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L Iannuzzi et al.
Cytogenetics and cell genetics, 95(3-4), 225-227 (2002-06-14)
During normal cytogenetic investigations on the Chianina cattle (BTA) breed, a normal looking young bull was found to carry an abnormal Y chromosome which was a product of a reciprocal translocation between chromosomes Y and 9. This was revealed by
Anil K Gorle et al.
Dalton transactions (Cambridge, England : 2003), 43(44), 16713-16725 (2014-10-02)
A series of inert tri- and tetra-nuclear polypyridylruthenium(II) complexes that are linked by the bis[4(4'-methyl-2,2'-bipyridyl)]-1,n-alkane ligand ("bb(n)" for n = 10, 12 and 16) have been synthesised and their potential as antimicrobial agents examined. Due to the modular nature of
[Sulbactam-ampicillin combination--a drug of broad antibacterial spectrum].
V Savko
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 36(1), 51-55 (1991-01-01)
Jogi Madhuprakash et al.
Biochimica et biophysica acta, 1840(9), 2685-2694 (2014-06-28)
Transglycosylation (TG) activity is a property of glycosyl hydrolases (GHs) with which new glycosidic bonds are introduced between donor and acceptor sugar molecules. This special property of the GHs has potential to generate longer chain chitooligosaccharides (CHOS) that show elicitor
Erika G Holland et al.
Journal of immunological methods, 417, 67-75 (2014-12-20)
The Eco29k I restriction endonuclease is a Sac II isoschizomer that recognizes the sequence 5'-CCGCGG-3' and is encoded, along with the Eco29k I methylase, in the Escherichia coli strain 29k. We have expressed the Eco29k I restriction-methylation system (RM2) in
Meseret Ashenafi et al.
Molecular and cellular biochemistry, 400(1-2), 9-15 (2014-10-31)
Recently, we showed that the fused chorismate-utilizing enzyme from the antibiotic-producing soil bacterium Streptomyces venezuelae is an anthranilate synthase (designated SvAS), not a 2-amino-2-deoxyisochorismate (ADIC) synthase, as was predicted based on its amino acid sequence similarity to the phenazine biosynthetic
Chieh Jason Chou et al.
Nestle Nutrition workshop series. Paediatric programme, 62, 127-137 (2008-07-16)
Recent data suggest that gut microbiota plays a significant role in fat accumulation. However, it is not clear whether gut microbiota is involved in the pathophysiology of type-2 diabetes. To address this issue, we modulated gut microbiota with two combinations
Carla B Schubiger et al.
Applied and environmental microbiology, 81(2), 658-665 (2014-11-09)
Flavobacterium psychrophilum causes bacterial cold-water disease in multiple fish species, including salmonids. An autochthonous Enterobacter strain (C6-6) inhibits the in vitro growth of F. psychrophilum, and when ingested as a putative probiotic, it provides protection against injection challenge with F.
Abubakar Babando Aliyu et al.
Phytochemistry, 111, 163-168 (2014-12-01)
Four eudesmanolide sesquiterpene lactones (1-4) were isolated from the aerial parts of Vernonia blumeoides used in Nigerian ethnomedicine for the treatment of diarrhea and malaria. Compound 1 demonstrated limited but interesting antibacterial activity against Bacillus, Staphylococcus and Streptococcus species. The
Dara P O'Halloran et al.
Infection and immunity, 83(4), 1598-1609 (2015-02-04)
The immunoglobulin binding protein A (SpA) of Staphylococcus aureus is synthesized as a precursor with a C-terminal sorting signal. The sortase A enzyme mediates covalent attachment to peptidoglycan so that SpA is displayed on the surface of the bacterium. Protein
Stephanie A Flowers et al.
Antimicrobial agents and chemotherapy, 59(1), 450-460 (2014-11-12)
In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance.
Eduard Ayuso et al.
Human gene therapy, 25(11), 977-987 (2014-10-03)
Abstract Gene therapy approaches using recombinant adeno-associated virus serotype 2 (rAAV2) and serotype 8 (rAAV8) have achieved significant clinical benefits. The generation of rAAV Reference Standard Materials (RSM) is key to providing points of reference for particle titer, vector genome
A new application of micellar liquid chromatography in the determination of free ampicillin concentration in the drug?human serum albumin standard solution in comparison with the adsorption
Stepnik KE, et al.
Talanta, 153, 1-7 (2016)
D A Schofield et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(2), 395-403 (2014-09-26)
Shigellosis is a significant cause of morbidity and mortality worldwide, most notably amongst children. Moreover, there is a global increase in the occurrence of multidrug-resistant isolates, including the epidemic and pandemic Shigella dysenteriae type 1 strain. We developed a bioluminescent
Bin Deng et al.
PloS one, 9(7), e102362-e102362 (2014-07-19)
Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA), produced by human macrophages. PCR mapping of 12-lipoxygenase (12-LOX) mRNA sequence in
H Lode
International journal of antimicrobial agents, 18(3), 199-209 (2001-10-24)
The emergence of beta-lactamase-mediated resistance to beta-lactam antibiotics among key respiratory tract pathogens has threatened the usefulness of the beta-lactam agents familiar to physicians as being clinically effective and well tolerated. This article reassesses the clinical usefulness of ampicillin when
Sheroy Minocherhomji et al.
Human molecular genetics, 23(23), 6163-6176 (2014-07-06)
Genome instability, epigenetic remodelling and structural chromosomal rearrangements are hallmarks of cancer. However, the coordinated epigenetic effects of constitutional chromosomal rearrangements that disrupt genes associated with congenital neurodevelopmental diseases are poorly understood. To understand the genetic-epigenetic interplay at breakpoints of
Kara Lea Vine et al.
Pharmaceutical research, 32(3), 1045-1054 (2014-09-19)
Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target. Plasminogen activator inhibitor type-2 (PAI-2/SerpinB2) is a specific uPA inhibitor with proven potential for use in targeted therapy. However
Martina Koeberl et al.
Journal of immunological methods, 415, 6-16 (2014-12-03)
Food allergies are increasing worldwide, demonstrating a considerable public health concern. Shellfish allergy is one of the major food groups causing allergic sensitization among adults and children, affecting up to 2% of the general world population. Tropomyosin (TM) is the
Yael Ganor-Paz et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 129(1), 13-16 (2015-01-15)
To evaluate whether carriers of group B streptococcus (GBS) have adverse obstetric and neonatal outcomes when preterm premature rupture of membranes (PPROM) occurs. In a retrospective study, data were reviewed for women with a singleton pregnancy and PPROM before 34
Susanne M Stieger-Vanegas et al.
Journal of the American Veterinary Medical Association, 242(2), 254-260 (2013-01-02)
To assess the feasibility and usefulness of CT enterography to evaluate the gastrointestinal tract in clinically normal llamas and alpacas. Prospective observational study. 7 clinically normal alpacas and 8 clinically normal llamas. The imaging protocol included orogastric administration of iodinated
Daniel R G Price et al.
BMC biology, 12, 110-110 (2014-12-21)
Genome evolution in intracellular microbial symbionts is characterized by gene loss, generating some of the smallest and most gene-poor genomes known. As a result of gene loss these genomes commonly contain metabolic pathways that are fragmented relative to their free-living
Julien Sourimant et al.
Journal of virology, 89(8), 4421-4433 (2015-02-06)
The minimum requirement for an active RNA-dependent RNA polymerase of respiratory syncytial virus (RSV) is a complex made of two viral proteins, the polymerase large protein (L) and the phosphoprotein (P). Here we have investigated the domain on P that
Felipe H Coutinho et al.
Microbial ecology, 68(3), 441-452 (2014-05-14)
Bacterial resistance to antibiotics has become a public health issue. Over the years, pathogenic organisms with resistance traits have been studied due to the threat they pose to human well-being. However, several studies raised awareness to the often disregarded importance
Siva Wu et al.
PloS one, 9(7), e99204-e99204 (2014-07-10)
Non-typeable Haemophilus influenzae (NTHi) is a common acute otitis media pathogen, with an incidence that is increased by previous antibiotic treatment. NTHi is also an emerging causative agent of other chronic infections in humans, some linked to morbidity, and all
Yuebin Ke et al.
Toxicology letters, 230(1), 62-68 (2014-08-17)
To investigate the potential compensatory effects of hOGG1 and hMTH1 in the repair of oxidative DNA damage. The hOGG1 and hMTH1 gene knockdown human embryonic pulmonary fibroblast cell lines were established by lentivirus-mediated RNA interference. The messenger RNA (mRNA) levels
Jang-Gi Choi et al.
PloS one, 9(7), e102697-e102697 (2014-07-23)
Galla rhois is a commonly used traditional medicine for the treatment of pathogenic bacteria in Korea as well as in other parts of Asia. Methyl gallate (MG), a major component of Galla Rhois, exhibits strong antibacterial activity, but its mechanism
Hazem E Ghoneim et al.
The Journal of infectious diseases, 209(9), 1459-1468 (2013-11-26)
Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute to these poor outcomes. Using Streptococcus pneumoniae in
Robert Hudek et al.
Journal of shoulder and elbow surgery, 23(12), 1763-1771 (2014-09-03)
Propionibacterium acnes has been linked to chronic infections in shoulder surgery. Whether the bacterium is a contaminant or commensal of the deep tissue is unclear. We aimed to assess P. acnes in intraoperative samples of different tissue layers in patients
Joanne L Porter et al.
ACS chemical biology, 10(2), 611-621 (2014-11-25)
The ease with which enzymes can be adapted from their native roles and engineered to function specifically for industrial or commercial applications is crucial to enabling enzyme technology to advance beyond its current state. Directed evolution is a powerful tool
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