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68475

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Alexis J Carulli et al.
Developmental biology, 402(1), 98-108 (2015-04-04)
The Notch signaling pathway regulates intestinal epithelial cell homeostasis, including stem cell maintenance, progenitor cell proliferation and differentiation. Notch1 and Notch2 receptors are expressed in the epithelium, but individual contributions to these functions are unclear. We used genetic deletion to
Annelies Geirnaert et al.
FEMS microbiology ecology, 91(6) (2015-05-23)
Butyrate-producing bacteria are promising probiotic candidates to target microbial dysbiosis in gastrointestinal disorders like inflammatory bowel diseases. Butyricicoccus pullicaecorum 25-3(T), a butyrate-producing clostridial cluster IV strain, is such a candidate. Little is known about its abundance in the colon microbiota
Rajesh Kumar G et al.
PloS one, 10(3), e0120359-e0120359 (2015-03-31)
Coronary Artery Disease (CAD) is clearly a multifactorial disease that develops from childhood and ultimately leads to death. Several reports revealed having a First Degree Relatives (FDRS) with premature CAD is a significant autonomous risk factor for CAD development. C
Bjoern Traenkle et al.
Molecular & cellular proteomics : MCP, 14(3), 707-723 (2015-01-18)
β-catenin is the key component of the canonical Wnt pathway and plays a crucial role in a multitude of developmental and homeostatic processes. The different tasks of β-catenin are orchestrated by its subcellular localization and participation in multiprotein complexes. To
S C Salvage et al.
Acta physiologica (Oxford, England), 214(3), 361-375 (2015-04-09)
Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Nav 1.5 currents in homozygous RyR2-P2328S (RyR2(S/S) ) mice with slowed conduction and increased
Giuseppe Mancuso et al.
Molecules (Basel, Switzerland), 20(10), 18907-18922 (2015-10-27)
Ruta graveolens (rue) is a spontaneous plant in the Mediterranean area with a strong aroma and a very intense bitter taste, used in gastronomy and in folk medicine. From the leaves, stems and fruits of rue, we isolated rutin, rutamarin
Joydeep Roy et al.
Molecular biology of the cell, 26(9), 1583-1600 (2015-03-06)
Hsp70 aids in protein folding and directs misfolded proteins to the cellular degradation machinery. We describe discrete roles of Hsp70,SSA1 as an important quality-control machinery that switches functions to ameliorate the cellular environment. SSA1 facilitates folding/maturation of newly synthesized protein
C Mamoulakis et al.
Andrologia, 46(9), 986-996 (2015-03-03)
This study investigated the hypothesis that genetic alterations of the human insulin-like 3 (INSL3) gene are associated with testicular maldescent (TMD). Genomic DNA was extracted and amplified from peripheral blood samples of 170 unrelated children with all possible phenotypical expressions
Christopher J Konop et al.
Journal of the American Society for Mass Spectrometry, 26(12), 2009-2023 (2015-07-16)
Neuromodulators have become an increasingly important component of functional circuits, dramatically changing the properties of both neurons and synapses to affect behavior. To explore the role of neuropeptides in Ascaris suum behavior, we devised an improved method for cleanly dissecting
Hojjat Bazzazi et al.
The Journal of physiology, 593(17), 3865-3884 (2015-06-23)
Novel fluorescence resonance energy transfer-based genetically encoded reporters of calcineurin are constructed by fusing the two subunits of calcineurin with P2A-based linkers retaining the expected native conformation of calcineurin. Calcineurin reporters display robust responses to calcium transients in HEK293 cells.
Christian Preußer et al.
Nucleic acids research, 42(10), 6603-6615 (2014-04-22)
Trans-splicing in trypanosomes adds a 39-nucleotide mini-exon from the spliced leader (SL) RNA to the 5' end of each protein-coding sequence. On the other hand, cis-splicing of the few intron-containing genes requires the U1 small nuclear ribonucleoprotein (snRNP) particle. To
Shunli Wang et al.
Plant cell reports, 34(8), 1459-1471 (2015-05-15)
The central flower integrator PsSOC1 was isolated and its expression profiles were analyzed; then the potential function of PsSOC1 in tree peony was postulated. The six flowering genes PrSOC1, PdSOC1, PsSOC1, PsSOC1-1, PsSOC1-2, and PsSOC1-3 were isolated from Paeonia rockii
Anke Loregger et al.
Science signaling, 8(393), ra90-ra90 (2015-09-10)
Given its fundamental role in development and cancer, the Wnt-β-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 (RNF43) is an E3 ubiquitin ligase originally found in stem cells and proposed to inhibit Wnt signaling by
Mamdoh R Mahmoud et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 91, 141-154 (2014-06-18)
A novel mesoporous silica-coated ferrocyanide (MSCFC) composite was successfully synthesized and evaluated as a dual-function material for simultaneous removal of (137)Cs(+) cations and (99)TcO4(-) anions from aqueous solutions. Sorption behavior of both radionuclides on MSCFC under different experimental conditions has
Kazuya Ishikawa et al.
Nature communications, 5, 5430-5430 (2014-11-13)
Pathogen effector proteins are delivered to host cells to suppress plant immunity. However, the mechanisms by which effector proteins function are largely unknown. Here we show that expression of XopP(Xoo), an effector of rice pathogen Xanthomonas oryzae pv. oryzae, in
Kanungnit Congpuong et al.
The Korean journal of parasitology, 52(6), 631-637 (2014-12-31)
Genetic characteristics of Plasmodium falciparum may play a role in the treatment outcome of malaria infection. We have studied the association between diversity at the merozoite surface protein-1 (msp-1), msp-2, and glutamate-rich protein (glurp) loci and the treatment outcome of
M Li et al.
Letters in applied microbiology, 61(2), 179-185 (2015-05-15)
Most of the current research into the quantification of soil-borne pathogenic oomycetes lacks determination of DNA extraction efficiency, probably leading to an incorrect estimation of DNA quantity. In this study, we developed a convenient method by using a 100 bp artificially
Heidi Stoll et al.
Biomicrofluidics, 9(3), 034111-034111 (2015-07-17)
Aptamers are promising cell targeting ligands for several applications such as for the diagnosis, therapy, and drug delivery. Especially, in the field of regenerative medicine, stem cell specific aptamers have an enormous potential. Using the combinatorial chemistry process SELEX (Systematic
Takao Iino et al.
Applied and environmental microbiology, 81(5), 1839-1846 (2014-12-31)
Microbiologically influenced corrosion (MIC) of metallic materials imposes a heavy economic burden. The mechanism of MIC of metallic iron (Fe(0)) under anaerobic conditions is usually explained as the consumption of cathodic hydrogen by hydrogenotrophic microorganisms that accelerates anodic Fe(0) oxidation.
Gang Wang et al.
International journal of nanomedicine, 10, 5005-5023 (2015-09-09)
Flavonoids, the major polyphenol components in Cotinus coggygria (CC), have been found to show an anticancer effect in our previous study; however, the exact mechanisms of inducing human glioblastoma (GBM) cell death remain to be resolved. In this study, a
Mareike Dabisch-Ruthe et al.
Clinical biochemistry, 47(15), 60-67 (2014-07-16)
Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder characterized by progressive calcification and fragmentation of elastic fibers. Because of the great clinical variability between PXE patients the involvement of modifier genes was recently suggested. Therefore, we investigated the association of
Maïté Amy et al.
Amyotrophic lateral sclerosis & frontotemporal degeneration, 16(7-8), 490-496 (2015-06-18)
Amyotrophic lateral sclerosis is sporadic (SALS) in 90% of cases and has complex environmental and genetic influences. Nogo protein inhibits neurite outgrowth and is overexpressed in muscle in ALS. Our aims were to study the reticulon 4 receptor gene RTN4R
Cécile Voisset et al.
Disease models & mechanisms, 7(4), 435-444 (2014-02-22)
Epstein-Barr virus (EBV) is tightly associated with certain human cancers, but there is as yet no specific treatment against EBV-related diseases. The EBV-encoded EBNA1 protein is essential to maintain viral episomes and for viral persistence. As such, EBNA1 is expressed
Andrée-Anne Bouvette-Turcot et al.
Genes, brain, and behavior, 14(3), 229-237 (2015-02-18)
We examined transgenerational effects of maternal childhood adversity on child temperament and a functional promoter polymorphism, 5-HTTLPR, in the serotonin-transporter gene (SLC6A4) as potential moderators of such maternal influences in 154 mother-child dyads, recruited into a longitudinal birth cohort study.
Wolf Holtkamp et al.
The EMBO journal, 33(9), 1073-1085 (2014-03-13)
Elongation factor G (EF-G) promotes the movement of two tRNAs and the mRNA through the ribosome in each cycle of peptide elongation. During translocation, the tRNAs transiently occupy intermediate positions on both small (30S) and large (50S) ribosomal subunits. How
Sanda Ravlić et al.
Environmental toxicology and pharmacology, 40(1), 300-309 (2015-07-16)
Cytochrome P450 enzymes (CYPs) are essential components of cellular detoxification system. We identified and characterized seven new cytochrome P450 gene transcript clusters in the populations of bivalve mollusc Mytilus galloprovincialis from three different locations. The phylogenetic analysis identified all transcripts
Ndongo Dia et al.
PloS one, 10(5), e0121704-e0121704 (2015-05-23)
In Senegal, with the variable routine vaccination coverage, the risk for illness and death from measles still exists as evidenced by the measles epidemic episode in 2009. Since 2002 a laboratory-based surveillance system of measles was established by the Ministry
V Kaushal et al.
Cell death and differentiation, 22(10), 1676-1686 (2015-03-07)
Neuronal active Caspase-6 (Casp6) is associated with Alzheimer disease (AD), cognitive impairment, and axonal degeneration. Caspase-1 (Casp1) can activate Casp6 but the expression and functionality of Casp1-activating inflammasomes has not been well-defined in human neurons. Here, we show that primary
Amel Alqadah et al.
The EMBO journal, 34(20), 2574-2589 (2015-09-06)
Diversification of neuron classes is essential for functions of the olfactory system, but the underlying mechanisms that generate individual olfactory neuron types are only beginning to be understood. Here we describe a role of the highly conserved HMG-box transcription factor
Yue Hu et al.
Journal of experimental botany, 66(15), 4733-4747 (2015-05-23)
The barley stripe mosaic virus (BSMV) triple gene block 1 (TGB1) protein is required for virus cell-to-cell movement. However, little information is available about how these activities are regulated by post-translational modifications. In this study, we showed that the BSMV
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