Search Within
Applied Filters:
Showing 1-30 of 3442 results for "


" within Papers
Tomáš Řezanka et al.
Phytochemistry, 104, 95-104 (2014-05-17)
Structured triacylglycerols (TAGs) were isolated from nine cultivated strains of microalgae belonging to different taxonomic groups, i.e. Audouinella eugena, Balbiania investiens, Myrmecia bisecta, Nannochloropsis limnetica, Palmodictyon varium, Phaeodactylum tricornutum, Pseudochantransia sp., Thorea ramosissima, and Trachydiscus minutus. They were separated and...
Aljona Saleh et al.
Journal of pharmaceutical and biomedical analysis, 104, 1-11 (2014-12-03)
MTH1 is a protein that is required for cancer cell survival and is overexpressed in cancer cells. TH588 and TH287 are two new compounds that inhibit the MTH1 protein. The inhibitors were tested in pharmacokinetic studies on mice. A bioanalytical...
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60...
Cuyue Tang et al.
Biochemical pharmacology, 91(4), 543-551 (2014-08-06)
Two investigational compounds (FRM-1, (R)-7-fluoro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and FRM-2, (R)-7-cyano-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide) resided in rat brain longer than in systemic circulation. In Caco-2 directional transport studies, they both showed good intrinsic passive permeability but differed significantly in efflux susceptibility (efflux ratio of <2 and...
J J Baeza-Baeza et al.
Journal of chromatography. A, 1284, 28-35 (2013-03-05)
The optimisation of the experimental conditions in gradient reversed-phase liquid chromatography requires reliable algorithms for the description of the retention and peak profile. As in isocratic elution, the linear relationship between the logarithm of the retention factor and the solvent...
Masafumi Sakono et al.
Biochimica et biophysica acta, 1840(9), 2904-2913 (2014-04-29)
Testis-specific chaperone calmegin is required for the generation of normal spermatozoa. Calmegin is known to be a homologue of endoplasmic reticulum (ER) residing lectin chaperone calnexin. Although functional similarity between calnexin and calmegin has been predicted, detailed information concerned with...
Haoyue Zhang et al.
Molecular genetics and metabolism, 114(2), 123-128 (2014-12-03)
Mucopolysaccharidoses (MPS) are complex storage disorders that result in the accumulation of glycosaminoglycans (GAGs) in urine, blood, brain and other tissues. Symptomatic patients are typically screened for MPS by analysis of GAG in urine. Current screening methods used in clinical...
Tianshi Feng et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1086-1093 (2014-10-12)
PLGA porous microspheres loaded with doxorubicin (DOX) and paclitaxel (PTX) were developed for in situ treatment of metastatic lung cancer. The synergistic effect of the combined drugs was investigated against B16F10 cells to obtain the optimal prescription for in vivo...
L Hernychová et al.
Physiological research, 64 Suppl 1, S85-S93 (2015-10-09)
As a part of the innate immunity, NK (Natural Killer) cells provide an early immune response to different stimuli, e.g. viral infections and tumor growths. However, their functions are more complex; they play an important role in reproduction, alloimmunity, autoimmunity...
Udita Agrawal et al.
Colloids and surfaces. B, Biointerfaces, 126, 414-425 (2015-01-21)
The object of the present study was to investigate the glioma targeting propensity of folic acid (F) decorated polymer-lipid hybrid nanoparticles (PLNs) encapsulating cyclo-[Arg-Gly-Asp-D-Phe-Lys] (cRGDfK) modified paclitaxel (PtxR-FPLNs). The prepared PLNs were supposed to bypass the blood-brain barrier (BBB) efficiently...
Dan Zhang et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(3), 239-243 (2014-09-19)
1.The aim of the study was to evaluate the pharmacokinetics of peramivir after single intravenous (i.v.) doses in healthy Chinese subjects. 2.In a cross-over study, 12 subjects were given 300 and 600 mg peramivir by i.v. infusion. Blood and urine samples...
Paul Dowling et al.
Molecular bioSystems, 11(3), 743-752 (2014-12-09)
Lung cancer is the second most common type of cancer in the world and is the most common cause of cancer-related death in both men and women. Research into causes, prevention and treatment of lung cancer is ongoing and much...
Bilal Yilmaz et al.
Journal of chromatographic science, 52(7), 584-589 (2013-06-25)
A simple high-performance liquid chromatography method has been developed for the determination of naproxen in human plasma. The method was validated on an Ace C18 column using ultraviolet detection. The mobile phase consisted of 20 mM phosphate buffer (pH 7)...
Gang-Tian Zhu et al.
The Analyst, 139(23), 6266-6271 (2014-10-16)
A novel in-syringe dispersive solid phase extraction (dSPE) system using electrospun silica fibers as adsorbents has been developed in the current work. A few milligrams of electrospun silica fibers were incubated in sample solution in the barrel of a syringe...
Holly A Reeve et al.
ChemCatChem, 7(21), 3480-3487 (2015-11-28)
We describe a new approach to selective H
Lakkireddy Prakash et al.
Journal of chromatographic science, 53(1), 122-126 (2014-05-20)
Nicorandil is a potent drug with a dual mechanism of action which results in its wide application in treating angina patients. Since the literature review showed no single preparative method for isolation and liquid chromatography-mass spectrometry (LC-MS) compatible [high-performance liquid...
Niclas Stephanson et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 189-196 (2015-02-18)
A mass spectrometric method for drugs of abuse testing in exhaled breath employing a sampling device collecting aerosol particles was developed and applied in routine use. Analytes covered were amphetamine, methamphetamine, 6-acetylmorphine, morphine, cocaine, benzoylecgonine, diazepam, oxazepam and tetrahydrocannabinol. The...
Regina Lohmayer et al.
Analytical chemistry, 87(6), 3388-3395 (2015-02-25)
Molybdenum precipitates preferentially under reducing conditions; therefore, its occurrence in sediment records is used as an indicator of paleoredox conditions. Although thiomolybdates (MoO4-xSx(2-) with x = 1-4) supposedly are necessary intermediates in the process of molybdenum precipitation under anoxic conditions...
Natalia Campillo et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(12), 2039-2047 (2015-09-29)
Seven strobilurin fungicides were pre-concentrated from soya-based drinks using dispersive liquid-liquid micro-extraction (DLLME) with a prior protein precipitation step in acid medium. The enriched phase was analysed by liquid chromatography (LC) with dual detection, using diode array detection (DAD) and...
Jenny L Pokorny et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(8), 1916-1924 (2015-01-23)
Wee1 regulates key DNA damage checkpoints, and in this study, the efficacy of the Wee1 inhibitor MK-1775 was evaluated in glioblastoma multiforme (GBM) xenograft models alone and in combination with radiation and/or temozolomide. In vitro MK-1775 efficacy alone and in...
John Eksterowicz et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1698-1707 (2014-07-31)
Cytochrome P450 4F12 is a drug-metabolizing enzyme that is primarily expressed in the liver, kidney, colon, small intestine, and heart. The properties of CYP4F12 that may impart an increased catalytic selectivity (decreased promiscuity) were explored through in vitro metabolite elucidation...
Yann Aminot et al.
Analytical and bioanalytical chemistry, 407(28), 8585-8604 (2015-09-12)
Comprehensive source and fate studies of pharmaceuticals in the environment require analytical methods able to quantify a wide range of molecules over various therapeutic classes, in aqueous and solid matrices. Considering this need, the development of an analytical method to...
Tao Chen et al.
Journal of pharmaceutical and biomedical analysis, 117, 304-310 (2015-09-26)
Antibody-drug conjugates (ADCs) offer new therapeutic options for advanced cancer patients through precision killing with fewer side effects. The stability and efficacy of ADCs are closely related, emphasizing the urgency and importance of gaining a comprehensive understanding of ADC stability....
M Masoodi et al.
Leukemia, 28(7), 1381-1387 (2014-01-15)
Oleoylethanolamide (OEA) is a bioactive lipid that stimulates nuclear and G protein-coupled receptors and regulates appetite and fat metabolism. It has not previously been shown to have a role in cancer. However, a mass spectrometry-based lipidomics platform revealed the presence...
Maria A Vlasova et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 96-102 (2014-06-26)
Intravenously administered nanocarriers are widely studied to improve the delivery of various therapeutic agents. However, recent in vivo studies have demonstrated that intravenously administered nanocarriers that do not contain any drug may affect cardiovascular function. Here we provide an example...
Coleman T Turgeon et al.
Molecular genetics and metabolism, 114(1), 46-50 (2014-12-08)
Pre-symptomatic hematopoietic stem cell transplantation is essential to achieve best possible outcomes for patients with the childhood cerebral form of X-linked adrenoleukodystrophy (X-ALD). We describe a high-throughput method for measurement of C20-C26 lysophosphatidylcholines (LPCs) and biochemical diagnosis of X-ALD using...
Yisheng Chen et al.
Journal of chromatography. A, 1356, 249-257 (2014-07-13)
The world-wide usage and partly abuse of veterinary antibiotics resulted in a pressing need to control residues in animal-derived foods. Large-scale screening for residues of antibiotics is typically performed by microbial agar diffusion tests. This work employing high-performance thin-layer chromatography...
Roberta Jeane B Jorge et al.
Journal of proteomics, 114, 93-114 (2014-12-03)
The Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic variability of its venom toxins were investigated applying a...
Boning Wu et al.
The journal of physical chemistry. B, 119(46), 14790-14799 (2015-10-27)
Ionic liquids with electron-donating anions are used to investigate rates and mechanisms of photoinduced bimolecular electron transfer to the photoexcited acceptor 9,10-dicyanoanthracene (9,10-DCNA). The set of five cyano anion ILs studied comprises the 1-ethyl-3-methylimidazolium cation paired with each of these...
Lauriane Goldwirt et al.
Journal of neuro-oncology, 122(2), 273-281 (2015-03-22)
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard of care of newly diagnosed GBM...
Page 1 of 115
Page 1 of 115