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Holly B Hindman et al.
Investigative ophthalmology & visual science, 51(4), 1935-1942 (2009-11-13)
Purpose. To characterize phenotypic differences between anterior and posterior corneal keratocytes after stimulation with the profibrotic agent transforming growth factor-beta1 (TGF-beta1) in vitro. Methods. Sixteen corneas from healthy felines were obtained immediately after death. Lamellar dissection was performed to separate
Dannel Yeo et al.
International journal of cancer, 140(9), 2101-2111 (2017-01-22)
Pancreatic cancer remains one of the most lethal of all solid tumors. Pancreatic stellate cells (PSCs) are primarily responsible for the fibrosis that constitutes the stroma and p21-activated kinase 1 (PAK1) may have a role in signalling pathways involving PSCs.
Tamrat M Mamo et al.
Human molecular genetics, 26(18), 3553-3563 (2017-06-29)
Heterozygous loss of Bmp4 results both in humans and mice in severe malformation of the urinary tract. These defects have at least partially been attributed to loss of expression of Bmp4 in the ureteric mesenchyme, yet the cellular and molecular
Yi Wen et al.
Journal of the American Society of Nephrology : JASN, 30(10), 1925-1938 (2019-07-25)
Polarized macrophage populations can orchestrate both inflammation of the kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney injury, but mechanisms through which persistent M1-dependent kidney damage culminates in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc-finger
Qishan Chen et al.
Journal of molecular and cellular cardiology, 121, 277-286 (2018-07-28)
Accumulating evidence indicates the presence of vascular stem/progenitor cells that may play a role in endothelial repair and lesion formation in the injured artery, in which c-kit+ stem/progenitor cells have been reported to differentiate into endothelial and smooth muscle cells
Ema C Ciucurel et al.
Tissue engineering. Part A, 20(7-8), 1222-1234 (2013-10-22)
Modular tissue engineering is a method of building vascularized tissue-engineered constructs. Submillimeter-sized collagen pieces (modules) coated with a layer of endothelial cells (EC; vascular component), and with embedded functional cells, are self-assembled into a larger, three-dimensional tissue. In this study
Yin-Yin Chen et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(10), 2563-2575 (2019-06-15)
In this study, we examined the association of PRMT1 with ER stress and epithelial-mesenchymal transition (EMT), two critical pathogenic mechanisms leading to DN development, in proximal tubular epithelial cells (PTECs). The level of PRMT1 was compared between the serum from
Yuri An et al.
Developmental biology, 446(1), 43-55 (2018-12-12)
Teratomas are tumors consisting of components of the three germ layers that differentiate from pluripotent stem cells derived from germ cells. In the normal mouse testis, teratomas rarely form, but a deficiency in Dead-end1 (Dnd1) in mice with a 129/Sv
Steffen Heeg et al.
Gastroenterology, 151(3), 540-553 (2016-06-19)
The ETS-transcription factor ETV1 is involved in epithelial-mesenchymal transition during pancreatic development and is induced in mouse pancreatic intraepithelial neoplasia (PanIN) and pancreatic ductal adenocarcinoma (PDAC). We investigated the function of ETV1 in stromal expansion of PDAC and metastasis, as
Kate M Herum et al.
Molecular biology of the cell, 28(14), 1871-1882 (2017-05-05)
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts, characterized by proliferation, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of
Maximilian Strunz et al.
Nature communications, 11(1), 3559-3559 (2020-07-18)
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling together with lineage tracing revealed
Raphael Yao et al.
Journal of biomechanical engineering, 137(2), 020907-020907 (2014-11-28)
For patients suffering from severe coronary heart disease (CHD), the development of a cell-based tissue engineered blood vessel (TEBV) has great potential to overcome current issues with synthetic graft materials. While marrow stromal cells (MSCs) are a promising source of
Lei Jiang et al.
Kidney international, 84(2), 285-296 (2013-03-22)
Mitochondria dysfunction has been reported in various kidney diseases but how it leads to kidney fibrosis and how this is regulated is unknown. Here we found that mitochondrial uncoupling protein 2 (UCP2) was induced in kidney tubular epithelial cells after
Niki Prakoura et al.
Journal of the American Society of Nephrology : JASN, 28(5), 1475-1490 (2016-12-07)
De novo expression in the kidney of periostin, a protein involved in odontogenesis and osteogenesis, has been suggested as a biomarker of renal disease. In this study, we investigated the mechanism(s) of induction and the role of periostin in renal
David Hortobagyi et al.
PloS one, 15(11), e0241901-e0241901 (2020-11-20)
Voice rest following phonotrauma or phonosurgery has a considerable clinical impact, but clinical recommendations are inconsistent due to inconclusive data. As biopsies of the vocal folds (VF) for molecular biology studies in humans are unethical, we established a new in
Brian Y Lee et al.
Nature communications, 12(1), 7336-7336 (2021-12-19)
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex microenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however the effects of individual stromal subsets remain incompletely characterised. Here, we describe how heterocellular Oncostatin
Anette Hübner et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(30), 12046-12051 (2012-07-04)
The c-Jun NH(2)-terminal kinase (JNK) signal transduction pathway is implicated in cancer, but the role of JNK in tumorigenesis is poorly understood. Here, we demonstrate that the JNK signaling pathway reduces the development of invasive adenocarcinoma in the phosphatase and
Liliya M Yamaleyeva et al.
American journal of physiology. Endocrinology and metabolism, 309(1), E84-E94 (2015-05-15)
Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight at late gestation; however, whether uteroplacental vascular and/or hemodynamic disturbances underlie this growth-restricted phenotype is unknown. Uterine artery reactivity and flow velocities, umbilical flow velocities, trophoblast invasion, and placental
María U Moreno et al.
Clinical science (London, England : 1979), 125(6), 291-300 (2013-04-05)
The NADPH oxidases are a key family of ROS (reactive oxygen species)-producing enzymes which may differentially contribute to cardiac pathophysiology. Animal studies show uncertain results regarding the regulation of cardiac Nox4 by pressure overload and no data are available on
Arantxa Bolinches-Amorós et al.
Stem cell research, 38, 101455-101455 (2019-05-15)
Dermal fibroblasts from an autosomal recessive retinitis pigmentosa (RP) patient, homozygous for the mutation c.769 C>T, p.Arg257Ter, in CERKL (Ceramide Kinase-Like) gene, and a healthy sibling were derived and reprogrammed by Sendai virus. The generated human induced pluripotent stem cell
Joe Swift et al.
Science (New York, N.Y.), 341(6149), 1240104-1240104 (2013-08-31)
Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation is unknown. Here, proteomics analyses revealed that levels of the
Seok Hui Kang et al.
Kidney research and clinical practice, 38(4), 472-480 (2019-09-26)
We investigated the effects of tranilast on epithelial-to-mesenchymal transition (EMT) in an animal model and on the EMT signaling pathway in human peritoneal mesothelial cells (HPMCs). We performed in vitro studies (cytotoxicity, cell morphology, and western blot analyses) on HPMCs
Louise A Hyslop et al.
Nature, 534(7607), 383-386 (2016-06-10)
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women to have a genetically related
Lucas Albacete-Albacete et al.
The Journal of cell biology, 219(11) (2020-10-15)
The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction critically depends on cell communication mediated by exosomes, small vesicles generated within multivesicular bodies
Nagako Yoshiba et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 63(6), 438-448 (2015-03-26)
Myofibroblasts and extracellular matrix are important components in wound healing. Alpha-smooth muscle actin (α-SMA) is a marker of myofibroblasts. Fibrillin-1 is a major constituent of microfibrils and an extracellular-regulator of TGF-β1, an important cytokine in the transdifferentiation of resident fibroblasts
Sara Chowdhury et al.
Regulatory peptides, 187, 42-50 (2013-11-05)
Xenin-25 (Xen) is a 25-amino acid neurotensin-related peptide that activates neurotensin receptor-1 (NTSR1). We previously showed that Xen increases the effect of glucose-dependent insulinotropic polypeptide (GIP) on insulin release 1) in hyperglycemic mice via a cholinergic relay in the periphery
Daniel J Gibson et al.
Investigative ophthalmology & visual science, 53(12), 7760-7765 (2012-11-08)
To determine the direct contribution of the epithelium to the generation of complications using a phototherapeutic keratectomy model. A mouse model with a genetically labeled epithelium was used to determine whether any epithelium-derived cells persist in the stroma up to
Deepak A Kaji et al.
eLife, 9 (2020-06-06)
Tendon injuries are common with poor healing potential. The paucity of therapies for tendon injuries is due to our limited understanding of the cells and molecular pathways that drive tendon regeneration. Using a mouse model of neonatal tendon regeneration, we
Eleanor B Reed et al.
Respiratory research, 20(1), 168-168 (2019-07-31)
Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosis. TGF-beta-induced myofibroblast differentiation characterized by expression of smooth muscle alpha-actin and extracellular
Xiaojun Fu et al.
Molecular medicine reports, 12(1), 127-132 (2015-02-20)
Hepatoblastoma (HB) is the most common malignant hepatic tumor in children and complete surgical resection offers the highest possibility for cure in this disease. Tumor metastasis is the principle obstacle to the development of efficient treatments for patients with HB.
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