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Ping He et al.
The American journal of pathology, 185(7), 1981-1990 (2015-06-22)
Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus. Peroxisome proliferator-activated receptors (PPARs) are implicated to be involved in parturition. In this study, we investigated whether PPARs are involved in
Julien Jorda et al.
PLoS computational biology, 11(2), e1004067-e1004067 (2015-02-04)
Bacterial microcompartments (MCPs) are protein-bound organelles that carry out diverse metabolic pathways in a wide range of bacteria. These supramolecular assemblies consist of a thin outer protein shell, reminiscent of a viral capsid, which encapsulates sequentially acting enzymes. The most
Veeradasan Perumal et al.
Scientific reports, 5, 12231-12231 (2015-07-17)
Hybrid gold nanostructures seeded into nanotextured zinc oxide (ZnO) nanoflowers (NFs) were created for novel biosensing applications. The selected 'spotted NFs' had a 30-nm-thick gold nanoparticle (AuNP) layer, chosen from a range of AuNP thicknesses, sputtered onto the surface. The
Audrey Beaussart et al.
Nanoscale, 7(36), 14996-15004 (2015-08-27)
Many fungal pathogens produce cell surface polysaccharides that play essential roles in host-pathogen interactions. In Aspergillus fumigatus, the newly discovered polysaccharide galactosaminogalactan (GAG) mediates adherence to a variety of substrates through molecular mechanisms that are poorly understood. Here we use
Ye-Jin Hwang et al.
Advanced materials (Deerfield Beach, Fla.), 27(31), 4578-4584 (2015-07-03)
By controlling the polymer/polymer blend self-organization rate, all-polymer solar cells composed of a high-mobility, crystalline, naphthalene diimide-selenophene copolymer acceptor and a benzodithiophene-thieno[3,4-b]thiophene copolymer donor are achieved with a record 7.7% power conversion efficiency and a record short-circuit current density (18.8
Jiyun Song et al.
ACS applied materials & interfaces, 7(33), 18460-18466 (2015-08-05)
We report a unique nanostructured electron-selective interlayer comprising of In-doped ZnO (ZnO:In) and vertically aligned CdSe tetrapods (TPs) for inverted polymer:fullerene bulkheterojunction (BHJ) solar cells. With dimension-controlled CdSe TPs, the direct inorganic electron transport pathway is provided, resulting in the
Juliana J Moreira et al.
Journal of veterinary science, 16(1), 47-55 (2014-10-02)
This experimental controlled study was performed to evaluate the composition of autologous processed plasma (APP), and the effects of APP intra-articular injection into healthy equine metacarpophalangeal joints. The effects on joints were analysed with a short-phase protocol and a prolonged-phase
Marzena Szwed et al.
Chemico-biological interactions, 220, 140-148 (2014-07-08)
In our research we compared the effect of doxorubicin (DOX) and doxorubicin-transferrin (DOX-TRF) conjugate on the induction of programmed cell death. All experiments were carried out on human leukemia cells: CCRF-CEM, K562 sensitive and resistant to DOX, (K562/DOX), which are
I S Mikhaevich et al.
Biomedical science, 2(6), 659-664 (1991-01-01)
The action of a new anticancer agent, the semisynthetic alkyl-phospholipid plasmanyl-(N-acyl)-ethanolamine (sPNAE), namely 1-O-octadecyl-2-oleoyl-sn-glycero-3-phospho-(N-palmitoyl)-ethanolamine, on protein kinase C (PKC) was investigated, and it was found to inhibit in a dose-dependent manner PKC isolated from mouse brain. The inhibition was competitive
Francis Y Kim et al.
American journal of physiology. Lung cellular and molecular physiology, 308(4), L368-L377 (2014-11-17)
Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors. Circulating ET-1 contributes to vascular remodeling by promoting SMC proliferation and migration and inhibiting SMC apoptosis. Although endothelial cells (EC)
Lee K Yong et al.
Journal of clinical microbiology, 53(9), 2816-2822 (2015-06-19)
Exophiala species are capable of causing cutaneous and subcutaneous infections in immunocompromised patients. An Exophiala isolate was cultured from a biopsy specimen of a lesion on the forearm of a patient with myasthenia gravis. The patient also had lesions on
E Halevas et al.
Journal of inorganic biochemistry, 147, 99-115 (2015-04-30)
Among the various roles of vanadium in the regulation of intracellular signaling, energy metabolism and insulin mimesis, its exogenous activity stands as a contemporary challenge currently under investigation and a goal to pursue as a metallodrug against Diabetes mellitus II.
E J Hammond et al.
Brain research, 583(1-2), 300-303 (1992-06-26)
An implanted stimulating device chronically stimulated the left cervical vagus nerve in epileptic patients. Cerebrospinal fluid concentrations of free and total gamma-aminobutyric acid, homovanillic acid, 5-hydroxyindoleacetic acid, aspartate, glutamate, asparagine, serine, glutamine, glycine, phosphoethanolamine, taurine, alanine, tyrosine, ethanolamine, valine, phenylalanine
Katharina Schücker et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2029-2033 (2015-02-04)
Synaptonemal complexes (SCs) are meiosis-specific multiprotein complexes that are essential for synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization of SCs remains unclear. We used immunofluorescence labeling in combination with super-resolution imaging and average position determination to
Jennifer Oberle et al.
Fungal biology, 119(11), 1100-1114 (2015-10-16)
Twenty distinct fungal isolates were analysed using three methods of sample preparation for FTIR spectroscopy and FTIR-ATR microspectroscopy to test for differences in surface chemical composition between living and dried fungal samples, as well as differences between surface chemistry and
Pratheeba Yogendrarajah et al.
Food microbiology, 52, 185-196 (2015-09-05)
A liquid chromatography triple quadrupole tandem mass spectrometry method was developed and validated to determine mycotoxins, produced by fungal isolates grown on malt extract agar (MEA). All twenty metabolites produced by different fungal species were extracted using acetonitrile/1% formic acid.
Ivana Vaněčková et al.
Journal of hypertension, 33(1), 161-169 (2014-09-26)
Our previous experiments demonstrated that selective endothelin A (ETA) receptor blockade had antihypertensive effects in Ren-2 transgenic rats (TGRs), but the mechanisms responsible for this change of blood pressure (BP) have not been explored yet. Four-week-old male heterozygous TGRs and
I Ojeda et al.
Analytical and bioanalytical chemistry, 406(25), 6363-6371 (2014-08-02)
A novel magnetoimmunosensor design for interleukin-6 (IL-6) which involved the covalent immobilization of anti-IL-6 antibodies onto carboxyl-functionalized magnetic microparticles and a sandwich-type immunoassay with signal amplification using poly-HRP-streptavidin conjugates is reported. All the variables concerning the preparation and the electroanalytical
Fátima Husein Abdalla et al.
Molecular and cellular biochemistry, 396(1-2), 201-211 (2014-07-30)
The ex vivo and in vitro effects of quercetin on NTPDase, adenosine deaminase (ADA), and acetycholinesterase (AChE) activities in lymphocytes, as well as the effects of quercetin on butyrylcholinesterase (BChE) activity in serum and myeloperoxidase (MPO) activity in plasma were
Hussein N Yassine et al.
PloS one, 10(1), e0115320-e0115320 (2015-01-22)
Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing
P Rockenfeller et al.
Cell death and differentiation, 22(3), 499-508 (2015-01-13)
Autophagy is a cellular recycling program that retards ageing by efficiently eliminating damaged and potentially harmful organelles and intracellular protein aggregates. Here, we show that the abundance of phosphatidylethanolamine (PE) positively regulates autophagy. Reduction of intracellular PE levels by knocking
Helmut Merk et al.
Biological chemistry, 396(9-10), 1097-1107 (2015-05-23)
G protein-coupled receptors, like many other membrane proteins, are notoriously difficult to synthesize in conventional cellular systems. Although expression in insect cells is considered the preferred technique for structural characterizations in particular, inefficient membrane translocation, instability, toxic effects and low
Chiao-Lin Chuang et al.
Journal of gastroenterology and hepatology, 30(1), 199-207 (2014-07-06)
Hypo-perfusion resulting from intense renal vasoconstriction is traditionally contributed to renal dysfunction in advanced liver disease, although cumulative studies demonstrated renal vasodilatation with impaired vascular contractility to endogenous vasoconstrictors in portal hypertension and compensated liver cirrhosis. The pathophysiology of altered
Ilaria Pelassa et al.
Human molecular genetics, 23(13), 3402-3420 (2014-02-06)
The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but
Chaitali N Mahajan et al.
Pediatric research, 77(3), 455-462 (2014-12-19)
Persistent pulmonary hypertension of the newborn (PPHN) is associated with decreased lung angiogenesis and impaired pulmonary vasodilatation at birth. Prostanoids are important modulators of vascular tone and angiogenesis. We hypothesized that altered levels of prostacyclin (PGI₂), a potent vasodilator, and
Nele Goeyvaerts et al.
Statistics in medicine, 34(20), 2858-2871 (2015-04-25)
Biomedical studies often generate repeated measures of multiple outcomes on a set of subjects. It may be of interest to develop a biologically intuitive model for the joint evolution of these outcomes while assessing inter-subject heterogeneity. Even though it is
Lulu Dai et al.
International journal of molecular sciences, 16(6), 12014-12034 (2015-05-29)
Leptographium qinlingensis is a fungal associate of the Chinese white pine beetle (Dendroctonus armandi) and a pathogen of the Chinese white pine (Pinus armandi) that must overcome the terpenoid oleoresin defenses of host trees. L. qinlingensis responds to monoterpene flow
Sanja Ramljak et al.
Clinical laboratory, 61(11), 1687-1693 (2016-01-07)
Modern biomarkers for the assessment of liver cell damage are indicative for distinct hepato-cellular deteriorations. We investigated the prevalence of these markers in healthy subjects and patients with early stage type 2 diabetes mellitus (T2DM) on metformin monotherapy. The study
Christian S Müller et al.
Biochemistry, 54(3), 711-721 (2014-12-30)
Cytochrome P450 3A4 (CYP3A4) is the major human P450 responsible for the metabolism of carbamazepine (CBZ). To explore the mechanisms of interactions of CYP3A4 with this anticonvulsive drug, we carried out multiple molecular dynamics (MD) simulations, starting with the complex
Fuiyee Lee et al.
PloS one, 9(7), e103254-e103254 (2014-07-23)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion.
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