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Noriko Shikama et al.
The EMBO journal, 22(19), 5175-5185 (2003-10-01)
p300 and CBP are large nuclear acetyltransferases exhibiting a complex multi-domain structure. Mouse embryos nullizygous for either p300 or Cbp die at midgestation, while heterozygotes are viable but in part display defects in neurulation or bone morphogenesis. To directly examine
Marc-Michael Zaruba et al.
Circulation, 121(18), 1992-2000 (2010-04-28)
C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart. In the present study, the cardiomyogenic
Milton Thomas et al.
Viruses, 10(6) (2018-06-09)
Influenza viruses infect the epithelial cells of the swine respiratory tract. Cell lines derived from the respiratory tract of pigs could serve as an excellent in vitro model for studying the pathogenesis of influenza viruses. In this study, we examined
Zhen Xiong et al.
Frontiers in cell and developmental biology, 9, 686886-686886 (2021-06-22)
Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that
Ophir Shani et al.
eLife, 10 (2021-06-26)
Mortality from breast cancer is almost exclusively a result of tumor metastasis, and lungs are one of the main metastatic sites. Cancer-associated fibroblasts are prominent players in the microenvironment of breast cancer. However, their role in the metastatic niche is
András Masszi et al.
The Journal of cell biology, 188(3), 383-399 (2010-02-04)
Epithelial-myofibroblast (MF) transition (EMyT) is a critical process in organ fibrosis, leading to alpha-smooth muscle actin (SMA) expression in the epithelium. The mechanism underlying the activation of this myogenic program is unknown. We have shown previously that both injury to
Yeqian Zhu et al.
Cell death discovery, 7(1), 84-84 (2021-04-21)
Ischemic cardiomyopathy seriously endangers human health leading to a poor prognosis. Acute myocardial infarction (AMI) is the primary etiology, and the pathophysiological process concludes with the death of cardiomyocytes caused by acute and persistent ischemia and hypoxia in the coronary
Rodney D Britt et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(2), 3024-3034 (2018-10-24)
Recent studies have demonstrated an effect of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), on airway contractility [ via increased airway smooth muscle (ASM) intracellular calcium [Ca2+]i] and remodeling (ASM proliferation and extracellular matrix formation) in the context of airway disease.
Jitsutaro Kawaguchi et al.
Development (Cambridge, England), 137(5), 693-704 (2010-02-12)
Neural crest is a source of diverse cell types, including the peripheral nervous system. The transcription factor Sox10 is expressed throughout early neural crest. We exploited Sox10 reporter and selection markers created by homologous recombination to investigate the generation, maintenance
Wen-Jie Ji et al.
PloS one, 8(11), e81090-e81090 (2013-11-22)
Recent experimental studies provide evidence indicating that manipulation of the mononuclear phagocyte phenotype could be a feasible approach to alter the severity and persistence of pulmonary injury and fibrosis. Mineralocorticoid receptor (MR) has been reported as a target to regulate
Ou Liu et al.
PloS one, 7(12), e51707-e51707 (2013-01-04)
Medial degeneration and inflammation are features of abdominal aortic aneurysms (AAAs). However, the early inflammatory event initiating aneurysm formation remains to be identified. Activated platelets release abundant proinflammatory cytokines and are involved in initial inflammation in various vascular diseases. We
K R Manda et al.
Oncogene, 35(25), 3282-3292 (2015-10-20)
Despite recent insights into prostate cancer (PCa)-associated genetic changes, full understanding of prostate tumorigenesis remains elusive owing to complexity of interactions among various cell types and soluble factors present in prostate tissue. We found the upregulation of nuclear factor of
Steven B Bleyl et al.
Human molecular genetics, 19(7), 1286-1301 (2010-01-15)
Total anomalous pulmonary venous return (TAPVR) is a congenital heart defect inherited via complex genetic and/or environmental factors. We report detailed mapping in extended TAPVR kindreds and mutation analysis in TAPVR patients that implicate the PDGFRA gene in the development
Koji Shindo et al.
Molecular cancer, 12(1), 168-168 (2013-12-21)
Interactions between cancer cells and surrounding cancer-associated fibroblasts (CAFs) play an important role in cancer progression. Invasive ductal carcinoma (IDC) of the pancreas is characterized by abundant fibrous connective tissue called desmoplasia. Podoplanin (PDPN) is a lymphatic vessel marker (D2-40)
Kerianne E Steucke et al.
Journal of biomechanics, 48(12), 3044-3051 (2015-08-19)
Vascular smooth muscle cells' primary function is to maintain vascular homeostasis through active contraction and relaxation. In diseases such as hypertension and atherosclerosis, this function is inhibited concurrent to changes in the mechanical environment surrounding vascular smooth muscle cells. It
von Willebrand factor does not influence atherogenesis in arteries subjected to altered shear stress.
Nichols, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 18, 323-330 (2019)
Roderick J Tan et al.
Scientific reports, 6, 36185-36185 (2016-11-03)
The Keap1/Nrf2 pathway is a master regulator of antioxidant, anti-inflammatory, and other cytoprotective mechanisms important in protection from kidney disease. For the first time in kidney disease, we describe the use of Keap1 hypomorphic mice, which possess Nrf2 hyperactivation. We
Wen Wu et al.
Redox biology, 22, 101137-101137 (2019-02-17)
Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced
Jin Yang et al.
Nature communications, 7, 13710-13710 (2016-12-15)
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstitial fibrosis and mechanical dysfunction of pathologically stressed hearts. In mice, cardiac
Sonya Hui et al.
Circulation research, 108(9), 1053-1062 (2011-03-05)
Cell cycle progression in vascular smooth muscle cells (VSMCs) is a therapeutic target for restenosis. Having discovered that calmodulin (CaM)-dependent cyclin E/CDK2 activity underlies Ca(2+)-sensitive G(1)-to-S phase transitions in VSMCs, we sought to explore the physiological importance of the CaM-cyclin
Wan Ru Lee et al.
PloS one, 10(4), e0124494-e0124494 (2015-04-18)
Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown. The current work determined the roles of
Long T Nguyen et al.
Scientific reports, 11(1), 12437-12437 (2021-06-16)
Calcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy in solid organ transplants but can paradoxically induce progressive nephropathy characterised by renal dysfunction and interstitial fibrosis. Lysyl oxidases (LOXs), a group of enzymes that catalyse extracellular matrix
Qi Cai et al.
The Journal of pharmacology and experimental therapeutics, 306(1), 35-42 (2003-03-29)
Chronic excess ingestion of nonsteroid anti-inflammatory drugs causes renal medullary necrosis. Previously, using an immortalized line of mouse inner medullary collecting ducts cells (mIMCD3), we found that acetaminophen, salicylic acid, and caffeine are toxic, and the effects of acetaminophen and
Clara Dees et al.
Arthritis and rheumatism, 63(5), 1396-1404 (2011-02-12)
Tissue fibrosis caused by pathologic activation of fibroblasts with increased synthesis of extracellular matrix components is a major hallmark of systemic sclerosis (SSc). Notch signaling regulates tissue differentiation, and abnormal activation of Notch signaling has been implicated in the pathogenesis
Hongyu Tian et al.
Arteriosclerosis, thrombosis, and vascular biology, 37(6), 1115-1126 (2017-04-30)
Endoglin, a transforming growth factor-β superfamily coreceptor, is predominantly expressed in endothelial cells and has essential roles in vascular development. However, whether endoglin is also expressed in vascular smooth muscle cells (VSMCs), especially in vivo, remains controversial. Furthermore, the roles
Areechun Sotthibundhu et al.
Stem cell research & therapy, 7(1), 166-166 (2016-11-17)
Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required for the derivation of induced pluripotent stem cells (iPSCs). However
E Landesman-Bollag et al.
Oncogene, 20(25), 3247-3257 (2001-06-26)
Protein kinase CK2 is a ubiquitous and evolutionarily conserved serine/threonine kinase that is upregulated in many human cancers and can serve as an oncogene in lymphocytes. Recently, we have demonstrated that CK2 potentiates Wnt/beta-catenin signaling in mammary epithelial cells. To
Edgar Maquigussa et al.
Molecular medicine reports, 12(1), 1009-1015 (2015-04-01)
Proteinuria is critical in the tubulointerstitial changes that ultimately lead to renal insufficiency. Increased protein filtration has direct toxic effects on tubular epithelial cells, leading to epithelial mesenchymal transition (EMT) to a myofibroblast phenotype. Angiotensin II and transforming growth factor
Gian Paolo Fadini et al.
Circulation research, 108(9), 1112-1121 (2011-03-12)
Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes. We aim to identify and characterize circulating calcifying cells, and to delineate a pathophysiological role for these cells
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