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Wipasiri Soonthornchai et al.
PloS one, 10(8), e0135783-e0135783 (2015-08-19)
Several species of Vibrio are the causative agent of gastroenteritis in humans. In aquaculture, Vibrio harveyi (Vh) and V. parahaemolyticus (Vp) have long been considered as shrimp pathogens in freshwater, brackish and marine environments. Here we show by using scanning...
Kyu-Yeon Han et al.
FEBS letters, 588(23), 4357-4363 (2014-10-05)
The vascular endothelial growth factor (VEGF)-C-induced down-regulation of VEGF receptor (VEGFR)-3 is important in lymphangiogenesis. Here, we demonstrate that VEGF-C, -D, and -C156S, but not VEGF-A, down-regulate VEGFR-3. VEGF-C stimulates VEGFR-3 tyrosyl phosphorylation and transient phosphorylation of extracellular signal-regulated kinase...
Suzanne M Underhill et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5260-5270 (2015-04-04)
The gene for EAAT2, the major astrocytic glutamate transporter, generates two carrier isoforms (EAAT2a and EAAT2b) that vary at their C termini as a consequence of alternative RNA splicing. The EAAT2b cytoplasmic C terminus contains a postsynaptic density-95/Discs large/zona occludens-1...
Christophe Varin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9900-9911 (2015-07-15)
Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poorly understood. Here, we...
Izrail Tsals et al.
Vaccine, 33(37), 4705-4711 (2015-05-13)
Although the number of vaccines and diagnostic tests currently delivered intradermally is limited, this route of administration offers potential advantages due to the high concentration of antigen-presenting cells in the skin. One factor which may in part be limiting development...
Valentina Fodale et al.
PloS one, 9(12), e112262-e112262 (2014-12-03)
In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that...
Kentu Lassiter et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(3), R173-R187 (2014-12-17)
Orexin A and B, orexigenic peptides produced primarily by the lateral hypothalamus that signal through two G protein-coupled receptors, orexin receptors 1/2, have been implicated in the regulation of several physiological processes in mammals. In avian (nonmammalian vertebrates) species; however...
Krishna Gokul et al.
Neurochemical research, 39(7), 1382-1394 (2014-05-17)
Although tomato seeds (an industrial by-product) are known to contain several bioactive compounds, studies describing their health effects are limited. Previously, we evidenced that aqueous extract of tomato seeds (TSE) markedly attenuated rotenone (ROT)-induced oxidative stress and neurotoxicity in Drosophila...
Justyna McIntyre et al.
The Journal of biological chemistry, 290(45), 27332-27344 (2015-09-16)
Human DNA polymerases (pols) η and ι are Y-family DNA polymerase paralogs that facilitate translesion synthesis past damaged DNA. Both polη and polι can be monoubiquitinated in vivo. Polη has been shown to be ubiquitinated at one primary site. When...
Amber L Jolly et al.
mBio, 6(2), e02533-e02533 (2015-02-26)
The opportunistic pathogen Pseudomonas aeruginosa can infect almost any site in the body but most often targets epithelial cell-lined tissues such as the airways, skin, and the cornea of the eye. A common predisposing factor is cystic fibrosis (CF), caused...
Haihao Ma et al.
Scientific reports, 5, 18186-18186 (2015-12-15)
The cotton bollworm, Helicoverpa armigera, has developed strong resistance to many insecticides. Sterol Carrier Protein-2 (SCP-2) is an important non-specific lipid transfer protein in insects and appears to be a potential new target. In order to elucidate the structure and...
Tristan P C van Doormaal et al.
The Journal of surgical research, 192(1), 200-205 (2014-06-04)
We aim to find a storage protocol for vessels that preserves their dimensional, histologic, and mechanical characteristics to facilitate reproducible anastomosis experiments and microsurgical training with constant quality. We compared stored rabbit aortas, harvested in a slaughterhouse, using five different...
Katja Sundström et al.
Endocrinology, 155(12), 4798-4807 (2014-09-23)
The growth-promoting effect of combined therapy with GH and IGF-I in normal rats is not known. We therefore investigated the efficacy of treatment with recombinant human (rh)GH and/or rhIGF-I on longitudinal bone growth and bone mass in intact, prepubertal, female...
Sheila López-Cobo et al.
Immunology, 146(1), 70-80 (2015-05-20)
After immune interactions, membrane fragments can be transferred between cells. This fast transfer of molecules is transient and shows selectivity for certain proteins; however, the constraints underlying acquisition of a protein are unknown. To characterize the mechanism and functional consequences...
Shogo Hayashi et al.
Medicine, 93(27), e196-e196 (2014-12-17)
This article evaluates the suitability of cadavers embalmed by the saturated salt solution (SSS) method for surgical skills training (SST). SST courses using cadavers have been performed to advance a surgeon's techniques without any risk to patients. One important factor...
Julia Krasensky et al.
Antioxidants & redox signaling, 21(9), 1289-1304 (2014-05-08)
High salinity stress impairs plant growth and development. Trehalose metabolism has been implicated in sugar signaling, and enhanced trehalose metabolism can positively regulate abiotic stress tolerance. However, the molecular mechanism(s) of the stress-related trehalose pathway and the role of individual...
Hoyong Park et al.
Scientific reports, 5, 13440-13440 (2015-08-28)
Influenza virus infection is one of common infectious diseases occurring worldwide. The human influenza virus can infect the central nervous system and cause brain dysfunctions affecting cognition and spatial memory. It has been previously shown that infection with the influenza...
M Javier Herrero-Turrión et al.
BMC genomics, 15, 874-874 (2014-10-09)
A great number of studies have investigated changes induced by morphine exposure in gene expression using several experimental models. In this study, we examined gene expression changes during chronic exposure to morphine during maturation and differentiation of zebrafish CNS. Microarray...
Sumihiro Koyama et al.
Marine biotechnology (New York, N.Y.), 17(5), 678-692 (2015-08-06)
The purpose of this study was to develop a novel electrical retrieval method (ER method) for living sponge-associated microorganisms from marine sponges frozen at -80 °C. A -0.3-V vs. Ag/AgCl constant potential applied for 2 h at 9 °C induced...
Ewa Augustin et al.
Acta pharmacologica Sinica, 36(3), 385-399 (2015-02-03)
FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on...
Constantine Chrysostomou et al.
ACS chemical biology, 10(3), 875-882 (2014-12-18)
Microbial arsenate resistance is known to be conferred by specialized oxidoreductase enzymes termed arsenate reductases. We carried out a genetic selection on media supplemented with sodium arsenate for multicopy genes that can confer growth to E. coli mutant cells lacking...
Joana Maciel et al.
Tissue engineering. Part A, 20(1-2), 250-263 (2013-08-14)
Macrophages are phagocytic cells with great importance in guiding multiple stages of inflammation and tissue repair. By producing a large number of biologically active molecules, they can affect the behavior of other cells and events, such as the foreign body...
Ioanna Tiniakou et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4676-4687 (2015-04-15)
Aberrant levels and function of the potent anti-inflammatory high-density lipoprotein (HDL) and accelerated atherosclerosis have been reported in patients with autoimmune inflammatory diseases. Whether HDL affects the development of an autoimmune response remains elusive. In this study, we used apolipoprotein...
Augusta Di Savino et al.
Blood, 125(14), 2245-2253 (2015-02-14)
We recently described morgana as an essential protein able to regulate centrosome duplication and genomic stability, by inhibiting ROCK. Here we show that morgana (+/-) mice spontaneously develop a lethal myeloproliferative disease resembling human atypical chronic myeloid leukemia (aCML), preceded...
Kyung Yuk Ko et al.
Journal of food protection, 78(6), 1090-1097 (2015-06-04)
The antimicrobial effects of thyme oil (TO), grapefruit seed extract (GSE), and basil essential oil, alone or in combination with cetylpyridinium chloride (CPC), sodium diacetate, or lactic acid, were evaluated against Escherichia coli O157:H7 in a moisture-enhanced beef model system....
Jynho Kim et al.
Science signaling, 8(379), ra55-ra55 (2015-06-04)
Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor Patched negatively regulates the activity and ciliary accumulation of Smoothened, a seven-transmembrane...
Eileen Workman et al.
The Journal of biological chemistry, 290(25), 15662-15669 (2015-04-26)
Reduced expression of SMN causes spinal muscular atrophy, a severe neurodegenerative disease. Despite the importance of maintaining SMN levels, relatively little is known about the mechanisms by which SMN levels are regulated. We show here that Gemin5, the snRNA-binding protein...
Qing-Bo Tang et al.
PloS one, 9(4), e95401-e95401 (2014-04-18)
Food selection behavior of lepidopteran larvae is predominantly governed by the activation of taste neurons present in two sensilla styloconica located on the galea of the maxilla. In this study, we present the ultrastructure of the sensilla styloconica and the...
Shigeo Nagashima et al.
The Journal of general virology, 95(Pt 10), 2166-2175 (2014-06-28)
Our previous studies indicated that hepatitis E virus (HEV) forms membrane-associated particles in the cytoplasm, most likely by budding into intracellular vesicles, and requires the multivesicular body (MVB) pathway to release virus particles, and the released HEV particles with a...
Satoshi Fujita et al.
Journal of vascular surgery, 62(5), 1312-1319 (2014-05-14)
The development of spinal cord injury is believed to be related to the vulnerability of spinal motor neurons to ischemia. However, the mechanisms underlying this vulnerability have not been fully investigated. Previously, we reported that spinal motor neurons are lost...
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