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Milena K Bulla et al.
Photochemistry and photobiology, 91(3), 558-566 (2015-01-13)
Schinus terebinthifolius is a plant rich in phenolic compounds, which have antioxidant properties and can provide new opportunities for treatment and prevention of diseases mediated by ultraviolet radiation like photoaging and skin cancer. The aim of this study was to
J S LaKind et al.
Critical reviews in toxicology, 29(4), 331-365 (1999-08-18)
The purpose of this article is to review and interpret the scientific literature on the mammalian toxicity of ethylene glycol (EG) and propylene glycol (PG), with the goal of comparing the toxicity of the two chemicals. This type of review
Stephen T Vito et al.
Toxicology and applied pharmacology, 281(2), 185-194 (2014-12-03)
Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote. The convulsant action of TETS is thought to be mediated by inhibition of type A gamma-aminobutyric acid receptor (GABAAR) function. We, therefore, investigated the effects
Luciana Pinato et al.
Brain structure & function, 220(2), 827-840 (2013-12-24)
Although melatonin is mainly produced by the pineal gland, an increasing number of extra-pineal sites of melatonin synthesis have been described. We previously demonstrated the existence of bidirectional communication between the pineal gland and the immune system that drives a
Khaled Mohamed Hosny et al.
International journal of pharmaceutics, 475(1-2), 191-197 (2014-09-03)
Saquinavir mesylate (SM) is a protease inhibitor with activity against human immunodeficiency virus type 1 (HIV-1) and is available in tablet form, which has three major problems. First, the drug undergoes extensive first pass metabolism. Second, the drug has a
Neha Garg et al.
European journal of medicinal chemistry, 45(4), 1529-1535 (2010-02-19)
A new series of 4-(4'-Hydroxyphenyl)-2-(3-substitutedphenyl)-3-(4-substitutedphenylamino methylene)-2,3-dihydro-1,5-benzothiazepines (3a-3j) and 4-(4'-Hydroxyphenyl)-2-(3-substituted phenyl)-3-(4-substitutedphenylaminomethylene)-2,3-dihydro-1,5-benzoxazepins (3a'-3j') were synthesized and evaluated for their anticonvulsant activity. All these compounds were screened in vivo, for their anticonvulsant activity and acute toxicity. Compound 3g was found to be most
Young Jin Jang et al.
Biochemical and biophysical research communications, 467(4), 941-947 (2015-10-17)
Shikonin is a naturally occurring naphthoquinone pigment and a major constituent present in Lithospermum erythrorhizon. Since microRNAs (miRNAs) are one of the key post-transcriptional regulators of adipogenesis, their manipulation represents a potential new strategy to inhibit adipogenesis. Our aim was
Laurent Imbert et al.
Journal of analytical toxicology, 38(9), 676-680 (2014-09-05)
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters
Poonamjot Deol et al.
PloS one, 10(7), e0132672-e0132672 (2015-07-23)
The obesity epidemic in the U.S. has led to extensive research into potential contributing dietary factors, especially fat and fructose. Recently, increased consumption of soybean oil, which is rich in polyunsaturated fatty acids (PUFAs), has been proposed to play a
Kenneth B Sloan et al.
Journal of cosmetic science, 64(3), 181-192 (2013-06-12)
It would be useful to develop a surrogate for animal skin, which could be use to predict flux through human skin. The fluxes (and physicochemical properties) of sunscreens and other compounds from propylene glycol (PG):water (AQ), 30:70, through human skin
Sabine Hauptstein et al.
International journal of pharmaceutics, 487(1-2), 25-31 (2015-04-04)
It was the aim of this study to investigate a novel strategy for oral gene delivery utilizing a self-nanoemulsifying drug delivery system (SNEDDS). After hydrophobic ion pairing a plasmid was incorporated into SNEDDS. The mean droplet size of resulting nanoemulsions
D Spadaro et al.
Journal of applied microbiology, 119(2), 510-520 (2015-05-16)
To identify cultivable filamentous fungi before ensiling, after silage conservation, in farm-silos covered with two different plastic films (polyethylene (PE) vs biodegradable (MB)), as well as after aerobic exposure of whole-crop corn silage. Molecular techniques coupled with traditional microbial counting
Fengjiao Zhou et al.
Journal of bioscience and bioengineering, 120(1), 9-16 (2014-12-31)
Several carbonaceous mesocellular foams (C-MCFs) were prepared with MCF-silica as template using the carbon precursors of sucrose, furfuryl alcohol and lab-made phenolic resin, and the corresponding C-MCFs were named as C-MCF-Suc, C-MCF-FA and C-MCF-PR, respectively. The results of SEM, transmission
P D Yorgin et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 30(1), 134-139 (1997-07-01)
Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. Although uncommon, acute renal failure has been attributed to propylene glycol. The mechanism of propylene glycol-mediated renal injury is unknown. We report a case of
Margit D Aaslyng et al.
Meat science, 110, 52-61 (2015-07-18)
Consumer liking was assessed for streaky bacon and pork belly roll from entire male pigs with an androstenone (AND) content of up to 9.4 ppm and a skatole (SKA) content of up to 0.92 ppm in the back fat and
Raquel S Teixeira et al.
International journal of pharmaceutics, 474(1-2), 212-222 (2014-08-12)
The aim of this study is to investigate the efficacy of new, biocompatible, lysine-based surfactants as chemical permeation enhancers for two different local anesthetics, tetracaine and ropivacaine hydrochloride, topically administered. Results show that this class of surfactants strongly influences permeation
Erin K Zinkhan et al.
Pediatric research, 76(5), 432-440 (2014-08-15)
Intrauterine growth restriction (IUGR) increases the risk of adult-onset hypercholesterolemia. High-fat diet (HFD) consumption potentiates IUGR-induced increased cholesterol. Cholesterol is converted to bile acids by Cyp7a1 in preparation for excretion. We hypothesized that IUGR rats fed a HFD will have
Luc A Cynober
Nutrition (Burbank, Los Angeles County, Calif.), 18(9), 761-766 (2002-09-26)
The plasma concentration of an amino acid (AA) is the result of its rates of appearance (Ra) in and disappearance (Rd) from plasma. As for most nutrients, AA Ra and Rd are tightly regulated and at the postabsorptive state Ra
Yasaman Damestani et al.
Lasers in surgery and medicine, 46(6), 488-498 (2014-05-28)
Optical clearing agents (OCAs) have shown promise for increasing the penetration depth of biomedical lasers by temporarily decreasing optical scattering within the skin. However, their translation to the clinic has been constrained by lack of practical means for effectively perfusing
Adriana Machado-Lima et al.
Journal of cellular physiology, 230(6), 1250-1257 (2014-11-22)
Advanced glycation end products (AGE) are elevated in diabetes mellitus (DM) and predict the development of atherosclerosis. AGE-albumin induces oxidative stress, which is linked to a reduction in ABCA-1 and cholesterol efflux. We characterized the glycation level of human serum
Justin D Delorit et al.
Water environment research : a research publication of the Water Environment Federation, 86(4), 366-371 (2014-05-24)
Aircraft deicing fluid used at airport facilities is often collected for treatment or disposal in order to prevent serious ecological threats to nearby surface waters. This study investigated lab scale degradation of propylene glycol, the active ingredient in a common
Simultaneous determination of plasma phenethylamine, phenylethanolamine, tyramine and octopamine by high-performance liquid chromatography using derivatization with fluorescamine.
T Yonekura et al.
Journal of chromatography, 427(2), 320-325 (1988-06-03)
A A Melo et al.
The Journal of laryngology and otology, 127(4), 359-363 (2013-02-15)
To determine whether the administration of mitomycin C prevents propylene glycol exposure from inducing middle-ear cholesteatoma and otitis media, in a rat model. Twenty-four Wistar rats underwent intratympanic injections on days 1, 8 and 15, via the tympanic membrane pars
Dehua Liao et al.
Drug delivery, 22(4), 516-521 (2014-01-29)
The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological
Osama Abdelhakim Aly Ahmed et al.
Journal of pharmaceutical sciences, 104(6), 2062-2075 (2015-04-16)
This study is aimed at developing glimepiride (GMD) liposomal films using quality by design (QbD) and process analytical technology (PAT) principles. Risk analysis and Plackett-Burman design were utilized to evaluate formulation variables in two paths. Internal path included liposomal parameters
Chi-Feng Hung et al.
International journal of pharmaceutics, 471(1-2), 135-145 (2014-05-27)
Intrinsic aging and photoaging modify skin structure and components, which subsequently change percutaneous absorption of topically applied permeants. The purpose of this study was to systematically evaluate drug/sunscreen permeation via young and senescent skin irradiated by ultraviolet (UV) light. Both
D L Miller et al.
The Journal of investigative dermatology, 69(3), 287-289 (1977-09-01)
Thermomechanical analysis (TMA) measurements were used to characterize the physical properties of normal and treated stratum corneum. TMA measures changes in the overall mechanical and dimensional properties of the material as a result of temperature-induced transformations such as lipid melting
Ana Serralheiro et al.
International journal of pharmaceutics, 490(1-2), 39-46 (2015-05-17)
Pharmacoresistance is considered one of the major causes underlying the failure of the anticonvulsant therapy, demanding the development of alternative and more effective therapeutic approaches. Due to the particular anatomical features of the nasal cavity, intranasal administration has been explored
H Fromme et al.
Chemosphere, 90(11), 2714-2721 (2013-01-08)
Glycol ethers are a class of semi-volatile substances used as solvents in a variety of consumer products like cleaning agents, paints, cosmetics as well as chemical intermediates. We determined 11 metabolites of ethylene and propylene glycol ethers in 44 urine
Quiz page October 2013: When things are not as they seem: a woman with anion gap metabolic acidosis after ingesting antifreeze.
Aswani Alavala et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 62(4), A25-A28 (2013-09-24)
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