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Andrea Speltini et al.
Journal of chromatography. A, 1379, 9-15 (2015-01-07)
This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer...
Yuan-long Wang et al.
Foodborne pathogens and disease, 12(8), 693-703 (2015-08-11)
A precise and simplified method of sample preparation for the simultaneous quantification of the antibiotics β-lactam, macrolide, tetracycline, sulfonamide, and quinolone in bovine milk was developed. The central composite design of response surface methodology was used to design and optimize...
Bahram Ebrahimi et al.
Journal of AOAC International, 98(3), 822-827 (2015-06-19)
A sensitive and low cost SPE method for the extraction, preconcentration, and flame atomic absorption spectrometric determination of nickel at ng/mL levels is described. Parameters governing the extraction efficiency including pH of the solution, eluent type, sample volume, and matrix...
Wenpei Fan et al.
Biomaterials, 35(32), 8992-9002 (2014-08-12)
To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may...
Han Yao et al.
Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)
L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance...
Mahesh Kumar Joshi et al.
Journal of colloid and interface science, 453, 159-168 (2015-05-20)
In this study, a fly ash based composite, Ag-iron oxide/fly ash, was synthesized via a facile one-pot hydrothermal process using fly ash, ferrous chloride, and silver nitrate as precursors. Field emission scanning electron microscopy (FE-SEM), EDX, transmission electron microscopy (TEM)...
Swen Langer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 73-81 (2014-05-06)
Water-soluble vitamins are an important class of compounds that require quantification from food sources to monitor nutritional value. In this study we have analysed six water-soluble B vitamins ([thiamine (B1), riboflavin (B2), nicotinic acid (B3, NAc), nicotinamide (B3, NAm), pyridoxal...
Wei Sun et al.
International immunopharmacology, 23(1), 247-253 (2014-09-15)
Resolvin D1 (RvD1), an endogenous lipid mediator derived from docosahexaenoic acid, has been reported to promote a biphasic activity in anti-inflammatory response and regulate inflammatory resolution. The present study aimed to determine the endogenous expression pattern of RvD1 in a...
Gayong Shim et al.
Journal of controlled release : official journal of the Controlled Release Society, 189, 80-89 (2014-06-29)
Here, we report reduced graphene oxide (rGO) nanosheets coated with an anti-angiogenic anticancer taurocholate derivative of low-molecular-weight heparin (LHT7) as a tumor-targeting nanodelivery platform for anticancer drugs. Surface coating of LHT7 onto rGO was confirmed using fluorescein isothiocyanate-labeled LHT7, monitored...
Yingying Wen et al.
Journal of chromatography. A, 1368, 18-25 (2014-12-03)
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was developed for the determination of non-steroidal estrogens in water samples. In this study, graphene...
Dana Hocková et al.
Organic & biomolecular chemistry, 13(15), 4449-4458 (2015-03-15)
Protected N-branched nucleoside phosphonates containing adenine and thymine bases were prepared as the monomers for the introduction of aza-acyclic nucleotide units into modified oligonucleotides. The phosphotriester and phosphoramidite methods were used for the incorporation of modified and natural units, respectively....
Siniša Sić et al.
Journal of chromatography. A, 1408, 93-100 (2015-07-18)
Investigation of oligosaccharides attached to proteins as post-translational modification remains an important research field in the area of glycoproteomics as well as in biotechnology. The development of new tools for qualitative and quantitative analysis of glycans has gained high importance...
Iván Castelló Serrano et al.
Nanoscale, 6(22), 13623-13629 (2014-10-03)
We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometric determination of trypsin in humans. Current detection methods for cystic fibrosis diagnosis are slow, costly and suffer from false positives. The 2nanoSi proved to be a...
Kazuo Hotta et al.
Anticancer research, 35(9), 4681-4689 (2015-08-09)
We investigated whether hepatic multidrug resistance-associated protein 2 (ABCC2) is involved in the hepatobiliary excretion of regorafenib, a novel multi-kinase inhibitor, using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR) lacking the efflux transporter ABCC2. The involvement of organic anion-transporting...
Milan Holecek
Nutrition (Burbank, Los Angeles County, Calif.), 29(10), 1186-1191 (2013-06-13)
The rationale for recommendation of branched-chain amino acids (BCAA; valine, leucine, and isoleucine) in treatment of liver failure is based on their unique pharmacologic properties, stimulatory effect on ammonia detoxification to glutamine (GLN), and decreased concentrations in liver cirrhosis. Multiple...
Yuanhua Sang et al.
Advanced materials (Deerfield Beach, Fla.), 27(2), 363-369 (2014-11-22)
Narrow-bandgap semiconductor WS2 nanosheets are active photocatalysts, either under visible or under NIR irradiation. The photocatalyst functions are confirmed via photogeneration of an electron-hole pair, with a low rate of recombination.
Marion Vallet et al.
Kidney international, 88(1), 137-145 (2015-03-12)
Recent studies suggest that alkalinizing treatments improve the course of chronic kidney disease (CKD), even in patients without overt metabolic acidosis. Here, we tested whether a decreased ability in excreting urinary acid rather than overt metabolic acidosis may be deleterious...
Varongsiri Kemsawasd et al.
Applied microbiology and biotechnology, 99(23), 10191-10207 (2015-08-11)
In this study, the influence of twenty different single (i.e. 19 amino acids and ammonium sulphate) and two multiple nitrogen sources (N-sources) on growth and fermentation (i.e. glucose consumption and ethanol production) performance of Saccharomyces cerevisiae and of four wine-related...
I David Weiner et al.
Comprehensive Physiology, 3(1), 201-220 (2013-05-31)
Renal ammonia metabolism and transport mediates a central role in acid-base homeostasis. In contrast to most renal solutes, the majority of renal ammonia excretion derives from intrarenal production, not from glomerular filtration. Renal ammoniagenesis predominantly results from glutamine metabolism, which...
Vernal N Richards et al.
Nuclear medicine and biology, 42(6), 530-535 (2015-03-26)
A proof of concept study was undertaken where non-carrier added (186 g)Re was produced from the cyclotron bombardment of (186)WC. (186)WC was carbo-thermally generated from a novel precursor synthesized from (186)WO3, aqueous ammonia and hexamethyltetramine. The inherent high electrical and...
Yossi Shemesh et al.
Nucleosides, nucleotides & nucleic acids, 34(11), 753-762 (2015-10-01)
Carboxylates and dicarboxylates are important phosphate mimics. Herein, we present a simple synthetic route for the preparation of RNA carboxylate/dicarboxylate conjugates, starting from suitably protected NH2- and COOH-containing molecules that are coupled to the RNA on the solid support. The...
Sarah Rodríguez-Martínez et al.
Water research, 77, 119-132 (2015-04-13)
Bacteria of the genus Legionella cause water-based infections, resulting in severe pneumonia. To improve our knowledge about Legionella spp. ecology, its prevalence and its relationships with environmental factors were studied. Seasonal samples were taken from both water and biofilm at...
Jonas Mechelke et al.
Environmental science & technology, 54(12), 7291-7301 (2020-05-12)
Many organic contaminants entering the aquatic environment feature stereogenic structural elements that give rise to enantiomerism. While abiotic processes usually act identical on enantiomers, biotic processes, such as biodegradation often result in enantiomeric fractionation (EFr), i.e., the change of the...
Krzysztof Helewski et al.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 56(11-12), 560-563 (2004-04-03)
Pathogenesis of hepatic encephalopathy has not been fully revealed and there are many factors which may affect its development. Ammonia and changes in GABA-ergic neurotransmission seem to be the most essential of these factors. Hepatic encephalopathy is frequently, though not...
Reassessing the role of astrocytes in ammonia neurotoxicity.
Tore Eid et al.
Nature medicine, 19(12), 1572-1574 (2013-12-07)
Caroline Lamalle et al.
Journal of pharmaceutical and biomedical analysis, 111, 344-350 (2015-01-21)
A simple and efficient MEKC method was developed to simultaneously determine human insulin, its five analogues, the main degradation products and the excipients usually present in injection formulations. A very fast method with a total analysis time of 3 min...
E Diamanti et al.
Langmuir : the ACS journal of surfaces and colloids, 31(31), 8623-8632 (2015-07-15)
The self-assembly of mixed vesicles of zwitterionic phosphatidylcholine (PC) and anionic phosphatidylserine (PS) phospholipids on top of polyelectrolyte multilayers (PEMs) of poly(allylamine hydrochloride) (PAH), as a polycation, and polystyrenesulfonate (PSS), as a polyanion, is investigated as a function of the...
Peter J McGuire et al.
Disease models & mechanisms, 7(2), 205-213 (2013-11-26)
The urea cycle functions to incorporate ammonia, generated by normal metabolism, into urea. Urea cycle disorders (UCDs) are caused by loss of function in any of the enzymes responsible for ureagenesis, and are characterized by life-threatening episodes of acute metabolic...
Karen Menuz et al.
PLoS genetics, 10(11), e1004810-e1004810 (2014-11-21)
Many insect vectors of disease detect their hosts through olfactory cues, and thus it is of great interest to understand better how odors are encoded. However, little is known about the molecular underpinnings that support the unique function of coeloconic...
Freimut Schliess et al.
Hepatology (Baltimore, Md.), 60(6), 2040-2051 (2014-03-29)
The impairment of hepatic metabolism due to liver injury has high systemic relevance. However, it is difficult to calculate the impairment of metabolic capacity from a specific pattern of liver damage with conventional techniques. We established an integrated metabolic spatial-temporal...
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