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51457

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Zan Dai et al.
Nanoscale, 7(28), 11991-11999 (2015-06-26)
Hierarchical Bi(3.64)Mo(0.36)O(6.55)/Bi2MoO6 isotype heterostructures were successfully prepared via a one-pot hydrothermal route by using Bi2O3 porous nanospheres as a sacrificial template. By tuning the reaction time, the formation process of the Bi(3.64)Mo(0.36)O(6.55)/Bi2MoO6 heterostructure involving Mo etching, phase transition and anisotropic...
Yang Hong et al.
Journal of proteomics, 124, 25-38 (2015-04-22)
The aim of this study was to search for immunogenic schistosomula proteins in the hope of identifying novel intervention targets. Schistosomula proteins were analyzed by immunoproteomic which the probes were sera derived from BALB/c mice (susceptible hosts) and Microtus fortis...
Keumhan Noh et al.
Archives of pharmacal research, 38(1), 68-72 (2014-03-19)
Aceclofenac is one of the most popular analgesic and anti-inflammatory drugs used for the relief of pain, rheumatoid arthritis, and osteoarthritis. To date, no intravenous preparation of aceclofenac has been developed because of its poor water solubility. In this study...
Leticia Monin et al.
The Journal of clinical investigation, 125(12), 4699-4713 (2015-11-17)
Parasitic helminth worms, such as Schistosoma mansoni, are endemic in regions with a high prevalence of tuberculosis (TB) among the population. Human studies suggest that helminth coinfections contribute to increased TB susceptibility and increased rates of TB reactivation. Prevailing models...
Mun Chiang Chan et al.
PloS one, 10(7), e0132004-e0132004 (2015-07-07)
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human hypoxic response can...
Diana A Papazova et al.
Disease models & mechanisms, 8(3), 281-293 (2015-01-31)
Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is currently the focus of preclinical studies. We performed a systematic review and meta-analysis to evaluate the efficacy of cell-based therapy in preclinical (animal) studies of CKD...
Ali Akal et al.
Indian journal of ophthalmology, 62(6), 671-674 (2014-07-10)
Resistive index (RI) is an indirect measurement of blood flow resistance that can be used to evaluate vascular damage in ophthalmologic disease. The purpose of this study was to evaluate the association between RI values of orbital arteries using the...
Zhonghua Liu et al.
Electrophoresis, 36(17), 2002-2016 (2015-06-04)
Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats fed either a...
Xiyu Ouyang et al.
Journal of chromatography. A, 1380, 139-145 (2015-01-13)
For the first time a comprehensive two-dimensional liquid chromatography (LC×LC) system coupled with a high resolution time-of-flight mass spectrometer (HR-ToF MS) was developed and applied for analysis of emerging toxicants in wastewater effluent. The system was optimized and validated using...
Mingliang Zhang et al.
Journal of chromatography. A, 1365, 148-155 (2014-09-25)
One-pot synthesis of surface-confined ionic liquid functionalized silica spheres was proposed using N-(3-aminopropyl)imidazole, γ-isopropyltriethoxysilane and 1-bromooctadecane as starting materials. The surface modification of the silica spheres was successful with a high surface density of octadecylimidazolium, enabling the utilization of this...
Takahiko Kawate et al.
Cancer science, 106(7), 938-943 (2015-04-14)
In patients with cancer and Parkinson's disease, the DJ-1 protein may be secreted into the serum during the impaired response of the underlying cell-protective mechanisms. In order to determine the clinical significance of DJ-1 protein in the sera of breast...
Andrés Castellanos-Martín et al.
Genome biology, 16, 40-40 (2015-04-09)
An essential question in cancer is why individuals with the same disease have different clinical outcomes. Progress toward a more personalized medicine in cancer patients requires taking into account the underlying heterogeneity at different molecular levels. Here, we present a...
Teslime Atli et al.
JPMA. The Journal of the Pakistan Medical Association, 62(10), 1061-1065 (2013-07-23)
To compare the sensitivity and specificity of C[14] urea breath test with histopathological findings in biopsies obtained through endoscopy. In this cross-sectional study, conducted at the Medical Faculty Ankara University, Ankara, Turkey between January and October 2009, 100 patients aged...
Budhaditya Mukherjee et al.
Journal of immunology (Baltimore, Md. : 1950), 195(6), 2731-2742 (2015-08-19)
Infection with antimony-resistant Leishmania donovani (Sb(R)LD) induces aggressive pathology in the mammalian hosts as compared with ones with antimony-sensitive L. donovani (Sb(S)LD) infection. Sb(R)LD, but not Sb(S)LD, interacts with TLR2/TLR6 to induce IL-10 by exploiting p50/c-Rel subunits of NF-κB in...
John S Ramsey et al.
PloS one, 10(11), e0140826-e0140826 (2015-11-19)
'Candidatus Liberibacter asiaticus' (CLas), the bacterial pathogen associated with citrus greening disease, is transmitted by Diaphorina citri, the Asian citrus psyllid. Interactions among D. citri and its microbial endosymbionts, including 'Candidatus Profftella armatura', are likely to impact transmission of CLas....
Minhee Park et al.
Journal of proteome research, 14(8), 3007-3014 (2015-07-08)
Solid-pseudopapillary neoplasm (SPN) is an uncommon pancreatic tumor with mutation in CTNNB1 and distinct clinical and pathological features. We compared the proteomic profiles of SPN to mRNA expression. Pooled SPNs and pooled non-neoplastic pancreatic tissues were examined with high-resolution mass...
Federica Mori et al.
Oncotarget, 6(16), 13946-13961 (2015-06-13)
High-grade osteosarcoma (OS) is characterized by low incidence, high aggressiveness and moderate 5-years survival rate after aggressive poly-chemotherapy and surgery. Here we used miRNA profiling as a tool to possibly predict and monitor OS's development and therapeutic outcome. First, we...
Dmitrij A Lisak et al.
Biochimica et biophysica acta, 1853(9), 2104-2114 (2015-03-15)
Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca²⁺ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6....
Frédéric Frippiat et al.
The Journal of antimicrobial chemotherapy, 70(1), 207-216 (2014-09-14)
The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial...
Hatam Amanzadeh et al.
Analytica chimica acta, 884, 52-60 (2015-06-16)
In this work, ZnO/PPy nanocomposite coating was fabricated on stainless steel and evaluated as a novel headspace solid phase microextraction (HS-SPME) fiber coating for extraction of ultra-trace amounts of environmental pollutants; namely, aliphatic hydrocarbons in water and soil samples. The...
S Fukahori et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 72(2), 238-244 (2015-07-16)
The combination of nitrogen recovery and pharmaceutical removal processes for livestock urine treatment were investigated to suppress the discharge of pollutants and recover nitrogen as resources. We combined methylene urea synthesis from urea and adsorption and photocatalytic decomposition of sulfonamide...
Jihye Kim et al.
Analytical and bioanalytical chemistry, 407(29), 8745-8752 (2015-09-26)
Single-drop microextraction (SDME) was in-line coupled with capillary electrophoresis-mass spectrometry to provide sample cleanup and enrichment simultaneously. Since there is no outlet vial in a conventional capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) configuration, it is not easy to hang a single...
Mariana Díaz-Zaragoza et al.
Immunobiology, 220(9), 1050-1058 (2015-06-01)
The early detection of cancer is one of the most promising approaches to reduce its growing burden and develop a curative treatment before the tumor is established. The early diagnosis of breast cancer is the most demanding of all tumors...
Aaron A Witham et al.
Chemical research in toxicology, 28(6), 1346-1356 (2015-05-26)
Certain phenoxyl radicals can attach covalently to the C8-site of 2'-deoxyguanosine (dG) to afford oxygen-linked C8-dG adducts. Such O-linked adducts can be chemically synthesized through a nucleophilic displacement reaction between a phenolate and a suitably protected 8-Br-dG derivative. This permits...
Giora van Straten et al.
PloS one, 9(6), e100077-e100077 (2014-06-20)
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy. In this study, the gene...
Hai-Guang Xin et al.
Molecular and cellular biochemistry, 392(1-2), 117-124 (2014-03-22)
In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of renal disease. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant...
Erik L de Graaf et al.
Journal of proteome research, 14(7), 2906-2914 (2015-05-27)
We report a straightforward strategy to comprehensively monitor signal transduction pathway dynamics in mammalian systems. Combining targeted quantitative proteomics with highly selective phosphopeptide enrichment, we monitor, with great sensitivity, phosphorylation dynamics of the PI3K-mTOR and MAPK signaling networks. Our approach...
Anton Khmelinskii et al.
Nature, 516(7531), 410-413 (2014-12-19)
The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression. The outer nuclear membrane is continuous with the...
Jing Wang et al.
Proteomics, 14(11), 1393-1402 (2014-03-13)
The rhesus macaque is similar to humans both anatomically and physiologically as a primate, and has therefore been used extensively in medical and biological research, including reproductive physiology. Despite sequencing of the macaque genome, limited postgenomic studies have been performed...
Stephanie Dille et al.
PloS one, 9(7), e103220-e103220 (2014-07-30)
Chlamydia grows inside a cytosolic vacuole (the inclusion) that is supplied with nutrients by the host through vesicular and non-vesicular transport. It is unclear in many respects how Chlamydia organizes this transport. One model posits that the Chlamydia-induced fragmentation of...
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