146, 326-334 (2015-12-24)
A rapid and sensitive analytical method for the simultaneous determination of thirteen endocrine disruptors (five phthalates, seven parabens, and bisphenol A) in a single chromatographic run has been developed for the first time. The separation method, based on ultra-high performance
Przemysław Piotrowski et al.
Advances in medical sciences, 60(1), 167-172 (2015-03-15)
The new analytical method of qualitative and quantitative determination of zolpidem and qualitative analysis of its main metabolite in blood and oral fluid samples was developed. Sample preparation was carried out using a polymeric ion-exchange sorbent in solid phase extraction
Michael V Gormally et al.
Nature communications, 5, 5165-5165 (2014-11-13)
The transcription factor FOXM1 binds to sequence-specific motifs on DNA (C/TAAACA) through its DNA-binding domain (DBD) and activates proliferation- and differentiation-associated genes. Aberrant overexpression of FOXM1 is a key feature in oncogenesis and progression of many human cancers. Here--from a
Kara Lea Vine et al.
Pharmaceutical research, 32(3), 1045-1054 (2014-09-19)
Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target. Plasminogen activator inhibitor type-2 (PAI-2/SerpinB2) is a specific uPA inhibitor with proven potential for use in targeted therapy. However
L M Berger et al.
Journal of dairy science, 98(8), 5688-5698 (2015-06-22)
The aim of the present study was to investigate the ruminal degradation of the flavonol quercetin and to determine its potential antimicrobial effects on ruminal fermentation in cows. Ruminal degradation of quercetin (0 or 100μmol/L, respectively) as well as its
Caroline Le Maréchal et al.
Journal of proteomics, 113, 447-461 (2014-08-26)
Propionibacterium freudenreichii is a beneficial bacterium used in the food industry as a vitamin producer, as a bio-preservative, as a cheese ripening starter and as a probiotic. It is known to adhere to intestinal epithelial cells and mucus and to
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