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74750

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Jaleh Varshosaz et al.
European journal of medicinal chemistry, 54, 429-438 (2012-06-13)
The aim of the present study was to reduce 5-FU side effects by targeted nanostructured lipid carriers (NLCs) to LDL receptors that are over expressed in colorectal carcinoma and also use of a new synthesized conjugate of retinoic acid as
Jiawei Li et al.
Drug development and industrial pharmacy, 40(7), 980-987 (2013-05-15)
In this study, tetrandrine-loaded cationic solid lipid nanoparticles (TET-CNP) and solid lipid nanoparticles (TET-NP) were prepared by the emulsion evaporation-solidification at low temperature method. The particle size, zeta potential, and entrapment efficiency of TET-CNP and TET-NP were characterized. The results
Tomáš Taubner et al.
International journal of biological macromolecules, 72, 11-18 (2014-08-12)
Carboxymethylcellulose (CMC) was selected as substrate for amidation based on previous results described for monocarboxy cellulose (MCC) with the aim to prepare highly substituted products. In comparison with MCC containing uronic carboxyl groups at C-6 position, O-carboxymethyl groups in CMC
Jayeeta Roychoudhury et al.
PloS one, 6(3), e17376-e17376 (2011-03-23)
Resistance of Leishmania donovani to pentavalent antimonials, the first-line treatment of visceral leishmaniasis (VL), has become a critical issue worldwide. Second-line and new drugs are also not devoid of limitations. Suitable drug-delivery systems can improve the mode of administration and
Yuanyuan Zhen et al.
Vaccine, 33(35), 4330-4340 (2015-04-11)
To develop effective, convenient and stable mucosal vaccines, mannose-PEG-cholesterol (MPC)/lipid A-liposomes (MLLs) entrapping model antigen bovine serum albumin (BSA) were prepared by the procedure of emulsification-lyophilization and used to constitute microneedles, forming the proMLL-filled microneedle arrays (proMMAs). The proMMAs were
Bibekananda De et al.
Materials science & engineering. C, Materials for biological applications, 56, 74-83 (2015-08-08)
The present work demonstrated a transparent thermosetting nanocomposite with antimicrobial and photoluminescence attributes. The nanocomposites are fabricated by incorporation of different wt.% (1, 2 and 3) of a biocide immobilized OMMT-carbon dot reduced Cu2O nanohybrid (MITH-NH) in the hyperbranched epoxy
Abdulaziz Mohsen Al-Mahallawi et al.
International journal of pharmaceutics, 472(1-2), 304-314 (2014-06-28)
Ciprofloxacin is a synthetic fluoroquinolone antibiotic that has been used for systemic treatment of otitis media in adults. It was approved for topical treatment of otorrhea in children with tympanostomy tubes. The aim of this work was to enhance the
Daniela Chirio et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 746-758 (2014-12-03)
Paclitaxel loaded solid lipid nanoparticles (SLN) of behenic acid were prepared with the coacervation technique. Generally, spherical shaped SLN with mean diameters in the range 300–600 nm were obtained. The introduction of charged molecules, such as stearylamine and glycol chitosan
Sunita Yadav et al.
Molecular pharmaceutics, 12(5), 1523-1533 (2015-03-19)
The main objective of this study was to evaluate comparative biodistribution and pharmacokinetics of cyclosporine-A (CsA) following intranasal (IN) administration versus intravenous (IV) administration in Sprague-Dawley rats using an oil-in-water nanoemulsion delivery system. CsA, a hydrophobic peptide that is also
Fei Wang et al.
Talanta, 84(1), 160-168 (2011-02-15)
The present paper describes to modify a double stranded DNA-octadecylamine (ODA) Langmuir-Blodgett film on a glassy carbon electrode (GCE) surface to develop a voltammetric sensor for the detection of trace amounts of baicalein. The electrode was characterized by atomic force
Chaoqun Yu et al.
Drug development and industrial pharmacy, 37(12), 1509-1516 (2011-06-16)
Submicron emulsion was prepared for rapid and effective nasal absorption of zolmitriptan (ZT). The different charge inducers and pH values of the formulations were evaluated to optimize the formulations. Submicron emulsion prepared by using stearylamine as positive charge inducer with
Cristiane Moraes Santos et al.
Journal of biomedical nanotechnology, 8(2), 322-329 (2012-04-21)
Topical treatment of cutaneous leishmaniasis represents an exciting alternative for reducing toxicity associated with parenteral administration of conventional amphotericin B. This work aims to develop and to characterize amphotericin B-loaded new carriers and to investigate their potential for topical delivery
Nataly Belman et al.
Physical chemistry chemical physics : PCCP, 13(11), 4974-4979 (2011-02-16)
We describe methodology for producing highly uniform, ordered and reproducible superstructures of surfactant-coated ZnS nanorod and nanowire assemblies, and propose a predictive multiscale "packing model" for superstructure formation based on electron microscopy and powder X-ray diffraction data on the superstructure
Kandadi Prabhakar et al.
Colloids and surfaces. B, Biointerfaces, 86(2), 305-313 (2011-05-14)
Indinavir, an antiretroviral protease inhibitor used in treatment of HIV infection has limited penetration into brain due to efflux of P-glycoprotein. The aim of this work was to develop transferrin coupled submicron lipid emulsions (SLEs) containing indinavir for delivery to
Freddy T Rabouw et al.
ACS nano, 9(10), 10366-10376 (2015-09-22)
Conventional colloidal quantum dots (QDs) suffer from rapid energy losses by nonradiative (Auger) processes, leading to sub-ns lifetimes in all excited states but the lowest-energy single exciton. Suppression of interband Auger decay, such as biexciton Auger recombination, has been achieved
Stela Maris Meister Meira et al.
Food chemistry, 188, 161-169 (2015-06-05)
Three different nanoclays (bentonite, octadecylamine-modified montmorillonite and halloysite) were studied as potential carriers for the antimicrobial peptides nisin and pediocin. Adsorption occurred from peptide solutions in contact with nanoclays at room temperature. Higher adsorption of nisin and pediocin was obtained
Alexander Rabkin et al.
Journal of colloid and interface science, 430, 283-292 (2014-06-29)
The optical properties of cadmium sulfide (CdS) nanoparticles in suspension are affected by morphology and suspending solvent. Time dependent stability of these properties is solvent dependent and is affected by illumination conditions under which the suspension is stored. Moreover, minute
Graphite oxide: chemical reduction to graphite and surface modification with primary aliphatic amines and amino acids.
Bourlinos AB, et al.
Langmuir, 19(15), 6050-6055 (2003)
Krishna Jayant et al.
Cell reports, 26(1), 266-278 (2019-01-04)
Intracellular recordings in vivo remains the best technique to link single-neuron electrical properties to network function. Yet existing methods are limited in accuracy, throughput, and duration, primarily via washout, membrane damage, and movement-induced failure. Here, we introduce flexible quartz nanopipettes (inner
Leila Rodrigues Caldeira et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 125-131 (2015-02-11)
This work aimed to develop nanoemulsions (NE) containing cholesterol and Amphotericin B (AmB) evaluating the influence of a lipophilic amine (stearylamine; STE) on drug encapsulation efficiency (EE), cytotoxicity on macrophages and in vitro antileishmanial activity. The EE of AmB in
Rajan Swami et al.
International journal of pharmaceutics, 486(1-2), 287-296 (2015-04-04)
Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs.
Elena V Basiuk et al.
Journal of nanoscience and nanotechnology, 11(6), 5546-5554 (2011-07-21)
Short pristine multi-walled carbon nanotubes (MWNTs) were functionalized with a series of long-chain (including polymeric) aliphatic amines, namely octadecylamine (ODA), 1,8-diaminooctane (DO), polyethylene glycol diamine (PEGDA) and polyethylenimine (PEI), via two "green" approaches: (1) gas-phase functionalization (for volatile ODA and
Self-assembly of novel core/shell structured blue fluorescent silica nanoparticles.
Zheng Jiao et al.
Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1, e262-e263 (2011-12-27)
Paola Mura et al.
International journal of pharmaceutics, 475(1-2), 306-314 (2014-09-10)
Transdermal administration of clonazepam, a poorly water-soluble benzodiazepine, is an interesting strategy for overcoming the drawbacks of its oral administration. With this aim, two nano-carrier formulations, based on ultra-deformable liposomes and microemulsions, have been developed to favour clonazepam transdermal delivery.
Ankita Thakur et al.
Parasitology international, 64(1), 70-78 (2014-10-16)
Despite a large number of field trials, till date no prophylactic antileishmanial vaccine exists for human use. Killed antigen formulations offer the advantage of being safe but they have limited immunogenicity. Recent research has documented that efforts to develop effective
Meng-Jie Gu et al.
International journal of nanomedicine, 10, 5187-5204 (2015-09-01)
Novel gadolinium-loaded liposomes guided by GBI-10 aptamer were developed and evaluated in vitro to enhance magnetic resonance imaging (MRI) diagnosis of tumor. Nontargeted gadolinium-loaded liposomes were achieved by incorporating amphipathic material, Gd (III) [N,N-bis-stearylamidomethyl-N'-amidomethyl] diethylenetriamine tetraacetic acid, into the liposome
Teresa Janas et al.
Biochimica et biophysica acta, 1808(9), 2322-2326 (2011-05-28)
Negatively-charged polysialic acid (polySia) chains are usually membrane-bound and are often expressed on the surface of neuroinvasive bacterial cells, neural cells, and tumor cells. PolySia can mediate both repulsive and attractive cis interactions between membrane components, and trans interactions between
Gregory Von White et al.
ACS nano, 6(6), 4678-4685 (2012-05-29)
The structure and stability of hybrid lipid vesicles containing bilayer-encapsulated hydrophobic nanoparticles is dependent upon lipid phase behavior. By embedding stearylamine-stabilized gold nanoparticles in dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol vesicles, we show that encapsulation at lipid to nanoparticle ratios from 10,000:1 to 5000:1 leads
Jaleh Varshosaz et al.
Journal of liposome research, 22(3), 224-236 (2012-03-06)
The aim of the present study was to design a targeted delivery system of 5-fluorouracil (5-FU) for hepatocellular carcinoma (HCC). Lactobionic acid (LB) was conjugated to stearyl amine (SA) by a chemical reaction. The nanostructured lipid carriers (NLCs), containing LB
D Pandita et al.
Die Pharmazie, 66(3), 171-177 (2011-05-11)
The objective of the study was to design and evaluate a solid lipid nanoparticle (SLN) drug delivery system for delivery of paclitaxel. Components of the SLN were lipid (stearylamine) and surfactants (Pluronic F68 and Soya lecithin). The paclitaxel loaded nanoparticles
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