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91010

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Abir Ben Bacha et al.
Lipids in health and disease, 10, 69-69 (2011-05-10)
Pancreatic colipase is a required co-factor for pancreatic lipase, being necessary for its activity during hydrolysis of dietary triglycerides in the presence of bile salts. In the intestine, colipase is cleaved from a precursor molecule, procolipase, through the action of...
Yongqing Hou et al.
The British journal of nutrition, 111(10), 1748-1758 (2014-02-11)
Tributyrin (TBU) is a good dietary source of butyrate and has beneficial effects on the maintenance of normal intestinal morphology. The present study tested the hypothesis that dietary TBU supplementation could alleviate intestinal injury in the acetic acid (ACA)-induced porcine...
Renato Heidor et al.
Toxicology and applied pharmacology, 276(2), 129-135 (2014-03-01)
The chemopreventive activity of the histone deacetylase inhibitor (HDACi) tributyrin (TB), a prodrug of butyric acid (BA), was evaluated in a rat model of colon carcinogenesis. The animals were treated with TB (TB group: 200mg/100g of body weight, b.w.) or...
Tao Zhang et al.
Microbial cell factories, 8, 67-67 (2009-12-24)
A metagenomic library was prepared using pCC2FOS vector containing about 3.0 Gbp of community DNA from the microbial assemblage of activated sludge. Screening of a part of the un-amplified library resulted in the finding of 1 unique lipolytic clone capable...
Mette U Anby et al.
Molecular pharmaceutics, 11(11), 4069-4083 (2014-09-30)
The impact of gastrointestinal (GI) processing and first pass metabolism on danazol oral bioavailability (BA) was evaluated after administration of self-emulsifying drug delivery systems (SEDDS) in the rat. Danazol absolute BA was determined following oral and intraduodenal (ID) administration of...
Christian C Gruber et al.
Methods in molecular biology (Clifton, N.J.), 861, 313-327 (2012-03-20)
Interactions of lipases with hydrophobic substrate-water interfaces are of great interest to design improved lipase variants and engineer reaction conditions. This chapter describes the necessary steps to carry out molecular dynamics simulations of Candida antarctica lipase B at tributyrin-water interface...
Sung Nam Kang et al.
International journal of pharmaceutics, 428(1-2), 76-81 (2012-03-13)
Tributyrin, a triglyceride analogue of butyrate, can act as a prodrug of an anticancer agent butyrate after being cleaved by intracellular enzymes. We recently demonstrated that the emulsion containing tributyrin as an inner oil phase possesses a potent anticancer activity....
Diana Martín et al.
Lipids, 46(3), 277-285 (2011-01-13)
Butyric acid has been the subject of much attention last years due to its bioactivity. However, the potential advantages of butyrate are limited by the problem to reach enough plasma concentrations; therefore, pro-drugs have been proposed as an alternative to...
María Teresa Tejedor-Junco et al.
Journal of clinical microbiology, 48(2), 596-598 (2009-12-25)
Two tributyrin hydrolysis-negative Moraxella isolates obtained in cases of keratoconjunctivitis in Camelus dromedarius in the Canary Islands showed highest degrees of 16S rRNA gene sequence similarity to Moraxella canis. A level of DNA relatedness to the M. canis type strain...
Peter J Richards et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 92(2), 439-446 (2009-11-21)
Epidural adhesion formation is believed to be a central governing factor in the prevalence of pain after spinal surgery and is regarded as being the primary instigator of neural tethering, leading to complications during revision surgery. In this study, we...
M H Sodergren et al.
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 99(3), 153-161 (2010-11-04)
current studies suggest immunonutrition decreases the inflammatory process, infection rates and reduces length of hospital stay in surgical patients, however studies are often conducted on heterogeneous groups of patients with varying composition of the immuno-nutrition. We aim to investigate the...
Ashish K Rehni et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(6), 605-619 (2012-03-01)
The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO), a selective interleukin-1β converting enzyme inhibitor, on the development of naloxone-induced opioid withdrawal syndrome both in vitro and in vivo and...
Yuping Shi et al.
BMC biotechnology, 13, 13-13 (2013-02-19)
BioH is one of the key enzymes to produce the precursor pimeloyl-ACP to initiate biotin biosynthesis de novo in bacteria. To date, very few bioH genes have been characterized. In this study, we cloned and identified a novel bioH gene...
Makoto Miyoshi et al.
Clinical nutrition (Edinburgh, Scotland), 30(2), 252-258 (2010-11-06)
Short-chain fatty acids, especially butyrate, have various biological activities including inhibition of tumor necrosis factor (TNF)-α secretion, via attenuation of nuclear factor-κB (NF-κB) activation. Here, we evaluated the protective effect of oral administration of tributyrin, a prodrug of butyrate, on...
Marco A R Vinolo et al.
The Journal of nutritional biochemistry, 22(9), 849-855 (2010-12-21)
Short chain fatty acids (SCFAs) are fermentation products of anaerobic bacteria. More than just being an important energy source for intestinal epithelial cells, these compounds are modulators of leukocyte function and potential targets for the development of new drugs. The...
Alberto Villa et al.
ChemSusChem, 3(2), 241-245 (2009-11-13)
Nitrogen-functionalized carbon nanotubes were synthesized by grafting amino groups to the surface of the nanotubes. The nanotubes exhibited promising results in the base-catalyzed liquid phase transesterification of glyceryl tributyrate with methanol, which is a model reaction for the production of...
Pazhamalai Anbarasan et al.
Nature, 491(7423), 235-239 (2012-11-09)
Nearly one hundred years ago, the fermentative production of acetone by Clostridium acetobutylicum provided a crucial alternative source of this solvent for manufacture of the explosive cordite. Today there is a resurgence of interest in solventogenic Clostridium species to produce...
Sung Nam Kang et al.
Drug delivery, 18(2), 143-149 (2010-10-16)
Histone deacetylase inhibitors such as butyrate are known to exhibit anti-cancer activities in a wide range of cancer including melanoma. In spite of these potencies, butyrate is not practically used for cancer treatment due to its rapid metabolism and very...
Renato Heidor et al.
Current drug targets, 13(14), 1720-1729 (2012-11-13)
Bioactive food compounds (BFCs) exhibit potential anticarcinogenic effects that deserve to be explored. Butyric acid (BA) is considered a promising BFC and has been used in clinical trials; however, its short half-life considerably restricts its therapeutic application. Tributyrin (TB), a...
Min Zhang et al.
Nuclear medicine communications, 32(7), 605-610 (2011-04-08)
Radioiodine ablation is ineffective in patients with radioiodine nonresponsive thyroid carcinoma. We investigated the effects of all-trans retinoic acid (ATRA) combined with histone deacetylase inhibitor, tributyrin on sodium-iodide symporter (NIS) expression, radioiodine uptake, and inhibition of cell proliferation in a...
Yanhua Fan et al.
Journal of invertebrate pathology, 106(2), 274-279 (2010-11-10)
The entomopathogenic fungus Beauveria bassiana displays a broad insect host range and serves as a model for examining host-pathogen interactions. Rapid construction and screening of random-insertion mutants of B. bassiana provides a powerful tool to dissect the molecular mechanisms of...
Aline H Guariento et al.
International journal of cancer, 135(1), 7-18 (2013-12-05)
The steady increase in the incidence and mortality of hepatocellular carcinoma (HCC) signifies a crucial need to understand better its pathogenesis to improve clinical management and prevention of the disease. The aim of this study was to investigate molecular mechanisms...
Soon-Seok Hong et al.
International journal of pharmaceutics, 483(1-2), 142-150 (2015-02-11)
A high drug-loading capacity is a critical factor for the clinical development of liposomal formulations. The accommodation of hydrophobic drugs within the liposomal membrane is often limited in saturated phosphatidylcholine (PC)-based liposomes owing to the rigidity of the lipid acyl...
Slim Abdelkafi et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 66(1), 34-40 (2011-01-27)
Triacylglycerol (TAG) lipases have been thoroughly characterized in mammals and microorganisms, whereas very little is known about plant TAG lipases. The lipolytic activity occurring in all the laticies is known to be associated with sedimentable particles, and all attempts to...
Alda J Leonel et al.
The British journal of nutrition, 109(8), 1396-1407 (2012-08-22)
Tributyrin (TBT) is a TAG composed of three butyric acids that has beneficial effects on ulcerative colitis due to its trophic, anti-inflammatory, pro-apoptotic and anti-carcinogenic properties. The goal of the present study was to evaluate the efficacy and mechanisms of...
Eduardo Mateos-Díaz et al.
Methods in molecular biology (Clifton, N.J.), 861, 89-100 (2012-03-20)
High-throughput screening (HTS) methods for lipases and esterases are generally performed by using synthetic chromogenic substrates (e.g., p-nitrophenyl, resorufin, and umbelliferyl esters) which may be misleading since they are not their natural substrates (e.g., partially or insoluble triglycerides). In previous...
Marco Aurélio Ramirez Vinolo et al.
American journal of physiology. Endocrinology and metabolism, 303(2), E272-E282 (2012-05-25)
The aim of this study was to investigate whether treatment with tributyrin (Tb; a butyrate prodrug) results in protection against diet-induced obesity and associated insulin resistance. C57BL/6 male mice fed a standard chow or high-fat diet were treated with Tb...
Xunjun Xiao et al.
Biochimica et biophysica acta, 1831(9), 1435-1441 (2013-06-19)
Efficient dietary fat digestion is essential for newborns who consume more dietary fat per body weight than at any other time of life. In many mammalian newborns, pancreatic lipase related protein 2 (PLRP2) is the predominant duodenal lipase. Pigs may...
Lu Han et al.
Journal of agricultural and food chemistry, 59(23), 12635-12642 (2011-11-16)
A kind of low-calorie structured lipid (LCSL) was obtained by interesterification of tributyrin (TB) and methyl stearate (St-ME), catalyzed by a commercially immobilized 1,3-specific lipase, Lipozyme RM IM from Rhizomucor miehei . The condition optimization of the process was conducted...
Gail A Cresci et al.
Alcoholism, clinical and experimental research, 38(6), 1489-1501 (2014-06-04)
Excessive alcohol consumption leads to liver disease. Interorgan crosstalk contributes to ethanol (EtOH)-induced liver injury. EtOH exposure causes gut dysbiosis resulting in negative alterations in intestinal fermentation byproducts, particularly decreased luminal butyrate concentrations. Therefore, in the present work, we investigated...
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