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740950

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Hanluo Li et al.
Cells, 9(9) (2020-09-16)
Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no
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Shin-Heng Chiou et al.
Genes & development, 29(14), 1576-1585 (2015-07-17)
Pancreatic ductal adenocarcinoma (PDAC) is a genomically diverse, prevalent, and almost invariably fatal malignancy. Although conventional genetically engineered mouse models of human PDAC have been instrumental in understanding pancreatic cancer development, these models are much too labor-intensive, expensive, and slow
Keijiro Hori et al.
Burns : journal of the International Society for Burn Injuries, 43(4), 846-851 (2016-11-22)
Various kinds of synthetic dermal substitutes are produced and used in clinical application and contribute to wound bed preparation for subsequent skin grafting. Although their appearance and outcomes are different, the criteria for the selection of proper synthetic dermal substitutes
Saki Hirakata et al.
JACC. Basic to translational science, 5(2), 126-144 (2020-03-07)
Aortic dissection (AD) is the acute destruction of aortic wall and is reportedly induced by inflammatory response. Here we investigated the role of smooth muscle Socs3 (a negative regulator of Janus kinases/signal transducer and activator of transcription signaling) in AD
Robert B Good et al.
The American journal of pathology, 185(7), 1850-1858 (2015-05-10)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an integral cellular barrier to regulate vascular homeostasis. During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac
Sheng-Yi Chen et al.
Biochimica et biophysica acta, 1853(5), 929-939 (2015-02-18)
Cancer-associated fibroblasts play a crucial role in accelerating tumor progression, but there is a knowledge gap regarding the chemotactic signal activated in a tumor microenvironment. In this study, the expression of type IV collagen was knocked down using a lentiviral-mediated
Angel Fernandez-Flores et al.
Journal of cutaneous pathology, 42(8), 578-586 (2015-05-01)
Endocrine mucin-producing sweat gland carcinoma is a cutaneous adnexal tumor that is rarely reported in the literature. We identified only 29 previously reported cases. All these cases share some clinical morphologic and immunohistochemical features. Among the immunohistochemical markers, cytokeratins 5/6
Sandra Sunitsch et al.
Diagnostic pathology, 13(1), 52-52 (2018-08-17)
Intramuscular / cellular myxomas and low-grade myxofibrosarcomas are two different tumor entities with a significant histological overlap, especially if dealing with small biopsies. Despite the morphological similarities, they differ considerably in their biological behaviour. Intramuscular / cellular myxoma rarely shows
Cédric Zeltz et al.
Cancers, 11(6) (2019-06-05)
Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further analyzed integrin α11
Joan Perelló et al.
British journal of pharmacology, 177(19), 4400-4415 (2020-06-20)
No therapy is approved for vascular calcification or calcific uraemic arteriolopathy (calciphylaxis), which increases mortality and morbidity in patients undergoing dialysis. Deposition of hydroxyapatite (HAP) crystals in arterial walls is the common pathophysiologic mechanism. The mechanism of action of SNF472
Hong-Ryul Jung et al.
Scientific reports, 7(1), 10499-10499 (2017-09-07)
We fabricated a spheroid-forming unit (SFU) for efficient and economic production of cell spheroids. We optimized the protocol for generating large and homogenous liver cancer cell spheroids using Huh7 hepatocellular carcinoma (HCC) cells. The large Huh7 spheroids showed apoptotic and
Nilotpal Roy et al.
Genes & development, 29(6), 658-671 (2015-03-21)
Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanism operative in mature
Toshihiro Fujiwara et al.
Experimental dermatology, 28(4), 485-492 (2017-07-06)
Reactive oxygen species (ROS) impair wound healing through destructive oxidation of intracellular proteins, lipids and nucleic acids. Intracellular superoxide dismutase (SOD1) regulates ROS levels and plays a critical role in tissue homoeostasis. Recent evidence suggests that age-associated wound healing impairments
Eugenia Manevitz-Mendelson et al.
Angiogenesis, 21(2), 287-298 (2018-02-06)
Generalized lymphatic anomaly (GLA or lymphangiomatosis) is a rare disease characterized by a diffuse proliferation of lymphatic vessels in skin and internal organs. It often leads to progressive respiratory failure and death, but its etiology is unknown. Here, we isolated
Inken Rothkirch et al.
NeuroImage. Clinical, 18, 149-159 (2018-06-06)
Writer's cramp (WC) is a focal task-specific dystonia characterized by sustained or intermittent muscle contractions while writing, particularly with the dominant hand. Since structural lesions rarely cause WC, it has been assumed that the disease might be caused by a
Mikako Warren et al.
Cancer genetics, 209(1-2), 21-29 (2015-12-25)
Lipoblastoma is a benign myxoid neoplasm arising in young children that typically demonstrates adipose differentiation. It is often morphologically indistinguishable from primitive myxoid mesenchymal tumor of infancy (PMMTI), which is characterized by a well-circumscribed myxoid mass with a proliferation of
Steven E Wilson
Experimental eye research, 198, 108136-108136 (2020-07-13)
The outcomes of refractive surgical procedures to improve uncorrected vision in patients-including photorefractive keratectomy (PRK), laser in-situ keratomileusis (LASIK), Small Incision Lenticule Extraction (SMILE) and corneal inlay procedures-is in large part determined by the corneal wound healing response after surgery.
Fabian B Fahlbusch et al.
Histochemistry and cell biology, 144(3), 281-291 (2015-06-14)
Gastrokines (GKNs) were originally described as stomach-specific tumor suppressor genes. Recently, we identified GKN1 in extravillous trophoblasts (EVT) of human placenta. GKN1 treatment reduced the migration of the trophoblast cell line JEG-3. GKN2 is known to inhibit the proliferation, migration
Takayuki Jujo et al.
PloS one, 10(8), e0133167-e0133167 (2015-08-08)
Chronic thromboembolic pulmonary hypertension (CTEPH) is generally recognized to be caused by persistent organized thrombi that occlude the pulmonary arteries. The aim of this study was to investigate the characteristics of small vessel remodeling and its impact on the hemodynamics
Wennan Li et al.
Basic research in cardiology, 112(5), 54-54 (2017-08-02)
Coronary transient receptor potential canonical (TRPC) channel expression is elevated in metabolic syndrome (MetS). However, differential contribution of TRPCs to coronary pathology in MetS is not fully elucidated. We investigated the roles of TRPC1 and TRPC6 isoforms in coronary arteries
Feng Zhao et al.
Tissue engineering. Part A, 26(1-2), 78-92 (2019-06-27)
Tissue engineering technology provides an alternative for bladder reconstruction, which remains confronted with challenges, such as insufficient vascularization in regenerated bladder tissue. Short-term hypoxic preconditioning has been reported to be an effective method to enhance the angiogenic effect of stem
Qingxia Zhao et al.
Scientific reports, 7(1), 11306-11306 (2017-09-14)
The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases (RTKs) regulates signaling pathways involved in cell proliferation and differentiation. Currently, the anti-tumor properties of FGFR inhibitors are being tested in preclinical and clinical studies. Nevertheless, reports on FGFR
Ji-Hyeong Lee et al.
Scientific reports, 9(1), 11251-11251 (2019-08-04)
Shape memory alloy (SMA) wire-based soft actuators have had their performance limited by the small stroke of the SMA wire embedded within the polymeric matrix. This intrinsically links the bending angle and bending force in a way that made SMA-based
Robert G Cowan et al.
Reproduction (Cambridge, England), 161(4), 437-448 (2021-03-16)
Cell-fate mapping was used to identify cells that respond to the hedgehog (HH) signaling pathway and that are incorporated into the theca cell layer during ovarian follicle development. Expression of Gli1 is increased by HH signaling and can be used
Marc-Olivier Deguise et al.
Human molecular genetics, 26(4), 801-819 (2017-01-22)
Spinal muscular atrophy (SMA) has long been solely considered a neurodegenerative disorder. However, recent work has highlighted defects in many other cell types that could contribute to disease aetiology. Interestingly, the immune system has never been extensively studied in SMA.
Xiaomeng Zhang et al.
Stem cells (Dayton, Ohio), 37(2), 190-201 (2018-10-30)
Smooth muscle cells (SMCs), which form the walls of blood vessels, play an important role in vascular development and the pathogenic process of vascular remodeling. However, the molecular mechanisms governing SMC differentiation remain poorly understood. Glycoprotein M6B (GPM6B) is a
Ye Fan et al.
Cardiovascular research, 113(5), 519-530 (2017-02-07)
Macrophage migration inhibitory factor (MIF) is an important proinflammatory mediator linked to arterial diseases. Although its inflammatory property such as macrophage recruitment is known for contributing to vascular pathogenesis, the direct effects of MIF on homeostasis and biological function of
Ruben A Alexanian et al.
Biochimica et biophysica acta. Molecular cell research, 1867(3), 118559-118559 (2019-10-22)
Native myocardium has limited regenerative potential post injury. Advances in lineage reprogramming have provided promising cellular sources for regenerative medicine in addition to research applications. Recently we have shown that adult mouse fibroblasts can be reprogrammed to expandable, multipotent, induced
Vittoria Pagliarini et al.
Nucleic acids research, 48(2), 633-645 (2019-11-30)
The Spinal Muscular Atrophy (SMA) gene SMN was recently duplicated (SMN1 and SMN2) in higher primates. Furthermore, invasion of the locus by repetitive elements almost doubled its size with respect to mouse Smn, in spite of an almost identical protein-coding
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