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650609

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Jin-Ah Lee et al.
Nutrients, 7(11), 9650-9661 (2015-11-28)
The aim of this study was to improve the anti-inflammatory activities of apigenin through co-treatment with resveratrol as a bioenhancer of apigenin. RAW 264.7 cells pretreated with hepatic metabolites formed by the co-metabolism of apigenin and resveratrol (ARMs) in HepG2...
Thomas G Hammond et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 387-402 (2014-06-07)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxylate drugs...
Hyun-Kyung Na et al.
Toxicology letters, 232(2), 429-437 (2014-12-03)
Tobacco smoking is a well-known cause of various diseases, however, its toxic mechanisms for diseases are not completely understood, yet. Therefore, we performed biological monitoring to find tobacco smoking-responsive mechanisms including oxidative stress in Korean men (N=36). Whole genome microarray...
Xingyu Dong et al.
Experimental and molecular pathology, 98(2), 192-199 (2015-01-27)
Glioma is an aggressive tumor with poor prognosis. Identification of precise prognostic marker and effective therapeutic target is important in the treatment of glioma. HTATIP2 is a novel tumor suppressor gene, which is frequently silenced by epigenetic mechanisms in many...
Zhigang Wang et al.
Journal of pharmaceutical and biomedical analysis, 107, 1-6 (2015-01-06)
The metabolism of gentiopicroside in vivo was studied by LC/MS following 2,4-dinitrophenylhydrazine derivatization for the first time. The ionization efficiency of the major metabolites erythrocentaurin and gentiopicral were greatly enhanced by the new analytical method developed, and they were successfully...
Jasna Nikolic et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 30-36 (2014-06-03)
Banana fruit (Musa acuminata) has become an important food allergen source in recent years. So far, 5 IgE reactive banana proteins have been identified, and the major allergens are: Mus a 2 (a class I chitinase, 31kDa), Mus a 4...
Li-Yuan Bai et al.
Biochemical pharmacology, 86(10), 1430-1440 (2013-09-18)
Indole-3-carbinol (I3C) is a broadly targeted phytochemical shown to prevent carcinogenesis in animal studies and to suppress the proliferation of cancer cells of human breast, colon, prostate, and endometrium. Here we demonstrate that OSU-A9, an I3C derivative with improved anticancer...
Simon Asbjørn Larsen et al.
Immunologic research, 62(3), 263-272 (2015-05-13)
Breast cancer tumors are composed of heterogeneous cell populations. These populations display a high variance in morphology, growth and metastatic propensity. They respond differently to therapeutic interventions, and some may be more prone to cause recurrence. Studying individual subpopulations of...
Candace Elaine Rapchak et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 93(4), 396-404 (2015-07-08)
The polo-like kinases are a family of conserved serine/threonine kinases that play multiple roles in regulation of the cell cycle. Unlike its four other family members, the role of Plk4 in embryonic development has not been well characterized. In mice...
Florian Noulin et al.
PloS one, 9(11), e112496-e112496 (2014-11-14)
The predilection of Plasmodium vivax (P. vivax) for reticulocytes is a major obstacle for its establishment in a long-term culture system, as this requires a continuous supply of large quantities of reticulocytes, representing only 1-2% of circulating red blood cells....
Si-Rui Ma et al.
Oncotarget, 6(11), 8807-8821 (2015-04-15)
Anterior gradient protein 2 (AGR2) is a novel biomarker with potential oncogenic role. We sought to investigate the diagnostic and prognostic role of AGR2 on head and neck squamous cell carcinoma (HNSCC) with an emphasis on its correlation of cancer...
Yuanyuan Zhang et al.
Archives of animal nutrition, 68(4), 320-335 (2014-07-01)
The aim of the present study was to investigate the sorption properties in vitro and the application feasibility of modified halloysite nanotubes (HNT) in reducing the toxic effect of ZEN in rats in vivo. HNT were modified using the surfactant...
Kazuhiko Kurosawa et al.
Bioresource technology, 193, 206-212 (2015-07-05)
Extracting lipids from oleaginous microbial cells in a cost effective and environmentally compatible manner remains a critical challenge in developing manufacturing paradigms for advanced liquid biofuels. In this study, a new approach using microbial growth inhibitors from lignocellulose-derived feedstocks was...
Hamid Hashemi-Moghaddam et al.
Journal of AOAC International, 97(5), 1434-1438 (2015-04-24)
A new molecularly imprinted polymer (MIP) was synthesized using methacrylic acid (functional monomer), ethylene glycol dimethacrylate (crosslinker), 2,2'-azobisisobutironitril (initiator), silver (Ag) dithizone complex (template), and chloroform (porogenic solvent). This process was a noncovalent, bulk, thermal radical-polymerization. To compare the performance...
Przemyslaw M Mrozikiewicz et al.
Acta pharmaceutica (Zagreb, Croatia), 64(2), 223-232 (2014-06-11)
There are a number of compounds that can modify the activity of ABC (ATP-binding cassette) and SLC (solute carrier) transporters in the blood-brain barrier (BBB). The aim of this study was to investigate the effect of natural and synthetic substances...
J L Barr et al.
British journal of pharmacology, 172(22), 5414-5424 (2015-09-17)
Ceftriaxone is a β-lactam antibiotic and glutamate transporter activator that reduces the reinforcing effects of psychostimulants. Ceftriaxone also reduces locomotor activation following acute psychostimulant exposure, suggesting that alterations in dopamine transmission in the nucleus accumbens contribute to its mechanism of...
Hideaki Matsuo et al.
Pain, 155(9), 1888-1901 (2014-07-11)
Although transcutaneous electrical nerve stimulation (TENS) is widely used for the treatment of neuropathic pain, its effectiveness and mechanism of action in reducing neuropathic pain remain uncertain. We investigated the effects of early TENS (starting from the day after surgery)...
Harald Jungnickel et al.
Environmental science & technology, 48(17), 10423-10431 (2014-08-06)
The search for model bioassay systems indicating activation of different toxicological signaling pathways is one of the paramount goals of modern toxicology. Especially coexposure scenarios need to be investigated with respect to synergistic and interdependent effects for the activation of...
Zhijie Chen et al.
Food chemistry, 194, 608-618 (2015-10-17)
Canaryseed is an important cereal crop in western Canada. The changes of the total phenolic content (TPC), antioxidant activities, phenolic acid profiles (free and bound) of canaryseed during germination were investigated in the present study. The growth properties also were...
Susanna Tse et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2023-2032 (2014-09-14)
Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer's disease. A human absorption, distribution, metabolism, and excretion...
A C Mamede et al.
Medical oncology (Northwood, London, England), 32(12), 257-257 (2015-10-29)
Hepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this reason, it is essential to invest in new therapies for this type of cancer. Our team already proved that human amniotic membrane (hAM) is able to inhibit the...
Xiao-Cui Qian et al.
Journal of pharmaceutical and biomedical analysis, 105, 64-73 (2014-12-30)
Rhizoma coptidis (R.C.), a widely used traditional Chinese medicine, has been used for centuries in the treatment of hypertension, inflammation, dysentery and liver diseases, etc. Wine-processing is a specialized technology by sautéing crude herbal medicine using Chinese rice wine. This...
Elias Ranjbari et al.
Talanta, 139, 216-225 (2015-04-18)
An exact, rapid and efficient method for the extraction of rhodamine B (RB) and rhodamine 6G (RG) as well as their determination in three different matrices was developed using magnetic stirring assisted dispersive liquid-liquid microextraction (MSA-DLLME) and HPLC-Vis. 1-Octanol and...
Karolina Gromadzka et al.
Arhiv za higijenu rada i toksikologiju, 66(2), 159-164 (2015-06-26)
Zearalenone (ZEA) is a mycotoxin produced by some Fusarium species in food and feed. The toxicity of ZEA and its metabolites is related to the chemical structure of the mycotoxin, which is similar to naturally occurring oestrogens. Currently, there is...
Pavel Štarha et al.
PloS one, 10(8), e0136338-e0136338 (2015-08-27)
The cis-[PtCl2(naza)2] complexes (1-3) containing monosubstituted 7-azaindole halogeno-derivatives (naza), showed significantly higher activity than cisplatin towards ovarian carcinoma A2780, its cisplatin-resistant variant A2780R, osteosarcoma HOS, breast carcinoma MCF7 and cervix carcinoma HeLa cell lines, with the IC50 values of 3.8...
Kangmin Chon et al.
Bioresource technology, 190, 499-507 (2015-03-24)
This study investigated the removal efficiency and mechanisms of water contaminants (mainly N-nitrosamines) during municipal wastewater reclamation by a membrane bioreactor (MBR) and nanofiltration (NF) hybrid system. The removal of bulk water contaminants was governed by the microbial activities in...
Weronika Hewelt-Belka et al.
Journal of chromatography. A, 1362, 62-74 (2014-08-28)
Staphylococcus aureus is a common pathogen known to cause relatively minor infections as well as severe disorders in humans. Although there is fair amount of published data concerning various aspects of its biology, epidemiology, genetics, etc., there is still a...
Xin Zhen et al.
Marine drugs, 13(11), 6947-6961 (2015-11-26)
Quinomycin G (1), a new analogue of echinomycin, together with a new cyclic dipeptide, cyclo-(l-Pro-4-OH-l-Leu) (2), as well as three known antibiotic compounds tirandamycin A (3), tirandamycin B (4) and staurosporine (5), were isolated from Streptomyces sp. LS298 obtained from...
Chien-Ming Chen et al.
Journal of pharmaceutical and biomedical analysis, 116, 150-155 (2015-08-13)
In this study, we aimed to develop a new enzymatic assay system of d-lactate with good precision, accuracy, and sensitivity for the determination of D-lactate concentrations in rat serum. D-Lactate dehydrogenase (D-LDH) was utilized to catalyze D-lactate and NAD(+) to...
Michael E El-Kommos et al.
Journal of fluorescence, 25(6), 1695-1709 (2015-10-07)
A validated simple, novel, and rapid spectrofluorimetric method was developed for the determination of some non-sedating antihistamines (NSAs); namely cetirizine (CTZ), ebastine (EBS), fexofenadine (FXD), and loratadine (LOR). The method is based on measuring the native fluorescence of the cited...
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