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Faten Shaeib et al.
PloS one, 10(3), e0120737-e0120737 (2015-04-04)
Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron. Here we show that the presence of melatonin (MLT) can prevent HOCl-mediated
Shogo Sasaki et al.
Journal of bioscience and bioengineering, 119(2), 200-205 (2014-07-26)
We demonstrated the synthesis of molecularly imprinted polymers (MIPs) with binding affinity toward a target protein, ribonuclease A (RNase) by atom transfer radical polymerization (ATRP) of acrylic acid, acrylamide, and N,N'-methylenebisacrylamide in the presence of RNase. The binding activity of
Aitor Sánchez-Ferrero et al.
Biomaterials, 68, 42-53 (2015-08-13)
Bone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population. In the present study, elastin-like recombinamers hydrogels were produced by means of carbodiimide-catalyzed crosslinking with citric acid, a molecule suggested
Jihye Son et al.
Journal of food science, 80(6), C1178-C1187 (2015-04-30)
This work aimed to determine the effects of different concentrations of antibrowning treatments (that is, distilled water [DW], 1% ascorbic acid [AA], 0.5% chamomile [CM], and 1% AA + 0.5% CM) and heat-treatment (55 °C for 45 s) combined with
Haoqi Liu et al.
Nanoscale research letters, 10(1), 959-959 (2015-06-17)
Mesenchymal stem cells (MSCs) have been used for therapy of type 1 diabetes mellitus. However, the in vivo distribution and therapeutic effects of transplanted MSCs are not clarified well. Herein, we reported that CdSe/ZnS quantum dots-labeled MSCs were prepared for
Søren Roi Midtgaard et al.
Biophysical journal, 109(2), 308-318 (2015-07-23)
Structural and functional aspects of high-density lipoproteins have been studied for over half a century. Due to the plasticity of this highly complex system, new aspects continue to be discovered. Here, we present a structural study of the human Apolipoprotein
Nobuko Tano et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(10), 1864-1871 (2014-06-17)
Transplantation of bone marrow mesenchymal stromal cells (MSCs) is an emerging treatment for heart failure. We have reported that epicardial placement of MSC-sheets generated using temperature-responsive dishes markedly increases donor MSC survival and augments therapeutic effects in an acute myocardial
Ilkka Alahuhta et al.
Experimental cell research, 336(1), 130-140 (2015-06-27)
The turnover of extracellular matrix liberates various cryptic molecules with novel biological activities. Endostatin is an endogenous angiogenesis inhibitor that is derived from the non-collagenous domain of collagen XVIII. Although there are a large number of studies on its anti-tumor
Dan Vershkov et al.
Cell reports, 26(10), 2531-2539 (2019-03-07)
Fragile X syndrome (FXS) is caused primarily by a CGG repeat expansion in the FMR1 gene that triggers its transcriptional silencing. In order to investigate the regulatory layers involved in FMR1 inactivation, we tested a collection of chromatin modulators for
Muriel Babey et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(6), 1064-1076 (2014-12-17)
The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with
Tsz Kin Ng et al.
Scientific reports, 5, 7828-7828 (2015-01-17)
Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in the cigarette smoke, inhibits the regenerative potentials of human periodontal ligament-derived stem cells (PDLSC) through
Soohwan Yum et al.
Fitoterapia, 103, 55-62 (2015-03-24)
We investigated a potential molecular target for anti-colitic effects of esculetin, 6,7-dihydroxycoumarin. Esculetin administered rectally effectively ameliorated TNBS-induced rat colitis and attenuated the expression of pro-inflammatory mediators in the inflamed colon. In human colon carcinoma HCT116 cells, esculetin induced hypoxia-inducible
Irene Dini et al.
Journal of natural products, 71(12), 2036-2037 (2008-11-28)
A new cysteine sulfoxide, (S(S)R(C))-S-(3-pentenyl)-L-cysteine sulfoxide (1), was identified from the seeds of Allium cepa var. tropeana, together with the known methiin, etiin, alliin, isoalliin, propiin, and butiin. The structure of compound 1 was established by analysis of its physical
Q Liu et al.
Scandinavian journal of rheumatology, 44(3), 182-191 (2014-12-03)
Progressive destruction of synovial joint cartilage and bone occurs in pathological conditions such as rheumatoid arthritis (RA) because of the overproduction of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-κB). Through the screening of NF-κB inhibitors by a
Kathryn Futrega et al.
Biomaterials, 62, 1-12 (2015-05-27)
Microwell platforms are frequently described for the efficient and uniform manufacture of 3-dimensional (3D) multicellular microtissues. Multiple partial or complete medium exchanges can displace microtissues from discrete microwells, and this can result in either the loss of microtissues from culture
Jae Hyeon Kim et al.
Oncology reports, 34(1), 221-226 (2015-05-23)
Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell
Changhao Fu et al.
Cell biology international, 39(7), 777-787 (2015-06-19)
We isolated human embryonic cartilage stem cells (hECSCs), a novel stem cell population, from the articular cartilage of eight-week-old human embryos. These stem cells demonstrated a marker expression pattern and differentiation potential intermediate to those of human embryonic stem cells
Courtney Washington et al.
Archives of biochemistry and biophysics, 577-578, 24-34 (2015-05-20)
Tyrosinase (EC catalyzes the monophenolase and diphenolase reaction associated with vertebrate pigmentation and fruit/vegetable browning. Tyrosinase is an oxygen-dependent, dicopper enzyme that has three states: Emet, Eoxy, and Edeoxy. The diphenolase activity can be carried out by both the
Judit Bartalis et al.
Bioorganic & medicinal chemistry, 19(8), 2757-2766 (2011-04-05)
The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten
Lan Ma et al.
Stem cell research & therapy, 6, 104-104 (2015-05-28)
Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic transplantation of mesenchymal stem cells could ameliorate bone loss
Naoki Okumura et al.
Laboratory investigation; a journal of technical methods and pathology, 95(11), 1291-1304 (2015-08-25)
Fuchs endothelial corneal dystrophy (FECD) due to corneal endothelial cell degeneration is a major cause of corneal transplantation. It is characterized by abnormal deposition of extracellular matrix (ECM), such as corneal guttae, accompanied by a loss of endothelial cells. Although
Madonna N Mashabela et al.
Journal of food science, 80(11), H2612-H2618 (2015-10-17)
In this study, influence of 3 types of photo-selective nets (pearl, red and yellow) and a standard black net on marketable yield, fruit quality and bioactive compounds after postharvest storage was investigated. Percentage marketable fruits were higher in green sweet
Rosa Tundis et al.
Bioorganic & medicinal chemistry, 17(13), 4542-4547 (2009-05-27)
Three triterpene saponins isolated from the roots of Physospermum verticillatum and identified as saikosaponin a (1), buddlejasaponin IV (2), and songarosaponin D (3) were investigated in vitro for their cytotoxic activity against a panel of seven different cancer cell lines
Yong-Jin Chen et al.
Cell and tissue research, 361(2), 439-455 (2015-03-24)
Our aim is to investigate the cytobiological effects of autologous platelet-rich fibrin (PRF) on dental pulp stem cells (DPSCs) and to explore the ectopic and orthotopic possibilities of dental pulp revascularization and pulp-dentin complex regeneration along the root canal cavities
Michiel Croes et al.
PloS one, 10(7), e0132781-e0132781 (2015-07-16)
Several inflammatory processes underlie excessive bone formation, including chronic inflammation of the spine, acute infections, or periarticular ossifications after trauma. This suggests that local factors in these conditions have osteogenic properties. Mesenchymal stem cells (MSCs) and their differentiated progeny contribute
Elena Brazhnik et al.
Experimental neurology, 261, 563-577 (2014-08-02)
Exaggerated beta range (13-30Hz) synchronized activity is observed in the basal ganglia of Parkinson's disease (PD) patients during implantation of deep brain stimulation electrodes and is thought to contribute to the motor symptoms of this disorder. To explore the translational
Justin R Yates et al.
Behavioural brain research, 291, 201-208 (2015-05-26)
Negative urgency is a facet of impulsivity that reflects mood-based rash action and is associated with various maladaptive behaviors in humans. However, the underlying neural mechanisms of negative urgency are not fully understood. Several brain regions within the mesocorticolimbic pathway
Silvia Benito-Kwiecinski et al.
Cell, 184(8), 2084-2102 (2021-03-26)
The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla, and chimpanzee cells to study developmental mechanisms
Jun Seop Lee et al.
Small (Weinheim an der Bergstrasse, Germany), 11(20), 2399-2406 (2015-01-22)
Dopamine (DA), as one of catecholamine family of neurotransmitters, is crucially important in humans owing to various critical effects on biometric system such as brine circuitry, neuronal plasticity, organization of stress responses, and control of cardiovascular and renal organizations. Abnormal
Adil Sattar et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 70(9), 782-786 (2013-04-18)
A potential interaction involving therapeutic doses of ascorbic acid and warfarin is described. A 65-year-old Caucasian man with chronic cardiac and pulmonary disorders was admitted to the emergency room for chest pain, shortness of breath, nausea, and diaphoresis. Imaging scans
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