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Darko Davitkov et al.
Acta veterinaria Hungarica, 63(2), 199-208 (2015-06-09)
Canine babesiosis is a frequent and clinically significant tick-borne disease. Sixty symptomatic dogs with clinical findings compatible with babesiosis were included in this study conducted in Serbia. After clinical examination, blood samples were taken for microscopic examination, complete blood count...
Benjamin Rothé et al.
Molecular and cellular biology, 35(19), 3339-3353 (2015-07-29)
Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/β-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adenylate cyclase 6 (AC6). RNA binding...
Feng Liu et al.
Scientific reports, 5, 15558-15558 (2015-11-03)
The common bed bug Cimex lectularius is a temporary ectoparasite on humans and currently resurgent in many developed countries. The ability of bed bugs to detect human odorants in the environment is critical for their host-seeking behavior. This study deciphered...
Ji Sook Kang et al.
International journal of molecular medicine, 36(2), 501-510 (2015-06-23)
Recent studies have demonstrated that 7,8-dihydroxyflavone (7,8-DHF), a newly identified tyrosine kinase receptor B agonist, is a potent antioxidant agent. The present study was designed to confirm the cytoprotective effects of 7,8-DHF against oxidative stress-induced cellular damage and to further...
S Rajkhowa
Letters in applied microbiology, 61(3), 293-298 (2015-06-23)
As the pathogenicity of Pasteurella multocida is associated with various virulence factors (VFs), the aim of the study was to develop a novel multiplex PCR (m-PCR) assay for the rapid detection of important virulence associated genes (VAGs) of P. multocida isolates...
Irene Sargiannidou et al.
Annals of neurology, 78(2), 303-316 (2015-05-27)
X-linked Charcot-Marie-Tooth disease (CMT1X) is a common inherited neuropathy caused by mutations in the GJB1 gene encoding the gap junction protein connexin32 (Cx32). Clinical studies and disease models indicate that neuropathy mainly results from Schwann cell autonomous, loss-of-function mechanisms; therefore...
Pushp Sheel Shukla et al.
AoB PLANTS, 7 (2015-05-20)
Abiotic stresses like drought, salinity and extreme temperature significantly affect crop productivity. Plants respond at molecular, cellular and physiological levels for management of stress tolerance. Functional and regulatory genes play a major role in controlling these abiotic stresses through an...
Jing Zhao et al.
Analytica chimica acta, 860, 23-28 (2015-02-16)
In this paper, we report an improved electrochemical aptasensor based on exonuclease III and double-stranded DNA (dsDNA)-templated copper nanoparticles (CuNPs) assisted signal amplification. In this sensor, duplex DNA from the hybridization of ligated thrombin-binding aptamer (TBA) subunits and probe DNA...
Shantashri Vaidya et al.
European journal of pharmacology, 765, 124-130 (2015-08-25)
There is an increasing body of evidence demonstrating that mechanisms independent of BCR/ABL gene also contribute to imatinib resistance in Chronic Myeloid Leukemia (CML). It has been extensively reported that polymorphisms of the genes associated with imatinib metabolization and imatinib...
Ehsan Taghiabadi et al.
Cell journal, 16(4), 476-487 (2015-02-17)
As a biological tissue material, amniotic membrane (AM) has low immunogenicity and to date has been widely adopted in clinical practice. However, some features such as low biomechanical consistency and rapid biodegradation is limited the application of AM. Therefore, in...
Siele Ceuppens et al.
International journal of environmental research and public health, 12(8), 10171-10197 (2015-08-27)
Fresh herbs such as basil constitute an important food commodity worldwide. Basil provides considerable culinary and health benefits, but has also been implicated in foodborne illnesses. The naturally occurring bacterial community on basil leaves is currently unknown, so the epiphytic...
Sonja Axmann et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(7), 1089-1098 (2015-04-03)
Since June 2013 the total feed ban of processed animal proteins (PAPs) was partially lifted. Now it is possible to mix fish feed with PAPs from non-ruminants (pig and poultry). To guarantee that fish feed, which contains non-ruminant PAPs, is...
Hanan Awad et al.
Pediatric pulmonology, 49(9), 885-897 (2013-10-30)
Hypoxia and reactive oxygen species (ROS) including H(2)O(2) play major roles in triggering and progression of pulmonary vascular remodeling in persistent pulmonary hypertension. Catalase (CAT), the major endogenous enzyme scavenging H(2)O(2), is regulated in a tissue- and context-specific manner. To...
Wesley P Black et al.
Scientific reports, 5, 17831-17831 (2015-12-08)
Here we attempted to identify the downstream target of the DifE histidine kinase in the regulation of exopolysaccharide (EPS) production in the Gram-negative bacterium Myxococcus xanthus. This bacterium is an important model system for the studies of Type IV pilus...
Rainer Nikolay et al.
Nucleic acids research, 42(12), e100-e100 (2014-05-06)
While the structure of mature ribosomes is analyzed in atomic detail considerably less is known about their assembly process in living cells. This is mainly due to technical and conceptual hurdles. To analyze ribosome assembly in vivo, we designed and...
Yoshiaki Nikaido et al.
Journal of biochemistry, 157(5), 311-320 (2014-11-27)
GPR84 is a G protein-coupled receptor for medium-chain fatty acids. Capric acid and 3,3'-diindolylmethane are specific agonists for GPR84. We built a homology model of a GPR84-capric acid complex to investigate the ligand-binding mode using the crystal structure of human...
Rebecca C Klein et al.
PloS one, 9(4), e94071-e94071 (2014-04-16)
The human apolipoprotein ε4 allele (APOE4) has been implicated as one of the strongest genetic risk factors associated with Alzheimer's disease (AD) and in influencing normal cognitive functioning. Previous studies have demonstrated that mice expressing human apoE4 display deficits in...
Olivier Biner et al.
PloS one, 10(12), e0143963-e0143963 (2015-12-03)
Hyaluronidases are important venom components acting as spreading factor of toxic compounds. In several studies this spreading effect was tested on vertebrate tissue. However, data about the spreading activity on invertebrates, the main prey organisms of spiders, are lacking. Here...
Catherine H Choi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 396-408 (2015-01-09)
Fragile X syndrome (FXS) is the leading cause of both intellectual disability and autism resulting from a single gene mutation. Previously, we characterized cognitive impairments and brain structural defects in a Drosophila model of FXS and demonstrated that these impairments...
Tatsuki Kunoh et al.
SpringerPlus, 3, 30-30 (2014-01-31)
Highly conserved chromatin assembly factor 1 (CAF-1) is required for histone deposition onto newly synthesized DNA to maintain genome stability. This study shows that the fission yeast Pcf1, the large subunit in CAF-1, is crucial for maintaining checkpoint kinase Cds1....
Shanye Yin et al.
Scientific reports, 5, 11992-11992 (2015-07-08)
Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. Here we have established a robust in vivo system in which pri-miRNA is transcribed by...
Joana Šalomskienė et al.
Journal of food science and technology, 52(7), 4124-4134 (2015-07-04)
The aim of the study was a detail evaluation of genetic diversity among the lactic acid bacteria (LAB) strains having an advantage of a starter culture in order to select genotypically diverse strains with enhanced antimicrobial effect on some harmfull...
Wen-Pin Su et al.
Oncotarget, 5(15), 6323-6337 (2014-07-23)
Cisplatin can cause intrastrand and interstrand crosslinks between purine bases and is a chemotherapeutic drug widely used to treat cancer. However, the major barrier to the efficacy of the treatment is drug resistance. Homologous recombination (HR) plays a central role...
Christina Kober et al.
Journal of translational medicine, 13, 216-216 (2015-07-08)
Oncolytic virotherapy is a novel approach for the treatment of glioblastoma multiforme (GBM) which is still a fatal disease. Pathologic features of GBM are characterized by the infiltration with microglia/macrophages and a strong interaction between immune- and glioma cells. The...
Gemma Slater et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 1831-1848 (2015-02-06)
Chemotaxis is important for the survival of most animals. How the brain translates sensory input into motor output beyond higher olfactory processing centers is largely unknown. We describe a group of excitatory neurons, termed Odd neurons, which are important for...
Alphonsine Kouassi M'Bengue et al.
Infectious agents and cancer, 10, 18-18 (2015-07-02)
Hepatocellular carcinoma (HCC) is a major public health concern in Sub-Saharan Africa. Early research in Ivory Coast showed that chronic hepatitis B and aflatoxin B1 exposure were the two most important etiological agents of HCC in the country but, surprisingly...
Carlos A Niño et al.
MicrobiologyOpen, 2(3), 525-539 (2013-04-25)
Ubiquitination is a highly dynamic and versatile posttranslational modification that regulates protein function, stability, and interactions. To investigate the roles of ubiquitination in a primitive eukaryotic lineage, we utilized the early-branching eukaryote Giardia intestinalis. Using a combination of biochemical, immunofluorescence-based...
Abdellatif Bahaji et al.
PloS one, 10(3), e0119641-e0119641 (2015-03-27)
Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. It is involved in glycolysis and in the regeneration of glucose-6-P molecules in the oxidative pentose phosphate pathway (OPPP). In chloroplasts of illuminated mesophyll cells PGI also connects the...
Hao-Ching Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(28), 8768-8773 (2015-07-01)
Decline in mitochondrial morphology and function is a hallmark of neuronal aging. Here we report that progressive mitochondrial fragmentation is a common manifestation of aging Caenorhabditis elegans neurons and body wall muscles. We show that sensory-evoked activity was essential for...
Crystal M Han et al.
Lab on a chip, 14(16), 2958-2967 (2014-06-13)
We present an on-chip electrokinetic method to increase the reaction kinetics and sensitivity of DNA microarray hybridization. We use isotachophoresis (ITP) to preconcentrate target molecules in solution and transport them over the immobilized probe sites of a microarray, greatly increasing...