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Gang Zheng et al.
Toxicology letters, 225(1), 110-118 (2013-12-10)
The blood-cerebrospinal fluid barrier (BCB) plays a key role in maintaining copper (Cu) homeostasis in the brain. Cumulative evidences indicate that lead (Pb) exposure alters cerebral Cu homeostasis, which may underlie the development of neurodegenerative diseases. This study investigated the
Ru Qiao et al.
Journal of nanoscience and nanotechnology, 13(6), 4247-4251 (2013-07-19)
In this paper, we report a preparation of CuZn dendritic microstructures through a tunable template-free electrochemical approach. By simply tunning the applied depositing current, the morphology of the product can be well controlled. The growth mechanism of CuZn dendritic alloys
Goldie Songra et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 145(5), 569-578 (2014-05-03)
The aim of this study was to compare the time to initial alignment and extraction space closure using conventional brackets and active and passive self-ligating brackets. One hundred adolescent patients 11 to 18 years of age undergoing maxillary and mandibular
E J Pappert et al.
Neurology, 47(4), 1037-1042 (1996-10-01)
To determine if ventricular cerebrospinal fluid (vCSF) alpha-tocopherol levels in Parkinson's disease (PD) patients can be increased by oral alpha-tocopherol supplementation and whether vCSF levels are linearly related to plasma alpha-tocopherol levels. In spite of its putative neuroprotective properties, alpha-tocopherol
A Moser et al.
Journal of the neurological sciences, 131(2), 183-189 (1995-08-01)
We could identify the MPTP-like compound and isoquinoline derivative N-methyl-norsalsolinol (2-MDTIQ) in cerebrospinal fluid (CSF) of patients with Parkinson's disease. The presence of 2-MDTIQ negatively correlated with the disease duration. In order to study the relationship between presence of 2-MDTIQ
Metals: setting a trap for copper.
Valeria Culotta
Nature chemical biology, 10(12), 986-987 (2014-10-27)
Sonia Melino et al.
The FEBS journal, 281(3), 657-672 (2013-11-14)
Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability
Norbert Ondo Zue Abaga et al.
Chemosphere, 113, 42-47 (2014-07-30)
In Burkina-Faso, urban vegetable agriculture is often characterized by urban solid waste fertilizer inputs containing heavy metals such as Cu and Cd. Thus, the relevance of surrounding urban vegetable plots with vetiver hedges to reduce environmental pollution by Cu and
Marten H Vos et al.
Biochimica et biophysica acta, 1847(1), 79-85 (2014-08-15)
The catalytic site of heme-copper oxidases encompasses two close-lying ligand binding sites: the heme, where oxygen is bound and reduced and the CuB atom, which acts as ligand entry and release port. Diatomic gaseous ligands with a dipole moment, such
Sejal Shah et al.
Survey of ophthalmology, 59(1), 115-123 (2013-10-12)
The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a
Christopher R Pope et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20491-20496 (2013-12-04)
Efficient delivery of copper ions to specific intracellular targets requires copper chaperones that acquire metal cargo through unknown mechanisms. Here we demonstrate that the human and yeast copper chaperones (CCS) for superoxide dismutase 1 (SOD1), long thought to exclusively reside
M Pelà et al.
Die Pharmazie, 69(7), 496-499 (2014-07-31)
The synthesis of non natural amino acid 2-amino-3,3,4-trimethyl-pentanoic acid (Ipv) ready for solid phase peptide synthesis has been developed. Copper (I) chloride Michael addition, followed by a Curtius rearrangement are the key steps for the lpv synthesis. The racemic valine/leucine
Helena Stecka et al.
Environmental monitoring and assessment, 186(10), 6145-6155 (2014-05-30)
A simple and fast solid phase extraction procedure was developed to pre-concentrate traces of Cu and Zn prior to their determination in honey samples by flame atomic absorption spectrometry. The sample preparation included dissolution of honey samples and the passage
Cord Langner et al.
Virchows Archiv : an international journal of pathology, 445(2), 111-118 (2004-06-19)
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. Since daily copper intake exceeds the body's requirements, effective means of excreting excess copper are essential. These are accomplished by ATP7B, a new member of the cation-transporting p-type ATPase
Duygu Cagirdi et al.
Journal of AOAC International, 97(4), 1137-1142 (2014-08-26)
A simple and selective separation and preconcentration method was developed for the determination of Cu(ll) ions. This method is based on adsorption of Cu(ll) ions from aqueous solution on a bis(3-aminopropyl)amine modified silica gel column and flame atomic absorption spectrometric
Valerio Leoni et al.
Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:
Xiaowen Xu et al.
Organic letters, 16(13), 3540-3543 (2014-06-17)
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare
Alica Pizent et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 17(3), 199-205 (2004-02-19)
The influence of exposure to lead and cadmium on serum concentrations of calcium, zinc, and copper was examined in 299 healthy Croatian men 20-55 years of age, including 143 workers in a lead battery factory and 156 control subjects. The
Vivien W W Bao et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 81-93 (2014-12-03)
Zinc pyrithione (ZnPT) is a widely used booster biocide in combination with copper (Cu) in antifouling paints as a substitute for tributyltin. The co-occurrence of ZnPT and Cu in coastal marine environments is therefore very common, and may pose a
Daniel L Priebbenow et al.
Organic letters, 15(24), 6155-6157 (2013-11-28)
A method has been developed for the preparation of N-alkynylated sulfoximines involving the copper-catalyzed decarboxylative coupling of sulfoximines with aryl propiolic acids. A range of substituents on both the sulfoximidoyl moiety and the aryl group of the propiolic acid were
Katla Sai Krishna et al.
Journal of visualized experiments : JoVE, (81)(81), doi:10-doi:10 (2013-12-12)
Procedures utilizing millifluidic devices for chemical synthesis and time-resolved mechanistic studies are described by taking three examples. In the first, synthesis of ultra-small copper nanoclusters is described. The second example provides their utility for investigating time resolved kinetics of chemical
L A Piruzian et al.
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 47(5), 48-53 (2014-02-04)
In experiment MARS-500 on remote space flight simulation, atomic emission spectral analysis with inductively coupled argon plasma was used to measure serum copper and its ultrafiltration fraction. It was shown that, in contrast to baseline data, the Cu serum level
C Liana Allen et al.
Organic letters, 15(24), 6178-6181 (2013-11-28)
Catalyst-controlled regioselective functionalization of partially protected saccharide molecules is a highly important yet under-developed area of carbohydrate chemistry. Such reactions allow for the reduction of protecting group manipulation steps required in syntheses involving sugars. Herein, an approach to these processes
J-M Serot et al.
Journal of neurology, neurosurgery, and psychiatry, 76(11), 1585-1587 (2005-10-18)
Homocysteine may be involved in the pathogenesis of late onset Alzheimer's disease. It is implicated in the metabolism of several important pathways in the brain. Methylmalonic acid (MMA) is related to the metabolism of branched chained amino acids and fatty
A Di Veroli et al.
Chemosphere, 112, 9-17 (2014-07-23)
Mouthpart deformities of Chironomus riparius larvae (Diptera) have been investigated to evaluate the toxic effects of contamination by heavy metals in the Genna Stream (Central Italy), situated in an area subjected to intensive swine farms (40000 heads). The livestock farming
Jonas Duus Stevens Lekfeldt et al.
Environmental pollution (Barking, Essex : 1987), 194, 78-85 (2014-08-06)
Copper (Cu) is known to accumulate in agricultural soils receiving urban waste products as fertilizers. We here report the use of the leucine incorporation technique to determine pollution-induced community tolerance (Leu-PICT) to Cu in a long-term agricultural field trial. A
J A Molina et al.
Journal of neural transmission (Vienna, Austria : 1996), 109(7-8), 1035-1044 (2002-07-12)
Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex (PDHC), and transketolase. Some investigators reported decreased thiamine-diphosphate levels and decreased activities of KGDHC, pyruvate-dehydrogenase complex and
Marius Andruh
Chimia, 67(6), 383-387 (2013-08-16)
The node-and-spacer approach is widely employed in crystal engineering to construct coordination polymers. It consists of self-assembly processes involving mononuclear cationic species and exo-dentate ligands. We enlarged this strategy using preformed homo- and heterometallic complexes as nodes. The presence of
Shaojuan Song et al.
Yi chuan = Hereditas, 36(12), 1261-1268 (2014-12-10)
Copper plays critical roles in biological system; however, it is toxic in excess. To identify novel genes involved in copper metabolism, we performed a whole genome-wide genetic screen in C. elegans model organism to search for mutants which are resistant
Matthew J Sullivan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(49), 19926-19931 (2013-11-20)
Global agricultural emissions of the greenhouse gas nitrous oxide (N2O) have increased by around 20% over the last 100 y, but regulation of these emissions and their impact on bacterial cellular metabolism are poorly understood. Denitrifying bacteria convert nitrate in
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