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466123

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Silke Schlaubitz et al.
PloS one, 9(10), e110251-e110251 (2014-10-21)
The repair of bone defects is of particular interest for orthopedic, oral, maxillofacial, and dental surgery. Bone loss requiring reconstruction is conventionally addressed through bone grafting. Depending on the size and the location of the defect, this method has limits
Mehrorang Ghaedi et al.
Journal of chromatographic science, 53(7), 1222-1231 (2015-02-01)
A novel vortex-assisted surfactant-enhanced dispersive liquid-liquid microextraction combined with high-performance liquid chromatography (VASEDLLME-HPLC) was developed for the determination of thymol and carvacrol (phenolic compound). In this method, the extraction solvent (CHCl3) was dispersed into the aqueous samples via a vortex
Liyun Ma et al.
Journal of chromatography. A, 1376, 64-73 (2014-12-22)
Cucurbit[7]uril (CB7), one host macromolecule, possesses a hydrophobic inner cavity and two identical hydrophilic carbonyl fringe portals, thus interacting with a variety of guest molecules through hydrophobic, hydrogen bonding and ion-dipole interactions. These characteristics make CB7 a good candidate as
Shuliang Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 183(9), 5537-5547 (2009-10-09)
Citrobacter koseri is a Gram-negative bacterium that can cause a highly aggressive form of neonatal meningitis, which often progresses to establish multifocal brain abscesses. Despite its tropism for the brain parenchyma, microglial responses to C. koseri have not yet been
Shailendra Asthana et al.
Journal of agricultural and food chemistry, 63(32), 7236-7244 (2015-08-12)
The structure-activity relationships of four hydroxycoumarins, two with the hydroxyl group on the aromatic ring of the molecule and two with the hydroxyl group replacing hydrogen of the pyrone ring, and their interactions with mushroom tyrosinase were studied. These compounds
Ariene A Leme et al.
Journal of biomechanics, 48(10), 2067-2071 (2015-04-15)
Degradation of the adhesive interface contributes to the failure of resin composite restorations. The hydrophilicity of the dentin matrix during and after bonding procedures may result in an adhesive interface that is more prone to degradation over time. This study
Theresa A Isbell et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 65-71 (2015-01-16)
The determination of morphine and its isobaric metabolites morphine-3-beta-d-glucuronide (M3G) and morphine-6-beta-d-glucuronide (M6G) is useful for therapeutic drug monitoring and forensic identification of drug use. In particular, capillary electrophoresis with mass spectrometry (CE-MS) represents an attractive tool for opioid analysis.
María González-Núñez et al.
Disease models & mechanisms, 8(11), 1427-1439 (2015-09-24)
The activin receptor-like kinase 1 (ALK-1) is a type I cell-surface receptor for the transforming growth factor-β (TGF-β) family of proteins. Hypertension is related to TGF-β1, because increased TGF-β1 expression is correlated with an elevation in arterial pressure (AP) and
G P Lv et al.
Journal of pharmaceutical and biomedical analysis, 109, 105-111 (2015-03-15)
It was shown that different extracts had significant differences in the toxicity of Polygonum multiflorum. In this study, the effect of sample preparation on components and liver toxicity of different extracts from P. multiflorum were determined. Hepatoxic components were discovered
Juan L Benedé et al.
Talanta, 147, 246-252 (2015-11-26)
In this work, a new approach that combines the advantages of stir bar sorptive extraction (SBSE) and dispersive solid phase extraction (DSPE), i.e. stir bar sorptive-dispersive microextraction (SBSDµE), is employed as enrichment and clean-up technique for the sensitive determination of
F Munarin et al.
International journal of biological macromolecules, 72, 199-209 (2014-08-12)
Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, specific
Changyong Yim et al.
Scientific reports, 5, 10674-10674 (2015-06-04)
Nanoporous anodic aluminum oxide (AAO) microcantilevers are fabricated and MIL-53 (Al) metal-organic framework (MOF) layers are directly synthesized on each cantilever surface by using the aluminum oxide as the metal ion source. Exposure of the MIL53-AAO cantilevers to various concentrations
Rushd Khalaf et al.
Journal of chromatography. A, 1397, 11-18 (2015-05-03)
The purification of therapeutic peptides is most often performed using one or more reversed phase chromatography steps. This ensures high purities while keeping the costs of purification under control. In this paper, a doped reversed phase chromatographic material is tested
P Kannampalli et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1694-1704 (2014-10-10)
Increasing evidence indicates a positive effect of probiotics on the nervous system. The objective of this study was to determine if probiotic Lactobacillus rhamnosus GG (LGG) and/or prebiotics polydextrose/galactooligosaccharide (PDX/GOS) can alter the colonic sensitivity in a neonatal rat model
Bo Tian et al.
Journal of materials science. Materials in medicine, 25(9), 2059-2068 (2014-05-27)
In order to improve the biocompatibility of metallic implants, bioactive components are often used as coatings so that a real bond with the surrounding bone tissue can be formed. We prepared ethyl cellulose/carbonated hydroxyapatite composite coatings (ECHCs) on Ti6Al4V substrates
Iara Maíra de Oliveira Viana et al.
Journal of pharmaceutical and biomedical analysis, 96, 241-248 (2014-05-02)
In this study, a simple method using microextraction by packed sorbent and high-performance liquid chromatography with ultraviolet detection for simultaneous determination of chlorpropamide, gliclazide and glimepiride in human plasma was developed and validated. A fractional factorial design and a complete
Min-Yu Chung et al.
Journal of medicinal food, 18(11), 1198-1206 (2015-04-04)
A number of compounds isolated from mushrooms have exhibited disease-modifying effects. We sought to investigate the mechanisms responsible for the anti-inflammatory effects of an extract from the mushroom species Sarcodon asparatus (SAE). Male BALB/c mice (N=42; 6 weeks old) were
Małgorzata Anita Bryszewska et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 91-98 (2014-12-04)
In this study, we investigate the type and quantity of selenium compounds in fish and marine organisms, using ion-pair reversed phase LC–ICP-MS, developed and applied for the analysis of Atlantic cod, Atlantic salmon, Greenland halibut, Atlantic herring, blue mussel, common
Axel Andrés et al.
Journal of chromatography. A, 1385, 42-48 (2015-02-11)
Retention of ionizable analytes under gradient elution depends on the pH of the mobile phase, the pKa of the analyte and their evolution along the programmed gradient. In previous work, a model depending on two fitting parameters was recommended because
Jack L Ferracane et al.
The journal of adhesive dentistry, 15(5), 407-412 (2013-04-06)
To evaluate the potential for phosphoric acid solutions - common constituents of dental adhesive systems - of varying pH to solubilize dentin matrix components (DMCs) from human dentin. Human dentin chips were ground under liquid nitrogen to a powder (ca
Yun Jeong Kim et al.
PloS one, 10(4), e0120840-e0120840 (2015-04-09)
Botulinum neurotoxin type A (BoNT/A) is the most potent protein toxin and causes fatal flaccid muscle paralysis by blocking neurotransmission. Application of BoNT/A has been extended to the fields of therapeutics and biodefense. Nevertheless, the global response of host immune
Sheila Pestana Passos et al.
The journal of adhesive dentistry, 15(5), 461-466 (2013-04-18)
To evaluate the microtensile bond strength (MTBS) of ceramic cemented to dentin varying the resin cement and ceramic shades. Two VITA VM7 ceramic shades (Base Dentine 0M1 and Base Dentine 5M3) were used. A spectrophotometer was used to determine the
Kolasani Srinivasa Rao et al.
The journal of contemporary dental practice, 14(1), 21-25 (2013-04-13)
The acid pretreatment and use of composite resins as the bonding medium has disadvantages like scratching and loss of surface enamel, decalcification, etc. To overcome disadvantages of composite resins, glass ionomers and its modifications are being used for bonding. The
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
S Schrank et al.
International journal of pharmaceutics, 478(2), 779-787 (2014-12-21)
Although drying is widely applied during the manufacturing of solid dosage forms, its potential effect on the product's (key) properties is often underestimated. Hence, the present study addresses drying related modifications of wet-extruded pellets comprising calcium stearate (CaSt, matrix former)
Jafar Nikbakht et al.
Pharmacological reports : PR, 67(6), 1061-1067 (2015-10-21)
Bleomycin (BLM), a chemotherapeutic agent is indicated in the management of some types of cancers. This drug produces a dose-dependent pulmonary fibrosis (PF) in most patients as well as experimental animals through oxidative injury. This study aimed to investigate the
Mahmoud Alebouyeh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 40-44 (2014-12-02)
A simple and rapid high-performance liquid chromatographic method with spectrophotometric detection was developed for the determination of lamivudine in human plasma. Sample preparation was accomplished through protein precipitation with acetonitrile followed by aqueous phase separation using dichloromethane. Lamivudine and the
Honghong Yao et al.
Nature communications, 5, 4386-4386 (2014-07-16)
Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a
Laura E Sidney et al.
Tissue engineering. Part A, 21(1-2), 362-373 (2014-08-12)
Nonunion fractures and large bone defects are significant targets for osteochondral tissue engineering strategies. A major hurdle in the use of these therapies is the foreign body response of the host. Herein, we report the development of a bone tissue
Lucy G Chastain et al.
Behavioural brain research, 280, 160-171 (2014-12-03)
Schizophrenia is thought to be caused, at least in part, by dysfunction in striatal dopamine neurotransmission. Both clinical studies and animal research have implicated the dopamine neuromodulator neurotensin (NT) in the pathophysiology of schizophrenia. Utilizing male mice lacking the NT
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