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493511

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Adam J Mellott et al.
Tissue engineering. Part A, 21(11-12), 1795-1809 (2015-03-12)
The transcription factor atonal homolog 1 (ATOH1) has multiple homologues that are functionally conserved across species and is responsible for the generation of sensory hair cells. To evaluate potential functional differences between homologues, human and mouse ATOH1 (HATH1 and MATH-1...
Joana Soares et al.
Pharmacological research, 95-96, 42-52 (2015-03-31)
Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for...
Eiji Tanaka
FEMS microbiology letters, 362(10) (2015-04-17)
Many phytopathogenic fungi form appressoria on some artificial substances. However, it is difficult to induce appressorium-mediated penetration into artificial substances. In the present study, novel artificial agar media were developed to investigate the in vitro penetration process of phytopathogenic fungi....
Mélanie Carquin et al.
Cellular and molecular life sciences : CMLS, 72(23), 4633-4651 (2015-06-17)
Although cholesterol is essential for membrane fluidity and deformability, the level of its lateral heterogeneity at the plasma membrane of living cells is poorly understood due to lack of appropriate probe. We here report on the usefulness of the D4...
Clare L Casteel et al.
Plant physiology, 169(1), 209-218 (2015-06-21)
Plants employ diverse responses mediated by phytohormones to defend themselves against pathogens and herbivores. Adapted pathogens and herbivores often manipulate these responses to their benefit. Previously, we demonstrated that Turnip mosaic virus (TuMV) infection suppresses callose deposition, an important plant...
Liang Chen et al.
Journal of hazardous materials, 286, 624-631 (2015-02-11)
Fluorides negatively affect the development of organisms and are a threat to human health and environmental safety. In this study, Bombyx mori N cell line (BmN) were used to explore effects of NaF on insect cells. We found that 8h...
James R Ferrell et al.
Biointerphases, 10(2), 021001-021001 (2015-03-27)
The generation of air-based plasmas under atmospheric plasma conditions was studied to assess their antimicrobial efficacy against commonly found pathogenic bacteria. The mixture of initial gases supplied to the plasma was found to be critical for the formation of bactericidal...
Evanthia Galanis et al.
Cancer research, 75(1), 22-30 (2014-11-16)
Edmonston vaccine strains of measles virus (MV) have significant antitumor activity in mouse xenograft models of ovarian cancer. MV engineered to express the sodium iodide symporter gene (MV-NIS) facilitates localization of viral gene expression and offers a tool for tumor...
H J Kim et al.
Bone & joint research, 3(3), 51-59 (2014-03-13)
Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of...
Elise Ivarsen et al.
Journal of AOAC International, 97(5), 1282-1290 (2015-04-24)
Clostridium perfringens is the causative agent of necrotic enteritis leading to significant losses in the poultry industry. Dichloromethane and n-hexane extracts of aerial parts of Artemisia annua (Asteraceae) exhibited activity against C. perfringens with minimum inhibitory concentrations (MIC) of 185...
J Reyes-Ocampo et al.
Neurotoxicology, 50, 81-91 (2015-08-10)
The kynurenines 3-hydroxyanthranilic acid (3-HANA) and its precursor 3-hydroxykynurenine (3-HK) are metabolites derived from tryptophan degradation. 3-HK, has been related to diverse neurodegenerative diseases including Huntington's, Alzheimer's and Parkinson's diseases that share mitochondrial metabolic dysregulation. Nevertheless, the direct effect of...
M A Caporizzo et al.
Langmuir : the ACS journal of surfaces and colloids, 31(10), 3027-3038 (2015-02-18)
This study systematically investigates how polymer composition changes nanoparticle (NP) grafting and diffusion in solvated random copolymer thin films. By thermal annealing from 135 to 200 °C, thin films with a range of hydrophobicity are generated by varying acrylic acid...
Janet van Eersel et al.
Neuropathology and applied neurobiology, 41(7), 906-925 (2015-03-13)
Tau becomes hyperphosphorylated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-tau), resulting in functional deficits of neurones, neurofibrillary tangle (NFT) formation and eventually dementia. Expression of mutant human tau in the brains of transgenic mice has produced different lines...
Yamila Romer et al.
The American journal of tropical medicine and hygiene, 91(6), 1156-1160 (2014-10-29)
Rickettsia parkeri, a newly recognized tick-borne pathogen of humans in the Americas, is a confirmed cause of spotted fever group rickettsiosis in Argentina. Until recently, almost all cases of R. parkeri rickettsiosis in Argentina have originated from the Paraná River...
Dae-Hee Lee et al.
PloS one, 10(3), e0117224-e0117224 (2015-03-03)
The characteristics of anterior cruciate ligament (ACL)-derived mesenchymal stem cells (MSCs), such as proportion and multilineage potential, can be affected by donor age. However, the qualitative and quantitative features of ACL MSCs isolated from younger and older individuals have not...
Huquan Yin et al.
The American journal of pathology, 185(5), 1286-1296 (2015-03-24)
Ethanol-mediated injury, combined with gut-derived lipopolysaccharide (LPS), provokes generation of proinflammatory cytokines in Kupffer cells, causing hepatic inflammation. Among the mediators of these effects, miR-217 aggravates ethanol-induced steatosis in hepatocytes. However, the role of miR-217 in ethanol-induced liver inflammation process...
Chrystalleni Hadjicharalambous et al.
Journal of biomedical materials research. Part A, 103(12), 3834-3842 (2015-06-23)
Functionalized calcium phosphate nanoparticles with osteogenic activity were prepared. Polyethyleneimine-stabilized calcium phosphate nanoparticles were coated with a shell of silica and covalently functionalized by silanization with thiol groups. Between the calcium phosphate surface and the outer silica shell, plasmid DNA...
Hiroaki Nabeka et al.
PloS one, 9(12), e110534-e110534 (2014-12-03)
Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in vivo or in vitro, is...
Nunu Huang et al.
Cancer biology & therapy, 16(6), 941-948 (2015-05-07)
It has been reported that persistent or excessive autophagy promotes cancer cell death during chemotherapy, either by enhancing the induction of apoptosis or mediating autophagic cell death. Here, we show that miR-15a and miR-16 are potent inducers of autophagy. Rictor...
Shingo Hino et al.
Bioscience, biotechnology, and biochemistry, 79(6), 992-996 (2015-03-03)
We histologically examined the effects of elemental diet (ED) on the goblet cell profile in the rat small intestine. The sulfomucin goblet cells were predominant throughout the small intestine in the control group, while sialomucin goblet cells were manifest in...
Sara Schubert et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 141-149 (2014-12-03)
Transient exposure of brown trout embryos from fertilization until hatch (70 days) to 17β-estradiol (E2) was investigated. Embryos were exposed to 3.8 and 38.0 ng/L E2 for 2h, respectively, under four scenarios: (A) exposure once at the day of fertilization...
C-Y Wang et al.
Oncogene, 34(10), 1263-1269 (2014-03-26)
The antineoplastic drug hydroxyurea (HU), when used at subtoxic doses, induces prolonged replication stress and centrosome amplification. This causes genomic instability and increases the malignancy of the recurring tumor. The mechanism of centrosome amplification induced by prolonged replication stress, however...
Ingvild Løberg Tangen et al.
European journal of cancer (Oxford, England : 1990), 50(17), 3003-3010 (2014-10-05)
In endometrial cancer loss of progesterone receptor (PR, gene name PGR) is associated with aggressive disease and altered response to hormonal treatment. The aim of this study was to investigate changes in PR expression level with disease progression, and explore...
Tricia H Smith et al.
Molecular pharmacology, 87(4), 747-765 (2015-02-07)
Cannabinoid CB1 receptors (CB1Rs) mediate the presynaptic effects of endocannabinoids in the central nervous system (CNS) and most behavioral effects of exogenous cannabinoids. Cannabinoid receptor-interacting protein 1a (CRIP1a) binds to the CB1R C-terminus and can attenuate constitutive CB1R-mediated inhibition of...
Christina Tang et al.
Colloids and surfaces. B, Biointerfaces, 133, 81-87 (2015-06-21)
We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of...
Yaxi Hu et al.
Food chemistry, 176, 123-129 (2015-01-28)
A novel biosensor combining molecularly imprinted polymers and surface-enhanced Raman spectroscopy (MIPs-SERS) determines melamine in whole milk. MIPs were synthesized by bulk polymerization of melamine (template), methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linking agent) and 2,2'-azobisisobutyronitrile (initiator). Static and...
Dan Wang et al.
Tissue engineering. Part A, 21(7-8), 1299-1308 (2015-01-22)
Craniofacial trauma is difficult to repair and presents a significant burden to the healthcare system. The inflammatory response following bone trauma is critical to initiate healing, serving to recruit inflammatory and progenitor cells and to promote angiogenesis. A role for...
Estela Giménez et al.
Journal of chromatography. A, 1410, 68-75 (2015-07-27)
Pentacyclic triterpenes are gaining interest due to their beneficial health effects, as anti-inflammatory, anti-diabetic and anti-tumoral, among others. In this study, an analytical LC-MS method was developed for the simultaneous determination of maslinic, oleanolic and ursolic acids along with erythrodiol...
Raquel García-González et al.
Talanta, 142, 11-19 (2015-05-25)
Amplification-free (referring to enzymatic amplification step) detection methodologies are increasing in biosensor development due to the need of faster and simpler protocols. However, for maintaining sensitivity without this step, highly detectable molecules or very sensitive detection techniques are required. The...
Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine...
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