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Andrew Philp et al.
American journal of physiology. Cell physiology, 299(2), C240-C250 (2010-04-23)
Sodium pyruvate can increase mitochondrial biogenesis in C2C12 myoblasts in a peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1alpha)-independent manner. The present study examined the effect of 72-h treatment with sodium pyruvate (5-50 mM) or sodium chloride (50 mM) as an osmotic control
D M Thomson et al.
The Journal of physiology, 587(Pt 9), 2077-2086 (2009-03-11)
One characteristic of ageing skeletal muscle is a decline in mitochondrial function. Activation of AMP-activated protein kinase (AMPK) occurs in response to an increased AMP/ATP ratio, which is one potential result of mitochondrial dysfunction. We have previously observed higher AMPK
Nathan C Winn et al.
American journal of physiology. Endocrinology and metabolism, 316(2), E156-E167 (2018-12-05)
The role of estrogen receptor-α (ERα) signaling in immunometabolic function is established in females. However, its necessity in males, while appreciated, requires further study. Accordingly, we first determined whether lower metabolic function in male mice compared with females is related
Anna-Maria Joseph et al.
PloS one, 8(7), e69327-e69327 (2013-08-13)
Mitochondrial DNA (mtDNA) mutations lead to decrements in mitochondrial function and accelerated rates of these mutations has been linked to skeletal muscle loss (sarcopenia). The purpose of this study was to investigate the effect of mtDNA mutations on mitochondrial quality
Ricardo J Samms et al.
The Journal of endocrinology, 227(1), 37-47 (2015-08-22)
The aim of this study was to investigate the mechanisms by which fibroblast growth factor 21 (FGF21) affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters
High-fat diets cause insulin resistance despite an increase in muscle mitochondria.
Hancock, CR; Han, DH; Chen, M; Terada, S; Yasuda, T; Wright, DC; Holloszy, JO
Proceedings of the National Academy of Sciences of the USA null
Kazuhiko Higashida et al.
PLoS biology, 11(7), e1001603-e1001603 (2013-07-23)
It has been reported that feeding mice resveratrol activates AMPK and SIRT1 in skeletal muscle leading to deacetylation and activation of PGC-1α, increased mitochondrial biogenesis, and improved running endurance. This study was done to further evaluate the effects of resveratrol
Anne Wulf et al.
Molecular and cellular endocrinology, 270(1-2), 57-63 (2007-03-27)
Thyroid hormone (T3) has a profound influence on normal development, differentiation and metabolism, processes which are known to be regulated by the transcriptional coactivator PGC-1alpha (peroxisome proliferator-activated receptor gamma coactivator-1alpha). Since T3 rapidly induces PGC-1alpha expression, we investigated whether reduced
S Timmers et al.
Nutrition & diabetes, 1, e11-e11 (2011-01-01)
In conditions of continuous high-fat (HF) intake, the degree of saturation of the fatty acids (FAs) in the diet might have a crucial role in the onset of obesity and its metabolic complications. In particular, the FA composition of the
A C Maher et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(9), R1115-R1123 (2014-08-29)
In skeletal muscle the Rab-GTPase-activating protein TBC1D1 has been implicated in the regulation of fatty acid oxidation by an unknown mechanism. We determined whether TBC1D1 altered fatty acid utilization via changes in protein-mediated fatty acid transport and/or selected enzymes regulating
Wessel F Theeuwes et al.
Biochimica et biophysica acta. Molecular basis of disease, 1866(6), 165740-165740 (2020-02-23)
Physical inactivity contributes to muscle wasting and reductions in mitochondrial oxidative phenotype (OXPHEN), reducing physical performance and quality of life during aging and in chronic disease. Previously, it was shown that inactivation of glycogen synthase kinase (GSK)-3β stimulates muscle protein
Chi-Chang Huang et al.
International journal of medical sciences, 13(4), 260-270 (2016-04-15)
The protein deacetylase sirtuin 1 (SIRT1) and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) pathway drives the muscular fiber-type switching, and can directly regulate the biophysiological functions of skeletal muscle. To investigate whether 12-week swimming exercise training modulates the SIRT1/PGC-1α pathway
Wataru Mizunoya et al.
PloS one, 8(11), e80152-e80152 (2013-11-19)
Dietary fat plays a major role in obesity, lipid metabolism, and cardiovascular diseases. To determine whether the intake of different types of dietary fats affect the muscle fiber types that govern the metabolic and contractile properties of the skeletal muscle
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance.
Schenk, et al.
The Journal of Clinical Investigation, 117, 1690-1698 (2018)
Robert S Rogers et al.
Diabetes, 65(11), 3341-3351 (2016-08-25)
Heat treatment (HT) effectively prevents insulin resistance and glucose intolerance in rats fed a high-fat diet (HFD). The positive metabolic actions of heat shock protein 72 (HSP72), which include increased oxidative capacity and enhanced mitochondrial function, underlie the protective effects
Kenya Takahashi et al.
FEBS open bio, 11(10), 2836-2844 (2021-09-13)
Lactate is considered to be a signaling molecule that induces mitochondrial adaptation and muscle hypertrophy. The purpose of this study was to examine whether lactate administration attenuates denervation-induced loss of mitochondrial content and muscle mass. Eight-week-old male Institute of Cancer
Pieter A Leermakers et al.
BMC pulmonary medicine, 20(1), 20-20 (2020-01-23)
Both mitophagy, a selective mechanism for clearance of mitochondria, and mitochondrial biogenesis are key processes determining mitochondrial content and oxidative capacity of the musculature. Abnormalities in these processes could therefore contribute to deterioration of peripheral muscle oxidative capacity as observed
J S McPhee et al.
Experimental physiology, 96(7), 699-707 (2011-05-17)
Skeletal muscles improve their oxidative fatty acid and glucose metabolism following endurance training, but the magnitude of response varies considerably from person to person. In 20 untrained young women we examined interindividual variability in training responses of metabolic enzymes following
A-M Joseph et al.
Biogerontology, 15(5), 517-534 (2014-08-12)
Mitochondrial dysfunction in various tissues has been associated with numerous conditions including aging. In testes, aging induces atrophy and a decline in male reproductive function but the involvement of mitochondria is not clear. The purpose of this study was to
Paula M Miotto et al.
American journal of physiology. Endocrinology and metabolism, 319(2), E345-E353 (2020-06-17)
Type 1 and type 2 diabetes are both tightly associated with impaired glucose control. Although both pathologies stem from different mechanisms, a reduction in insulin action coincides with drastic metabolic dysfunction in skeletal muscle and metabolic inflexibility. However, the underlying
Paula M Miotto et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 314(6), R909-R915 (2018-03-08)
Mitochondrial bioenergetic contributions to sex differences in human skeletal muscle metabolism remain poorly defined. The primary aim of this study was to determine whether mitochondrial respiratory kinetics differed between healthy young men and women in permeabilized skeletal muscle fibers. While
Jin-Ho Koh et al.
American journal of physiology. Endocrinology and metabolism, 316(5), E931-E939 (2019-03-20)
The objective of this study is to determine whether AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), or peroxisome proliferator-activated receptor β (PPARβ) can independently mediate the increase of glucose transporter type 4 (GLUT4) expression that occurs
Zachary I Grunewald et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 314(4), R584-R597 (2018-01-20)
Brown adipose tissue (BAT) is considered protective against obesity and related cardiometabolic dysfunction. Indeed, activation of BAT improves glucose homeostasis and attenuates cardiovascular disease development. However, whether a reduction in BAT mass perturbs metabolic function and increases risk for cardiovascular
Nicholas R Wawrzyniak et al.
Oncotarget, 7(33), 52695-52709 (2016-07-23)
Fatigue is a symptom of many diseases, but it can also manifest as a unique medical condition, such as idiopathic chronic fatigue (ICF). While the prevalence of ICF increases with age, mitochondrial content and function decline with age, which may
Ilse G M Slot et al.
Journal of cellular physiology, 231(2), 377-392 (2015-07-02)
Skeletal muscle of patients with chronic respiratory failure is prone to loss of muscle mass and oxidative phenotype. Tissue hypoxia has been associated with cachexia and emphysema in humans. Experimental research on the role of hypoxia in loss of muscle
Shinya Kawabe et al.
Endocrinology, 154(4), 1648-1660 (2013-03-09)
Liver receptor homolog-1 (LRH-1) is a member of the nuclear receptor 5A (NR5A) subfamily. It is expressed in granulosa cells of the ovary and is involved in steroidogenesis and ovulation. To reveal the transcriptional regulatory mechanism of LRH-1, we determined
Kevin Nay et al.
American journal of physiology. Endocrinology and metabolism, 317(1), E158-E171 (2019-05-01)
Gut microbiota is involved in the development of several chronic diseases, including diabetes, obesity, and cancer, through its interactions with the host organs. It has been suggested that the cross talk between gut microbiota and skeletal muscle plays a role
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