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78314

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Cai Tie et al.
Journal of pharmaceutical and biomedical analysis, 111, 14-20 (2015-04-02)
Oligosaccharides, which exist widely in herbs, present diverse important pharmacological activities. However, the complexity of oligosaccharides seriously challenges their profiling, quality control, and elucidation of activity. In this paper, a novel oligosaccharide analytical method based on a new derivatization pretreatment
A Hafeez et al.
Poultry science, 93(7), 1754-1763 (2014-05-28)
Minerals play an important role for growth and bone stability in broilers. Thermal treatment and inclusion of organic acids in feed may affect the mineral absorption and tibial quality in broilers. The study was conducted to investigate the effect of
Gomathinayagam Ponniah et al.
Analytical chemistry, 87(5), 2718-2726 (2015-02-04)
Oligosaccharides are critical for structural integrity, stability, and biological functions of recombinant monoclonal antibodies. It is relatively easy to characterize, quantify, and determine the impact of major glycoforms. While challenging to detect and quantify, certain low abundance oligosaccharides are highly
Yuji Mano et al.
Biomedical chromatography : BMC, 29(9), 1343-1349 (2015-02-03)
A simple and reproducible bioanalytical method for the determination of gemcitabine in human plasma treated with tetrahydrouridine (THU) was developed and validated using a hydrophilic interaction ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS). To prevent deamination of gemcitabine, blood
Charlotte Sy et al.
Marine drugs, 13(11), 7020-7039 (2015-11-28)
Recently isolated spore-forming pigmented marine bacteria Bacillus indicus HU36 are sources of oxygenated carotenoids with original structures (about fifteen distinct yellow and orange pigments with acylated d-glucosyl groups). In this study, we evaluated the stability (sensitivity to iron-induced autoxidation) and
Minli Zhang et al.
Journal of pharmaceutical and biomedical analysis, 100, 357-364 (2014-09-10)
Quantification of amino acid based neurotransmitters in extracellular fluids, such as those in the neuron synapse, presents a challenge to the analytical chemistry because of the absence of UV- or fluorescence-detectable functional groups and the low sensitivity in mass spectrometric
Sabine Kokarnig et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 83-90 (2014-07-27)
Selenium metabolic patterns in the human body originating from five distinct selenium dietary sources, selenate, selenite, selenomethionine (SeMet), methylselenocysteine (MeSeCys) and selenized yeast, were investigated by performing concurrent HPLC-mass spectrometric analysis of human serum and urine. Total selenium and selenium
Jan Srbek et al.
Talanta, 130, 518-526 (2014-08-28)
In this study, direct analysis in real time-mass spectrometry (DART-MS) was assessed for the analysis of various pharmaceutical formulations with intention to summarize possible applications for the routine pharmaceutical development. As DART is an ambient ionization technique, it allows direct
Jessica Momb et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(2), 549-554 (2012-12-26)
Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70%. Despite the strong clinical link between folate and NTDs, the biochemical mechanisms through which folic acid acts during neural
Mauro Serricchio et al.
Biology open, 4(9), 1143-1153 (2015-08-16)
The observation that the membranes of flagella are enriched in sterols and sphingolipids has led to the hypothesis that flagella might be enriched in raft-forming lipids. However, a detailed lipidomic analysis of flagellar membranes is not available. Novel protocols to
Tejia Zhang et al.
Journal of lipid research, 56(8), 1501-1510 (2015-06-11)
Apoptosis is an intricately regulated cellular process that proceeds through different cell type- and signal-dependent pathways. In the mitochondrial apoptotic program, mitochondrial outer membrane permeabilization by BCL-2 proteins leads to the release of apoptogenic factors, caspase activation, and cell death.
Rui Weng et al.
Rapid communications in mass spectrometry : RCM, 29(16), 1491-1500 (2015-07-28)
Although serotonin deficiency is involved with various physiological disorders such as Alzheimer's disease, Parkinson's disease, schizophrenia and depression, the serotonin-dependent pathomechanisms remain poorly understood, particularly from a lipidomics perspective. This study therefore aimed to identify novel lipid biomarkers associated with
Grant A Abernethy
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(9), 1416-1430 (2015-07-04)
This paper proposes a mechanism to explain the trace levels of natural semicarbazide occasionally observed in foods. The analytical derivative of semicarbazide, 2-nitrobenzaldehyde semicarbazone, is often measured as a metabolite marker to detect the widely banned antibiotic nitrofurazone. However, this
Jun Ueyama et al.
Environmental health and preventive medicine, 19(6), 405-413 (2014-10-09)
Biological monitoring of organophosphorus insecticide (OP) metabolites, specifically dialkylphosphates (DAP) in urine, plays a key role in low-level exposure assessment of OP in individuals. The aims of this study are to develop a simple and sensitive method for determining four
Élida Alechaga et al.
Analytical and bioanalytical chemistry, 406(20), 4941-4953 (2014-06-03)
A novel LC-MS/MS method has been developed for the determination of 13 aminoglycoside antibiotics in meat products. Among the chromatographic columns tested, the mixed-mode Obelisc R provided the best performance. Electrospray has been used for the coupling of the LC
Jixia Wang et al.
Journal of chromatography. A, 1398, 29-46 (2015-05-04)
Nowadays more and more hydrophilic interaction liquid chromatography (HILIC) columns with diverse functional groups have become commercially available, which pose a challenge to select an appropriate one. However, there is no universal model to provide guidance for selecting HILIC columns.
Carol L Cheatham et al.
Nutrients, 7(11), 9079-9095 (2015-11-06)
The aim was to explore the relation of human milk lutein; choline; and docosahexaenoic acid (DHA) with recognition memory abilities of six-month-olds. Milk samples obtained three to four months postpartum were analyzed for fatty acids, lutein, and choline. At six
Yannick Lecompte et al.
Journal of pharmaceutical and biomedical analysis, 96, 127-134 (2014-04-20)
Methoxyisoflavone (5-methyl-7-methoxyisoflavone) is a synthetic isoflavone used by bodybuilders for its ergogenic properties. A recent study demonstrated that methoxyisoflavone metabolites can induce false-positive results in urinary immunoassay screening tests for cannabinoids, and only one metabolite has been identified. To improve
Khaled M Mohamed et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 1-6 (2015-06-16)
In some developing countries, p-phenylenediamine (PPD) is used in combination with Henna as hair dye or skin decoration. A sensitive LC-MS/MS method was developed and validated for the simultaneous determination of p-phenylenediamine (PPD) and its metabolites N-acetyl-p-phenylenediamine (MAPPD) and N,N-diacetyl-p-phenylenediamine
Takayuki Nakajima et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(7), 1099-1104 (2015-05-15)
A simple and accurate analytical method for the determination of acaricides in honey was developed and validated in accordance with Japanese validation guidelines. Analytes - amitraz, N-2,4-dimethylphenyl-N-methylformamidine (DMPF), etoxazole, fenpyroximate, fipronil, hexythiazox, propargite, pyridaben and spirodiclofen - were extracted with
Romée van der Zee et al.
PloS one, 10(7), e0131611-e0131611 (2015-07-15)
This article presents results of an analysis of honey bee losses over the winter of 2011-2012 in the Netherlands, from a sample of 86 colonies, located at 43 apiaries. The apiaries were selected using spatially stratified random sampling. Colony winter
Jie Zhou et al.
Journal of pharmaceutical sciences, 104(8), 2619-2626 (2015-06-09)
There is an increasing interest in using N-acetylcysteine (NAC) as a treatment for neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The purpose of this study was to characterize the biosynthesis of NAC to GSH using a
Christian Sattler et al.
Molecular genetics and genomics : MGG, 288(9), 413-424 (2013-06-27)
Methane is a key intermediate in the carbon cycle and biologically produced by methanogenic archaea. Most methanogens are able to conserve energy by reducing CO2 to methane using molecular hydrogen as electron donor (hydrogenotrophic methanogenesis), but several hydrogenotrophic methanogens can
Yoon Kim et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(7), 627-634 (2014-04-18)
1. The absorption, distribution, metabolism and excretion of a novel dipeptidyl peptidase IV inhibitor, gemigliptin, were examined following single oral administration of (14)C-labeled gemigliptin to rats. 2. The (14)C-labeled gemigliptin was rapidly absorbed after oral administration, and its bioavailability was 95.2% (by
Songlin Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 222-229 (2014-05-14)
We described a rapid and precise method for simultaneous quantification of eleven fatty acids in human serum cholesteryl esters (CEFAs) by liquid chromatography and tandem mass spectrometry (LC-MS/MS). After extraction of serum lipids with isopropanol, CEFAs were separated on reversed
Veronika Krtkova et al.
Analytical and bioanalytical chemistry, 406(16), 3909-3918 (2014-05-09)
This study focused on the detection and quantification of organic micelle-type nanoparticles (NPs) with polysorbate components (polysorbate 20 and polysorbate 80) in their micelle shells that could be used to load biologically active compounds into fruit juice. Several advanced analytical
Kyle C Costa et al.
Journal of bacteriology, 195(22), 5160-5165 (2013-09-17)
Flavin-based electron bifurcation has recently been characterized as an essential energy conservation mechanism that is utilized by hydrogenotrophic methanogenic Archaea to generate low-potential electrons in an ATP-independent manner. Electron bifurcation likely takes place at the flavin associated with the α
Hye-In Lee et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 58-63 (2014-09-30)
Flurbiprofen (FLB) is one of the phenylalkanoic acid derivatives of non-steroidal anti-inflammatory drugs used for the management of pain and inflammation in patients with arthritis. We developed and validated a rapid and sensitive high-performance liquid chromatography analytical method utilizing tandem
Georgina Balcells et al.
Journal of chromatography. A, 1389, 65-75 (2015-03-10)
In order to improve the detection capabilities of anabolic androgenic steroids (AAS) in sports, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) screening method for the simultaneous detection of AAS phase I and phase II intact urinary metabolites (glucuronides and sulfates) was
Jiake He et al.
Molecular pharmaceutics, 11(8), 2745-2754 (2014-06-25)
A novel positron emission tomography (PET) tracer, [(11)C]-rosuvastatin (RSV), was developed to dynamically and noninvasively measure hepatobiliary transport and tissue distribution of [(11)C]-RSV in rats. Male Sprague-Dawley rats were administered either an Oatp inhibitor, rifampin (RIF, 40 mg/kg iv bolus
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