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Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization.
R Cinti et al.
Cytogenetics and cell genetics, 92(3-4), 354-355 (2001-07-04)
Kyoung-Woon Joung et al.
Journal of cardiothoracic and vascular anesthesia, 28(6), 1440-1447 (2014-09-24)
Recent studies suggested that elevated serum uric acid levels may be associated with the risk of acute kidney injury (AKI) in several settings. However, the effect of uric acid on the risk of AKI after cardiovascular surgery remains uncertain. A...
Philemon Karli et al.
The spine journal : official journal of the North American Spine Society, 14(12), 2976-2984 (2014-06-10)
In canine intervertebral disc (IVD) disease, a useful animal model, only little is known about the inflammatory response in the epidural space. To determine messenger RNA (mRNA) expressions of selected cytokines, chemokines, and matrix metalloproteinases (MMPs) qualitatively and semiquantitatively over...
Corey Scurlock et al.
ASAIO journal (American Society for Artificial Internal Organs : 1992), 60(4), 376-380 (2014-03-25)
Patients with advanced heart failure and poor nutritional status are predisposed to higher rates of infection, bleeding, and mortality. We have increasingly used perioperative parenteral nutrition (PN) in ventricular assist device (VAD) patients and now report our initial experience. We...
Yu Fen Zheng et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 117-127 (2014-03-19)
We evaluated the potential of BST204, a purified dry extract of ginseng, to inhibit or induce human liver cytochrome P450 enzymes (CYPs) and UDP-glucuronosyltransferases (UGTs) in vitro to assess its safety. In vitro drug interactions of four bioactive ginsenosides of...
Hua Sun et al.
Journal of pharmaceutical sciences, 104(1), 244-256 (2014-11-14)
In this study, we aimed to determine the modulatory effects of warfarin (an extensively used anticoagulant drug) and its metabolites on UDP-glucuronosyltransferase (UGT) activity and to assess the potential of warfarin to alter the pharmacokinetics of zidovudine (AZT). The effects...
Y Liu et al.
Acta anaesthesiologica Scandinavica, 59(3), 319-328 (2015-01-08)
Breath analysis of propofol is a potential noninvasive method for approximating the plasma propofol concentration. There have been various reported techniques for measuring the exhaled propofol concentration at steady state; however, the propofol concentration undergoes marked changes during clinical anesthesia....
E E Lindholm et al.
Anaesthesia, 69(6), 558-572 (2014-04-12)
The aim of this study was to define pre-operative echocardiographic data and explore if postoperative indices of cardiac function after open abdominal aortic surgery were affected by the anaesthetic regimen. We hypothesised that volatile anaesthesia would improve indices of cardiac...
J E Trzil et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(12), 1546-1557 (2014-09-16)
Mesenchymal stem cells (MSCs) decrease airway eosinophilia, airway hyperresponsiveness (AHR), and remodelling in murine models of acutely induced asthma. We hypothesized that MSCs would diminish these hallmark features in a chronic feline asthma model. To document effects of allogeneic, adipose-derived...
Anesthesia, sleep, and nasendoscopy.
David R Hillman
Anesthesia and analgesia, 119(4), 753-754 (2014-09-19)
Michael J Erdman et al.
Critical care medicine, 42(7), 1696-1702 (2014-04-11)
Dexmedetomidine and propofol are commonly used sedatives in neurocritical care as they allow for frequent neurologic examinations. However, both agents are associated with significant hemodynamic side effects. The primary objective of this study is to compare the prevalence of severe...
Arnaud Vincent Vanlander et al.
Anesthesiology, 122(2), 343-352 (2014-10-09)
Propofol is a short-acting intravenous anesthetic agent. In rare conditions, a life-threatening complication known as propofol infusion syndrome can occur. The pathophysiologic mechanism is still unknown. Some studies suggested that propofol acts as uncoupling agent, others suggested that it inhibits...
Y Ren et al.
Neuroscience letters, 584, 287-291 (2014-12-03)
Propofol is well-known for its anterograde amnesic actions. However, a recent experiment showed that propofol can also produce retrograde memory enhancement effects via an interaction with the endocannabinoid CB1 system. Therefore, the authors hypothesized that the regulating effect of propofol...
Heng Zhang et al.
PloS one, 9(5), e96518-e96518 (2014-05-07)
Soft drugs are molecules that are purposefully designed to be rapidly metabolized (metabolically labile). In anesthesia, the soft drug is useful because it enables precise titration to effect and rapid recovery, which might allow swift and clear-headed recovery of consciousness...
J K Jellyman et al.
Domestic animal endocrinology, 50, 45-49 (2014-09-23)
The present study tested the hypothesis that overexposure to endogenous glucocorticoids in neonatal life alters the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis in ponies at 1 and 2 yr of age. Newborn foals received saline (0.9% NaCl, n = 8, control)...
Yozo Manabe et al.
Anesthesia progress, 61(2), 47-52 (2014-06-17)
The purpose of this study was to determine the relationship between the head position and the subsequent ease of nasotracheal intubation by using the lightwand device Trachlight (TL). Patients requiring nasotracheal intubation were subdivided into 3 groups according to the...
Edyta Kotlinska-Hasiec et al.
Archivum immunologiae et therapiae experimentalis, 63(2), 129-137 (2014-09-11)
Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation. The aim of this study was to analyse changes in plasma KYNA concentration and neutrophil/lymphocyte ratio (NLR) in cardiac surgery patients. Additionally, the effect of anaesthesia was...
Charles H Vite et al.
Science translational medicine, 7(276), 276ra26-276ra26 (2015-02-27)
Niemann-Pick type C1 (NPC) disease is a lysosomal storage disease caused by mutations in the NPC1 gene, leading to an increase in unesterified cholesterol and several sphingolipids, and resulting in hepatic disease and progressive neurological disease. We show that subcutaneous...
Yasuo M Tsutsumi et al.
BioMed research international, 2014, 307025-307025 (2014-07-23)
The incidence of postoperative nausea and vomiting (PONV) is 30-50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant...
Ayse Baysal et al.
Cardiology in the young, 24(2), 351-358 (2008-02-07)
Our aim is to compare the haemodynamic and adverse effects of propofol versus the mixture of midazolam and ketamine as used in sedation for cardiac catheterization in children. In a prospective randomized trial, we divided patients needing sedation into 72...
What is the ke0 and what does it tell me about propofol?
L I Cortínez
Anaesthesia, 69(5), 399-402 (2014-04-18)
In reply.
Espen E Lindholm et al.
Anesthesiology, 120(5), 1292-1297 (2014-04-24)
Torsten Herzog et al.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, 27(5), 273-281 (2014-05-17)
After pancreatectomy, an isolated bile leak from the hepaticojejunostomy is a severe surgical complication that is underrepresented both, in the literature and in the awareness of pancreatic surgeons. The goal of this study was to analyze the incidence and outcome...
Neal Benedict et al.
Journal of critical care, 29(6), 1132-1132 (2014-08-19)
Patient-reported outcomes (PROs) are recommended as indicators of quality in the intensive care unit. We studied the correlation between PROs of sedation quality and a universal sedation assessment scale in critically ill patients. Twenty-nine mechanically ventilated adults admitted to a...
Martin Schläpfer et al.
Critical care (London, England), 19, 45-45 (2015-04-19)
Severe sepsis is associated with approximately 50% mortality and accounts for tremendous healthcare costs. Most patients require ventilatory support and propofol is commonly used to sedate mechanically ventilated patients. Volatile anesthetics have been shown to attenuate inflammation in a variety...
Philippe E Dubois et al.
European journal of anaesthesiology, 31(8), 404-410 (2013-07-26)
Disturbances in the thumb's movement interfere with the functioning of acceleromyography in many clinical settings. The short and light (SL) train-of-four (TOF)-Tube is a new version of a rigid tubular device that was designed to protect the thumb from external...
Athanasios Chalkias et al.
Shock (Augusta, Ga.), 43(3), 285-291 (2014-11-14)
Cardiopulmonary resuscitation in patients with severe sepsis and septic shock is challenging and usually unsuccessful. The aim of the present study is to describe our swine model of cardiac arrest and resuscitation in severe sepsis and septic shock. In this...
S Brás et al.
Research in veterinary science, 97(3), 597-604 (2014-12-03)
Hypnotic drug administration causes alterations in the electroencephalogram (EEG) in a dose-dependent manner. These changes cannot be identified easily in the raw EEG, therefore EEG based indices were adopted for assessing depth of anaesthesia (DoA). This study examines several indices...
P Cortellazzi et al.
Anaesthesia, 70(3), 290-295 (2014-10-02)
Although videolaryngoscopy can provide excellent views of the laryngeal structures as both the primary method of tracheal intubation and as a rescue technique for difficult direct laryngoscopy, the existing literature is inadequate to define expertise or even competence. We observed...
Cheng Yang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(10), 1817-1828 (2014-06-17)
The naked small interfering RNA (siRNA) of caspase-3, a key player in ischemia reperfusion injury, was effective in cold preserved and hemoreperfused kidneys, but not autotransplanted kidneys in our porcine models. Here, chemically modified serum stabilized caspase-3 siRNAs were further...
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