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Jonathan C Y Tang et al.
Nature neuroscience, 18(9), 1334-1341 (2015-08-11)
There are many transgenic GFP reporter lines that allow the visualization of specific populations of cells. Using such lines for functional studies requires a method that transforms GFP into a molecule that enables genetic manipulation. We developed a method that...
Tenna Jørgensen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(6), 943-950 (2015-03-12)
It is well known that few weeks of high fat (HF) diet may induce metabolic disturbances and mitochondrial dysfunction in skeletal muscle. However, little is known about the effects of long-term HF exposure and effects on brain mitochondria are unknown....
Deborah A Samac et al.
BMC plant biology, 15, 283-283 (2015-12-03)
Alfalfa (Medicago sativa L.) is a widely adapted perennial forage crop that has high biomass production potential. Enhanced cellulose content in alfalfa stems would increase the value of the crop as a bioenergy feedstock. We examined if increased expression of...
Jiannan Sun et al.
Journal of chromatography. A, 1379, 112-117 (2015-01-13)
This study achieved resolution improvement for iodine speciation in the presence of an ion-pairing reagent by a pressure-driven capillary electrophoresis (CE) system. Addition of 0.01mM tetrabutyl ammonium hydroxide (TBAH) as the ion-pairing reagent into the electrophoretic buffer resulted in the...
Sung-Ah Lim et al.
Journal of alternative and complementary medicine (New York, N.Y.), 21(9), 530-538 (2015-07-17)
The aim of the present study is to highlight the beneficial effects of yoga practice on bio-parameters, such as oxidative stress, antioxidant components, immune functions, and secretion of stress hormones, in healthy young people. This study was conducted on healthy...
Timothy D Rohrbach et al.
International journal of oncology, 46(3), 1079-1088 (2014-12-20)
Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pro-growth, pro-survival signaling pathways. Myristoylated alanine rich C-kinase substrate...
Shiv Shankar et al.
Physical chemistry chemical physics : PCCP, 17(33), 21517-21524 (2015-07-30)
This study illustrates a facile strategy for efficient immobilization of enzymes on a metal nanoparticle surface. The strategy proposed here enables the enzymatic activity to be retained while increasing the enzyme thermostability. It is demonstrated that the use of a...
Ashfaq Ahmad et al.
Drug design, development and therapy, 14, 2165-2178 (2020-07-02)
The current study was designed to synthesize derivatives of succinimide and compare their biological potency in anticholinesterase, alpha-glucosidase inhibition, and antioxidant assays. In this research, two succinimide derivatives including (S)-1-(2,5-dioxo-1-phenylpyrrolidin-3-yl) cyclohexanecarbaldehyde (Compound 1) and (R)-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-phenylpropanal (Compound 2) were synthesized using...
Dario Melgari et al.
Journal of the American Heart Association, 4(4) (2015-04-26)
Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal HCN-channels. This study investigated the propensity of ivabradine to interact with KCNH2-encoded human Ether-à-go-go-Related Gene (hERG) potassium channels...
Yoshihiro Takemura et al.
Plant physiology and biochemistry : PPB, 86, 121-129 (2014-12-02)
Endodormancy is an important feature of perennial deciduous fruit trees that survive in the extreme climates brought about by seasonal variation. To acquire a comprehensive knowledge of the biochemical processes occurring just before endodormancy breaking, the buds collected in the...
Ilaria Carafa et al.
Food microbiology, 53(Pt B), 94-103 (2015-12-19)
The microbial population of Traditional Mountain (TM) cheese was investigated and characterized for the selection of cocci suitable for developing new starter cultures. Samples of milk, curd and cheese at different ripening times were enumerated in selective culture media and...
Luís Rato et al.
The international journal of biochemistry & cell biology, 66, 1-10 (2015-07-08)
The incidence of type 2 diabetes mellitus and its prodromal stage, pre-diabetes, is rapidly increasing among young men, leading to disturbances in testosterone synthesis. However, the impact of testosterone deficiency induced by these progressive stages of diabetes on the metabolic...
Gang Yang et al.
Fish & shellfish immunology, 45(2), 800-807 (2015-06-09)
Probiotics have positive effects on the nutrient digestibility and absorption, immune responses, and growth of aquatic animals, including the sea cucumber (Apostichopus japonicus Selenka). A 60-day feeding trial was conducted to evaluate the effects of Bacillus cereus G19, B. cereus...
Wenchao Sheng et al.
Nature communications, 6, 5848-5848 (2015-01-09)
The hydrogen oxidation/evolution reactions are two of the most fundamental reactions in distributed renewable electrochemical energy conversion and storage systems. The identification of the reaction descriptor is therefore of critical importance for the rational catalyst design and development. Here we...
Pilar Viñas et al.
Journal of chromatography. A, 1376, 18-25 (2014-12-30)
Phthalic acid esters (PEs) were preconcentrated from cleaning products, detergents and cosmetics using ultrasound assisted extraction (UAE) in the presence of acetonitrile, and then submitted to dispersive liquid-liquid microextraction (DLLME). For DLLME, 3mL of acetonitrile extract, 150μL carbon tetrachloride and...
Su-yang Wang et al.
Acta pharmacologica Sinica, 36(12), 1444-1450 (2015-11-26)
To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels (K(ATP)) by iptakalim in cultured rat mesenteric microvascular endothelial cells (MVECs). Whole-cell KATP currents were recorded in MVECs using automated patch clamp devices. Nucleotides (ATP, ADP and UDP) were...
Emanuela Papaianni et al.
PloS one, 10(6), e0126645-e0126645 (2015-06-02)
Viruses can trigger apoptosis of infected host cells if not counteracted by cellular or viral anti-apoptotic proteins. These protective proteins either inhibit the activation of caspases or they act as Bcl-2 homologs to prevent Bax/Bak-mediated outer mitochondrial membrane permeabilization (MOMP)....
Ulrike Lambertz et al.
BMC genomics, 16, 151-151 (2015-03-15)
Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRNAs and small...
Dany Spaggiari et al.
Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05)
The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight...
David Ilko et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 569-574 (2014-12-03)
The fatty acid (FA) composition of polysorbate 80 (PS80), a sorbitan oleic acid ester copolymerized with about 20mole of ethylene oxide, is typically characterized by gas chromatography. Here, an alternative method was developed. After saponification with potassium hydroxide the FA...
Oluwasesan Adegoke et al.
Talanta, 146, 780-788 (2015-12-24)
Environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), become widely distributed in the environment after emission from a range of sources, and they have potential biological effects, including toxicity and carcinogenity. In this work, we have demonstrated the analytical...
Steiner; E.C.;
Journal of the American Chemical Society, 86, 4678-4678 (1964)
Zaiwen Fan et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 37(5), 381-387 (2015-04-10)
To test the hypothesis that chronic hypoxic pulmonary hypertension (CH-PH) is associated with increased survivin and decreased voltage-gated potassium (KV) channels expression in pulmonary arteries, rats were randomized as: normoxia (N); normoxia + YM155, survivin suppressor (NY); hypoxia (H); hypoxia + YM155 (HY). HY...
Weverton M Luchi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(3), R215-R222 (2015-06-05)
Vitamin D deficiency (VDD) is widespread in the general population. Iodinated (IC) or gadolinium-based contrast media (Gd) may decrease renal function in high-risk patients. This study tested the hypothesis that VDD is a predisposing factor for IC- or Gd-induced nephrotoxicity....
Bruno Gabriel Lucca et al.
Electrophoresis, 36(16), 1886-1893 (2015-04-18)
This report describes the development and application of a novel graphene-modified electrode to be used as amperometric sensor in microchip electrophoresis (ME) devices. The modified electrode was achieved based on electroreduction of graphene oxide on an integrated Pt working electrode...
José L Martínez et al.
Biotechnology and bioengineering, 112(1), 181-188 (2014-08-02)
Efficient production of appropriate oxygen carriers for transfusions (blood substitutes or artificial blood) has been pursued for many decades, and to date several strategies have been used, from synthetic polymers to cell-free hemoglobin carriers. The recent advances in the field...
A Mohammad et al.
Clinical toxicology (Philadelphia, Pa.), 53(2), 102-107 (2015-01-23)
Prussian blue, ferric hexacyanoferrate is approved for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide makes up 35-40% of Prussian blue's molecular composition; thus, cyanide may be released during transit through the digestive tract under physiological...
Andrew R Chandna et al.
The European journal of neuroscience, 41(3), 341-351 (2014-11-29)
Autonomic dysfunction is a serious complication of diabetes and can lead to cardiovascular abnormalities and premature death. It was recently proposed that autonomic dysfunction is triggered by oxidation-mediated inactivation of neuronal nicotinic acetylcholine receptors (nAChRs), impairing synaptic transmission in sympathetic...
Xin-Jun Yu et al.
Applied biochemistry and biotechnology, 177(6), 1229-1240 (2015-08-25)
High-fructose corn syrup (HFCS) is an agro-source product and has been the most commonly used substitute for sugar as sweetener in food industry due to its low price and high solution property. In this study, the F55 HFCS, rich in...
Qing Zhu et al.
Viral immunology, 28(9), 495-503 (2015-09-24)
Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120) has been reported to be toxic to the hippocampal neurons, and to be involved in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Accumulating evidence has demonstrated that voltage-gated potassium (Kv)...
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