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Charlene L McCord et al.
Molecular phylogenetics and evolution, 94(Pt A), 397-409 (2015-09-27)
The triggerfishes (family Balistidae) and filefishes (family Monacanthidae) comprise a charismatic superfamily (Balistoidea) within the diverse order Tetraodontiformes. This group of largely marine fishes occupies an impressive ecological range across the world's oceans, and is well known for its locomotor
María C Ovejero-Benito et al.
Cell cycle (Georgetown, Tex.), 14(14), 2311-2322 (2015-05-07)
Nuclear DNA duplication in the absence of cell division (i.e. endoreplication) leads to somatic polyploidy in eukaryotic cells. In contrast to some invertebrate neurons, whose nuclei may contain up to 200,000-fold the normal haploid DNA amount (C), polyploid neurons in
Shaik Mohammad Naushad et al.
Molecular and cellular biochemistry, 392(1-2), 273-280 (2014-03-29)
Obesity, genetic polymorphisms of xenobiotic metabolic pathway, hypermethylation of tumor suppressor genes, and hypomethylation of proapoptotic genes are known to be independent risk factors for breast cancer. The objective of this study is to evaluate the combined effect of these
Joanna K Hubbard et al.
Ecology and evolution, 5(16), 3436-3449 (2015-09-19)
Phenotypic differences among individuals are often linked to differential survival and mating success. Quantifying the relative influence of genetic and environmental variation on phenotype allows evolutionary biologists to make predictions about the potential for a given trait to respond to
Milene R da Costa et al.
Proteomics, 14(12), 1480-1493 (2014-04-12)
Acute kidney injury (AKI) is one of the more frequent and lethal pathological conditions seen in intensive care units. Currently available treatments are not totally effective but stem cell-based therapies are emerging as promising alternatives, especially the use of mesenchymal
Charlotte D'Mello et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10821-10830 (2015-08-01)
Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease, chronic liver disease) commonly develop debilitating symptoms (i.e., sickness behaviors) that arise from changes in brain function. The microbiota-gut-brain axis alters brain function and probiotic ingestion can influence behavior.
Rangarajan Padmanabhan et al.
Journal of cell science, 128(9), 1773-1786 (2015-03-22)
The epithelial-to-mesenchymal transition (EMT) is important for the formation of migratory neural crest cells during development and is co-opted in human diseases such as cancer metastasis. Chick premigratory cranial neural crest cells lose intercellular contacts, mediated in part by Cadherin-6B
Seyed-Mostafa Pirseyedi et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 128(12), 2403-2414 (2015-08-05)
A compensating, recombined Lr59 translocation with greatly reduced alien chromatin was identified. Microsatellite locus Xdupw217 occurs within the remaining segment and can be used as a co-dominant marker for Lr59. In earlier studies, leaf rust (caused by Puccinia triticina Eriks.)
Cong Xu et al.
Nature communications, 5, 5758-5758 (2014-12-17)
Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that vein-derived
Emilie Le Goff et al.
Biology open, 4(9), 1109-1121 (2015-08-16)
The paradigm of developmental regulation by Polycomb group (PcG) proteins posits that they maintain silencing outside the spatial expression domains of their target genes, particularly of Hox genes, starting from mid embryogenesis. The Enhancer of zeste [E(z)] PcG protein is
Nicolas Aznar et al.
eLife, 4, e07091-e07091 (2015-07-01)
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain
Ikue Nagakura et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10256-10263 (2014-08-01)
Accumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we show that one of its components, STAT1, negatively regulates the
Michael S Hildebrand et al.
Scientific reports, 5, 17816-17816 (2015-12-10)
Febrile seizures (FS) are the most common seizure syndrome and are potentially a prelude to more severe epilepsy. Although zinc (Zn(2+)) metabolism has previously been implicated in FS, whether or not variation in proteins essential for Zn(2+) homeostasis contributes to
Deepshikha Verma et al.
PloS one, 10(7), e0133186-e0133186 (2015-07-16)
The study of genomic variability within various pathogenic and non-pathogenic strains of mycobacteria provides insight into their evolution and pathogenesis. The mycobacterial genome encodes seven cutinase-like proteins and each one of these exhibit distinct characteristics. We describe the presence of
Dhilushi D Wijayakumara et al.
The Journal of pharmacology and experimental therapeutics, 354(3), 417-425 (2015-07-15)
Given the prime importance of UDP-glucuronosyltransferase (UGT) 2B15 and UGT2B17 in inactivating testosterone and dihydrotestosterone, control of their expression and activity in the prostate is essential for androgen signaling homeostasis in this organ. Although several studies provide evidence of transcriptional
Giselli Scaini et al.
Neurochemical research, 40(5), 885-893 (2015-02-15)
Maple syrup urine disease (MSUD) is caused by an inborn error in metabolism resulting from a deficiency in the branched-chain α-keto acid dehydrogenase complex activity. This blockage leads to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine and valine
J Velíšková et al.
Journal of neuroendocrinology, 27(12), 911-920 (2015-11-07)
Neuropeptide Y (NPY) is an endogenous modulator of neuronal activity affecting both GABAergic and glutamatergic transmission. Previously, we found that oestradiol modifies the number of NPY immunoreactive neurones in the hippocampal dentate gyrus. In the present study, we investigated which
Sureewan Bumrungthai et al.
PloS one, 10(5), e0127109-e0127109 (2015-05-27)
MicroRNA-21 (miR-21) is recognized as an oncomir and shows up-regulation in many types of human malignancy. The aim of this study was to investigate the association of miR-21 expression associated with HPV infection in normal and abnormal cervical tissues. Cervical
Min Li et al.
Nature communications, 6, 6720-6720 (2015-04-09)
DNA topoisomerase I (TOP1) has an important role in maintaining DNA topology by relaxing supercoiled DNA. Here we show that the K391 and K436 residues of TOP1 are SUMOylated by the PIAS1-SRSF1 E3 ligase complex in the chromatin fraction containing
David P Tchouassi et al.
PLoS neglected tropical diseases, 8(12), e3364-e3364 (2014-12-05)
Rift Valley fever (RVF) outbreaks in Kenya have increased in frequency and range to include northeastern Kenya where viruses are increasingly being isolated from known (Aedes mcintoshi) and newly-associated (Ae. ochraceus) vectors. The factors contributing to these changing outbreak patterns
Er-Ping Liu et al.
Genetic testing and molecular biomarkers, 19(11), 610-616 (2015-09-12)
Point-of-care genetic analysis may require polymerase chain reaction (PCR) to be carried out on whole blood. However, human blood contains natural inhibitors of PCR such as hemoglobin, immunoglobulin G, lactoferrin, and proteases, as well as anticoagulant agents, including EDTA and
Lian Cai et al.
Theriogenology, 84(7), 1075-1087 (2015-07-22)
Granulocyte colony-stimulating factor (G-CSF) is required for proliferation, differentiation, and survival of cells. It is also a biomarker of human oocyte developmental competence for embryo implantation. In humans, the G-CSF concentration peaks during the ovulatory phase of the ovarian cycle.
Samuel T Keating et al.
Cellular and molecular life sciences : CMLS, 71(22), 4471-4486 (2014-05-31)
Methyl-dependent regulation of transcription has expanded from a traditional focus on histones to encompass transcription factor modulation. While the Set7 lysine methyltransferase is associated with pro-inflammatory gene expression in vascular endothelial cells, genome-wide regulatory roles remain to be investigated. From
Qing Wang et al.
Talanta, 129, 438-447 (2014-08-17)
In the current study, zirconia (ZrO2) and its composite, magnesia-zirconia (MgO-ZrO2), were prepared as the hydrophilic interaction chromatographic (HILIC) stationary phases (SPs). Different experimental variables including water content, pH and buffer concentration in the mobile phase (MP) as well as
Andrés Gómez-Palacio et al.
PLoS neglected tropical diseases, 8(3), e2734-e2734 (2014-03-15)
Triatoma dimidiata is one of the most significant vectors of Chagas disease in Central America and Colombia, and, as in most species, its pattern of genetic variation within and among populations is strongly affected by its phylogeographic history. A putative
Sandeep C Chaudhary et al.
Oncotarget, 6(34), 36789-36814 (2015-09-29)
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder that is due, in large measure, to aberrant Shh signaling driven by mutations in the tumor suppressor gene Ptch1. Here, we describe the development of Ptch1+/-/ SKH-1 mice
Ronghua Wu et al.
PloS one, 10(5), e0127940-e0127940 (2015-05-30)
The 27.8 kDa membrane protein from flounder (Paralichthys olivaceus) gill (FG) cells was previously identified as a putative cellular receptor involved in lymphocystis disease virus (LCDV) infection. In this paper, the expression of receptor-27.8 kDa (27.8R) and LCDV loads in
Shenghong Zhong et al.
Soft matter, 11(35), 6999-7004 (2015-08-05)
Here, we report the development of an experimental system based on liquid crystals (LCs) confined in microcapillaries for imaging interfacial phenomena. The inner surfaces of the microcapillaries were modified with octadecyltrichlorosilane to promote an escaped-radial configuration of LCs. We checked
Maria R D'Aimmo et al.
Anaerobe, 30, 169-177 (2014-10-15)
Bifidobacteria, one of the most common bacteria of the intestinal tract, help establish balance in the gut microbiota and confer health benefits to the host. One beneficial property is folate biosynthesis, which is dependent on species and strains. It is
Masayuki Okamoto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2942-2958 (2015-02-24)
Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3β activity. Then, transported Lis1 is retrogradely
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