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Liang Ye et al.
Pakistan journal of pharmaceutical sciences, 26(2), 315-322 (2013-03-05)
Acetylcholinesterase inhibitors (AChEIs), including Huperzine A (HupA), have been the mainstay of treatment for Alzheimer's disease (AD). However, AChEIs can cause gastrointestinal side effects, which has been related to the high Cmax and short tmax after oral administration. Clinical trials
Wen Jen Lin et al.
Expert opinion on drug delivery, 11(10), 1537-1550 (2014-06-21)
The aim of this study was to develop the hexapeptide-conjugated active targeting micelles for delivery of doxorubicin (DOX) and paclitaxel (PTX) to EGFR high-expressed cancer cells. A hexapeptide, which mimicked the EGFR, was applied as a targeting ligand. The active
B H Laster et al.
Journal of cancer research and clinical oncology, 141(1), 23-34 (2014-07-31)
Telomerase activation and an alternative lengthening of telomeres (ALT) mechanism are two telomere-lengthening cancer cell survival mechanisms elicited by both chemo- and/or radiotherapy. Telomere lengthening interferes with cell lethality and results in the immortalization of cancer cells. To counteract these
K A Athanasiou et al.
Biomaterials, 17(2), 93-102 (1996-01-01)
This is a review of salient studies of sterilization, toxicity, biocompatibility, clinical applications and current work in the field of orthopaedics, using implants made of polylactic acid (PLA), polyglycolic acid (PGA) and their copolymers. The intrinsic nature of these biomaterials
Seong J Cho et al.
Journal of nanoscience and nanotechnology, 12(12), 9047-9050 (2013-03-02)
Controlling the architecture of electrospun fibers is one of the key issues in tissue engineering. This report describes a rapid and reproducible patterning method for the fabrication of an electrospun fibrous scaffold. The electrospun fibers were deposited on a patterned
Huaping Chen et al.
Biomaterials, 34(16), 4159-4172 (2013-03-14)
The absence of safe, efficient, cost-effective, and easily scalable delivery platforms is one of the most significant hurdles and critical issues that limit the bench to bedside translation of oligonucleotides-based therapeutics. Acid-labile materials are of special interest in developing nonviral
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.
Shuang Hou et al.
Angewandte Chemie (International ed. in English), 52(12), 3379-3383 (2013-02-26)
Jian Zhao et al.
The Journal of surgical research, 187(2), 394-402 (2013-11-28)
The transmural biodegradable polycaprolactone/poly(D,L-lactic/glycolic acid) (PCL/PLGA) scaffold is a promising modality for diffuse coronary atherosclerosis cases that are not suitable for bypass grafting. The purpose of this study was to evaluate the long-term performance of the PCL/PLGA scaffold in vivo in
Jun-Hua Wei et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(8), 1160-1164 (2013-08-16)
To prepare ligustrazine (TMPZ) ocular sustained-release implant, and investigate its in vitro drug release, pharmacokinetics in rabbit vitreum and in vitro correlation. Ligustrazine ocular sustained-release implants were prepared by micro-twin conical screw mixers with hot-melting extrusion method, with polyactic-co-glycolic acid
M A Tiunin et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(1), 3-6 (2013-03-07)
Technological parameters for the effective encapsulation of n-(1-phenethyl-4-piperidyl)propionanilide in poly(lactid-co-glycolide) (PLG) nanoparticles have been determined. Depending on the ratio of drug fractions adsorbed on the particle surface and associated with the polymer matrix, n-(1-phenethyl-4-piperidyl)propionanilide (200 microg/kg, i/m) loaded PLG nanospheres
Per Aspenberg
Acta orthopaedica, 85(6), 687-690 (2014-10-29)
Due to the known drawbacks of metal implants, new biomaterials for internal fracture fixation are attracting increasing interest, among them poly(lactic-co-glucolic) acids (PLGAs) and the recently developed silk-tenoin derived materials (STDMs). In accordance with the new philosophy of bio-derived biomaterials
Daniel E Levin et al.
Methods in molecular biology (Clifton, N.J.), 1001, 299-309 (2013-03-16)
Here, we describe the use of a mouse model as a living bioreactor for the generation of tissue-engineered small intestine. Small intestine is harvested from donor mice with subsequent isolation of organoid units (a cluster of mesenchymal and epithelial cells).
P R Arany et al.
Journal of dental research, 93(12), 1250-1257 (2014-08-22)
Tissue loss due to oral diseases requires the healing and regeneration of tissues of multiple lineages. While stem cells are native to oral tissues, a current major limitation to regeneration is the ability to direct their lineage-specific differentiation. This work
Toyin A Knight et al.
Methods in molecular biology (Clifton, N.J.), 1001, 179-188 (2013-03-16)
A tissue-engineered product needs to be properly characterized in order to be used in vivo. Many methods can be used to characterize a scaffold during creation of a tissue-engineered product. This chapter looks at the mechanical (tensile testing) and biological
A M Ribeiro et al.
Journal of biomedical nanotechnology, 9(2), 221-230 (2013-05-01)
Vaccines play an essential role in keeping humans healthy. Innovative approaches to their use include the utilization of plasmid DNA encoding sequences to express foreign antigens. DNAhsp65 from Mycobacterium leprae is suitable for this purpose due to its ability to
Gurinder Singh et al.
Expert opinion on drug delivery, 11(5), 647-659 (2014-03-26)
Trans-resveratrol (t-RVT) is a potent antioxidant. The drug suffers enterohepatic recirculation and extensive first-pass metabolism by CYP3A4 in liver, resulting in very low bioavailability (almost zero). The current studies entail a novel formulation approach to develop systematically optimized (OPT) nanoparticles
Archana Swami et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10287-10292 (2014-07-02)
Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability and microenvironment-induced resistance. Herein, we engineered bone-homing
Kevin S Tang et al.
Nanotechnology, 24(12), 125101-125101 (2013-03-06)
Magnetic PLGA nanoparticles are a significant advancement in the quest to translate MRI-based cell tracking to the clinic. The benefits of these types of particles are that they encapsulate large amounts of iron oxide nanocrystals within an FDA-approved polymer matrix
Seokkee Lee et al.
The Annals of thoracic surgery, 95(6), 1919-1923 (2013-04-30)
Various procedures have been performed to decrease the incidence of recurrent postoperative pneumothorax after thoracoscopic bullectomy. The purpose of this study was to determine the efficacy of a polyglycolic acid (PGA) sheet and pleural abrasion for prevention of recurrent postoperative
Julia Schneider et al.
Langmuir : the ACS journal of surfaces and colloids, 29(12), 4092-4095 (2013-02-27)
When polymeric nanoparticles (NPs) are formed by nanoprecipitation, which is a nucleation-growth process, the control over size requires changing the polymer concentration or solvent composition. Here, we demonstrate that the NP size can be controlled independent of polymer variables by
Nicole Y C Yu et al.
European cells & materials, 25, 190-203 (2013-02-28)
We describe two studies encompassing the iterative refinement of a polymer-based rhBMP-2 delivery system for bone tissue engineering. Firstly, we compared the bone-forming capacity of porous poly(D,L-lactic-co-glycolic acid) (PLGA) scaffolds produced by thermally induced phase separation (TIPS) with non-porous solvent
Roshan Pradhan et al.
Journal of nanoscience and nanotechnology, 13(8), 5948-5956 (2013-07-26)
In the present study, we developed novel docetaxel (DTX)-loaded polylactic acid-co-glycolic acid (PLGA) nanoparticles (NPs) using the combination of sodium lauryl sulfate (SLS) and poloxamer 407, the anionic and non-ionic surfactants respectively for stabilization. The NPs were prepared by emulsification/solvent
Xiaoxin Zheng et al.
Journal of biomedical nanotechnology, 10(6), 900-910 (2014-04-23)
Biodegradable polymers used as vascular stent coatings and stent platforms encounter a major challenge: biocompatibility in vivo, which plays an important role in in-stent restenosis (ISR). Co-formulating amorphous calcium phosphate (ACP) into poly(lactic-co-glycolic acid) (PLGA) or poly-L-lactic acid (PLLA) was
Chen Zong et al.
Journal of biomedical nanotechnology, 10(6), 1091-1104 (2014-04-23)
Copolymer composite scaffolds and bioceramic/polymer composite scaffolds are two representative forms of composite scaffolds used for bone tissue engineering. Studies to compare biocompatibility and bone-repairing effects between these two scaffolds are significant for selecting or improving the scaffold for clinical
K S Snima et al.
Journal of biomedical nanotechnology, 10(4), 559-570 (2014-04-17)
Silymarin, a clinically proved hepato-protective herbal drug having significant anti-cancerous property towards prostate cancer, is inadequately utilized for cancer therapy due to its hydrophobic nature and poor bioavailability. In this work, we have developed silymarin Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs)
Jason D Wink et al.
Plastic and reconstructive surgery, 134(1), 51-59 (2014-03-14)
Commercially available recombinant human bone morphogenetic protein 2 (rhBMP2) has demonstrated efficacy in bone regeneration, but not without significant side effects. The authors used rhBMP2 encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres placed in a rabbit cranial defect model to test
Hiroaki Akasaka et al.
International journal of radiation oncology, biology, physics, 90(5), 1177-1185 (2014-12-30)
To evaluate the efficacy and safety of a polyglycolic acid (PGA) spacer through physical and animal experiments. The spacer was produced with surgical suture material made of PGA, forming a 3-dimensional nonwoven fabric. For evaluation or physical experiments, 150-MeV proton
Omolbanin Mirdailami et al.
Pharmaceutical development and technology, 19(5), 539-547 (2013-06-20)
The objective of this study was to prepare poly lactic-co-glycolic acid (PLGA)-based microparticles as potential carriers for recombinant human epidermal growth factor (rhEGF). In order to optimize characteristic parameters of protein-loaded microspheres, bovine serum albumin (BSA) was selected as the
Matilde Durán-Lobato et al.
Journal of biomedical nanotechnology, 10(6), 1068-1079 (2014-04-23)
This article aimed to produce, characterize and evaluate different surface-modified naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (CB13) loaded poly(lactic-co-glycolic acid) nanoparticles in order to improve their oral absorption and in vivo biodistribution. Plain and surface-modified PLGA nanoparticles were successfully prepared using a nanoprecipitation method. Chitosan
Ranjith Ramachandran et al.
Journal of biomedical nanotechnology, 10(8), 1401-1415 (2014-07-16)
Migratory capacity of cancer plays a critical role in the process of metastasis. Aberrant focal adhesions activated by the phosphorylation of Src kinase enables cancer cells to anchor on its micro-environment and migrate towards biochemically favorable niche, causing metastasis. Effective
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