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Vid V Flis et al.
PloS one, 10(8), e0135084-e0135084 (2015-08-05)
In the yeast Saccharomyces cerevisiae, phosphatidylcholine (PC), the major phospholipid (PL) of all organelle membranes, is synthesized via two different pathways. Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through
Olli H Tuovinen et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(10), 718-726 (2015-08-15)
The purpose of this study was to assess atrazine mineralization in surface and subsurface samples retrieved from vertical cores of agricultural soils from two farm sites in Ohio. The Defiance site (NW-Ohio) was on soybean-corn rotation and Piketon (S-Ohio) was
Shashwati U Atwe et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 45-52 (2014-08-26)
Oral vaccination can offer a painless and convenient method of vaccination. Furthermore, in addition to systemic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-associated lymphoid tissues. In this study we propose the concept that pollen
K M Bekers et al.
Yeast (Chichester, England), 32(8), 541-557 (2015-06-11)
With the current quantitative metabolomics techniques, only whole-cell concentrations of NAD and NADH can be quantified. These measurements cannot provide information on the in vivo redox state of the cells, which is determined by the ratio of the free forms
Yanhong Li et al.
PloS one, 10(3), e0121884-e0121884 (2015-03-27)
Nosema bombycis, the first identified microsporidium, is a destructive pathogen of the silkworm Bombyx mori and causes severe worldwide economic losses in sericulture. Major microsporidian structural proteins, such as the spore wall protein (SWP), are known to be involved in
Tenna Jørgensen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(6), 943-950 (2015-03-12)
It is well known that few weeks of high fat (HF) diet may induce metabolic disturbances and mitochondrial dysfunction in skeletal muscle. However, little is known about the effects of long-term HF exposure and effects on brain mitochondria are unknown.
Frank Lippert et al.
Caries research, 49(5), 467-476 (2015-08-01)
The aims of this laboratory study were to compare the effects of lesion baseline severity, mineral distribution and substrate on remineralization and progression of caries lesions created in root dentin. Lesions were formed in dentin specimens prepared from human and
Dong Liang et al.
Endocrine journal, 62(10), 907-920 (2015-07-28)
Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder resulting from defects in both insulin secretion and insulin activity. The deficit and dysfunction of insulin secreting β-cells are signature symptoms of T2D. Additionally, in pancreatic β-cells, a small group
Milan Jana et al.
Nanotechnology, 26(7), 075402-075402 (2015-02-03)
Co9S8/reduced graphene oxide (RGO) composites were prepared on nickel foam substrate through hydrothermal reaction and used directly as supercapacitor electrode. The field emission scanning electron microscopy analysis of the composites showed the formation of Co9S8 nano-rods on the RGO surfaces.
Matthew C Henn et al.
Journal of the American Heart Association, 4(8), e002016-e002016 (2015-08-26)
ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism. The renal outer medullary kidney potassium channel subunit, potassium inward rectifying (Kir)1.1, has been implicated as
Qian Ran et al.
Scientific reports, 5, 16209-16209 (2015-11-06)
Fe3O4 magnetic nanoparticles (Fe3O4-MNPs) have been widely used in clinical diagnosis. Hemocompatibility of the nanoparticles is usually evaluated by hemolysis. However, hemolysis assessment does not measure the dysfunctional erythrocytes with pathological changes on the unbroken cellular membrane. The aim of
Benjamin Scholl et al.
The Journal of physiology, 593(22), 4979-4994 (2015-09-04)
In vivo whole-cell patch-clamp recordings in cat visual cortex revealed small deflections in the membrane potential of neurons, termed spikelets. Spikelet statistics and functional properties suggest these deflections originate from a single, nearby cell. Spikelets shared a number sensory selectivities
Anja Balk et al.
Pharmaceutical research, 32(6), 2154-2167 (2014-12-24)
A poorly water soluble acidic active pharmaceutical ingredient (API) was transformed into an ionic liquid (IL) aiming at faster and higher oral availability in comparison to a prodrug. API preparations were characterized in solid state by single crystal and powder
Danny C LeBert et al.
Development (Cambridge, England), 142(12), 2136-2146 (2015-05-28)
Acute and chronic injuries are characterized by leukocyte infiltration into tissues. Although matrix metalloproteinase 9 (Mmp9) has been implicated in both conditions, its role in wound repair remains unclear. We previously reported a zebrafish chronic inflammation mutant caused by an
Deborah A Samac et al.
BMC plant biology, 15, 283-283 (2015-12-03)
Alfalfa (Medicago sativa L.) is a widely adapted perennial forage crop that has high biomass production potential. Enhanced cellulose content in alfalfa stems would increase the value of the crop as a bioenergy feedstock. We examined if increased expression of
Sung-Ah Lim et al.
Journal of alternative and complementary medicine (New York, N.Y.), 21(9), 530-538 (2015-07-17)
The aim of the present study is to highlight the beneficial effects of yoga practice on bio-parameters, such as oxidative stress, antioxidant components, immune functions, and secretion of stress hormones, in healthy young people. This study was conducted on healthy
Jiannan Sun et al.
Journal of chromatography. A, 1379, 112-117 (2015-01-13)
This study achieved resolution improvement for iodine speciation in the presence of an ion-pairing reagent by a pressure-driven capillary electrophoresis (CE) system. Addition of 0.01mM tetrabutyl ammonium hydroxide (TBAH) as the ion-pairing reagent into the electrophoretic buffer resulted in the
Leonor C Costa et al.
Environmental science and pollution research international, 22(23), 18574-18589 (2015-09-24)
This study aimed to assess the mechanisms of innate immune function responses to silica-coated iron oxide nanoparticle functionalized with dithiocarbamate groups (IONP) exposure alone and its associated mercury (Hg) in European eel (Anguilla anguilla L.) phagocytes isolated from peritoneum (P-phagocytes)
Masayuki Sugimoto et al.
Biochimica et biophysica acta, 1851(12), 1554-1565 (2015-09-24)
Sphingomyelin (SM) is synthesized by SM synthase (SMS) from ceramide (Cer). SM regulates signaling pathways and maintains organ structure. SM comprises a sphingoid base and differing lengths of acyl-chains, but the importance of its various forms and regulatory synthases is
Luqman A Olayaki et al.
Journal of basic and clinical physiology and pharmacology, 26(6), 585-593 (2015-07-01)
Glucose-lowering effects of Moringa oleifera extracts have been reported. However, the mechanism for its hypoglycemic effects is not yet understood. This study investigated the effect of oral administration of methanolic extracts of M. oleifera (MOLE) on glucose tolerance, glycogen synthesis
Lifang Liu et al.
FEMS yeast research, 15(7) (2015-07-30)
Oxygen is important for normal aerobic metabolism, as well as for protein production where it is needed for oxidative protein folding. However, several studies have reported that anaerobic conditions seem to be more favorable in terms of recombinant protein production.
Su-yang Wang et al.
Acta pharmacologica Sinica, 36(12), 1444-1450 (2015-11-26)
To investigate the mechanisms underlying the activation of ATP-sensitive potassium channels (K(ATP)) by iptakalim in cultured rat mesenteric microvascular endothelial cells (MVECs). Whole-cell KATP currents were recorded in MVECs using automated patch clamp devices. Nucleotides (ATP, ADP and UDP) were
Ulrike Lambertz et al.
BMC genomics, 16, 151-151 (2015-03-15)
Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRNAs and small
Chen-Ting Lee et al.
PloS one, 10(3), e0120327-e0120327 (2015-03-21)
Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has
Emanuela Papaianni et al.
PloS one, 10(6), e0126645-e0126645 (2015-06-02)
Viruses can trigger apoptosis of infected host cells if not counteracted by cellular or viral anti-apoptotic proteins. These protective proteins either inhibit the activation of caspases or they act as Bcl-2 homologs to prevent Bax/Bak-mediated outer mitochondrial membrane permeabilization (MOMP).
Dany Spaggiari et al.
Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05)
The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight
Oluwasesan Adegoke et al.
Talanta, 146, 780-788 (2015-12-24)
Environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), become widely distributed in the environment after emission from a range of sources, and they have potential biological effects, including toxicity and carcinogenity. In this work, we have demonstrated the analytical
Shiv Shankar et al.
Physical chemistry chemical physics : PCCP, 17(33), 21517-21524 (2015-07-30)
This study illustrates a facile strategy for efficient immobilization of enzymes on a metal nanoparticle surface. The strategy proposed here enables the enzymatic activity to be retained while increasing the enzyme thermostability. It is demonstrated that the use of a
Cecilia Bender et al.
International journal of food sciences and nutrition, 66(5), 553-558 (2015-05-27)
The aim of our study was to determine the antioxidant activities, cytotoxicity and proliferative properties in Stevia rebaudiana leaves and stems. Leaves extracts exhibited a higher antioxidant activity than stems extract, through oxygen radical absorbance capacity (ORAC) and cellular antioxidant
Maria A Vorontsova et al.
Faraday discussions, 179, 27-40 (2015-04-11)
The two-step mechanism of nucleation of crystals in solutions posits that the formation of crystal nuclei occurs within structures of extended lifetimes, in which the nucleating solute is at high concentration. The validity of this mechanism has been demonstrated for
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