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[Sulbactam-ampicillin combination--a drug of broad antibacterial spectrum].
V Savko
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 36(1), 51-55 (1991-01-01)
Eduard Ayuso et al.
Human gene therapy, 25(11), 977-987 (2014-10-03)
Abstract Gene therapy approaches using recombinant adeno-associated virus serotype 2 (rAAV2) and serotype 8 (rAAV8) have achieved significant clinical benefits. The generation of rAAV Reference Standard Materials (RSM) is key to providing points of reference for particle titer, vector genome
Martina Koeberl et al.
Journal of immunological methods, 415, 6-16 (2014-12-03)
Food allergies are increasing worldwide, demonstrating a considerable public health concern. Shellfish allergy is one of the major food groups causing allergic sensitization among adults and children, affecting up to 2% of the general world population. Tropomyosin (TM) is the
Anil K Gorle et al.
Dalton transactions (Cambridge, England : 2003), 43(44), 16713-16725 (2014-10-02)
A series of inert tri- and tetra-nuclear polypyridylruthenium(II) complexes that are linked by the bis[4(4'-methyl-2,2'-bipyridyl)]-1,n-alkane ligand ("bb(n)" for n = 10, 12 and 16) have been synthesised and their potential as antimicrobial agents examined. Due to the modular nature of
Bin Deng et al.
PloS one, 9(7), e102362-e102362 (2014-07-19)
Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA), produced by human macrophages. PCR mapping of 12-lipoxygenase (12-LOX) mRNA sequence in
H Lode
International journal of antimicrobial agents, 18(3), 199-209 (2001-10-24)
The emergence of beta-lactamase-mediated resistance to beta-lactam antibiotics among key respiratory tract pathogens has threatened the usefulness of the beta-lactam agents familiar to physicians as being clinically effective and well tolerated. This article reassesses the clinical usefulness of ampicillin when
Sheroy Minocherhomji et al.
Human molecular genetics, 23(23), 6163-6176 (2014-07-06)
Genome instability, epigenetic remodelling and structural chromosomal rearrangements are hallmarks of cancer. However, the coordinated epigenetic effects of constitutional chromosomal rearrangements that disrupt genes associated with congenital neurodevelopmental diseases are poorly understood. To understand the genetic-epigenetic interplay at breakpoints of
Yael Ganor-Paz et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 129(1), 13-16 (2015-01-15)
To evaluate whether carriers of group B streptococcus (GBS) have adverse obstetric and neonatal outcomes when preterm premature rupture of membranes (PPROM) occurs. In a retrospective study, data were reviewed for women with a singleton pregnancy and PPROM before 34
Yuki Abiko et al.
PloS one, 9(11), e113565-e113565 (2014-11-18)
Treponema denticola, a gram-negative and anaerobic spirochete, is associated with advancing severity of chronic periodontitis. In this study, we confirmed that two major antigenic proteins were Msp and TmpC, and examined their physiological and pathological roles using gene-deletion mutants. Msp
Daniela Münch et al.
Antimicrobial agents and chemotherapy, 59(2), 772-781 (2014-11-19)
Oritavancin is a semisynthetic derivative of the glycopeptide antibiotic chloroeremomycin with activity against Gram-positive pathogens, including vancomycin-resistant staphylococci and enterococci. Compared to vancomycin, oritavancin is characterized by the presence of two additional residues, a hydrophobic 4'-chlorobiphenyl methyl moiety and a
Suman Kumar Tripathy et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 5114-5124 (2015-02-13)
Mononuclear half-sandwiched complexes [(p-cym)RuCl(bpmo)](ClO4) {[1](ClO4)} and [(p-cym)RuCl(bpms)](PF6) {[2](PF6)} have been prepared by reacting heteroscorpionate ligands bpmo = 2-methoxyphenyl-bis(3,5-dimethylpyrazol-1-yl)methane and bpms = 2-methylthiophenyl-bis(3,5-dimethylpyrazol-1-yl)methane, respectively, with a dimeric precursor complex [(p-cym)RuCl(μ-Cl)]2 (p-cym = 1-isopropyl-4-methylbenzene) in methanol. The corresponding aqua derivatives [(p-cym)Ru(H2O)(bpmo)](ClO4)2 {[3](ClO4)2}
Iván Pastor-Fernández et al.
Veterinary parasitology, 207(3-4), 203-215 (2015-01-13)
Currently there are no effective vaccines for the control of bovine neosporosis. During the last years several subunit vaccines based on immunodominant antigens and other proteins involved in adhesion, invasion and intracellular proliferation of Neospora caninum have been evaluated as
Esther H M N Westen et al.
Acta obstetricia et gynecologica Scandinavica, 94(1), 43-49 (2014-09-30)
To investigate the efficacy of a single prophylactic dose of ampicillin combined with metronidazole to prevent postcesarean section infections compared with a multiple day regimen in low-resource settings. An evaluator-blinded randomized, controlled, noninferiority trial. Two rural hospitals in Tanzania. Of
Takahito Kawano et al.
International journal of molecular sciences, 16(1), 148-158 (2014-12-31)
Matrix metalloproteinase 2 (MMP-2) in metastatic cancer tissue, which is associated with a poor prognosis, is a potential target for tumor imaging in vivo. Here, we describe a metastatic cancer cell-targeted protein nanocage. An MMP-2-binding peptide, termed CTT peptide (CTTHWGFTLC)
Alaa H Al-Charrakh et al.
BioMed research international, 2014, 736259-736259 (2014-08-16)
This study was conducted to determine the frequency of Staphylococcus lugdunensis in different clinical samples. Out of 690 clinical samples, a total of 178 coagulase negative staphylococci (CoNS) isolates were recovered. CoNS were identified as 10 different species; 22 isolates
Patxi San Martin-Uriz et al.
PloS one, 9(4), e95041-e95041 (2014-04-18)
Acidiphilium spp. are conspicuous dwellers of acidic, metal-rich environments. Indeed, they are among the most metal-resistant organisms; yet little is known about the mechanisms behind the metal tolerance in this genus. Acidiphilium sp. PM is an environmental isolate from Rio
Mauricio Arenas-Salinas et al.
Biochimie, 106, 39-47 (2014-08-01)
Ferritins are ubiquitous iron-storage proteins found in all kingdoms of life. They share a common architecture made of 24 subunits of five α-helices. The recombinant Chlorobium tepidum ferritin (rCtFtn) is a structurally interesting protein since sequence alignments with other ferritins
Guodong Chen et al.
The international journal of biochemistry & cell biology, 57, 157-166 (2014-12-03)
The transcription factor c-MAF could be polyubiquitinated and subsequently degraded in the proteasomes. Theoretically, any lysine residues in c-MAF could be ubiquitinated. In the present study, we tried to find out the specific lysine residue(s) mediating c-MAF ubiquitination. Through a
Mwafaq Ibdah et al.
Phytochemistry, 107, 24-31 (2014-08-26)
The apple tree (Malus sp.) is an agriculturally and economically important source of food and beverages. Many of the health beneficial properties of apples are due to (poly)phenolic metabolites that they contain, including various dihydrochalcones. Although many of the genes
Anthony R Flores et al.
Infection and immunity, 83(3), 1122-1129 (2015-01-07)
Group A Streptococcus (GAS) predominantly exists as a colonizer of the human oropharynx that occasionally breaches epithelial barriers to cause invasive diseases. Despite the frequency of GAS carriage, few investigations into the contributory molecular mechanisms exist. To this end, we
Tao Ma et al.
Pharmaceutical biology, 52(9), 1179-1188 (2014-03-22)
c-Myc plays a key role in glioma cancer stem cell maintenance. A drug delivery system, nanoparticles loading plasmid DNAs inserted with siRNA fragments targeting c-Myc gene (NPs-c-Myc-siRNA-pDNAs), for the treatment of glioma, has not previously been reported. NPs-c-Myc-siRNA-pDNAs were prepared
Stephen P J Macdonald et al.
PloS one, 9(10), e110678-e110678 (2014-10-25)
To identify biomarkers which distinguish severe sepsis/septic shock from uncomplicated sepsis in the Emergency Department (ED). Patients with sepsis underwent serial blood sampling, including arrival in the ED and up to three subsequent time points over the first 24 hours.
Lim S Jones et al.
Antimicrobial agents and chemotherapy, 59(2), 923-929 (2014-11-26)
The blaNDM-1 gene is associated with extensive drug resistance in Gram-negative bacteria. This probably spread to Enterobacteriaceae from Acinetobacter spp., and we characterized plasmids associated with blaNDM-1 in Acinetobacter spp. to gain insight into their role in this dissemination. Four
Hiroko Kobayashi et al.
Biological & pharmaceutical bulletin, 37(6), 968-978 (2014-06-03)
RNase Po1 is a guanylic acid-specific ribonuclease member of the RNase T1 family from Pleurotus ostreatus. We previously reported that RNase Po1 inhibits the proliferation of human tumor cells, yet RNase T1 and other T1 family RNases are non-toxic. We
Jiahui Wu et al.
Nature communications, 5, 5262-5262 (2014-11-02)
The introduction of calcium ion (Ca(2+)) indicators based on red fluorescent proteins (RFPs) has created new opportunities for multicolour visualization of intracellular Ca(2+) dynamics. However, one drawback of these indicators is that they have optimal two-photon excitation outside the near-infrared
Kangming Chen et al.
Applied microbiology and biotechnology, 99(4), 1779-1793 (2014-12-02)
Determining spatiotemporal gene expression and analyzing knockout mutant phenotypes have become powerful tools in elucidating the function of genes; however, genetic approaches for simultaneously inactivating a gene and monitoring its expression have not been reported in the literature. In this
Anna M Siemiatkowska et al.
Molecular vision, 20, 753-759 (2014-06-19)
The gene encoding nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) was recently found to be mutated in a subset of patients with Leber congenital amaurosis (LCA) with macular atrophy. The aim of this study was to determine the occurrence and frequency of
Shayesteh Sepehr et al.
PloS one, 9(7), e101677-e101677 (2014-07-08)
Biofilm formation by food-related bacteria and food-related pathogenesis are significant problems in the food industry. Even though much disinfection and mechanical procedure exist for removal of biofilms, they may fail to eliminate pre-established biofilms. cis-2 decenoic acid (CDA), an unsaturated
Danielle L Sexton et al.
Journal of bacteriology, 197(5), 848-860 (2014-12-17)
Dormancy is a common strategy adopted by bacterial cells as a means of surviving adverse environmental conditions. For Streptomyces bacteria, this involves developing chains of dormant exospores that extend away from the colony surface. Both spore formation and subsequent spore
Weiyi Gong et al.
Anesthesia and analgesia, 119(1), 186-195 (2014-05-07)
Spinal cord stimulation (SCS) is an effective treatment for neuropathic pain, but its effect on chronic muscle pain is unclear. We designed this study to test the effect of SCS in an animal model of noninflammatory muscle pain. Male Sprague-Dawley
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