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Dimitrios Moustakas et al.
PloS one, 10(4), e0123310-e0123310 (2015-04-17)
The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct
Georgios Petrides et al.
The American journal of psychiatry, 172(1), 52-58 (2014-08-27)
Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. In a
Yueming Zhou et al.
The Analyst, 139(21), 5387-5392 (2014-08-26)
Better sensitivity and interface of ambient sampling/ionization mass spectrometry remain a challenge. Herein, a novel, plasma-based, ambient sampling/ionization/transmission (PASIT) integrated source in a pin-to-funnel configuration was developed for the sensitive analysis of complex samples. With the funnel sleeve directly affected
Rachel A Newman et al.
Perceptual and motor skills, 116(1), 280-293 (2013-07-09)
Naps are an effective strategy for maintaining alertness and cognitive performance; however, upon abrupt wakening from naps, sleep inertia (temporary performance degradation) may ensue. In the present study, attenuation of post-nap sleep inertia was attempted by administration of caffeine gum.
Fouad F Al-Qaim et al.
Journal of chromatography. A, 1345, 139-153 (2014-04-29)
An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure
Carolina Paola García et al.
Stem cell research, 12(2), 400-414 (2014-01-02)
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, if not
Elizabeth C Lowcock et al.
Nutrition and cancer, 65(3), 398-409 (2013-03-28)
Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were
Biomedicine. Human stem cells from cloning, finally.
Gretchen Vogel
Science (New York, N.Y.), 340(6134), 795-795 (2013-05-21)
Lianguo Wang et al.
Circulation research, 114(9), 1410-1421 (2014-02-27)
Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). Simultaneous optical mapping
[How much coffee is healthy?].
Franziska Etter
Praxis, 103(25), 1531-1532 (2014-12-11)
S Uccella et al.
British journal of cancer, 109(7), 1908-1913 (2013-09-12)
Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases. Type I
Mariana N Batista et al.
Archives of virology, 160(2), 399-407 (2014-12-11)
Hepatitis C is considered the major cause of cirrhosis and hepatocellular carcinoma. Conventional treatment is not effective against some hepatitis C virus (HCV) genotypes; therefore, new treatments are needed. Coffee and, more recently, caffeine, have been found to have a
Regina Wierzejska
Roczniki Panstwowego Zakladu Higieny, 63(2), 141-147 (2012-08-30)
Caffeine is widely consumed by people of all ages. In the last period a market of caffeine-containing products, particularly energy drinks and food supplements increased. Caffeine for years is under discussion, whether has positive whether adverse impact on health. Children
Rosario Villegas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7179-7189 (2014-05-23)
Axonal degeneration represents an early pathological event in neurodegeneration, constituting an important target for neuroprotection. Regardless of the initial injury, which could be toxic, mechanical, metabolic, or genetic, degeneration of axons shares a common mechanism involving mitochondrial dysfunction and production
M Sandeep et al.
Indian journal of experimental biology, 52(12), 1165-1172 (2015-02-06)
Meclizine and caffeine combination is used for the treatment of morning sickness. Both compounds are teratogenic and caffeine is known to possess anti-fertility activity also. The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine
Xiao-Yu Bai et al.
Behavioural pharmacology, 25(7), 648-660 (2014-08-30)
To characterize the sedative and hypnotic profile of the novel adenosine derivative ((3S,4R,5R)-3,4-dihydroxy-5-(6-((4-hydroxy-3-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl) methyl diaconate (WS0701), we performed a variety of behavioural tests and investigated the influence of WS0701 on various sleep stages. In mice, WS0701 significantly increased the number
Hazit Zayas et al.
Organic & biomolecular chemistry, 12(36), 6994-7003 (2014-06-17)
Six novel functional monomers: 4-(4-vinylphenyl)pyridine (M1), 4′-vinylbiphenyl-4-ol (M2), N,N-dimethyl-4′-vinylbiphenyl-3-amine (M3), (4′-vinylbiphenyl-4-yl)methanol (M4), 4′-vinylbiphenyl-4-carboxylic acid (M5) and 4-hydroxy-5-methyl-4′-vinylbiphenyl-3-carboxylic acid (M6), were examined for their ability to imprint theophylline (1). Using a molecular modelling-NMR titration approach, M2 and M6 were predicted to
Nélio Gonçalves et al.
Annals of neurology, 73(5), 655-666 (2013-04-30)
Machado-Joseph disease (MJD) is a neurodegenerative disorder associated with an abnormal CAG expansion, which translates into an expanded polyglutamine tract within ataxin-3. There is no therapy to prevent or modify disease progression. Because caffeine (a nonselective adenosine receptor antagonist) and
Mirosława Zydroń et al.
Journal of separation science, 27(14), 1166-1172 (2004-11-13)
An SPE method, using RP18 phases, for the simultaneous extraction of caffeine, theobromine, theophylline, paraxanthine, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid, 1,7-dimethyluric acid, and 1,3,7-trimethyluric acid from urine has been developed. Besides a gradient HPLC system for the analysis
Jasbir D Upadhyaya et al.
PloS one, 9(10), e110373-e110373 (2014-10-24)
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved in
Laurel K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 198, 144-153 (2015-01-17)
The reuse of treated wastewater for agricultural irrigation in arid and hot climates where plant transpiration is high may affect plant accumulation of pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs). In this study, carrot, lettuce, and
Jun Ren et al.
American journal of respiratory and critical care medicine, 191(6), 704-710 (2015-01-17)
Apnea of prematurity, which is prevalent among infants born at less than 34 weeks gestation, is treated with caffeine, theophylline, or aminophylline. However, not all newborns respond adequately to, or tolerate, methylxanthine administration, and thus alternative pharmacological therapies are required.
Jie Ping et al.
Toxicology, 321, 53-61 (2014-04-11)
Prenatal caffeine ingestion is one of the risk factors for intrauterine growth retardation (IUGR). Adrenal plays a pivotal role, mainly through steroidogenesis, in the regulation of intrauterine homeostasis and in fetal development and maturation. We have shown that prenatal caffeine
How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations.
Jonathan A Dranoff et al.
Hepatology (Baltimore, Md.), 60(2), 464-467 (2014-01-28)
Ayuko Imaoka et al.
Drug metabolism and pharmacokinetics, 29(5), 414-418 (2014-05-09)
The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs
Steve Septer et al.
AANA journal, 74(3), 219-225 (2006-06-22)
Tuberous sclerosis (TS) is a relatively rare, autosomal dominant syndrome that displays high genetic penetrance in affected families. It is identified by a classic triad of symptoms including epilepsy, skin lesions, and mental retardation. Tuberous sclerosis causes hamartomas in multiple
Surajit Sahu et al.
Experimental neurology, 248, 470-481 (2013-08-08)
It has been established that sleep deprivation (SD) reduces the proliferation of neuronal precursors in the adult hippocampus. It has also been reported that psychostimulant drugs modulate adult neurogenesis. We examined the modulatory role of two psychostimulant drugs modafinil and
Chikako Kiyohara et al.
Arthritis care & research, 66(7), 1048-1056 (2014-01-29)
N-acetyltransferase 2 (NAT2) is involved in the metabolism of various environmental substances, both with and without carcinogenic potential. Alcoholic and nonalcoholic caffeine-rich beverages may be associated with markers of inflammation. Systemic lupus erythematosus (SLE) is a chronic, multifaceted inflammatory disease.
Nancy N Maserejian et al.
American journal of epidemiology, 177(12), 1399-1410 (2013-06-01)
Evidence to substantiate recommendations for restriction of caffeinated or acidic beverages as self-management for lower urinary tract symptoms (LUTS) is limited. We examined longitudinal and acute associations between beverage intake and LUTS in the Boston Area Community Health (BACH) cohort
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