Merck
Search Within
Applied Filters:
Keyword:'409286'
Showing 1-30 of 107 results for "

409286

" within Papers
Sort by Relevance
Christos Tsabaris et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 69(10), 1546-1553 (2011-07-12)
An algorithm for automated analysis of in-situ NaI γ-ray spectra in the marine environment is presented. A standard wavelet denoising technique is implemented for obtaining a smoothed spectrum, while the stability of the energy spectrum is achieved by taking advantage
Benoît Chatin et al.
Molecular therapy. Nucleic acids, 4, e244-e244 (2015-06-24)
The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzyme and the anti-cytokeratin8 (K8) antibody, using liposome-based formulation.
Nick Frazier et al.
Molecular pharmaceutics, 12(5), 1605-1614 (2015-04-04)
Previously, water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been used with gold nanorod (GNR) mediated plasmonic photothermal therapy (PPTT) to induce hyperthermia (43 °C for 10 min) and have been shown to improve delivery of hydrophobic drugs to treat cancer. However, it
Shuzhong Zhang et al.
Frontiers in immunology, 11, 1871-1871 (2020-09-26)
Macrophage dysfunction is fundamentally related to altered immunity in cystic fibrosis (CF). How genetic deficits in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to these defects remains unknown. Rapid advances in genomic editing such as the clustered regularly interspaced
Nadia Malek Saied et al.
European journal of medicinal chemistry, 97, 280-288 (2015-05-21)
The goal of this study is to develop a novel brain receptor imaging agent. This study reports the synthesis, characterization and the biological evaluation of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99 m ((99m)Tc-MP). The (99m)Tc-MP was obtained quickly (radiolabelling time < 5 min), in 90%
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 21(12), 3591-3595 (2011-05-17)
Two new β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Salmonella enterica serovar Typhimurium, stCA 1 and stCA 2, were characterized kinetically. The two enzymes possess appreciable activity as catalysts for the hydration of CO(2) to bicarbonate, with k(cat)
Vinod Vellora Thekkae Padil et al.
Journal of agricultural and food chemistry, 63(14), 3757-3765 (2015-03-24)
Esterifications of the tree-based gum, gum karaya (GK), using dodecenylsuccinic anhydride (DDSA) were carried out in aqueous solutions. GK was deacetylated using alkali treatment to obtain deacetylated gum karaya (DGK). The DGK and its DDSA derivative were characterized using gel
Hanieh Shirazi et al.
Beilstein journal of nanotechnology, 6, 1677-1689 (2015-10-02)
The unique properties and applications of iron oxide and Au nanoparticles have motivated researchers to synthesize and optimize a combined nanocomposite containing both. By using various polymers such as chitosan, some of the problems of classic core-shell structures (such as
Gel polymer electrolyte based on poly (acrylonitrile-co-styrene) and a novel organic iodide salt for quasi-solid state dye-sensitized solar cell
Wu J, et al.
Electrochimica Acta, 51(20), 4243-4249 (2006)
Bert Wouters et al.
Journal of chromatography. A, 1370, 63-69 (2014-12-03)
The gradient-performance limits of capillary ion chromatography have been assessed at maximum system pressure (34.5 MPa) using capillary columns packed with 4.1 μm macroporous anion-exchange particles coated with 65 nm positively-charged nanobeads. In analogy to the van-Deemter curve, the gradient
Panayota Kolypetri et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 96-101 (2014-06-01)
Enhanced iodide ingestion is known to accelerate the incidence and severity of spontaneous autoimmune thyroiditis [iodide-accelerated spontaneous autoimmune thyroiditis (ISAT)] in NOD.H2(h4) mice. CD4+ cells are required for the development and maintenance of ISAT, but their target epitopes remain unknown.
Amita Datta-Mannan et al.
mAbs, 7(3), 483-493 (2015-02-20)
Lowering the isoelectric point (pI) through engineering the variable region or framework of an IgG can improve its exposure and half-life via a reduction in clearance mediated through non-specific interactions. As such, net charge is a potentially important property to
Hyojung Cha et al.
ACS applied materials & interfaces, 6(18), 15774-15782 (2014-08-26)
The molecular packing structures of two conjugated polymers based on alkoxy naphthalene, one with cyano-substituents and one without, have been investigated to determine the effects of electron-withdrawing cyano-groups on the performance of bulk-heterojunction solar cells. The substituted cyano-groups facilitate the
M E Manley et al.
Scientific reports, 1, 4-4 (2012-02-23)
Intrinsic localized modes (ILMs) - also known as discrete breathers - are localized excitations that form without structural defects in discrete nonlinear lattices. For crystals in thermal equilibrium ILMs were proposed to form randomly, an idea used to interpret temperature
Suyitno Suyitno et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 148, 99-104 (2015-04-16)
The present article reports on the enhancement of the performance and stability of natural dye-based dye-sensitized solar cells (DSSCs). Natural dyes extracted from papaya leaves (PL) were investigated as sensitizers in TiO2-based DSSCs and evaluated in comparison with N719 dye.
Timothy D Kayes et al.
Cellular immunology, 285(1-2), 84-91 (2013-10-19)
IFN-γ(-/-) NOD.H-2h4 mice develop a spontaneous autoimmune thyroid disease, thyroid epithelial cell hyperplasia and proliferation (TEC H/P) when given NaI in their water for 7+ mo. TEC H/P can be transferred to IFN-γ(-/-) SCID mice by splenocytes from mice with
Peter Volkovitsky et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 70(9), 2037-2042 (2012-03-20)
Detection of two and more γ-rays in coincidence by two NaI(Tl) detectors with almost 4π geometry allows absolute characterization of radionuclides emitting coincidence gammas. The method is a generalization of the Eldridge-Crowther method developed originally for x-rays and low energy
Peter Burghout et al.
Bioorganic & medicinal chemistry, 19(1), 243-248 (2010-12-18)
The Gram-positive bacterium Streptococcus pneumoniae is a human respiratory tract pathogen that contributes significantly to global mortality and morbidity. It was recently shown that this bacterial pathogen depends on a conserved β-carbonic anhydrase (CA, EC 4.2.1.1) for in vitro growth
Zi-Ming Zhao et al.
Chemical & pharmaceutical bulletin, 63(3), 180-186 (2015-03-12)
Two types of amphoteric calix[n]arene carboxylic acid (CnCA) derivative, i.e., calix[6]arene hexa-carboxylic acid (C6HCA) and calix[8]arene octo-carboxylic acid (C8OCA), were synthesized by introducing acetoxyls into the hydroxyls of calix[n]arene (n=6, 8). C6HCA and C8OCA nanoparticles (NPs) were prepared successfully using
Yayoi S Kikkawa et al.
Journal of translational medicine, 12, 280-280 (2014-10-05)
A cochlear implant (CI) is an artificial hearing device that can replace a damaged cochlea. The present study examined the use of growth factor-eluting gelatin hydrogel coatings on the electrodes to minimize inner ear trauma during electrode insertion. Insulin-like growth
Neeta Pandit-Taskar et al.
EJNMMI research, 5, 28-28 (2015-05-20)
J591 is a monoclonal antibody that targets the external domain of the prostate-specific membrane antigen (PSMA). Besides prostate cancer cells, it also targets the neovasculature of non-prostate solid tumors. We provide an analysis of the antibody mass-dose dependency of lesion
Anna Ohradanova et al.
Bioorganic & medicinal chemistry letters, 22(3), 1314-1316 (2012-01-10)
An α-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex anions and other small molecules known to interact with these zinc enzymes. Astrosclerin is
Małgorzata Wolny et al.
Endokrynologia Polska, 58(6), 512-521 (2008-01-22)
The sodium iodide symporter, called also the NIS protein is responsible for iodine trapping to the cell what is significant for the thyroid function. Identified and described for the first time in 1996 NIS protein is the matter of interest
Immacolata Venditto et al.
Acta crystallographica. Section F, Structural biology communications, 71(Pt 6), 784-789 (2015-06-10)
A number of anaerobic microorganisms produce multi-modular, multi-enzyme complexes termed cellulosomes. These extracellular macromolecular nanomachines are designed for the efficient degradation of plant cell-wall carbohydrates to smaller sugars that are subsequently used as a source of carbon and energy. Cellulolytic
Iodine and iodine compounds
Lyday PA and Kaiho T
Ullmann's Encyclopedia of Industrial Chemistry, 1-13 (2000)
Chul-Young Yi et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 70(9), 2133-2136 (2012-03-20)
Response functions of a 7.62 cm-diameter spherical NaI(Tl) detector to gamma-ray point sources in the energy range up to 1.5 MeV were calculated by means of the Monte Carlo method using PENELOPE-2006 (Salvat et al., 2006). The detector materials and
Nan Zhang et al.
Pharmaceutical research, 31(9), 2326-2334 (2014-03-07)
To evaluate the therapeutic efficacy of dexamethasone (DM) and methotrexate (MTX) entrapped within polysialic acid (PSA)-trimethyl chitosan (TMC) nanoparticles using an in vitro model of rheumatoid arthritis (RA). The loading capacity of the PSA-TMC nanoparticles was determined. An RA in
Caroline Barrère et al.
Rapid communications in mass spectrometry : RCM, 26(11), 1347-1354 (2012-05-05)
Polyamides (PA) belong to the most used classes of polymers because of their attractive chemical and mechanical properties. In order to monitor original PA design, it is essential to develop analytical methods for the characterization of these compounds that are
Alessandra Cincinelli et al.
Bioorganic & medicinal chemistry, 19(6), 1847-1851 (2011-03-08)
A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity for the physiologic CO(2) hydration to bicarbonate reaction, similar to that
John Metyko et al.
Health physics, 103(5 Suppl 3), S204-S208 (2012-10-17)
Yittrium-90 microsphere brachytherapy procedures have increased in number due to their efficacy in treating some unresectable metastatic liver tumors. The discovery of long-lived impurities in two microsphere products, first reported between 2006 and 2007, has resulted in some radiation safety
Page 1 of 4
Page 1 of 4