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Peng Zhang et al.
Journal of clinical pharmacology, 50(8), 858-860 (2010-02-13)
Prolonged prosthetic life span is a goal that orthopedic surgeons are pursuing. Both septic and aseptic loosening may lead to prosthetic failure. For decades, antibiotics have been applied in arthroplasty to prevent septic loosening, with excellent clinical results, although few
Yaoquan Liu et al.
Bioorganic & medicinal chemistry letters, 20(19), 5658-5661 (2010-08-31)
A series of 9-dihydroerythromycin A and B analogues with modification of the desosamine nitrogen have been synthesized and screened for motilin agonist activity, antibiotic activity, tachyphylaxis and hERG channel current inhibition. Small alkyl groups resulted in the potency while compounds
Zuzana Svetlíková et al.
Antimicrobial agents and chemotherapy, 53(9), 4015-4018 (2009-07-08)
Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin
Sarbani Mohan et al.
Molecular immunology, 62(1), 249-264 (2014-07-22)
Streptococcus pneumoniae is a Gram-positive bacterium, causing acute sinusitis, otitis media, and severe diseases such as pneumonia, bacteraemia, meningitis and sepsis. Here we identify elongation factor Tu (Tuf) as a new Factor H binding protein of S. pneumoniae. The surface
Stephen J Baker et al.
Bioorganic & medicinal chemistry letters, 16(23), 5963-5967 (2006-09-26)
A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and -negative bacteria. Our lead compounds were then screened for anti-inflammatory activity. From these studies, we identified 3-hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)borane (2g, AN0128) as
James J Leyden
Journal of drugs in dermatology : JDD, 11(12), 1434-1438 (2013-02-05)
To quantify the antimicrobial effect of clindamycin phosphate 1.2% and tretinoin 0.025% gel and 1% clindamycin phosphate gel in patients with Propionibacterium acnes of varying sensitivity to clindamycin. Study 1 was an initial range-finding study that was neither blinded nor
Yaya Rukayadi et al.
Antimicrobial agents and chemotherapy, 53(10), 4529-4532 (2009-08-05)
In vitro antistaphylococcal activities of panduratin A, a natural chalcone compound isolated from Kaempferia pandurata Roxb, were compared to those of commonly used antimicrobials against clinical staphylococcal isolates. Panduratin A had a MIC at which 90% of bacteria were inhibited
Kevin A Nash et al.
Antimicrobial agents and chemotherapy, 53(4), 1367-1376 (2009-01-28)
Mycobacterium abscessus infections tend to respond poorly to macrolide-based chemotherapy, even though the organisms appear to be susceptible to clarithromycin. Circumstantial evidence suggested that at least some M. abscessus isolates might be inducibly resistant to macrolides. Thus, the purpose of
Giovanni Appendino et al.
Journal of natural products, 71(8), 1427-1430 (2008-08-07)
Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Henrik Kempe et al.
Pharmaceutical research, 32(2), 375-388 (2014-08-12)
To develop and evaluate molecularly imprinted nanocarriers for sustained release of erythromycin in physiological buffer media. Erythromycin-imprinted poly(methacrylic acid-co-trimethylolpropane trimethacrylate) nanocarriers and corresponding control nanocarriers were prepared by free-radical precipitation polymerization. The nanocarriers were characterized by transmission electron microscopy, dynamic
Christiane Gaudreau et al.
Antimicrobial agents and chemotherapy, 52(12), 4475-4477 (2008-10-08)
With disk diffusion, the following zone diameters are suggested to be resistant and susceptible breakpoints, respectively: for susceptibility testing of Campylobacter coli, no inhibition zone and 15 mm or more for erythromycin, and 20 mm or less and 25 mm
Amera Gibreel et al.
Antimicrobial agents and chemotherapy, 51(9), 3212-3216 (2007-07-04)
We investigated the involvement of the CmeABC efflux pump in acquired resistance of Campylobacter jejuni to macrolides and tetracycline. Inactivation of the cmeB gene had no effect on macrolide resistance when all copies of the target gene carried an A2074C
Ken-ichi Nakao et al.
Antimicrobial agents and chemotherapy, 53(12), 5308-5311 (2009-09-30)
Antimicrobial susceptibilities of 23 strains of Desulfovibrio spp. were tested by Etest. Generally, Desulfovibrio spp. were highly susceptible to sulbactam-ampicillin, meropenem, clindamycin, metronidazole, and chloramphenicol: MIC(90)s of 6, 4, 0.19, 0.25, and 8 microg/ml, respectively. In addition, these strains generally
Yasuki Yasuda et al.
Antimicrobial agents and chemotherapy, 51(5), 1741-1752 (2007-03-14)
Sub-MIC levels of macrolides down-regulate bacterial virulence factors and suppress inflammatory processes. The ability of macrolides to reduce the production of pneumolysin has been shown to explain the discrepancy between in vitro resistance and outcomes with macrolides against macrolide-resistant Streptococcus
Lincomycin versus erythromycin: a choice or an echo.
E Sanders
Annals of internal medicine, 70(3), 585-590 (1969-03-01)
Xiaodong Ma et al.
Current medicinal chemistry, 18(13), 1993-2015 (2011-04-27)
As a well-established class, macrolide antibiotics continue to enjoy a remarkable interest within pharmaceutical industry. Several stunning breakthroughs in semi-synthetic study of erythromycin A (EMA) contribute to the important role played by the macrolide class in search for new anti-infectious
Christina S Hölzel et al.
Antimicrobial agents and chemotherapy, 54(3), 1351-1353 (2010-01-13)
Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new
Noureddin Nakhostin Ansari et al.
Physiotherapy theory and practice, 31(3), 166-172 (2014-12-17)
Therapeutic ultrasound, an important physiotherapy modality, has been used successfully in the treatment of patients with chronic rhinosinusitis (CRS). No study has compared pulsed ultrasound (PUS) with erythromycin phonophoresis (EP). The aim of this randomized, double-blind, parallel group study with
Tom D Heightman et al.
Bioorganic & medicinal chemistry letters, 18(24), 6423-6428 (2008-11-05)
High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure-activity relationship
Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance.
Caroline Wehmeier et al.
Antimicrobial agents and chemotherapy, 53(1), 329-330 (2008-10-22)
C R Bourne et al.
Antimicrobial agents and chemotherapy, 54(9), 3825-3833 (2010-07-08)
The bacterial burden on human health is quickly outweighing available therapeutics. Our long-term goal is the development of antimicrobials with the potential for broad-spectrum activity. We previously reported phthalazine-based inhibitors of dihydrofolate reductase (DHFR) with potent activity against Bacillus anthracis
Anna Fàbrega et al.
Antimicrobial agents and chemotherapy, 54(3), 1218-1225 (2009-12-17)
Elevated levels of fluoroquinolone resistance are frequently found among Escherichia coli clinical isolates. This study investigated the antibiotic resistance mechanisms of strain NorE5, derived in vitro by exposing an E. coli clinical isolate, PS5, to two selection steps with increasing
Radosław Izdebski et al.
Antimicrobial agents and chemotherapy, 51(4), 1155-1163 (2007-01-11)
The frequency of tetracycline resistance in Streptococcus pneumoniae isolates in Poland is one of the highest in Europe. The aim of this study was to analyze the clonal diversity and resistance determinants of tetracycline-nonsusceptible S. pneumoniae isolates identified in Poland
J Hummelova et al.
Letters in applied microbiology, 60(3), 242-247 (2014-11-26)
In this study, we tested 15 naturally occurring isoflavones and their metabolites for their possible antibacterial properties against nine Gram-positive and Gram-negative bacteria. The in vitro antibacterial activity was determined using the broth microdilution method, and the results were expressed
Macrolides and bronchiectasis: clinical benefit with a resistance price.
J Stuart Elborn et al.
JAMA, 309(12), 1295-1296 (2013-03-28)
Alexander Hahn et al.
The Journal of biological chemistry, 288(43), 31192-31205 (2013-09-10)
The TolC-like protein HgdD of the filamentous, heterocyst-forming cyanobacterium Anabaena sp. PCC 7120 is part of multiple three-component "AB-D" systems spanning the inner and outer membranes and is involved in secretion of various compounds, including lipids, metabolites, antibiotics, and proteins.
Holger Fischer et al.
Journal of medicinal chemistry, 55(1), 126-139 (2011-11-30)
Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids.The in silico method described utilizes the amphiphilic moment ΔΔG(AM) (kJ/mol) together with basic pK(a) values to assign PLD inducing
Dave Bryson Caldwell et al.
Antimicrobial agents and chemotherapy, 52(11), 3947-3954 (2008-09-10)
Previous studies of macrolide resistance in Campylobacter were primarily focused on strains from various origins or used in vitro systems. In this study, we conducted both in vitro and in vivo experiments to examine the development, stability, and genetic basis
C Nagelreiter et al.
International journal of pharmaceutics, 478(2), 429-438 (2014-12-06)
In order to customise treatment for patients, topical formulations are often diluted with drug-free cream bases to adjust the drug dose and thereby the formulations' activity to the patients' needs. However, the process of dilution influences properties of the formulations.
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