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Casimiro Gerarduzzi et al.
Journal of proteome research, 13(11), 5262-5280 (2014-09-17)
The Prostaglandin E2 (PGE2) signaling mechanism within fibroblasts is of growing interest as it has been shown to prevent numerous fibrotic features of fibroblast activation with limited evidence of downstream pathways. To understand the mechanisms of fibroblasts producing tremendous amounts
Mi-Hsueh Tai et al.
Molecular nutrition & food research, 58(11), 2133-2145 (2014-08-29)
Curcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti-inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect and molecular mechanism of curcumin. We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as
Ivana Crnovčić et al.
The Journal of antibiotics, 66(4), 211-218 (2013-02-21)
Streptomyces chrysomallus and Streptomyces parvulus produce novel C-demethylactinomycins besides their normal actinomycins when fed with 3-hydroxyanthranilic acid (3-HA). The 3-HA is incorporated into pentapeptide lactone precursors in competition with the regular precursor 4-methyl-3-hydroxyanthranilic acid (4-MHA). The resultant 3-HA pentapeptide lactones
Jen-Chung Ko et al.
Biochemical and biophysical research communications, 456(1), 506-512 (2014-12-10)
The anti-estrogen tamoxifen has been used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been identified. Human MutS homolog
Jiunn-Chang Lin et al.
Transplantation, 95(6), 791-800 (2013-01-29)
Sorafenib, a multikinase inhibitor approved for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma, has been reported inhibitory on the function of dendritic cells. This study was aimed to determine the effects of sorafenib on inducing autophagy and
Elaine Gutierrez et al.
The Journal of biological chemistry, 289(48), 33568-33589 (2014-10-11)
Autophagy functions as a survival mechanism during cellular stress and contributes to resistance against anticancer agents. The selective antitumor and antimetastatic chelator di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) causes lysosomal membrane permeabilization and cell death. Considering the integral role of lysosomes in autophagy
Paulina Podszywalow-Bartnicka et al.
Cell cycle (Georgetown, Tex.), 13(23), 3727-3741 (2014-12-09)
BRCA1 tumor suppressor regulates crucial cellular processes involved in DNA damage repair and cell cycle control. We showed that expression of BCR-ABL1 correlates with decreased level of BRCA1 protein, which promoted aberrant mitoses and aneuploidy as well as altered DNA
Olga A Efimova et al.
Reproduction (Cambridge, England), 149(3), 223-233 (2014-12-17)
We report the sequential changes in 5-hydroxymethylcytosine (5hmC) patterns in the genome of human preimplantation embryos during DNA methylation reprogramming. We have studied chromosome hydroxymethylation and methylation patterns in triploid zygotes and blastomeres of cleavage-stage embryos. Using indirect immunofluorescence, we
Shilpi Verma et al.
PLoS pathogens, 10(8), e1004268-e1004268 (2014-08-15)
TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and inflammation, but their role in antiviral defense is poorly understood. Cytomegaloviruses (CMV) encode many immune-modulatory genes that shape host immunity, and they utilize multiple strategies to target the TNF-family
Eduardo P Amaral et al.
PLoS pathogens, 10(7), e1004188-e1004188 (2014-07-06)
The purinergic P2X7 receptor (P2X7R) is a sensor of extracellular ATP, a damage-associated molecule that is released from necrotic cells and that induces pro-inflammatory cytokine production and cell death. To investigate whether the innate immune response to damage signals could
Haifeng Zhu et al.
Molecular cancer research : MCR, 13(5), 809-818 (2015-02-14)
Hepatocellular carcinomas (HCC) show resistance to chemotherapy and have blunt response to apoptotic stimuli. HCC cell lines express low levels of the Fas death receptor and are resistant to FasL stimulation, whereas immortalized hepatocytes are sensitive. The variable Fas transcript
Barbara Chipczyńska et al.
Klinika oczna, 114(2), 124-126 (2013-01-26)
To present a case of Haemangiopericytoma (HPC), a rare neopalsm which originates from the vascular pericytes. HPC occurs most commonly in adults. Only 5-10% of cases occur in children. Congenital orbital HPC is generally unknown in the field of ophthalmology.
Lioudmila V Sharova et al.
DNA research : an international journal for rapid publication of reports on genes and genomes, 16(1), 45-58 (2008-11-13)
Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for
Jonathan Steinman et al.
Journal of surgical oncology, 109(5), 405-409 (2013-12-10)
Isolated limb infusion (ILI) is a percutaneous method of delivering regional chemotherapy to patients with recurrent tumors of the extremity. This study determines predictors of response, survival, and limb salvage. Single institution data from a prospective clinical trial and subsequent
Karoline St-Martin Crites et al.
Journal of inflammation (London, England), 12, 62-62 (2015-11-10)
Hyperinflammation is a hallmark feature of cystic fibrosis (CF) airways. However, inflammation has also been documented systemically and, more recently, in extrapulmonary CF-affected tissues such as the pancreas and intestine. The pathogenesis of CF-related inflammation and more specifically the role
Sriramkumar Sundaramoorthy et al.
The EMBO journal, 33(22), 2623-2642 (2014-09-27)
Sister chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation during cell division. Using functional genomic screening, we identify a set of 26 pre-mRNA splicing factors that are required for sister chromatid cohesion in human cells. Loss
Antao Chang et al.
The Journal of infectious diseases, 212(9), 1509-1520 (2015-10-16)
Treatment of mice with lipopolysaccharide (LPS) and the liver-specific transcriptional inhibitor D-(+)-galactosamine (GalN) induces fatal hepatitis, which is mediated by tumor necrosis factor α (TNF-α) and characterized by massive hepatic apoptosis. Previous studies suggest that GalN increases the sensitivity to
Igor Arregi et al.
PloS one, 10(6), e0130610-e0130610 (2015-06-20)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia (AML), where mutant NPM seems to play an oncogenic role.
Emanuela Matteucci et al.
Experimental cell research, 319(12), 1865-1874 (2013-05-11)
Here, we report a complex regulation of endothelin-1 (ET-1) axis driven by epigenetic reactions in 1833-bone metastatic cells, emphasizing the importance in skeletal metastasis from breast carcinoma. Inhibitors of histone deacetylases, trichostatin A (TSA), and of DNA methylases, 5'-Azacytidine (Aza)
Kate L Henry et al.
Science signaling, 11(541) (2018-08-02)
Members of the family of nuclear factor κB (NF-κB) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-κB complexes are retained in the cytoplasm by the inhibitory
B Walker et al.
Journal of thrombosis and haemostasis : JTH, 13(7), 1325-1334 (2015-05-07)
Platelet secretion is critical to development of acute thrombotic occlusion. Platelet dense granules contain a variety of important hemostatically active substances. Nevertheless, biogenesis of platelet granules is poorly understood. Serum- and glucocorticoid-inducible kinase 1 (SGK1) has been shown to be
Thomas Schwarzl et al.
Journal of molecular biology, 427(21), 3368-3374 (2015-09-13)
Identifying changes in the transcriptional regulation of target genes from high-throughput studies is important for unravelling molecular mechanisms controlled by a given perturbation. When measuring global transcript levels only, the effect of the perturbation [e.g., transcription factor (TF) overexpression or
Laura Pisapia et al.
International journal of oncology, 47(2), 481-489 (2015-06-18)
Many solid tumours including melanoma, glioblastoma, and breast carcinomas express MHC class II molecules (MHC II). The surface expression of these molecules confers to non-hematopoietic tumour cells the role of non-professional antigen presenting cells and the ability to potentially stimulate
Ross O Meyers et al.
Bioorganic & medicinal chemistry letters, 19(16), 4752-4755 (2009-07-21)
Synthesis of seven semi-synthetic analogs of NDGA is described. An approach to NDGA derivatization is described in which the ortho-phenolic groups are tethered together by one atom, forming a 5-membered heterocyclic ring. The analogs were evaluated for cytotoxicity in four
Maayan Salton et al.
PloS one, 6(8), e23882-e23882 (2011-08-23)
Matrin 3 (MATR3) is a highly conserved, inner nuclear matrix protein with two zinc finger domains and two RNA recognition motifs (RRM), whose function is largely unknown. Recently we found MATR3 to be phosphorylated by the protein kinase ATM, which
Cristina Moncunill-Massaguer et al.
Oncotarget, 6(39), 41750-41765 (2015-10-27)
We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines. Fluorizoline directly binds to prohibitin 1 and 2 (PHBs), two proteins
Lucia Morgado-Palacin et al.
Carcinogenesis, 35(12), 2822-2830 (2014-10-27)
Nucleolar disruption has recently emerged as a relevant means to activate p53 through inhibition of HDM2 by ribosome-free RPL11. Most drugs that induce nucleolar disruption also possess important genotoxic activity, which can have lasting mutagenic effects. Therefore, it is of
Audrey Delmas et al.
Oncotarget, 6(17), 15250-15264 (2015-06-23)
The response of BRAF-mutant melanoma patients to BRAF inhibitors is dramatically impaired by secondary resistances and rapid relapse. So far, the molecular mechanisms driving these resistances are not completely understood. Here, we show that, in BRAF-mutant melanoma cells, inhibition of
Hidde M Kroon et al.
Journal of surgical oncology, 109(4), 348-351 (2014-02-14)
Isolated limb infusion (ILI) was developed as a simplified and minimally invasive alternative to isolated limb perfusion (ILP) to treat unresectable limb melanoma. A number of centers around the world have reported their results using this procedure. In this study
Li-Na Zhang et al.
Biochimica et biophysica acta, 1853(2), 522-534 (2014-12-17)
Regulation of mRNA decay plays a crucial role in the post-transcriptional control of cell growth, survival, differentiation, death and senescence. Deadenylation is a rate-limiting step in the silence and degradation of the bulk of highly regulated mRNAs. However, the physiological
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