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Satoko Baba et al.
Journal of pharmacological sciences, 127(3), 326-331 (2015-04-04)
Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their
D C Riley et al.
Journal of neuroscience research, 93(4), 572-583 (2014-11-27)
Restoration of neuronal functions by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all, especially after ablation of nerve segments. Distal segments of severed axons typically
Anastasia Tsigkou et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(12), 1597-1602 (2015-07-04)
Uterine leiomyoma is the most common benign neoplasm of female reproductive system, found in about 50% of women in reproductive age. The mechanisms of leiomyoma growth include cell proliferation, which is modulated by growth factors, and deposition of extracellular matrix
Dongmei Wang et al.
Cellular and molecular neurobiology, 34(8), 1209-1221 (2014-08-20)
The role of mitochondrial dysfunction and oxidative stress has been well-documented in Alzheimer's disease (AD). Bioflavonoids are being utilised as neuroprotectants in the treatment of various neurological disorders, including AD. Therefore, we conducted this current study in order to explore
Francisco de Borja Callejas et al.
PloS one, 9(6), e100537-e100537 (2014-06-20)
Primary human airway epithelial cells cultured in an air-liquid interface (ALI) develop a well-differentiated epithelium. However, neither characterization of mucociliar differentiation overtime nor the inflammatory function of reconstituted nasal polyp (NP) epithelia have been described. 1st) To develop and characterize
Muhammad Asif et al.
Analytica chimica acta, 898, 34-41 (2015-11-04)
We report a facile and green method for the fabrication of new type of electrocatalysts based on MnO2 nanoparticles incorporated on MgAl LDH P-type semiconductive channel and explore its practical applications as high-performance electrode materials for electrochemical biosensor. A series
Ala Muala et al.
Particle and fibre toxicology, 12, 33-33 (2015-10-30)
Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this study was to determine whether exposure to wood smoke from incomplete combustion would elicit airway
Panjaphorn Nimmanee et al.
International journal of medical microbiology : IJMM, 305(1), 65-74 (2014-12-04)
Eukaryotes utilize stress activated protein kinase (SAPK) pathways to adapt to environmental stress, including heat, osmotic, oxidative or nutrient stresses. Penicillium marneffei (Talaromyces marneffei), the dimorphic pathogenic fungus that can cause disseminated mycosis in HIV-infected patients, has to encounter various
Liam Clifford et al.
Experimental physiology, 100(4), 388-398 (2015-02-03)
What is the central question of this study? Blockade of orexin receptors reduces blood pressure in spontaneously hypertensive rats (SHRs) but not in normotensive Wistar-Kyoto (WKY) rats, suggesting that upregulation of orexin signalling underlies the hypertensive phenotype of the SHR.
Sukrutha Chettimada et al.
American journal of physiology. Lung cellular and molecular physiology, 308(3), L287-L300 (2014-12-07)
Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-yr life expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and remodeling of the pulmonary arteries. We now know that pulmonary arterial remodeling is a consequence
André Ferreira-da-Silva et al.
PloS one, 10(3), e0122308-e0122308 (2015-03-31)
Oncocytic cell tumors are characterized by the accumulation of morphologically abnormal mitochondria in their cells, suggesting a role for abnormal mitochondrial biogenesis in oncocytic cell transformation. Little is known about the reason for the dysmorphology of accumulated mitochondria. The proteins
Javier Martin et al.
American journal of dentistry, 26(1), 10-14 (2013-06-04)
To comparatively and prospectively compare in a randomized clinical trial, dentin hypersensitivity after treatment with three in-office bleaching systems, based on hydrogen peroxide at different concentrations, with and without light source activation. 88 individuals were included according to inclusion and
Tomoyuki Watanabe et al.
Experimental cell research, 323(2), 314-325 (2014-03-19)
Evidence suggests an association between aberrant mitochondrial dynamics and cardiac diseases. Because myocardial metabolic deficiency caused by insulin resistance plays a crucial role in heart disease, we investigated the role of dynamin-related protein-1 (DRP1; a mitochondrial fission protein) in the
Dimitrios Karvelis et al.
Journal of AOAC International, 97(6), 1519-1525 (2015-01-30)
A novel, fast, and sensitive stability-indicating HPLC method was developed, fully validated, and applied to the simultaneous determination of aliskiren and hydrochlorothiazide in a combined formulation. Effective chromatographic separation was achieved using a phenyl analytical column with isocratic elution using
Giulia Leoni et al.
Current gene therapy, 15(6), 581-590 (2015-10-17)
A key challenge in pulmonary gene therapy for cystic fibrosis is to provide long-term correction of the genetic defect. This may be achievable by targeting airway epithelial stem/progenitor cells with an integrating vector. Here, we evaluated the ability of a
Jia Xu et al.
PloS one, 9(5), e97906-e97906 (2014-05-17)
Typically, most nephropathies can be categorized as complex human diseases in which the cumulative effect of multiple minor genes, combined with environmental and lifestyle factors, determines the disease phenotype. Thus, multi-target drugs would be more likely to facilitate comprehensive renoprotection
Stavros Melemenidis et al.
Theranostics, 5(5), 515-529 (2015-03-15)
Angiogenesis is an essential component of tumour growth and, consequently, an important target both therapeutically and diagnostically. The cell adhesion molecule α(v)β(3) integrin is a specific marker of angiogenic vessels and the most prevalent vascular integrin that binds the amino
Joanna H Sliwowska et al.
Alcoholism, clinical and experimental research, 38(11), 2780-2789 (2014-11-26)
Prenatal alcohol exposure (PAE) has adverse effects on reproductive function and hypothalamic-pituitary-gonadal (HPG) activity. Kisspeptin neurons play a role in mediating feedback effects of estradiol (E2 ) and progesterone (P4 ) on the HPG axis. We hypothesized that PAE will
Mingyi Yang et al.
Scientific reports, 5, 17409-17409 (2015-12-01)
The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription regulation. In total, in non-treated and
Milan Jana et al.
Nanotechnology, 26(7), 075402-075402 (2015-02-03)
Co9S8/reduced graphene oxide (RGO) composites were prepared on nickel foam substrate through hydrothermal reaction and used directly as supercapacitor electrode. The field emission scanning electron microscopy analysis of the composites showed the formation of Co9S8 nano-rods on the RGO surfaces.
Chuan Shen et al.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 48(2), 137-146 (2014-01-07)
The roles of CD4(+)CD25(+) regulatory T cells (Treg) in chronicity of hepatitis B virus (HBV) infection have been confirmed. We aimed to explore alteration of Treg in patients with HBV-related acute-on-chronic liver failure (ACLF). Thirty-two HBV-related ACLF patients, 44 chronic
Akif Hakan Kurt et al.
Oncology letters, 10(5), 3177-3182 (2016-01-02)
Estrogen mediates fast signal responses or transcriptional events via G protein-coupled estrogen receptor 1 (GPER1). However, there is no data on the effect of GPER1 on lung cancer cell proliferation and apoptosis. The present study aimed to analyze the anticancer
J M Monteagudo et al.
Journal of environmental management, 141, 61-69 (2014-04-29)
The mineralization of pharmaceutical wastewater containing chloride ions using a UV/H2O2/Fe(II) process was studied. The addition of Fe(II) to the UV/H2O2 system did not improve the degradation efficiency due to inhibition of the photo-Fenton reaction, at acid pH, in the
Seunghee Lee et al.
Age (Dordrecht, Netherlands), 36(6), 9724-9724 (2014-12-04)
Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal
Tak-Heun Kim et al.
Biochemical and biophysical research communications, 459(4), 706-712 (2015-03-17)
The TGF-β/BMP family plays an important role in multiple stages of tooth development. TGF-β/BMP signaling is required for odontoblast differentiation and dentin formation; however, the precise molecular mechanisms underlying dentin formation remain unclear. To address the role of TGF-β/BMP signaling
Ramila Cristiane Rodrigues et al.
Gut pathogens, 7, 30-30 (2015-11-26)
Campylobacter jejuni is a leading cause of bacterial enteritis worldwide. This microaerophilic bacterium can survive in aerobic environments, suggesting it has protective mechanisms against oxidative stress. The clinical C. jejuni Bf strain is characterized by an increased resistance to oxygen.
Xiaojing Li et al.
Scientific reports, 5, 16130-16130 (2015-11-27)
Hemerythrin-like proteins are oxygen-carrying non-heme di-iron binding proteins and their functions have effect on oxidation-reduction regulation and antibiotic resistance. Recent studies using bioinformatic analyses suggest that multiple hemerythrin-like protein coding sequences might have been acquired by lateral gene transfer and
Mohammad Behbahani et al.
Environmental monitoring and assessment, 186(11), 7245-7257 (2014-07-16)
We are introducing graphene oxide modified with amine groups as a new solid phase for extraction of heavy metal ions including cadmium(II), copper(II), nickel(II), zinc(II), and lead(II). Effects of pH value, flow rates, type, concentration, and volume of the eluent
Ching-Chung Tsai et al.
Scientific reports, 5, 15879-15879 (2015-11-03)
Gastroesophageal reflux disease (GERD) is a disorder that is related to an incompetent lower esophageal sphincter (LES). Previous studies showed that bombesin could increase LES pressure in humans and opossums. The aim of the present study was to characterize the
Diane R Leigh et al.
Journal of biomaterials science. Polymer edition, 26(1), 1-15 (2014-11-18)
We postulate that immobilization of tyramine-substituted hyaluronan (THA) into an extracellular matrix (ECM) scaffold may be a strategy to promote an anti-inflammatory response to the ECM. Further, we posit that the implantation site could influence the inflammatory response and remodeling
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