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Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Han Yao et al.
Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)
L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance
Treatment in the face of uncertainty following traumatic anhydrous ammonia exposure.
Jill Termaat et al.
The Journal of family practice, 62(12), 710-718 (2013-12-18)
Carolina Nebot et al.
Environmental science and pollution research international, 22(14), 10559-10568 (2015-03-05)
Incomplete removal of pharmaceuticals during wastewater treatment can result in their discharge into the aquatic environment. The discharge of pharmaceuticals in wastewater treatment plant (WWTP) effluents into rivers, lakes and the oceans has led to detectable concentrations of pharmaceuticals in
Jacek Wójcikowski et al.
Biochemical pharmacology, 90(2), 188-195 (2014-05-21)
The aim of the present study was to identify cytochrome P450 isoenzymes (CYPs) involved in the 5-sulfoxidation and N-demethylation of the aliphatic-type phenothiazine neuroleptic levomepromazine in human liver. Experiments were performed in vitro using cDNA-expressed human CYP isoforms (Supersomes 1A2
Manuela Herklotz et al.
Biomaterials, 60, 121-129 (2015-05-20)
To explore the space-filling growth of adherent mesenchymal stem cells (MSC) into tissue-like structures in vitro, human bone marrow derived MSC were exposed to fibronectin-coated, millimeter-sized, triangular channels casted in poly(dimethyl siloxane) carriers. The results revealed that the three dimensional (3D)
Man-Young Jung et al.
The ISME journal, 8(5), 1115-1125 (2013-11-15)
N2O gas is involved in global warming and ozone depletion. The major sources of N2O are soil microbial processes. Anthropogenic inputs into the nitrogen cycle have exacerbated these microbial processes, including nitrification. Ammonia-oxidizing archaea (AOA) are major members of the
Krzysztof Helewski et al.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 56(11-12), 560-563 (2004-04-03)
Pathogenesis of hepatic encephalopathy has not been fully revealed and there are many factors which may affect its development. Ammonia and changes in GABA-ergic neurotransmission seem to be the most essential of these factors. Hepatic encephalopathy is frequently, though not
Jonas Mechelke et al.
Environmental science & technology, 54(12), 7291-7301 (2020-05-12)
Many organic contaminants entering the aquatic environment feature stereogenic structural elements that give rise to enantiomerism. While abiotic processes usually act identical on enantiomers, biotic processes, such as biodegradation often result in enantiomeric fractionation (EFr), i.e., the change of the
Kazuo Hotta et al.
Anticancer research, 35(9), 4681-4689 (2015-08-09)
We investigated whether hepatic multidrug resistance-associated protein 2 (ABCC2) is involved in the hepatobiliary excretion of regorafenib, a novel multi-kinase inhibitor, using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR) lacking the efflux transporter ABCC2. The involvement of organic anion-transporting
Yifen Wen et al.
Colloids and surfaces. B, Biointerfaces, 133, 246-253 (2015-06-30)
Polysaccharide-based crosslinked nanogles (bionanogels) exhibiting multiple stimuli-responsive release of encapsulated therapeutics hold a great potential as tumor-targeting intracelluar durg delivery nanocarriers. Herein, we report the synthesis of monodisperse dual temperature/acidic pH-responsive bionanogels (DuR-BNGs) by aqueous crosslinking polymerization through temperature-induced self-association
Mayumi Sasaki et al.
Nucleic acids research, 41(10), 5382-5399 (2013-04-09)
The Schizosaccharomyces pombe genome is one of the smallest among the free-living eukaryotes. We further reduced the S. pombe gene number by large-scale gene deletion to identify a minimal gene set required for growth under laboratory conditions. The genome-reduced strain
Chun Kong Mak et al.
Journal of chromatography. A, 1419, 81-88 (2015-10-13)
Thyroxine (T4) is one of the major thyroid hormones, which regulates cellular metabolism, central nervous system development, body temperature, reproduction and growth. The simulation of oxidation reactions of T4 may provide further information about the fate of T4 in cells
Oana A Cuzman et al.
Journal of biotechnology, 214, 49-56 (2015-09-17)
The ureolytic bacteria are one of the most efficient organisms able to produce high amounts of carbonate that easily react with the free calcium ions from the environment. Sporosarcina pasteurii, a robust microbe in alkaline environments, was tested in this
Laurie Bruzzese et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(2), 140-147 (2015-05-23)
The nucleoside adenosine acts on the nervous and cardiovascular systems via the A2A receptor (A2AR). In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine
Hakim Rahma et al.
ACS applied materials & interfaces, 7(21), 11536-11546 (2015-05-06)
The fabrication of highly effective antimicrobial materials is an important strategy for coping with the growing concern of bacterial resistance. In this study, N-chloramine-functionalized hollow hemispherical structures were designed and prepared to examine possible enhancement of antimicrobial performance. Antimicrobial testing
T T H Pham et al.
Biochimie, 107 Pt A, 143-153 (2014-06-22)
Visceral leishmaniasis is a life-threatening disease that affects nearly a million people every year. The emergence of Leishmania strains resistant to existing drugs complicates its treatment. The purpose of this study was to develop a new lipid formulation based on
Measurement and interpretation of plasma ammonia.
H J Lee et al.
British journal of hospital medicine (London, England : 2005), 75(3), C40-C43 (2014-03-14)
Maciej Jarosz et al.
Analytica chimica acta, 851, 72-77 (2014-12-03)
Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the
Natalie Kolderová et al.
Journal of chromatography. A, 1625, 461286-461286 (2020-07-28)
In the past two decades, supercritical fluid chromatography has evolved from a niche application to a comprehensive technology and a fully-fledged alternative to conventional high-performance liquid chromatography. In this study, we have focused on chiral separation of synthetic cathinones in
M Isabel Barba et al.
Talanta, 147, 111-116 (2015-11-26)
This paper proposes a methodology based on short-wave near-infrared spectroscopy to determine the ammonia content of ammonia/water mixtures with ammonia mass fraction in the range 0.35-0.65. Establishing this methodology meant modeling the relationship between the pressure bar (15-25)bar, temperature (20-50)°C
Clinical and biochemical consequences of soybean meal intoxication in cattle.
D Raboisson et al.
The Veterinary record, 172(20), 529-529 (2013-04-23)
Nahid Dayyani et al.
European journal of medicinal chemistry, 98, 190-202 (2015-05-30)
Novel pH-sensitive, biocompatible and biodegradable magneto-dendrimers with OH and/or NH2 functional groups based on poly amino-ester were synthesized for delivery of anti-cancer drugs. Magnetite nanoparticles (MNPs) were synthesized by the co-precipitation method and their surfaces were modified by 3-aminopropyl triethoxysilane.
Aneta Woźniakiewicz et al.
Journal of pharmaceutical and biomedical analysis, 111, 177-185 (2015-04-19)
The aim of the research was to develop a new sensitive method for simultaneously the determination of psychoactive drugs: 1-benzylpiperazine, 7-aminoclonazepam, alprazolam, clonazepam, diazepam, estazolam, lorazepam and tetrazepam in human serum and hair samples. In the preparation step, microwave-assisted extraction
Karen Menuz et al.
PLoS genetics, 10(11), e1004810-e1004810 (2014-11-21)
Many insect vectors of disease detect their hosts through olfactory cues, and thus it is of great interest to understand better how odors are encoded. However, little is known about the molecular underpinnings that support the unique function of coeloconic
Guoqiang Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2807-2816 (2015-02-05)
A facile route to fabricate a nanocomposite of Fe3O4@poly[N-isopropylacrylamide (NIPAM)-co-2-(dimethylamino)ethyl methacrylate (DMAEMA)]@Au (Fe3O4@PND@Au) is developed for magnetically recyclable and thermally tunable catalysis. The negatively charged Au nanoparticles with an average diameter of 10 nm are homogeneously loaded onto positively charged
Mette Thing et al.
Journal of pharmaceutical sciences, 103(12), 4021-4029 (2014-10-31)
Long-acting nonsteroidal anti-inflammatory drug formulations for intra-articular injection might be effective in the management of joint pain and inflammation associated sports injuries and osteoarthritis. In this study, a prodrug-based delivery system was evaluated. The synthesized diclofenac ester prodrug, a weak
André M P T Pereira et al.
Journal of toxicology and environmental health. Part A, 78(15), 959-975 (2015-08-12)
The growth of aquaculture over the past few years is widely recognized as one of the main sources of antibiotics, mainly fluoroquinolones (FQ) and tetracyclines (TC), in the aquatic environment, consequently, increasing the risk of the emergence of antibiotic bacterial
Freimut Schliess et al.
Hepatology (Baltimore, Md.), 60(6), 2040-2051 (2014-03-29)
The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial-temporal
R Rodríguez-Gómez et al.
Talanta, 130, 561-570 (2014-08-28)
In recent decades, in parallel to industrial development, a large amount of new chemicals have emerged that are able to produce disorders in human endocrine system. These groups of substances, so-called endocrine disrupting chemicals (EDCs), include many families of compounds
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