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Ramazan Gümral et al.
Turkish journal of medical sciences, 45(3), 587-592 (2015-08-19)
Mycological media that promote spore production are essential for the diagnosis of dermatophytosis. However, these culture media frequently become contaminated by multiple fungal or bacterial species during culture. The aim of this study was to compare the contamination rates of
Ashish Punia et al.
International journal of molecular sciences, 16(10), 23867-23880 (2015-10-17)
Synthetic amphiphilic polymers have been established as potentially efficient agents to combat widespread deadly infections involving antibiotic resistant superbugs. Incorporation of poly(ethylene glycol) (PEG) side chains into amphiphilic copolymers can reduce their hemolytic activity while maintaining high antibacterial activity. Our
Wei Wang et al.
Microbes and infection, 16(6), 461-471 (2014-04-09)
Human immunodeficiency virus (HIV)-1 subtype CRF01_AE is one of the major HIV-1 subtypes that dominate the global epidemic. However, its drug resistance, associated mutations, and viral fitness have not been systemically studied, because available chimeric simian-HIVs (SHIVs) usually express the
Amy A Mrazek et al.
The Journal of surgical research, 196(1), 8-16 (2015-03-24)
Chronic pancreatitis (CP) is characterized by recurrent pancreatic injury, resulting in inflammation, necrosis, and fibrosis. There are currently no drugs limiting pancreatic fibrosis associated with CP, and there is a definite need to fill this void in patient care. Pancreatitis
An iridium oxide nanoparticle and polythionine thin film based platform for sensitive Leishmania DNA detection.
Mayorga-Martinez CC, et al.
Journal of Material Chemistry B: Materials for Biology and Medicine, 3(26), 5166-5171 (2015)
Anthony J Donato et al.
Life sciences, 118(2), 238-243 (2014-01-15)
The role of vascular smooth muscle endothelin A receptors (ETA) in development and normal physiology remains incompletely understood. To address this, mice were generated with smooth muscle-specific knockout (KO) of ETA. Mice were homozygous for loxP-flanked exons 6-8 of the
Buyong Ma et al.
Growth factors (Chur, Switzerland), 32(6), 236-246 (2014-11-21)
EphB2 interacts with cell surface-bound ephrin ligands to relay bidirectional signals. Overexpression of the EphB2 receptor protein has been linked to different types of cancer. The SNEW (SNEWIQPRLPQH) peptide binds with high selectivity and moderate affinity to EphB2, inhibiting Eph-ephrin
Helga Pankoke et al.
Journal of insect physiology, 82, 99-108 (2015-08-27)
Iridoid glycosides are plant defence compounds with potentially detrimental effects on non-adapted herbivores. Some plant species possess β-glucosidases that hydrolyse iridoid glycosides and thereby release protein-denaturing aglycones. To test the hypothesis that iridoid glycosides and plant β-glucosidases form a dual
Andrea Boni et al.
The Journal of cell biology, 209(5), 705-720 (2015-06-10)
Targeting of inner nuclear membrane (INM) proteins is essential for nuclear architecture and function, yet its mechanism remains poorly understood. Here, we established a new reporter that allows real-time imaging of membrane protein transport from the ER to the INM
Jonatan Barrera-Chimal et al.
International journal of biological sciences, 11(8), 892-900 (2015-07-15)
Administration of the mineralocorticoid receptor antagonist spironolactone prevents the development of chronic kidney disease (CKD) after a severe ischemic injury. However, whether brief periods of ischemia lead to CKD and whether spironolactone administration after ischemia may be a useful therapeutic
Anne Schwerk et al.
Cytotherapy, 17(2), 199-214 (2014-12-03)
In Parkinson's disease (PD), neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) axis is affected as the result of the lack of dopaminergic innervations reaching the SVZ. This aberrant network has been related to the hyposmia of PD patients, which
L Ginsberg et al.
Brain research, 698(1-2), 223-226 (1995-11-06)
A significant and selective deficiency of ethanolamine plasmalogen (PPE) relative to phosphatidylethanolamine was identified in post mortem brain samples from patients with Alzheimer's disease (AD). This lipid defect showed anatomic specificity, being more marked at a site of neurodegeneration in
Betul Kul Babur et al.
Cell and tissue research, 361(3), 755-768 (2015-05-01)
Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral
Tsunashi Kamo et al.
Journal of chemical ecology, 38(12), 1552-1560 (2012-11-28)
The cowpea aphid Aphis craccivora that infests the black locust Robinia pseudoacacia shows toxicity to its predator, the multicolored Asian ladybird beetle, Harmonia axyridis. In contrast, the same aphid species that infests the common vetch, Vicia angustifolia, is suitable prey
Eu Jin Lim et al.
The Journal of general virology, 95(Pt 10), 2204-2215 (2014-06-29)
Chronic hepatitis C virus (HCV) infection results in progressive liver fibrosis leading to cirrhosis and liver cancer. The mechanism for this remains unclear but hepatocyte apoptosis is thought to play a major role. Hepatocyte apoptosis in human liver tissue was
K Mirzaei et al.
Minerva endocrinologica, 40(3), 177-185 (2015-02-11)
Peroxisome proliferator-activated receptor γ (PPAR γ) is a critical factor for some pathways that involve in adipogenesis and osteogenesis. The aim of study was to compare PPARγ gene expression, different cytokines' levels and bone markers in osteopenic and non-osteopenic obese
Yu-Jeng Shiau et al.
Nanoscale, 7(29), 12698-12705 (2015-07-15)
Solution-processed silver nanowire (AgNW) electrodes have been considered to be promising materials for next-generation flexible transparent conductive electrodes. Despite the fact that a single AgNW has extremely high conductivities, the high junction resistance between nanowires limits the performance of the
Sabato Fusco et al.
Acta biomaterialia, 23, 63-71 (2015-05-26)
Mechanical properties of materials strongly influence cell fate and functions. Focal adhesions are involved in the extremely important processes of mechanosensing and mechanotransduction. To address the relationship between the mechanical properties of cell substrates, focal adhesion/cytoskeleton assembly and cell functions
Paula Urquhart et al.
Journal of lipid research, 56(8), 1419-1433 (2015-06-03)
Arachidonoyl ethanolamine (anandamide) and pros-taglandin ethanolamines (prostamides) are biologically active derivatives of arachidonic acid. Although available through different precursor phospholipids, there is considerable overlap between the biosynthetic pathways of arachidonic acid-derived eicosanoids and anandamide-derived prostamides. Prostamides exhibit physiological actions and
Seung Up Kim et al.
Yonsei medical journal, 56(5), 1296-1306 (2015-08-11)
Dickkopf-1 (DKK-1) is a Wnt/β-catenin signaling pathway inhibitor. We investigated whether DKK-1 is related to progression in hepatocellular carcinoma (HCC) cells and HCC patients. In vitro reverse-transcription polymerase chain reaction (RT-PCR), wound healing assays, invasion assays, and ELISAs of patient
E Halevas et al.
Journal of inorganic biochemistry, 147, 99-115 (2015-04-30)
Among the various roles of vanadium in the regulation of intracellular signaling, energy metabolism and insulin mimesis, its exogenous activity stands as a contemporary challenge currently under investigation and a goal to pursue as a metallodrug against Diabetes mellitus II.
E J Hammond et al.
Brain research, 583(1-2), 300-303 (1992-06-26)
An implanted stimulating device chronically stimulated the left cervical vagus nerve in epileptic patients. Cerebrospinal fluid concentrations of free and total gamma-aminobutyric acid, homovanillic acid, 5-hydroxyindoleacetic acid, aspartate, glutamate, asparagine, serine, glutamine, glycine, phosphoethanolamine, taurine, alanine, tyrosine, ethanolamine, valine, phenylalanine
Marzena Szwed et al.
Chemico-biological interactions, 220, 140-148 (2014-07-08)
In our research we compared the effect of doxorubicin (DOX) and doxorubicin-transferrin (DOX-TRF) conjugate on the induction of programmed cell death. All experiments were carried out on human leukemia cells: CCRF-CEM, K562 sensitive and resistant to DOX, (K562/DOX), which are
Audrey Beaussart et al.
Nanoscale, 7(36), 14996-15004 (2015-08-27)
Many fungal pathogens produce cell surface polysaccharides that play essential roles in host-pathogen interactions. In Aspergillus fumigatus, the newly discovered polysaccharide galactosaminogalactan (GAG) mediates adherence to a variety of substrates through molecular mechanisms that are poorly understood. Here we use
Katharina Schücker et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2029-2033 (2015-02-04)
Synaptonemal complexes (SCs) are meiosis-specific multiprotein complexes that are essential for synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization of SCs remains unclear. We used immunofluorescence labeling in combination with super-resolution imaging and average position determination to
Marc P Raphael et al.
Plasmonics (Norwell, Mass.), 10(6), 1649-1655 (2015-11-26)
Localized surface plasmon resonance (LSPR) spectroscopy and imaging are emerging biosensor technologies which tout label-free biomolecule detection at the nanoscale and ease of integration with standard microscopy setups. The applicability of these techniques can be limited by the restrictions that
I S Mikhaevich et al.
Biomedical science, 2(6), 659-664 (1991-01-01)
The action of a new anticancer agent, the semisynthetic alkyl-phospholipid plasmanyl-(N-acyl)-ethanolamine (sPNAE), namely 1-O-octadecyl-2-oleoyl-sn-glycero-3-phospho-(N-palmitoyl)-ethanolamine, on protein kinase C (PKC) was investigated, and it was found to inhibit in a dose-dependent manner PKC isolated from mouse brain. The inhibition was competitive
Juliana J Moreira et al.
Journal of veterinary science, 16(1), 47-55 (2014-10-02)
This experimental controlled study was performed to evaluate the composition of autologous processed plasma (APP), and the effects of APP intra-articular injection into healthy equine metacarpophalangeal joints. The effects on joints were analysed with a short-phase protocol and a prolonged-phase
Jiyun Song et al.
ACS applied materials & interfaces, 7(33), 18460-18466 (2015-08-05)
We report a unique nanostructured electron-selective interlayer comprising of In-doped ZnO (ZnO:In) and vertically aligned CdSe tetrapods (TPs) for inverted polymer:fullerene bulkheterojunction (BHJ) solar cells. With dimension-controlled CdSe TPs, the direct inorganic electron transport pathway is provided, resulting in the
Ping He et al.
The American journal of pathology, 185(7), 1981-1990 (2015-06-22)
Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus. Peroxisome proliferator-activated receptors (PPARs) are implicated to be involved in parturition. In this study, we investigated whether PPARs are involved in
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