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Hua Huang et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(47), 18666-18670 (2007-11-16)
Hepatitis C virus (HCV) is a single-stranded positive-sense RNA virus of the Flaviviridae family. HCV-infected hepatocytes are known to produce reactive oxygen species (ROS), which initiate lipid peroxidation, a reaction that converts polyunsaturated fatty acids, such as arachidonate, into reactive
T Cuisset et al.
Journal of thrombosis and haemostasis : JTH, 4(3), 542-549 (2005-12-24)
Low response to antiplatelet therapy may be a risk factor for the development of ischemic complications in patients with non-ST segment elevation acute coronary syndrome (NSTE ACS) undergoing coronary stenting. We prospectively studied the platelet response to both clopidogrel and
Millie Hughes-Fulford et al.
Carcinogenesis, 26(9), 1520-1526 (2005-05-10)
For the past 60 years, dietary intake of essential fatty acids has increased. Moreover, the omega-6 fatty acids have recently been found to play an important role in regulation of gene expression. Proliferation of human prostate cells was significantly increased
Patricia Pereiro et al.
Developmental and comparative immunology, 109, 103698-103698 (2020-04-15)
GDF15 is frequently detected in patients suffering from various diseases, especially those associated with pro-inflammatory processes and/or metabolic disorders. Accordingly, sepsis, whose major complications are related to metabolic alterations and systemic inflammation, significantly increases the secretion of GDF15. Indeed, this
Andrew O Jo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(39), 13525-13537 (2015-10-02)
Brain edema formation occurs after dysfunctional control of extracellular volume partly through impaired astrocytic ion and water transport. Here, we show that such processes might involve synergistic cooperation between the glial water channel aquaporin 4 (AQP4) and the transient receptor
Dongjuan Yuan et al.
Biochimica et biophysica acta, 1841(9), 1272-1284 (2014-05-08)
Eicosanoids play an important role in inducing complex and crucial physiological processes in animals. Eicosanoid biosynthesis in animals is widely reported; however, eicosanoid production in invertebrate tissue is remarkably different to vertebrates and in certain respects remains elusive. We, for
Yuji Wang et al.
International journal of nanomedicine, 10, 6905-6918 (2015-11-26)
The hot water extract of Rabdosia rubescens was traditionally used as an antithrombotic medicine. To explore its antithrombotic utility and mechanism, we carried out a series of in vitro and in vivo assays in this study. In vitro platelet aggregation
Thaiane Robeldo et al.
Scientific reports, 10(1), 7063-7063 (2020-04-29)
Tahiti lemon juice (Citrus latifolia) (TLJ), as a natural source of flavonoids, has been used as an alternative to anti-inflammatory drugs for the treatment of dysmenorrhea and menstrual excessive bleeding, often associated with an imbalance of the prostaglandins (PG) levels.
Sowmya Venkatasubramanian et al.
Journal of the American Heart Association, 2(1), e004267-e004267 (2013-03-26)
Urocortin 2 and urocortin 3 are endogenous peptides with an emerging role in cardiovascular pathophysiology. We assessed their pharmacodynamic profile and examined the role of the endothelium in mediating their vasomotor effects in vivo in man. Eighteen healthy male volunteers
Gisela Scharbert et al.
Transfusion, 55(6), 1320-1326 (2015-02-03)
Bleeding complications are a common side effect in patients under dual antiplatelet (anti-PLT) therapy. PLT transfusion provides a treatment option for these patients. However it is currently unclear if, and to what extent, P2Y12 inhibitors influence PLT function of donor
African hominin stable isotopic data do not necessarily indicate grass consumption.
Maelán Fontes-Villalba et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(43), E4055-E4055 (2013-09-26)
Abdulaziz M S Alsaad et al.
Drug metabolism reviews, 45(2), 173-195 (2013-04-23)
A plethora of studies have demonstrated the expression of cytochrome P450 (CYP) and soluble epoxide hydrolase (sEH) enzymes in the heart and other cardiovascular tissues. In addition, the expression of these enzymes is altered during several cardiovascular diseases (CVDs), including
Shao Liu et al.
Biochemical and biophysical research communications, 461(1), 186-192 (2015-04-18)
Renal interstitial fibrosis closely relates to chronic kidney disease and is regarded as the final common pathway in most cases of end-stage renal disease. Metabolomic biomarkers can facilitate early diagnosis and allow better understanding of the pathogenesis underlying renal fibrosis.
D Hailemariam et al.
Reproduction, fertility, and development, 26(6), 898-913 (2013-07-31)
An impaired uterine environment triggered by the incidence of subclinical endometritis often compromises fertility in the bovine. The uterus is a dynamic organ with tight regulation of specific genes at the transcriptional and translational levels. Herein, we hypothesised that subclinical
Lingman Ma et al.
Platelets, 26(4), 342-348 (2014-05-17)
I4 is a new synthetic anti-diabetes sulfonylurea compound. The aim of present study was to investigate the preventive effects and primary action mechanisms of I4 on platelet-mediated arterial thrombosis. Platelet aggregation and 5-hydroxytryptamine (5-HT) secretion ex vivo was detected. The
Kristian H Christensen et al.
Platelets, 26(3), 230-235 (2014-04-23)
Reduced antiplatelet effect of aspirin has been reported in patients with type 2 diabetes, and recent studies suggest that once-daily aspirin provides insufficient platelet inhibition. We investigated if the effect of aspirin declined during the 24-hour dosing interval in patients
Yilin Ren et al.
Hypertension (Dallas, Tex. : 1979), 62(6), 1123-1128 (2013-09-26)
Connecting tubule glomerular feedback (CTGF) is a mechanism in which Na reabsorption in the connecting tubule (CNT) causes afferent arteriole (Af-Art) dilation. CTGF is mediated by eicosanoids, including prostaglandins and epoxyeicosatrienoic acids; however, their exact nature and source remain unknown.
Manjunatha M Venkataswamy et al.
Journal of immunology (Baltimore, Md. : 1950), 183(3), 1644-1656 (2009-07-22)
The attenuated strain of Mycobacterium bovis known as bacille Calmette-Guérin (BCG) has been widely used as a vaccine for prevention of disease by Mycobacterium tuberculosis, but with relatively little evidence of success. Recent studies suggest that the failure of BCG
Andrea Dichlberger et al.
Clinical science (London, England : 1979), 125(3), 121-130 (2013-04-13)
LDs (lipid droplets) are metabolically highly active intracellular organelles. The lipid and protein profiles of LDs are cell-type-specific, and they undergo dynamic variation upon changes in the physiological state of a cell. It is well known that the main function
Marie Takai et al.
Bioscience, biotechnology, and biochemistry, 78(2), 238-244 (2014-07-19)
Transmembrane protein CD36 binds multiple ligands, including oxidized low-density lipoproteins (oxLDLs) and long-chain fatty acids (LCFAs). Our aim was to determine whether LCFAs compete with oxLDLs for binding to CD36. We addressed this issue by examining the inhibitory effect of
[Effect of biological factors on morphogenesis, growth, and lipid composition of fungus Mucor hiemalis mycelium].
I S Mysiakina et al.
Mikrobiologiia, 81(6), 733-740 (2013-04-25)
M K Sim et al.
Regulatory peptides, 111(1-3), 179-182 (2003-03-01)
The plasma levels of des-aspartate-angiotensin I (DAA-I) in three models of hypertensive rats and hypertensive subjects were determined and compared with their normotensive controls. The rationale for the study was based on our earlier findings showing that DAA-I is a
Astrid Stefanie Kahnt et al.
Biochemical pharmacology, 86(2), 286-296 (2013-05-21)
Because of their favourable safety profile and beneficial anti-inflammatory properties, the CysLT1 receptor antagonists (LTRA), montelukast, zafirlukast and pranlukast are approved for the treatment of asthma and are frequently prescribed as add-on therapeutics to reduce the amount of inhaled glucocorticoids
M Brown et al.
British journal of cancer, 110(8), 2099-2108 (2014-03-07)
Bone metastases in prostate cancer (CaP) result in CaP-related morbidity/mortality. The omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA) and lipophilic statins affect metastasis-like behaviour in CaP cells, regulating the critical metastatic step of CaP migration to the bone marrow
É G Dediukhina et al.
Prikladnaia biokhimiia i mikrobiologiia, 47(2), 125-134 (2011-03-01)
Arachidonic acid (ARA, 5,8,11,14-cis-eicosatetraenoic acid) is widely used in medicine, pharmaceutics, cosmetics, dietary nutrition, agriculture, and other fields. Microbiological production of ARA is of increased interest since the natural sources (pig liver, adrenal glands, and egg-yolk) cannot satisfy its growing
Telemachos Daskalou et al.
Hellenic journal of nuclear medicine, 9(1), 49-52 (2006-04-18)
This article reviews our current knowledge of the role of oxygen free radicals (OFR) in the process of arachidonic acid metabolism and platelet activation. During this activation several platelet enzymatic products are formed, which are measured by radioimmunoassays (RIA) and
Jiunn-Ming Sheen et al.
Life sciences, 132, 41-48 (2015-04-30)
Antenatal glucocorticoids can induce long-term effects on offspring health, including hypertension. Programmed hypertension has been observed in a prenatal dexamethasone (DEX) exposure model. However, how renal programming responds to prenatal DEX at different stages of development and the impact of
J Y Westcott et al.
Prostaglandins, 34(6), 877-887 (1987-12-01)
Recent evidence has shown that a variety of prostaglandins and leukotrienes can be produced in brain tissue after injury in animals. It has also been speculated that increases in brain prostaglandins occur in humans following injury. Ventricular cerebrospinal fluid (CSF)
Leilei Cong et al.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 26(9), 1232-1238 (2010-12-15)
Arachidonic acid, as an important polyunsaturated fatty acid, is identified as potential food additives or pharmaceuticals for their biological activities. In recent years, arachidonic acid production by Mortierella alpina is becoming a research highlight. The prophase relevant researches focused on
Jee Hee Suh et al.
Chemical & pharmaceutical bulletin, 63(8), 573-578 (2015-06-05)
We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. A novel structural moiety containing oxazole
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