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Shohei Ikeda et al.
The Journal of clinical investigation, 131(5) (2020-12-30)
Lysosomal dysfunction caused by mutations in lysosomal genes results in lysosomal storage disorder (LSD), characterized by accumulation of damaged proteins and organelles in cells and functional abnormalities in major organs, including the heart, skeletal muscle, and liver. In LSD, autophagy
Yang-Ming Yang et al.
Molecular medicine (Cambridge, Mass.), 20, 625-638 (2014-12-04)
Chronic hypoxia typically elicits pulmonary hypertension (PH) in mice with a male-dominant phenotype. There is an opposite-sex bias in human PH, with a higher prevalence in women, but greater survival (the "estrogen paradox"). We investigated the involvement of the STAT5a/b
Yao Xie et al.
Arteriosclerosis, thrombosis, and vascular biology, 37(11), 2114-2127 (2017-09-25)
Leptin is an adipokine initially thought to be a metabolic factor. Recent publications have shown its roles in inflammation and vascular disease, to which Sca-1 Sca-1 Upregulation of leptin levels in both the vessel wall and the circulation after vessel
Laura Pintado-Berninches et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21422-e21422 (2021-02-28)
Idiopathic pulmonary fibrosis is a lethal lung fibrotic disease, associated with aging with a mean survival of 2-5 years and no curative treatment. The GSE4 peptide is able to rescue cells from senescence, DNA and oxidative damage, inflammation, and induces telomerase
Alice E Stanton et al.
Frontiers in cell and developmental biology, 9, 725785-725785 (2021-12-21)
Mechanical forces are increasingly recognized as important determinants of cell and tissue phenotype and also appear to play a critical role in organ development. During the fetal stages of lung morphogenesis, the pressure of the fluid within the lumen of
Eva S Rodansky et al.
Experimental and molecular pathology, 98(3), 346-351 (2015-04-02)
Intestinal fibrosis is a critical complication of Crohn's disease (CD). Current in vitro models of intestinal fibrosis cannot model the complex intestinal architecture, while in vivo rodent models do not fully recapitulate human disease and have limited utility for large-scale
Daniel S J Miller et al.
Cell reports, 25(7), 1841-1855 (2018-11-15)
Signal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The trafficking of cell surface receptors is emerging as a key step for regulating appropriate cellular responses, with perturbations
Eva Moran-Salvador et al.
Gastroenterology, 157(5), 1398-1412 (2019-07-29)
Methyl-CpG binding protein 2, MECP2, which binds to methylated regions of DNA to regulate transcription, is expressed by hepatic stellate cells (HSCs) and is required for development of liver fibrosis in mice. We investigated the effects of MECP2 deletion from
Chanbin Lee et al.
International journal of molecular sciences, 20(9) (2019-05-16)
Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty
Shizheng Huang et al.
PLoS biology, 16(9), e2005233-e2005233 (2018-09-19)
While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathways targeted by Notch signaling and the precise ligand and receptor pair that are responsible for kidney disease remain poorly defined. In this study
Xincai Zhang et al.
BioMed research international, 2017, 4941379-4941379 (2017-06-24)
Atherosclerosis is an important pathological condition which is accompanied by a vascular smooth muscle cell (VSMC) phenotype switch toward a synthetic phenotype. As an acute-phase protein, Serum Amyloid A (SAA) is thought to have a close relationship to atherosclerosis development.
Sylvia J Horne et al.
Diabetes, 67(11), 2420-2433 (2018-08-18)
Mitochondrial injury is uniformly observed in several murine models as well as in individuals with diabetic kidney disease (DKD). Although emerging evidence has highlighted the role of key transcriptional regulators in mitochondrial biogenesis, little is known about the regulation of
Jun Wu et al.
Nature, 521(7552), 316-321 (2015-05-07)
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells
Louise A Hyslop et al.
Nature, 534(7607), 383-386 (2016-06-10)
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women to have a genetically related
Carina Henning et al.
Thrombosis and haemostasis, 121(6), 741-754 (2021-01-21)
Short episodes of myocardial ischemia can protect from myocardial infarction. However, the role of endothelial β1 integrin in these cardioprotective ischemic events is largely unknown. In this study we investigated whether endothelial β1 integrin is required for cardiac adaptation to
Cheng-Chao Ruan et al.
Cell metabolism, 28(3), 476-489 (2018-07-19)
Adipocytes play important roles in regulating cardiovascular health and disease. However, the molecular mechanism underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remains unknown. Herein we show that adenosine A2A receptor (A2AR) knockout (A2ARKO) causes
Jie Hu et al.
Aging, 12(21), 22112-22121 (2020-11-14)
Mesenchymal-to-endothelial transition (MEndT) is one of the mechanisms that influences cardiac fibrosis, which is a key process in cardiac remodeling. It has been reported that autophagy inhibits endothelial cell transition. However, whether autophagy could modulate MEndT in cardiac fibrosis has
Holly B Hindman et al.
Investigative ophthalmology & visual science, 51(4), 1935-1942 (2009-11-13)
Purpose. To characterize phenotypic differences between anterior and posterior corneal keratocytes after stimulation with the profibrotic agent transforming growth factor-beta1 (TGF-beta1) in vitro. Methods. Sixteen corneas from healthy felines were obtained immediately after death. Lamellar dissection was performed to separate
Lara M Durrant et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(6), R401-R410 (2014-01-31)
Although the effects of prenatal undernutrition on adult cardiovascular health have been well studied, its effects on the cerebrovascular structure and function remain unknown. We used a pair-fed rat model of 50% caloric restriction from day 11 of gestation to
Margarita Barriga et al.
British journal of pharmacology, 178(21), 4368-4388 (2021-07-09)
Acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary fibrosis remain major causes of morbidity, mortality and a healthcare burden in critically ill patient. There is an urgent need to identify factors causing susceptibility and for the design
Caroline L Wilson et al.
Journal of hepatology, 63(6), 1421-1428 (2015-08-13)
Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation
Anette Hübner et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(30), 12046-12051 (2012-07-04)
The c-Jun NH(2)-terminal kinase (JNK) signal transduction pathway is implicated in cancer, but the role of JNK in tumorigenesis is poorly understood. Here, we demonstrate that the JNK signaling pathway reduces the development of invasive adenocarcinoma in the phosphatase and
Huizhen Wang et al.
Cell death & disease, 12(12), 1087-1087 (2021-11-19)
Phosphatase and Tensin Homolog on chromosome Ten (PTEN) has emerged as a key protein that governs the response to kidney injury. Notably, renal adaptive repair is important for preventing acute kidney injury (AKI) to chronic kidney disease (CKD) transition. To
Inyoub Chang et al.
Technology in cancer research & treatment, 20, 15330338211038487-15330338211038487 (2021-09-08)
Objective: To investigate a feasible candidate for an appropriate cell line for the orthotopic renal cell carcinoma (RCC) model. Methods: Normal human proximal tubule cells (HK-2) and RCC cells were used for MTT assay, Western blotting, sphere-forming assay, and orthotopic
Lucas Albacete-Albacete et al.
The Journal of cell biology, 219(11) (2020-10-15)
The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction critically depends on cell communication mediated by exosomes, small vesicles generated within multivesicular bodies
Joe Swift et al.
Science (New York, N.Y.), 341(6149), 1240104-1240104 (2013-08-31)
Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation is unknown. Here, proteomics analyses revealed that levels of the
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