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Matthew Fankhauser et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(21), 5547-5557 (2014-04-29)
It has been recognized for almost a decade that concentrations of signaling androgens sufficient to activate the androgen receptor are present in castration-resistant prostate cancer tissue. The source of these androgens is highly controversial, with three competing models proposed. We
Kalaiselvi Senthil et al.
PloS one, 10(4), e0123360-e0123360 (2015-04-16)
Free radical scavenging activity (FRSA), total phenolic content (TPC), and total flavonoid content (TFC) of in vitro cultured and field grown Withania somnifera (Ashwagandha) roots were investigated. Withanolides analysis and comprehensive metabolic profiling between 100% methanol extracts of in vitro
Rosa María González Paredes et al.
Journal of chromatography. A, 1359, 52-59 (2014-08-13)
A method based on the coupling of in situ extraction and derivatization of chlorophenols (CPs) (2-chlorophenol, 4-chloro-3-methylphenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol) from soils, accomplishing their preconcentration by means of automated microextraction by packed sorbent (MEPS), is proposed. After extraction and acylation
Marianne de Villiers et al.
The FEBS journal, 281(20), 4731-4753 (2014-08-27)
N-substituted pantothenamides are analogues of pantothenic acid, the vitamin precursor of CoA, and constitute a class of well-studied bacterial growth inhibitors that show potential as new antibacterial agents. Previous studies have highlighted the importance of pantothenate kinase (PanK; EC
Katherine Chulvi et al.
Molecules (Basel, Switzerland), 20(11), 20688-20698 (2015-11-28)
The crystal structure of two neutral triarylmethane dyes with a p-quinone methide core was determined by X-ray diffraction analysis. The spectroscopic characteristics of both compounds in 23 solvents with different polarities or hydrogen-bonding donor (HBD) abilities has been studied as
Kenji Takahashi et al.
Applied and environmental microbiology, 81(23), 8022-8036 (2015-09-13)
Sphingobium sp. strain SYK-6 is able to degrade various lignin-derived biaryls, including a phenylcoumaran-type compound, dehydrodiconiferyl alcohol (DCA). In SYK-6 cells, the alcohol group of the B-ring side chain of DCA is initially oxidized to the carboxyl group to generate
Ariel R Topletz et al.
Molecular pharmacology, 87(3), 430-441 (2014-12-11)
All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have
Deependra Kumar et al.
Bioorganic chemistry, 57, 57-64 (2014-09-16)
Some 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives were rationally designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity relationships are presented. The compounds 6g, 6h and 6e were found to be significantly active
Cunliu Zhou et al.
Pakistan journal of pharmaceutical sciences, 26(5), 1023-1025 (2013-09-17)
Berberine and palmatine are two of the main bioactive components in Huangbai, a major Chinese medicinal herb. The current methods to extract these compounds usually involving the usage of inorganic acid and base, are not only complex and time-consuming, but
Shupeng Yang et al.
Analytical and bioanalytical chemistry, 407(13), 3579-3589 (2015-03-17)
Ochratoxin A (OTA) is a mycotoxin that frequently contaminates a wide variety of food and feedstuffs. The metabolism of OTA greatly affects fate and toxicity in humans and animals, because of its possible carcinogenic character (International Agency for Research on
Ashish Punia et al.
International journal of molecular sciences, 16(10), 23867-23880 (2015-10-17)
Synthetic amphiphilic polymers have been established as potentially efficient agents to combat widespread deadly infections involving antibiotic resistant superbugs. Incorporation of poly(ethylene glycol) (PEG) side chains into amphiphilic copolymers can reduce their hemolytic activity while maintaining high antibacterial activity. Our
Rasika S Phansalkar et al.
Fitoterapia, 101, 169-178 (2014-12-30)
Grape seeds are a rich source of polyphenols, especially proanthocyanidins (PACs), and are also known for the presence of galloylated oligomeric PACs (OPACs). The present study focuses on the phytochemical methodology for grape seed (O)PACs and their potential role as
Valentina Manzo et al.
Talanta, 128, 486-492 (2014-07-26)
In this study, six non-steroidal anti-inflammatory drugs (NSAIDs) were extracted from water samples using the rotating-disk sorptive extraction (RDSE) technique. The extraction disk device contains a central cavity that allows for the incorporation of a powdered sorbent phase (Oasis™ HLB).
Yosie Andriani et al.
Molecules (Basel, Switzerland), 20(3), 4410-4429 (2015-03-12)
In vitro and in vivo studies of the activity of Phaleria macrocarpa Boerl (Thymelaeaceae) leaves against the therapeutic target for hypercholesterolemia were done using the HDL receptor (SR-BI) and hypercholesterolemia-induced Sprague Dawley rats. The in vitro study showed that the
Gisele C da Silva et al.
Food chemistry, 167, 71-77 (2014-08-26)
Two methods for the extraction, identification and quantification of the highest occurrence and lowest perception threshold off-flavours in fifteen different samples of Brazilian Pilsner beers were developed. For this purpose, headspace solid phase microextraction in combination with a gas chromatography
Arun K Ghosh et al.
ChemMedChem, 10(1), 107-115 (2014-10-23)
The structure-based design, synthesis, biological evaluation, and X-ray structural studies of fluorine-containing HIV-1 protease inhibitors are described. The synthesis of both enantiomers of the gem-difluoro-bis-THF ligands was carried out in a stereoselective manner using a Reformatskii-Claisen reaction as the key
Ewa Wunsch et al.
Hepatology (Baltimore, Md.), 60(3), 931-940 (2014-02-13)
Ursodeoxycholic acid (UDCA) is no longer recommended for management of adult patients with primary sclerosing cholangitis (PSC). We undertook a prospective evaluation of UDCA withdrawal in a group of consecutive patients with PSC. Twenty six patients, all treated with UDCA
Christy Echakachi Manyi-Loh et al.
Pakistan journal of pharmaceutical sciences, 26(5), 897-906 (2013-09-17)
The growing problem of antibiotic resistance by Helicobacter pylori demands the search for novel compounds, especially from natural sources. We evaluated the anti-H. pylori activity of six local honeys at different concentrations as well as their solvent extracts by the
Susana Grimalt et al.
Analytical and bioanalytical chemistry, 407(11), 3083-3091 (2015-01-30)
The feasibility of the production of a reference material for pesticide residue analysis in a cucumber matrix was investigated. Cucumber was spiked at 0.075 mg/kg with each of the 15 selected pesticides (acetamiprid, azoxystrobin, carbendazim, chlorpyrifos, cypermethrin, diazinon, (α + β)-endosulfan, fenitrothion, imazalil
Laishram Shantikumar Singh et al.
BMC microbiology, 14, 278-278 (2014-11-20)
Actinomycetes have provided a wealth of bioactive secondary metabolites with interesting activities such as antimicrobial, antiviral and anticancer. The study aims at isolation, characterization and the antimicrobial potentiality of Streptomyces sannanensis SU118 obtained from Phoomdi, a unique habitat of Loktak
Dilek Battal et al.
Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)
Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative
Cristiane dos Santos Giuberti et al.
Journal of liposome research, 23(3), 220-227 (2013-05-11)
Recent studies using long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) have resulted in a formulation with improved pharmacokinetic, toxicity and tumor localization properties. In this study, SpHL-CDDP were prepared in both laboratory and pilot scales. This study evaluated the possibility
Yung-Chih Kuo et al.
International journal of pharmaceutics, 479(1), 138-149 (2015-01-07)
Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs (Lf/FA/PLGA NPs) were employed to permeate the monolayer
Anthony Tomlinson et al.
Molecular pharmaceutics, 12(11), 3805-3815 (2015-10-01)
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months) storage of two monoclonal antibody (mAb, mAb-A, and mAb-B) drug products at 2-8 °C. The PS20 degradation resulted in the accumulation of free fatty acids
Laura Trabalón et al.
Environmental research, 143(Pt B), 116-122 (2015-04-29)
The occurrence of ten synthetic musks in samples of 10 widely consumed fish and shellfish species from Tarragona (Catalonia, Spain) was determined. The most used nitro and polycyclic musks, as well as a well-known transformation product in tissues, were analyzed.
Gabriel B Akanni et al.
Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)
The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces
Rune Gangsøy Kristiansen et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(10), G1024-G1031 (2014-09-27)
Glycine is an important ammoniagenic amino acid, which is increased in acute liver failure (ALF). We have previously shown that L-ornithine phenylacetate (OP) attenuates ammonia rise and intracranial pressure in pigs suffering from ALF but failed to demonstrate a stoichiometric
Bilal Yilmaz et al.
Journal of AOAC International, 97(4), 1061-1066 (2014-08-26)
This paper describes a GCIMS method for the determination of flurbiprofen in human plasma. Flurbiprofen and internal standard ibuprofen were extracted from plasma by using a liquid-liquid extraction method. Derivatization was carried out using N-Methyl-N-(trimethylsilyl)trifluoroacetamide. The calibration curve was linear
Clara H Jeong et al.
Environmental science & technology, 49(23), 13749-13759 (2015-05-06)
The introduction of drinking water disinfection greatly reduced waterborne diseases. However, the reaction between disinfectants and natural organic matter in the source water leads to an unintended consequence, the formation of drinking water disinfection byproducts (DBPs). The haloacetaldehydes (HALs) are
Benito F García et al.
Molecules (Basel, Switzerland), 20(11), 20079-20106 (2015-11-13)
The citrus by-products released from citrus processing plants may contain high levels of potentially bioactive compounds such as flavonoids, which are a widely distributed group of polyphenolic compounds with health-related properties based on their antioxidant activity. In the study reported
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