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Richard T Addo et al.
Journal of pharmaceutical sciences, 104(5), 1677-1690 (2015-02-06)
The overall study goal was to produce a microparticle formulation containing atropine sulfate for ocular administration with improved efficacy and lower side effects, compared with that of the standard marketed atropine solution. The objective was to prepare an atropine sulfate-loaded
Yao-Yue Yang et al.
Langmuir : the ACS journal of surfaces and colloids, 29(5), 1709-1716 (2013-01-15)
The dissociative adsorption and electrooxidation of CH(3)OH at a Pd electrode in alkaline solution are investigated by using in situ infrared spectroscopy with both internal and external reflection modes. The former (ATR-SEIRAS) has a higher sensitivity of detecting surface species
Wei Ren et al.
Journal of pharmaceutical sciences, 103(6), 1692-1700 (2014-04-10)
Passive and iontophoretic transport of fluoride from three fluoride sources, NaF, sodium monofluorophosphate (MFP), and SnF2 solutions, across bovine enamel was investigated to (1) determine the characteristics of the intrinsic barrier of enamel for ion transport, (2) examine the feasibility
Jasmin Matuszak et al.
Clinical hemorheology and microcirculation, 61(2), 259-277 (2015-09-28)
Superparamagnetic iron oxide nanoparticles (SPIONs) are versatile and easily functionalized agents with high potential for diagnostic and therapeutic intravascular applications. In this study, we analyzed the responses of endothelial (ECs) and monocytic cells to three different types of SPIONs, in
Erika Della Mina et al.
European journal of human genetics : EJHG, 23(3), 354-362 (2014-05-23)
We analyzed by next-generation sequencing (NGS) 67 epilepsy genes in 19 patients with different types of either isolated or syndromic epileptic disorders and in 15 controls to investigate whether a quick and cheap molecular diagnosis could be provided. The average
Zhiqiang Chen et al.
Electromagnetic biology and medicine, 34(4), 309-316 (2014-05-27)
Magnetic nano-Fe3O4 particles (MNPs), static magnetic field (SMF) and extremely low-frequency altering electric magnetic field (ELFF) were utilized to treat nude mice loading hepatoma Bel-7402 cell lines to investigate the therapeutic values of MNPs combined with ELFF in vivo. Magnetic
Xi Juan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 123, 493-497 (2014-12-03)
The citrus process industry produces annually a huge amount of pomace, which is a rich source of citrus pectin. Here, we report the hydrogel of citrus pectin mediated by sodium hydroxide can be used to prepare fluorescent carbon dots (CDs).
Lili Wu et al.
Acta biomaterialia, 27, 294-304 (2015-09-01)
Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how magnesium (Mg)-based implants influence the bone metabolism and remodeling upon degradation. Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were first differentiated into
Priscilia Y Heredia-Castro et al.
Journal of dairy science, 98(12), 8285-8293 (2015-10-20)
Lactobacillus spp. from Mexican Cocido cheese were shown to produce bacteriocin-like substances (BLS) active against Staphylococcus aureus,Listeria innocua,Escherichia coli, andSalmonella typhimurium by using the disk diffusion method. Crude extracts of Lactobacillus fermentum showed strong inhibitory activity against Staph. aureus, L.
Kazumi Matsubara et al.
Chromosoma, 124(4), 529-539 (2015-07-25)
Highly repetitive DNA sequences of the centromeric heterochromatin provide valuable molecular cytogenetic markers for the investigation of genomic compartmentalization in the macrochromosomes and microchromosomes of sauropsids. Here, the relationship between centromeric heterochromatin and karyotype evolution was examined using cloned repetitive
L E Jamieson et al.
The Analyst, 140(7), 2330-2335 (2015-02-24)
Intracellular redox potential is a highly regulated cellular characteristic and is critically involved in maintaining cellular health and function. The dysregulation of redox potential can result in the initiation and progression of numerous diseases. Redox potential is determined by the
Nasim Heshmati et al.
The Journal of pharmacy and pharmacology, 66(11), 1567-1575 (2014-06-26)
Anticancer indirubins are poorly soluble in water. Here, digestion of four self-emulsifying drug delivery systems (SEDDS) containing E804 (indirubin-3'-oxime 2,3-dihydroxypropyl ether) was compared by dynamic lipolysis and bioavailability studies. Used lipids were either medium-chain or long-chain glycerides. SEDDS E804 were
Jing Ji et al.
Nanoscale research letters, 10(1), 453-453 (2015-11-27)
Carboplatin (CRB) possesses superior anticancer effect in cervical cancer cells with lower incidence of side effects compared to that of cisplatin. However, CRB suffers from severe side effects due to undesirable tissue distributions which contribute to the low therapeutic efficacy.
Mieke H van Marion et al.
Journal of molecular and cellular cardiology, 87, 79-91 (2015-08-19)
Cardiomyocyte progenitor cells (CMPCs) are a candidate cell source for cardiac regenerative therapy. However, like other stem cells, after transplantation in the heart, cell retention and differentiation capacity of the CMPCs are low. Combining cells with biomaterials might overcome this
Ramon Weishaupt et al.
Biomacromolecules, 16(11), 3640-3650 (2015-09-29)
Controlled and efficient immobilization of specific biomolecules is a key technology to introduce new, favorable functions to materials suitable for biomedical applications. Here, we describe an innovative and efficient, two-step methodology for the stable immobilization of various biomolecules, including small
M A Jarzabek et al.
British journal of cancer, 111(12), 2275-2286 (2014-11-07)
Glioblastoma (GBM), being a highly vascularised and locally invasive tumour, is an attractive target for anti-angiogenic and anti-invasive therapies. The GBM/endothelial cell response to gossypol/temozolomide (TMZ) treatment was investigated with a particular aim to assess treatment effects on cancer hallmarks.
Ying Pei et al.
Carbohydrate polymers, 92(2), 1752-1760 (2013-02-13)
In this work, a series of cellulose/collagen hydrolysate (RC/CH) films were prepared in NaOH/urea aqueous solution via a simple, low-cost and green pathway. To overcome the disadvantages (brittleness, poor water resistance) of CH as biomaterials, CH was combined with regenerated
Lung-Shuo Wang et al.
International journal of nanomedicine, 10, 2685-2696 (2015-04-17)
Silver nanoparticles have been used in various fields, and several synthesis processes have been developed. The stability and dispersion of the synthesized nanoparticles is vital. The present article describes a novel approach for one-step synthesis of silver nanoparticles-embedded chitosan particles.
Victoria E González-Rodríguez et al.
Archives of microbiology, 197(2), 117-133 (2014-08-22)
Botrytis cinerea is one of the most relevant plant pathogenic fungi. The first step during its infection process is the germination of the conidia. Here, we report on the first proteome analysis during the germination of B. cinerea conidia, where
Uwe Lindner et al.
Analytical and bioanalytical chemistry, 407(9), 2415-2422 (2014-12-10)
Hydrophilic interaction chromatography (HILIC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) were optimised for the direct determination of gadolinium-based contrast agents in tap water. In comparison to our previous work, a new developed zwitterionic HILIC column (ZIC-cHILIC) was used
Shihoko Suwa et al.
International journal of oncology, 46(3), 1369-1376 (2015-01-13)
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catalyzes tryptophan degradation and induces immunosuppression. Although IDO is an important factor that allows tumors to escape from immunological attack, its effect on lymphoid malignancies has not been fully revealed. We evaluated the
Raffaela Biesuz et al.
The Analyst, 139(16), 3932-3939 (2014-06-27)
The synthesis and the physico-chemical characterisation of a novel solid phase, designed for iron(iii) sorption, are presented. The solid (indicated in the following as DFO-SAMMS) is made with a hydroxamate siderophore, the deferoxamine (DFO), covalently bound on a self-assembled monolayer
Jin Sun Yoon et al.
International journal of oncology, 46(5), 1953-1962 (2015-02-20)
Sodium metaarsenite (NaAs2O3: code name KML001) is an orally bioavailable arsenic compound with potential anti-cancer activity. However, the effect of KML001 has not been studied in acute myeloid leukemia (AML). We investigated the anti-leukemic effect of KML001 in AML, and
Nadine J Ortner et al.
Nature communications, 5, 3897-3897 (2014-06-20)
Cav1.2 and Cav1.3 are the main L-type Ca(2+) channel subtypes in the brain. Cav1.3 channels have recently been implicated in the pathogenesis of Parkinson's disease. Therefore, Cav1.3-selective blockers are developed as promising neuroprotective drugs. We studied the pharmacological properties of
Kobra Sadat Hasheminasab et al.
Journal of chromatography. A, 1378, 1-7 (2015-01-07)
This paper proposes for the first time the use of a nonionic surfactant for the enhancement of electromembrane extraction performance. The presence of nonionic surfactant in donor phase promotes ionic analytes efficient migration through the organic liquid membrane. Surfactant assisted
Y Guyot et al.
Biotechnology and bioengineering, 112(12), 2591-2600 (2015-06-11)
Bone tissue engineering strategies use flow through perfusion bioreactors to apply mechanical stimuli to cells seeded on porous scaffolds. Cells grow on the scaffold surface but also by bridging the scaffold pores leading a fully filled scaffold following the scaffold's
Maria C Fernandes et al.
Bioresource technology, 186, 309-315 (2015-04-04)
The correct choice of the specific lignocellulosic biomass pretreatment allows obtaining high biomass conversions for biorefinery implementations and cellulosic bioethanol production from renewable resources. Cynara cardunculus (cardoon) pretreated by steam explosion (SE) was involved in second-generation bioethanol production using separate
Stefan Vestring et al.
Pflugers Archiv : European journal of physiology, 467(12), 2589-2601 (2015-08-10)
Calcium buffering by mitochondria plays a relevant physiological function in the regulation of Ca(2+) and exocytotic signals in mature chromaffin cells (CCs) from various adult mammals. Whether a similar or different role of mitochondrial Ca(2+) buffering is present in immature
Wei-Nan Zhu et al.
PLoS neglected tropical diseases, 8(8), e3103-e3103 (2014-08-22)
Previous genomic analysis of pathogenic Leptospira has identified two circular chromosomes but no plasmid. This study aims to investigate potential extrachromosomal elements of L.interrogans serovar Canicola strain Gui44. Two novel plasmids, pGui1 and pGui2, were isolated from the pathogenic strain
Tedros M Berhane et al.
Journal of hazardous materials, 282, 183-193 (2014-12-03)
Palygorskite-montmorillonite (PM) was studied as a potential sewage treatment effluent filter material for carbamazepine. Batch sorption experiments were conducted as a function of granule size (0.3-0.6, 1.7-2.0 and 2.8mm) and different sewage effluent conditions (pH, ionic strength and temperature). Results
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