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Dhong Hyun Lee et al.
Scientific reports, 5, 12580-12580 (2015-07-30)
Dedifferentiated liposarcoma (DDLPS) is a highly malignant subtype of human liposarcoma (LPS), whose genomic profile is characterized by chromosomal amplification at 12q13-q22. miR-26a-2 is one of the most frequently amplified genes in the region, and inhibition of its downstream target
Edgardo Salvatierra et al.
PloS one, 10(8), e0134714-e0134714 (2015-08-08)
Cell transition to a more aggressive mesenchymal-like phenotype is a hallmark of cancer progression that involves different steps and requires tightly regulated cell plasticity. SPARC (Secreted Protein Acidic and Rich in Cysteine) is a matricellular protein that promotes this transition
Agnieszka K Witkiewicz et al.
Nature communications, 6, 6744-6744 (2015-04-10)
Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA cases were subjected to whole-exome sequencing. Microdissection enriches tumour cellularity and enhances mutation calling. Here
Adam Linley et al.
Blood, 126(16), 1902-1910 (2015-07-22)
The vast majority of cases of follicular lymphoma (FL), but not normal B cells, acquire N-glycosylation sites in the immunoglobulin variable regions during somatic hypermutation. Glycans added to sites are unusual in terminating at high mannoses. We showed previously that
Angelika Drynda et al.
Immunopharmacology and immunotoxicology, 37(2), 148-157 (2015-01-13)
5-Amino-3-methyl-4-isoxazolecarboxylic acid hydrazide is a non-cytotoxic synthetic isoxazole derivative with considerable immunomodulatory properties demonstrated in in vitro experiments. The aim of this study was to investigate the influence of this compound, depending on the dosage and schedule of treatment, on
Monica K VanKlompenberg et al.
BMC cancer, 15, 457-457 (2015-06-08)
The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70% of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties remain unexplored. Using the ApcMin/+ mouse crossed to the
Jose F Camargo et al.
Clinical transplantation, 29(6), 492-498 (2015-02-19)
CCR6 is a chemokine receptor involved in homing memory T cells, particularly Th17 cells, to sites of mucosal inflammation. Despite the critical role of memory T cells in long-term protective immunity against cytomegalovirus (CMV), a virus that reactivates at multiple
SongCun Wang et al.
Scientific reports, 5, 9013-9013 (2015-03-12)
Toll-like receptors (TLRs) are important in mediating immune responses against various pathogens during pregnancy. However, uncontrolled TLR-triggered inflammation will endanger normal pregnancy, resulting in pregnancy loss. Therefore, maintenance of a moderate inflammatory response is crucial for successful pregnancy under conditions
Liping Xiang et al.
Oncotarget, 6(11), 9295-9312 (2015-04-01)
Here we showed that ursolic acid (UA), a pentacyclic triterpene natural product, and its novel prodrug derivative US597 suppressed cancer cells adhesion, invasion and migration. This effect was accompanied by inhibition of focal adhesion signaling pathway including alterations in ICAM-1
Matthew J Tomlinson et al.
Cell and tissue research, 361(2), 529-540 (2015-02-01)
The cell surface hydrolase tissue non-specific alkaline phosphatase (TNAP) (also known as MSCA-1) is used to identify a sub-population of bone marrow stromal cells (BMSCs) with high mineralising potential and is found on subsets of cells within the dental pulp.
Merav Cohen et al.
The EMBO journal, 33(24), 2906-2921 (2014-11-12)
Tissue microenvironment influences the function of resident and infiltrating myeloid-derived cells. In the central nervous system (CNS), resident microglia and freshly recruited infiltrating monocyte-derived macrophages (mo-MΦ) display distinct activities under pathological conditions, yet little is known about the microenvironment-derived molecular
E M Faioni et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(8), 1042-1048 (2015-02-11)
In mice, trophoblasts are equipped with a potent anticoagulant mechanism, the protein C pathway. In human placenta, no functional studies of the protein C pathway are available. Human first-trimester trophoblasts (CK(++) HLA-G(+/-) Vim(-)) were isolated and kept in culture for
Kohei Tsuji et al.
Bioorganic & medicinal chemistry, 23(17), 5909-5914 (2015-07-19)
CXCL14 is a CXC-type chemokine that exhibits chemotactic activity for immature dendritic cells, activated macrophages, and activated natural killer cells. However, its specific receptor and signaling pathway remain obscure. Recently, it was reported that CXCL14 binds to CXCR4 with high
Alice Parisi et al.
The Journal of cell biology, 210(5), 717-726 (2015-08-26)
The tumor suppressor adenomatous polyposis coli (APC) is a crucial regulator of many stem cell types. In constantly cycling stem cells of fast turnover tissues, APC loss results in the constitutive activation of a Wnt target gene program that massively
Luc Bruyndonckx et al.
Pediatrics, 135(3), e653-e661 (2015-02-11)
Endothelial dysfunction is the first, although reversible, sign of atherosclerosis and is present in obese adolescents. The primary end point of this study was to investigate the influence of a multicomponent treatment on microvascular function. Additional objectives and end points
Xingrao Ke et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(2), R119-R127 (2015-05-15)
Intrauterine growth restriction (IUGR) increases the risk for neurodevelopment delay and neuroendocrine reprogramming in both humans and rats. Neuroendocrine reprogramming involves the glucocorticoid receptor (GR) gene that is epigenetically regulated in the hippocampus. Using a well-characterized rodent model, we have
Hui Zhang et al.
Toxicology and applied pharmacology, 282(2), 139-150 (2014-12-17)
Alcohol consumption exhibits diverse effects on different types of immune cells. NKT cells are a unique T cell population and play important immunoregulatory roles in different types of immune responses. The effects of chronic alcohol consumption on NKT cells remain
Darin L Wiesner et al.
PLoS pathogens, 11(3), e1004701-e1004701 (2015-03-13)
Pulmonary mycoses are often associated with type-2 helper T (Th2) cell responses. However, mechanisms of Th2 cell accumulation are multifactorial and incompletely known. To investigate Th2 cell responses to pulmonary fungal infection, we developed a peptide-MHCII tetramer to track antigen-specific
Avik K Ghosh et al.
The Journal of biological chemistry, 287(1), 196-209 (2011-11-01)
Telomeres are structures at the ends of chromosomes and are composed of long tracks of short tandem repeat DNA sequences bound by a unique set of proteins (shelterin). Telomeric DNA is believed to form G-quadruplex and D-loop structures, which presents
Thabe M Matsebatlela et al.
Chemico-biological interactions, 233, 95-105 (2015-04-07)
Didox (3,4-dihydroxy-benzohydroxamic acid), is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid, and originally developed as an anti-cancer agent. Some studies indicate that didox may have anti-oxidative stress-like properties, while other studies hint that didox may have
Shu-Ching Chen et al.
PloS one, 9(11), e109961-e109961 (2014-11-13)
Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens mortality rate of cancer. It is not clear, however, whether antitumor CD8+ cytotoxic T lymphocyte (CTL) response is down-modulated in diabetic hosts. We investigated the impact
Fatima-Zohra Braikia et al.
Molecular and cellular biology, 35(19), 3370-3380 (2015-07-22)
Eukaryotic gene expression is often controlled by distant regulatory elements. In developing B lymphocytes, transcription is associated with V(D)J recombination at immunoglobulin loci. This process is regulated by remote cis-acting elements. At the immunoglobulin heavy chain (IgH) locus, the 3'
Yue-Juan Chen et al.
Journal of molecular neuroscience : MN, 56(4), 999-1008 (2015-06-06)
Our previous study has showed that co-grafted Schwann cells (SCs) promote proliferation and migration of the grafted oligodendrocyte precursor cells (OPCs). However, how the co-grafted SCs affect OPCs has not been clarified. In the present study, we confirmed that SC-induced
Li Xue et al.
Immunobiology, 220(6), 744-752 (2015-01-21)
Previous studies have demonstrated that methamphetamine (METH) alter inflammatory and anti-inflammatory cytokine production in the periphery. However, the effect of METH on lipopolysaccharide (LPS)-induced immune responses and its underlying mechanism of action remains unclear. The dopamine D3 receptor (D3R) plays
Chi Y Lo et al.
Biomaterials, 74, 19-30 (2015-10-05)
Promising results are emerging in clinical trials focused on stem cell therapy for cardiology applications. However, the low homing and engraftment of the injected cells to target tissue continues to be a problem. Cellular glycoengineering can address this limitation by
Karolina Kucharova et al.
Journal of neuroinflammation, 12, 161-161 (2015-09-05)
The NG2 proteoglycan is expressed by several cell types in demyelinated lesions and has important effects on the biology of these cells. Here we determine the cell-type-specific roles of NG2 in the oligodendrocyte progenitor cell (OPC) and myeloid cell contributions
Hai-Bin Zhou et al.
Chinese journal of cancer, 34(5), 198-204 (2015-06-11)
Breast cancer is a leading tumor with a high mortality in women. This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012. The data on breast cancer incidence were obtained from
Mohammad Arif et al.
PloS one, 10(6), e0129810-e0129810 (2015-06-19)
Several species of the genus Liposcelis are common insect pests that cause serious qualitative and quantitative losses to various stored grains and processed grain products. They also can contaminate foods, transmit pathogenic microorganisms and cause allergies in humans. The common
Bijorn Omar Balzamino et al.
Neuromolecular medicine, 17(3), 314-325 (2015-06-13)
We recently reported that increased NGF and p75(NTR) as well as decreased trkA(NGFR) characterized the Reelin-deprived (E-Reeler) retina, prospecting a potential contribution of NGF during E-Reeler retinogenesis. Herein, retinal ganglion cells (RGCs), glial cells and rod bipolar cells (RBCs) were
Francesca Ferrera et al.
Clinical and experimental medicine, 15(3), 255-260 (2014-07-26)
A previous study showed that a tolerogenic gene vaccine based on a IgG1Fc-pCons chimera (here named GX101) protects NZB/NZW mice from SLE development. The present study was aimed at identifying the most effective schedule of immunization and the possible involvement
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