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Leopold Kong et al.
Journal of molecular biology, 427(16), 2617-2628 (2015-07-03)
Hepatitis C virus (HCV) is a positive-strand RNA virus within the Flaviviridae family. The viral "spike" of HCV is formed by two envelope glycoproteins, E1 and E2, which together mediate viral entry by engaging host receptors and undergoing conformational changes
Sebastian P Fuchs et al.
PLoS pathogens, 11(8), e1005090-e1005090 (2015-08-08)
Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high
Ju-Hyung Shin et al.
PloS one, 10(6), e0130684-e0130684 (2015-06-19)
Influenza is one of the critical infectious diseases globally and vaccination has been considered as the best way to prevent. In this study, immunogenicity and protection efficacy between intranasal (IN) and microneedle (MN) vaccination was compared using inactivated swine-origin influenza
Jesse H Erasmus et al.
PLoS neglected tropical diseases, 9(10), e0004119-e0004119 (2015-10-23)
In December of 2013, chikungunya virus (CHIKV), an alphavirus in the family Togaviridae, was introduced to the island of Saint Martin in the Caribbean, resulting in the first autochthonous cases reported in the Americas. As of January 2015, local and
Dionisia Quiroga et al.
Cancer immunology, immunotherapy : CII, 64(4), 479-491 (2015-02-07)
The need for novel, effective adjuvants that are capable of eliciting stronger cellular and humoral adaptive immune responses to antigenic targets is well understood in the vaccine development field. Unfortunately, many adjuvants investigated thus far are either too toxic for
Martín A Rossotti et al.
Analytical chemistry, 87(23), 11907-11914 (2015-11-07)
Single domain heavychain binders (nanobodies) obtained from camelid antibody libraries hold a great promise for immunoassay development. However, there is no simple method to select the most valuable nanobodies from the crowd of positive clones obtained after the initial screening.
Liquan Yu et al.
Journal of medical microbiology, 63(Pt 12), 1732-1740 (2014-10-08)
Staphylococcal and streptococcal species are the most common pathogens that cause bovine mastitis. Induction of a broad-spectrum protective immunity against staphylococci and streptococci by combining multiple antigens into a single vaccine is highlighted. To develop a universal vaccine candidate, a
Ying Huang et al.
Developmental and comparative immunology, 52(2), 155-165 (2015-05-26)
Integrins belong to a superfamily of conserved α β heterodimeric cell surface receptors that have critical function in cell migration, differentiation, and survival. In this study, an integrin called EsIntegrin was identified from Chinese mitten crab Eriocheir sinensis. EsIntegrin cDNA
Majid Motaghinejad et al.
Fundamental & clinical pharmacology, 29(3), 299-309 (2015-04-08)
Chronic consumption of morphine induces physical dependency, anxiety, and neurodegeneration. In this study, morphine on its own has been used for the management of morphine-induced dependency, oxidative stress, and apoptosis. Forty-eight male rats were randomly divided into six groups. Rats
Wen-Hsiang Chen et al.
Human vaccines & immunotherapeutics, 10(3), 648-658 (2013-12-21)
Development of vaccines for preventing a future pandemic of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) and for biodefense preparedness is urgently needed. Our previous studies have shown that a candidate SARS vaccine antigen consisting of the
Maria Grazia Clemente et al.
The Journal of pediatrics, 166(1), 79-84 (2014-12-03)
To analyze the prevalence of acute asymptomatic group A and C rotavirus (RV-A and RV-C) infection in neonates with cholestasis. Participants were infants <180 days of age with cholestasis (serum direct or conjugated bilirubin >20% of total and ≥2 mg/dL)
Shih-Yeh Lin et al.
Vaccine, 33(44), 5966-5973 (2015-05-06)
Enterovirus 71 (EV71) causes the outbreaks of hand-foot-and-mouth disease and results in deaths of hundreds of young children. EV71 virus-like particles (VLPs) are empty capsids consisting of viral structural proteins and can elicit potent immune responses, thus holding promise as
Jun He et al.
The journal of spinal cord medicine, 38(6), 717-728 (2015-01-15)
Background Establishing bladder reflex arcs only with the efferent pathway to induce micturition after spinal cord injury (SCI) has been successful. However, the absence of sensory function and micturition desires can lead to serious complications. Objectives To reconstruct a bladder
Marie Hagbom et al.
Scientific reports, 5, 11431-11431 (2015-06-24)
By the use of a modified ionizer device we describe effective prevention of airborne transmitted influenza A (strain Panama 99) virus infection between animals and inactivation of virus (>97%). Active ionizer prevented 100% (4/4) of guinea pigs from infection. Moreover
K J Taylor et al.
Parasite immunology, 37(1), 23-31 (2014-11-08)
Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial
G M Proshkina et al.
Biochimie, 118, 116-122 (2015-09-01)
Cytotoxic effects of a new targeted phototoxin DARPin-miniSOG and mechanism of its action were investigated in vitro. It was determined that DARPin-miniSOG causes light-induced death of HER2/neu-positive cancer cells (IC50 0.8 μM). Treatment of the cells with DARPin-miniSOG in the presence of
Daniel Menezes-Souza et al.
PloS one, 9(6), e99216-e99216 (2014-06-13)
The search toward the establishment of novel serological tests for the diagnosis of leishmaniasis and proper differential diagnosis may represent one alternative to the invasive parasitological methods currently used to identify infected individuals. In the present work, we investigated the
Erin K Johnston et al.
In vitro cellular & developmental biology. Animal, 51(7), 730-738 (2015-05-08)
Angiogenesis, or the formation of new blood vessels, is stimulated by angiogenic factors such as vascular endothelial growth factor (VEGF). Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis. To explore the mechanism by which PEDF acts, recombinant PEDF
Islam Amine Larabi et al.
Journal of analytical toxicology, 39(9), 720-725 (2015-09-06)
A liquid chromatography-MS-MS turbulent flow on-line extraction method was developed for the determination of trimebutine (TMB) and its main active metabolite N-mono-desmethyltrimebutine (nortrimebutine or nor-TMB) in human plasma. After protein precipitation and internal standard (IS, haloperidol-d4) addition, 50 µL of
Shian-Ying Sung et al.
Oncotarget, 5(20), 9911-9929 (2014-10-09)
The L1 cell adhesion molecule (L1CAM) has been implicated in tumor progression of many types of cancers, but its role in prostate cancer and its application in targeted gene therapy have not been investigated. Herein, we demonstrated that the L1CAM
Jiang Chen et al.
ACS applied materials & interfaces, 7(7), 4423-4432 (2015-02-14)
Recently, UV irradiation has been reported as a new approach to significantly improve the anticoagulant properties of titanium dioxide (TiO2) films by suppressing fibrinogen adsorption and platelet adhesion. This study focuses on how fibrinogen adsorption of and platelet adhesion to
Chuang Xu et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(5), 341-345 (2015-10-23)
When abrin-a was combined with several polyclonal antibodies (PAb), the detection limit could be increased. In this way, a monoclonal antibody (capture) and polyclonal antibody (detection) sandwich enzyme-linked immunosorbent assay (ELISA) and a colloidal gold-PAb conjugate-based immunochromatographic assay for detection
Angela L Man et al.
Clinical science (London, England : 1979), 129(7), 515-527 (2015-05-08)
The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7-12 years), adult (20-40 years) and aging (67-77 years) individuals not showing symptoms of gastrointestinal (GI) pathologies were used to assess levels of
Elena Pascual et al.
Journal of virology, 89(5), 2563-2574 (2014-12-19)
Bioengineering of viruses and virus-like particles (VLPs) is a well-established approach in the development of new and improved vaccines against viral and bacterial pathogens. We report here that the capsid of a major avian pathogen, infectious bursal disease virus (IBDV)
Hadas Cohen-Dvashi et al.
Journal of virology, 89(15), 7584-7592 (2015-05-15)
Lassa virus is a notorious human pathogen that infects many thousands of people each year in West Africa, causing severe viral hemorrhagic fevers and significant mortality. The surface glycoprotein of Lassa virus mediates receptor recognition through its GP1 subunit. Here
Francisco A Guardiola et al.
Fish & shellfish immunology, 47(1), 352-359 (2015-09-20)
Although the skin is one of the main defense barriers of fish to date, very little is known about the immune implications and the properties of the numerous substances present in skin cells. In the present study, terminal carbohydrate composition
D J Begg et al.
Veterinary immunology and immunopathology, 166(3-4), 125-131 (2015-07-07)
Many studies have examined the serum antibody response to Mycobacterium avium subspecies paratuberculosis (MAP) infection in cases of Johne's disease (JD), but there are no reports on the mucosal antibody response. Faecal immunoglobulin (Ig) G and IgA ELISA responses were
Shin'ichi Akiyama et al.
Clinical and experimental nephrology, 19(4), 653-660 (2014-11-22)
Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. Anti-M-type phospholipase A2 receptor (anti-PLA2R) antibodies are found in most patients with idiopathic MN (iMN) worldwide, but the prevalence of anti-PLA2R antibodies among Japanese patients with MN is
Jarmila Knitlova et al.
PloS one, 9(12), e114374-e114374 (2014-12-09)
Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replicating Modified vaccinia virus Ankara (MVA) has been under clinical development. MVA seems to
N A Taranova et al.
International journal of analytical chemistry, 2015, 347621-347621 (2015-12-23)
A rapid immunochromatographic assay was developed for the control of tetracycline (TC). The assay is based on the competition between immobilized TC-protein conjugate and TC in a tested sample for binding with polyclonal anti-TC antibodies conjugated to colloidal gold during
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