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Sebastien Racinais et al.
International journal of sports physiology and performance, 9(4), 598-603 (2013-10-04)
To examine the physiological and performance responses to a heat-acclimatization camp in highly trained professional team-sport athletes. Eighteen male Australian Rules Football players trained for 2 wk in hot ambient conditions (31-33°C, humidity 34-50%). Players performed a laboratory-based heat-response test
Rosalinda Madonna et al.
Vascular pharmacology, 59(5-6), 127-130 (2013-10-22)
Sodium-hydrogen exchangers (NHE) are among the main regulators of cell volume and intracellular concentration of hydrogen and sodium ions. By indirectly affecting sodium/calcium exchange across the plasma membrane, NHE can also influence the intracellular concentration of calcium. Excess activation of
Jia-Wei Wang et al.
The Journal of surgical research, 191(2), 448-454 (2014-05-20)
A wealth of evidence from animal experiments has indicated that hypertonic saline (HS) maybe a better choice for fluid resuscitation in traumatic hypovolemic shock in comparison with conventional isotonic saline. However, the results of several clinical trials raised controversies on
Michael Biet et al.
Circulation. Arrhythmia and electrophysiology, 8(4), 912-920 (2015-06-13)
Arrhythmias associated with QT prolongation on the ECG often lead to sudden unexpected death in epilepsy. The mechanism causing a prolongation of the QT interval during epilepsy remains unknown. Based on observations showing an upregulation of neuronal sodium channels in
Umut Yucel et al.
Journal of agricultural and food chemistry, 63(34), 7494-7498 (2015-08-11)
There is a broad need to reformulate lower sodium food products without affecting their original taste. The present study focuses on characterizing the role of protein-salt interactions on the salt release in low-moisture systems and saltiness perception during hydration. Sodium
Stéphane Roger et al.
The European physical journal. E, Soft matter, 38(8), 88-88 (2015-08-13)
We present a structural and a multi-scale rheophysical investigation of magneto-sensitive materials based on biopolymers, namely aqueous solutions of sodium alginate incorporating magnetic maghemite nanoparticles, functionalized with adsorbed negative citrate ions. The large alginate ionic strength impacts the structure and
Young Jo Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(52), 20912-20917 (2013-12-11)
Biodegradable electronics represents an attractive and emerging paradigm in medical devices by harnessing simultaneous advantages afforded by electronically active systems and obviating issues with chronic implants. Integrating practical energy sources that are compatible with the envisioned operation of transient devices
Pierre Martin et al.
Chimia, 67(4), 204-206 (2013-08-24)
The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2.
Liangjie Yin et al.
Health physics, 106(6), 734-744 (2014-04-30)
Electrolyte and nutrient absorption occur in villous epithelial cells. Radiation often results in reduced electrolyte and nutrient absorption, which leads to gastrointestinal toxicity. Therefore, the authors studied: (1) radiation-induced changes in glucose and amino acid absorption across ileal tissues and
Liangjie Yin et al.
American journal of physiology. Cell physiology, 306(7), C687-C696 (2014-01-31)
The sodium-coupled glucose transporter-1 (SGLT1)-based oral rehydration solution (ORS) used in the management of acute diarrhea does not substantially reduce stool output, despite the fact that glucose stimulates the absorption of sodium and water. To explain this phenomenon, we investigated
August Wrotek et al.
Advances in experimental medicine and biology, 835, 31-36 (2014-09-26)
Copeptin has been associated with the severity of pneumonia and its complications. This study was designed to assess the usefulness of copeptin measurement in children with community-acquired pneumonia (CAP) and copeptin's relation with disease severity and sodium equilibrium. The study
Supriya S Jalimarada et al.
Investigative ophthalmology & visual science, 54(6), 4330-4340 (2013-06-08)
Mutations in SLC4A11, a member of the SLC4 superfamily of bicarbonate transporters, give rise to corneal endothelial cell dystrophies. SLC4A11 is a putative Na⁺ borate and Na⁺:OH⁻ transporter. Therefore we ask whether SLC4A11 in corneal endothelium transports borate (B[OH]₄⁻), bicarbonate
Srinivas Rengarajan et al.
American journal of physiology. Renal physiology, 306(9), F1059-F1068 (2014-03-07)
Dietary potassium loading results in rapid kaliuresis, natriuresis, and diuresis associated with reduced phosphorylation (p) of the distal tubule Na(+)-Cl(-) cotransporter (NCC). Decreased NCC-p inhibits NCC-mediated Na(+) reabsorption and shifts Na(+) downstream for reabsorption by epithelial Na(+) channels (ENaC), which
Yasser Elshahawy et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(3), 507-513 (2013-05-04)
To evaluate the individualization of dialysate sodium (Na + ) concentration in hemodialysis (HD), we studied 40 stable chronic HD patients in a single-blind crossover design. They underwent 36 consecutive HD sessions with the dialysate Na + concentration set at
Elisabeth Darrouzet et al.
Biochimica et biophysica acta, 1838(1 Pt B), 244-253 (2013-08-31)
The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. It plays a crucial role in iodine metabolism and thyroid regulation and its function is widely exploited in the diagnosis and
Zaida Andrés et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), E1806-E1814 (2014-04-16)
Stomatal movements rely on alterations in guard cell turgor. This requires massive K(+) bidirectional fluxes across the plasma and tonoplast membranes. Surprisingly, given their physiological importance, the transporters mediating the energetically uphill transport of K(+) into the vacuole remain to
Robert D Gray et al.
Journal of molecular biology, 426(8), 1629-1650 (2014-02-04)
Sequence analogs of human telomeric DNA such as d[AGGG(TTAGGG)3] (Tel22) fold into monomeric quadruplex structures in the presence of a suitable cation. To investigate the pathway for unimolecular quadruplex formation, we monitored the kinetics of K(+)-induced folding of Tel22 by
Tahir Rafique et al.
Water environment research : a research publication of the Water Environment Federation, 85(7), 579-586 (2013-08-16)
The role of seawater dilution, along with other water-quality components, has been studied to determine the causes of spatial distribution of high fluoride concentrations in the groundwater of the Diplo sub-district, Thar Desert, Pakistan. Fluoride ion concentration ranges of up
Paul A Welling
Current opinion in nephrology and hypertension, 23(1), 1-8 (2013-11-21)
Recent efforts to explore the genetic underpinnings of hypertension revealed rare mutations in kidney salt transport genes contribute to blood pressure (BP) variation and hypertension susceptibility in the general population. The current review focuses on these latest findings, highlighting a
Wei-Zhong Ying et al.
American journal of physiology. Renal physiology, 307(1), F58-F63 (2014-05-03)
The amount of Na(+) and K(+) in the diet promotes significant changes in endothelial cell function. In the present study, a series of in vitro and in vivo experiments determined the role of Na(+) and K(+) in the regulation of
Hana R Pohl et al.
Metal ions in life sciences, 13, 29-47 (2014-01-29)
Sodium and potassium are essential for human health. They are important ions in the body and are associated with many physiologic and pathophysiologic processes. The chapter summarizes the basic physiologic actions of sodium and potassium on membranes of the neurologic
The reply.
Gregor Lindner et al.
The American journal of medicine, 126(6), e15-e15 (2013-05-21)
Julijana Vuchkova et al.
American journal of physiology. Renal physiology, 307(5), F525-F532 (2014-07-06)
Albuminuria in nephrotic states is thought to arise from the formation of large pores in the glomerular capillary wall as large hydrodynamic probes, like Ficoll, have increased fractional clearance. In the present study, we tested for large pore formation in
Matthew F Rouhier et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R850-R861 (2014-07-25)
The effect of two small molecules VU342 and VU573 on renal functions in the yellow fever mosquito Aedes aegypti was investigated in vitro and in vivo. In isolated Malpighian tubules, VU342 (10 μM) had no effect on the transepithelial secretion
Jeffrey D Calhoun et al.
Handbook of experimental pharmacology, 221, 51-89 (2014-04-17)
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α subunits in brain. The other family members, β1B, β3, and β4, were identified by homology and shown to modulate sodium current in heterologous
Nicole Li et al.
American heart journal, 166(5), 815-822 (2013-11-02)
Cardiovascular diseases are the leading cause of death and disability in China. High blood pressure caused by excess intake of dietary sodium is widespread and an effective sodium reduction program has potential to improve cardiovascular health. This study is a
Hwa Yeon Yi et al.
The American journal of emergency medicine, 32(10), 1200-1207 (2014-08-26)
Unlike other sodium-channel-blocking antiarrhythmic agents, propafenone has β-blocking effects and calcium-channel-blocking effects. Yi et al recently studied insulin's treatment effect on acute propafenone toxicity in rats. However, because the degree of effectiveness of insulin compared to the previously known antidote
M Shriver et al.
Oncogene, 34(32), 4248-4259 (2014-11-11)
Obscurins, encoded by the single OBSCN gene, are giant cytoskeletal proteins with structural and regulatory roles. The OBSCN gene is highly mutated in different types of cancers. Loss of giant obscurins from breast epithelial cells confers them with a survival
Aurélien Vidal et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 101, 1-9 (2015-03-31)
The cartilage-targeting strategy is based on the strong affinity of quaternary ammonium (QA) functions for cartilage proteoglycans. We use a bifunctional agent containing QA moiety and a polyazamacrocycle structure able to complex technetium-99m. (99m)Tc-NTP 15-5 was selected for its high
Amiraj Banga et al.
American journal of physiology. Lung cellular and molecular physiology, 306(10), L937-L946 (2014-04-08)
Calu-3 is a well-differentiated human bronchial cell line with the characteristics of the serous cells of airway submucosal glands. The submucosal glands play a major role in mucociliary clearance because they secrete electrolytes that facilitate airway hydration. Given the significance
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