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Przemysław Duda et al.
Cells, 9(1) (2020-01-18)
Fibroblasts are important contributors to cancer development. They create a tumor microenvironment and modulate our metabolism and treatment resistance. In the present paper, we demonstrate that healthy fibroblasts induce metabolic coupling with non-small cell lung cancer cells by down-regulating the...
Chiung Chi Peng et al.
Scientific reports, 9(1), 3392-3392 (2019-03-06)
Bicalutamide (Bic) is frequently used in androgen deprivation therapy (ADT) for treating prostate cancer. ADT-induced hypogonadism was reported to have the potential to lead to acute kidney injury (AKI). ADT was also shown to induce bladder fibrosis via induction of...
Wencheng Zhou et al.
Scientific reports, 6, 38646-38646 (2016-12-17)
Epithelial-mesenchymal transition (EMT) is a phenotype conversion that plays a critical role in the development of pulmonary fibrosis (PF). It is known that snail could regulate the progression of EMT. Nuclear factor erythroid 2 related factor 2 (Nrf2), a key...
Homare Ito et al.
Biochemical and biophysical research communications, 519(1), 15-22 (2019-09-02)
Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. However, the underlying mechanism is not yet fully understood. Toll-like receptor 5 (TLR5) is highly expressed in mucosa and recognizes flagellin, the main component...
Da-Hai Zhao et al.
Experimental and therapeutic medicine, 14(1), 759-764 (2017-07-05)
The present study was performed to assess the protective effect of salvianolic acid B on lipopolysaccharide (LPS)-induced acute lung injury (ALI). Sprague Dawley rats were injected with 100 µg/kg LPS through a 24-gauge catheter. One group of rats was pre-treated...
Hong-Bing Wu et al.
Artificial organs, 44(6), 611-619 (2019-12-28)
Our aim was to investigate the effect of avβ3 single-stranded DNA aptamer (avβ3 ssDNA) on vascular restenosis in rats after percutaneous transluminal coronary angioplasty (PTCA) via the Ras-PI3K/MAPK pathway. Sixty Sprague-Dawley rats were randomly divided into six groups: sham-operated, PTCA...
Mana Higashihara et al.
Muscle & nerve, 58(6), 824-827 (2018-07-19)
Needle electromyography (EMG) has been an important diagnostic tool, although discomfort may limit its use in some children. We investigated the diagnostic utility of the clustering index (CI) method, a quantitative analysis for surface EMG (SEMG), in children. SEMG was...
Wenjing Wu et al.
Experimental eye research, 180, 23-28 (2018-12-01)
We previously demonstrated that β6 knockout mice showed impaired wound repair in corneal debridement and keratectomy wounds. In the current investigation, we continued our examination of integrin αvβ6 in order to determine if it was required for the initiation of...
Julien Dagher et al.
Virchows Archiv : an international journal of pathology, 471(1), 107-115 (2017-05-11)
Clear cell renal cell carcinoma (ccRCC) has a poor prognosis with a 50% risk of metastases. Little is known about the phenotypic and molecular profiles of metastases regarding their corresponding primary tumors. This study aimed to screen phenotypic and genotypic...
Won Hee Lee et al.
Stem cells (Dayton, Ohio), 35(10), 2138-2149 (2017-07-16)
Both human embryonic stem cell-derived cardiomyocytes (ESC-CMs) and human induced pluripotent stem cell-derived CMs (iPSC-CMs) can serve as unlimited cell sources for cardiac regenerative therapy. However, the functional equivalency between human ESC-CMs and iPSC-CMs for cardiac regenerative therapy has not...
Wineke Bakker et al.
International journal of molecular sciences, 22(4) (2021-03-07)
Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor endoglin. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1 patients display an impaired immune response. To date it is...
Valérie Jolivel et al.
Acta neuropathologica, 129(2), 279-295 (2014-12-17)
The contribution of microglia to ischemic cortical stroke is of particular therapeutic interest because of the impact on the survival of brain tissue in the ischemic penumbra, a region that is potentially salvable upon a brain infarct. Whether or not...
Shin-Ichi Abe et al.
PloS one, 12(11), e0188705-e0188705 (2017-12-01)
Tissue reconstruction in vitro can provide, if successful, a refined and simple system to analyze the underlying mechanisms that drive the morphogenesis and maintain the ordered structure. We have recently succeeded in reconstruction of seminiferous cord-like and tubule-like structures using...
Tetsuya Imamura et al.
Neurourology and urodynamics, 36(4), 1026-1033 (2016-07-02)
This study determined if combined treatment with the muscarinic receptor (MR) antagonist solifenacin and the β Thirty-two female 10-week-old SHRs were fed an 8% NaCl-supplemented diet for 4 weeks. Cystometric measurements of the unanesthetized, unrestricted rats were performed at room...
Vasa vasorum formation is associated with rupture of intracranial aneurysms.
Miyata, et al.
Journal of Neurosurgery, 1-11 (2019)
Yao-Chi Chuang et al.
International urology and nephrology, 51(4), 617-626 (2019-02-24)
To investigate the long-term functional change of cryoinjury-induced detrusor underactivity (DU) and the therapeutic potential of repeated low-energy shock wave therapy (LESW). Fifty-six female Sprague-Dawley rats were assigned into sham and cryoinjury of bladder with or without LESW (0.05 or...
Josephine K Dermawan et al.
The American journal of surgical pathology, 44(11), 1515-1521 (2020-06-05)
Intravascular lobular capillary hemangioma (ILCH), or intravascular pyogenic granuloma, is relatively rare and likely underrecognized. We reviewed all ILCH cases from our institution confirmed pathologically from 2006 to 2019. Immunostains for smooth muscle actin and Wilms tumor 1 were performed...
Icíar Paula López et al.
Transgenic research, 24(2), 279-294 (2014-09-23)
Insulin-like growth factor type 1 receptor (IGF1R) is a ubiquitously expressed tyrosine kinase that regulates cell proliferation, differentiation and survival. It controls body growth and organ homeostasis, but with specific functions depending on developmental time and cell type. Human deficiency...
Yi-Hsuan Wei et al.
Frontiers in endocrinology, 11, 607968-607968 (2021-02-19)
Transforming growth factor-β (TGF-β)-induced differentiation of orbital fibroblasts into myofibroblasts is an important pathogenesis of Graves' ophthalmopathy (GO) and leads to orbital tissue fibrosis. In the present study, we explored the antifibrotic effects of simvastatin and ROCK inhibitor Y-27632 in...
K'Shylah S Whitehurst et al.
International journal of molecular sciences, 21(16) (2020-08-23)
EphrinA1-Fc abolishes acute I/R injury and attenuates nonreperfused cardiac injury 4 days after permanent occlusion in mice. The goal of this study was to assess the capacity of a single intramyocardial administration of ephrinA1-Fc at the time of coronary artery...
Yue Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(10), 3474-3488 (2016-07-08)
Mammary epithelium is comprised of an inner layer of luminal epithelial cells and an outer layer of contractile myoepithelial cells with mesenchymal properties. These two compartments interact throughout mammary morphogenesis to form branching ducts during puberty and terminate in secretory...
Shuichiro Ogawa et al.
Molecular and cellular endocrinology, 508, 110790-110790 (2020-03-14)
The tumor suppressor gene Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) encodes a membrane-anchored protease regulator expressed in multiple tissues in mouse embryos and is essential for embryonic development. In postnatal mice, however, physiological roles for the RECK protein remain...
Mi Tian et al.
American journal of physiology. Renal physiology, 315(3), F558-F571 (2018-06-07)
Adiponectin (ApN) is a multifunctional adipokine. However, high, rather than low, concentrations of ApN are unexpectedly found in patients with chronic kidney disease (CKD) via an as yet unknown mechanism, and the role of ApN in CKD is unclear. Herein...
Chieh-Cheng Huang et al.
Biomaterials, 73, 12-22 (2015-09-21)
Although the induction of neovascularization by cell-based approaches has demonstrated substantial potential in treating myocardial infarction (MI), the process of cell-mediated angiogenesis and its correlation with therapeutic mechanisms of cardiac repair remain elusive. In this work, three-dimensional (3D) aggregates of...
Jing Yang et al.
International journal of molecular medicine, 42(1), 123-130 (2018-04-06)
NADPH oxidases (NOXs) are important in the pathophysiology of fibrotic diseases. The expression and activity of NOXs are regulated by growth factors, including transforming growth factor (TGF‑β). The proliferation of retinal pigment epithelial (RPE) cells following epithelial‑ to‑mesenchymal transition (EMT) is...
Guillaume Lezmi et al.
American journal of respiratory and critical care medicine, 192(2), 164-171 (2015-05-12)
Airway wall structure in preschoolers with severe recurrent wheeze is poorly described. To describe airway wall structure and inflammation in preschoolers with severe recurrent wheeze. Flexible bronchoscopy was performed in two groups of preschoolers with severe recurrent wheeze: group 1...
Margaux Pontailler et al.
Tissue engineering. Part A, 21(9-10), 1552-1564 (2015-01-23)
As part of a program targeted at developing a resorbable valved tube for replacement of the right ventricular outflow tract, we compared three biopolymers (polyurethane [PU], polyhydroxyalkanoate (the poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxyvalerate) [PHBVV]), and polydioxanone [PDO]) and two biofunctionalization techniques (using adipose-derived stem...
Sang Woo Lee et al.
Scientific reports, 8(1), 2365-2365 (2018-02-07)
In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo, bridging the gap between conventional 2D in vitro testing and animal models. Stromal and cancer tissues with extracellular matrix (ECM) can provide a tumour microenvironment (TME) with cell-to-cell...
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