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Paula Szalai et al.
Experimental cell research, 333(1), 21-38 (2015-02-17)
LC3, a mammalian homologue of yeast Atg8, is assumed to play an important part in bulk sequestration and degradation of cytoplasm (macroautophagy), and is widely used as an indicator of this process. To critically examine its role, we followed the
Ramzi N El Accaoui et al.
American journal of physiology. Heart and circulatory physiology, 306(9), H1302-H1313 (2014-03-13)
Risk factors for fibrocalcific aortic valve disease (FCAVD) are associated with systemic decreases in bioavailability of endothelium-derived nitric oxide (EDNO). In patients with bicuspid aortic valve (BAV), vascular expression of endothelial nitric oxide synthase (eNOS) is decreased, and eNOS(-/-) mice
F Buchholz et al.
Antimicrobial agents and chemotherapy, 54(1), 312-319 (2009-10-14)
Chip calorimetry is introduced as a new monitoring tool that provides real-time information about the physiological state of biofilms. Its potential for use for the study of the effects of antibiotics and other biocides was tested. Established Pseudomonas putida biofilms
Noriko Nakajima et al.
Journal of pharmacological sciences, 127(3), 339-343 (2015-04-04)
Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia. We focused on the antioxidant effects of edaravone
Shih-Feng Hsu et al.
Journal of virology, 89(7), 3671-3682 (2015-01-16)
Influenza A virus (IAV) depends on cellular factors to complete its replication cycle; thus, investigation of the factors utilized by IAV may facilitate antiviral drug development. To this end, a cellular transcriptional repressor, DR1, was identified from a genome-wide RNA
Emiliano Ricardo Vasconcelos Rios et al.
Chemico-biological interactions, 203(3), 573-579 (2013-04-09)
Citronellyl acetate (CAT), a monoterpene product of the secondary metabolism of plants, has been shown in the literature to possess several different biological activities. However, no antinociceptive abilities have yet been discussed. Here, we used acute pain animal models to
Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens.
Neus Masqué-Soler et al.
Blood, 122(11), 1985-1986 (2013-09-14)
Sayoko Kanie et al.
Urology, 82(4), 975-975 (2013-10-01)
To investigate the effects of TRK-380, a selective β3-adrenoceptor (β3-AR) agonist, on voiding behavior in rats with pollakiuria and on carbachol (CCh)-induced bladder contraction in dogs. The voiding behavior of female Sprague Dawley rats was recorded continuously with a balance.
Greta Minonzio et al.
Cryobiology, 69(2), 211-216 (2014-07-19)
In recent years, there has been a shift toward tissue-engineering strategies using stem cells for plastic and reconstructive surgical procedures. Therefore, it is important to develop safe and reproducible protocols for the extraction of adipose-derived stromal cells (ASCs) to allow
Holly A Leddy et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(6), 2525-2537 (2014-03-01)
Point mutations in the calcium-permeable TRPV4 ion channel have been identified as the cause of autosomal-dominant human motor neuropathies, arthropathies, and skeletal malformations of varying severity. The objective of this study was to determine the mechanism by which TRPV4 channelopathy
Massimiliano Secchi et al.
Antimicrobial agents and chemotherapy, 58(10), 6215-6223 (2014-08-13)
R4.0, a synthetic CCL5/RANTES-derived peptide, exerts potent anti-HIV-1 activity via its nonactivating interaction with CCR5, the major HIV-1 coreceptor. CCR5 chronic activation may promote undesirable inflammatory effects and enhance viral infection; thus, receptor antagonism is a necessary requisite. HIV-1 gp120
Alexandra Schuetz et al.
PLoS pathogens, 10(12), e1004543-e1004543 (2014-12-17)
Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell depletion, microbial translocation and subsequent immune-activation, which remain elevated despite antiretroviral therapy (ART) correlating
Hideaki Matsuo et al.
Pain, 155(9), 1888-1901 (2014-07-11)
Although transcutaneous electrical nerve stimulation (TENS) is widely used for the treatment of neuropathic pain, its effectiveness and mechanism of action in reducing neuropathic pain remain uncertain. We investigated the effects of early TENS (starting from the day after surgery)
Diogo Pestana et al.
Environmental research, 133, 170-177 (2014-06-21)
The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects
Mi Ae Kang et al.
International journal of oncology, 46(1), 342-350 (2014-10-24)
The tumor suppressor p53 plays a key role in regulation of the cell cycle, apoptosis and senescence in response to various stresses. We screened a library of 7920 chemical compounds for the p53 activator and identified N-[2-(dimethylamino)ethyl]-2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-9-carboxamide (PTP), which significantly
Afshin Amini et al.
Journal of experimental & clinical cancer research : CR, 33, 92-92 (2014-11-27)
Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing compounds with good safety profiles which have been investigated for their benefits and application in health and disease for more than fifty years. As such, the potential values of these agents in cancer
M Sałaga et al.
Journal of Crohn's & colitis, 8(9), 998-1009 (2014-02-18)
Pharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBD) is currently one of the biggest challenge in the field of gastroenterology. Available therapies are mostly limited to overcoming the symptoms, but not the cause of the disease. Recently
Michael Wolf et al.
The International journal of oral & maxillofacial implants, 29(4), 976-983 (2014-07-18)
Maxillary sinus floor augmentation is a treatment that has been proposed for patients in whom the alveolar bone height is insufficient. This procedure is commonly used in patients aged 40 to 70 years and older. However, little information exists whether
Yun Hua et al.
Assay and drug development technologies, 12(7), 395-418 (2014-09-03)
The androgen receptor-transcriptional intermediary factor 2 (AR-TIF2) positional protein-protein interaction (PPI) biosensor assay described herein combines physiologically relevant cell-based assays with the specificity of binding assays by incorporating structural information of AR and TIF2 functional domains along with intracellular targeting
Xianqing Zhang et al.
Molecular medicine reports, 10(3), 1184-1194 (2014-07-26)
The aim of the present study was to investigate the anti‑tumor effect of apogossypolone (ApoG2) on human LNCaP cells in vitro and in vivo. Cell viability was evaluated using an MTT assay. Cell autophagy and apoptosis were detected by flow
Jason D Wink et al.
Plastic and reconstructive surgery, 134(1), 51-59 (2014-03-14)
Commercially available recombinant human bone morphogenetic protein 2 (rhBMP2) has demonstrated efficacy in bone regeneration, but not without significant side effects. The authors used rhBMP2 encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres placed in a rabbit cranial defect model to test
Vokkaliga Thammegowda Harshavardhan et al.
PloS one, 9(10), e110065-e110065 (2014-10-22)
Crop plants are regularly challenged by a range of environmental stresses which typically retard their growth and ultimately compromise economic yield. The stress response involves the reprogramming of approximately 4% of the transcriptome. Here, the behavior of AtRD22 and AtUSPL1
André Kübler et al.
The Journal of pathology, 235(3), 431-444 (2014-09-05)
Active tuberculosis (TB) often presents with advanced pulmonary disease, including irreversible lung damage and cavities. Cavitary pathology contributes to antibiotic failure, transmission, morbidity and mortality. Matrix metalloproteinases (MMPs), in particular MMP-1, are implicated in TB pathogenesis. We explored the mechanisms
Gerardo Leyva-Gómez et al.
Journal of pharmaceutical sciences, 103(8), 2509-2519 (2014-06-12)
To document the efficacy of clonazepam (CLZ) either free as a solution or loaded in solid lipid nanoparticles (CLZ-SLN) or mixed micelles (CLZ-MM), the in vitro blood-brain barrier permeability of the formulations was determined. Behavior and/or electroencephalograms (EEGs) of rodents
Sarmistha Bandyopadhyay et al.
PloS one, 9(10), e109525-e109525 (2014-10-09)
Francisella tularensis is a Gram-negative, facultative intracellular pathogen that replicates in the cytosol of macrophages and is the causative agent of the potentially fatal disease tularemia. A characteristic feature of F. tularensis is its limited proinflammatory capacity, but the mechanisms
Xiao-Hua Zeng et al.
Medical oncology (Northwood, London, England), 31(9), 145-145 (2014-08-07)
The aim of this study was to determine the frequency of axillary lymph node (ALN) metastasis of early breast cancers by evaluating the status of DARC, D6 and CCX-CKR and the levels of VEGF and MMP-9. The status of DARC
Friederike Behler et al.
Infection and immunity, 83(1), 184-196 (2014-10-22)
The macrophage-inducible C-type lectin Mincle has recently been identified to be a pattern recognition receptor sensing mycobacterial infection via recognition of the mycobacterial cell wall component trehalose-6',6-dimycolate (TDM). However, its role in systemic mycobacterial infections has not been examined so
Camilia R Martin et al.
PloS one, 9(6), e98773-e98773 (2014-06-04)
The critical fatty acids Docosahexaenoic Acid (DHA) and Arachidonic Acid (AA) decline in preterm infants within the first postnatal week and are associated with neonatal morbidities, including bronchopulmonary dysplasia (BPD). DHA and AA are precursors to downstream metabolites that terminate
Lin Gao et al.
Lasers in surgery and medicine, 46(9), 679-688 (2014-10-02)
Administration of topical rapamycin (RPM) suppresses the regeneration and revascularization of photocoagulated blood vessels induced by pulsed dye laser (PDL). To systematically elucidate the molecular pathophysiology of the inhibition of PDL-induced angiogenesis by topical RPM in a rodent model. The
Markryan Dwyer et al.
Journal of innate immunity, 6(6), 765-779 (2014-05-28)
Neutrophils are the main proinflammatory cell type in chronically infected lungs of cystic fibrosis (CF) patients; however, they fail to effectively clear the colonizing pathogens. Here, we investigated the molecular composition of non-mucoid and mucoid Pseudomonas aeruginosa-induced neutrophil extracellular traps
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