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A6141

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V Mistretta et al.
Acta clinica Belgica, 69(1), 53-61 (2014-03-19)
Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major active metabolite, hydroxy-itraconazole) in serum can be useful...
Jonathan Ashby et al.
ACS applied materials & interfaces, 6(17), 15412-15419 (2014-08-22)
Nanoparticles (NPs) adsorb proteins when in the biological matrix, and the resulted protein corona could affect NP-cell interactions. The corona has a dynamic nature with the adsorbed proteins constantly exchanging with the free proteins in the matrix at various rates....
Joanna A Majchrzykiewicz-Koehorst et al.
Journal of virological methods, 213, 75-83 (2014-12-17)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in...
Jian Xu et al.
Comparative biochemistry and physiology. Part D, Genomics & proteomics, 16, 36-47 (2015-08-16)
We reported previously that baculovirus AcMNPV host-ranges in silkworm strains are controlled by a novel third chromosomal locus. To further isolate the potential host factor and uncover the functional pathway involved, in this study we analyzed hemolymph proteins from AcMNPV-resistant...
Thea S B Kjeldsen et al.
The Journal of antimicrobial chemotherapy, 70(1), 62-70 (2014-09-04)
Knowledge about the regulatory mechanisms of CTX-M β-lactamase-encoding genes in Escherichia coli is limited. The objectives of this study were to determine the growth response of CTX-M-1-producing E. coli exposed to cefotaxime and to investigate how blaCTX-M-1 expression at mRNA...
Liron Feldberg et al.
Journal of mass spectrometry : JMS, 55(1), e4482-e4482 (2019-11-30)
Ricin, a plant-derived toxin extracted from the seeds of Ricinus communis (castor bean plant), is one of the most toxic proteins known. Ricin's high toxicity, widespread availability, and ease of its extraction make it a potential agent for bioterrorist attacks....
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Dinh-Duy Pham et al.
International journal of pharmaceutics, 454(2), 668-677 (2013-04-23)
We have designed a novel formulation of pyrazinamide (PZA), an antitubercular drug within large porous particles intended for deep lung delivery. By simply spray-drying PZA, we have obtained crystalline particles of the δ polymorph of PZA that were unstable and...
Lior Doron et al.
PloS one, 9(10), e111329-e111329 (2014-10-31)
Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. A serine endopeptidase of 61-65 kDa capable of damaging host tissue and of inactivating immune effectors was detected previously in F. nucleatum. Here we...
Kélen Fabíola Arroteia et al.
PloS one, 9(8), e103566-e103566 (2014-08-02)
The epididymis has an important role in the maturation of sperm for fertilization, but little is known about the epididymal molecules involved in sperm modifications during this process. We have previously described the expression pattern for an antigen in epididymal...
Nida Siddiqui et al.
Nature communications, 10(1), 2693-2693 (2019-06-21)
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of...
Chi-De Chen et al.
Journal of proteome research, 13(6), 2818-2829 (2014-05-03)
The ability to discriminate lung cancer malignant pleural effusion (LC-MPE) from benign pleural effusion has profound implications for the therapy and prognosis of lung cancer. Here, we established a pipeline to verify potential biomarkers for this purpose. In the discovery...
John D Lapek et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(2), 161-173 (2014-11-07)
We have developed a method to identify previously undetected histidine and aspartic acid phosphorylations in a human prostate cancer progression model. A phosphoproteome of our cell line model is presented, with correlation of modified protein expression between the three states...
Nico P M Smit et al.
Journal of proteomics, 109, 143-161 (2014-06-28)
In this study, we have followed up on previous liquid chromatography (LC) multiple reaction monitoring (MRM) mass spectrometry (MS) approaches for measurement of apolipoprotein (apo) A-I and apo B100 in serum aiming for implementation of a multiplexed assay in a...
Yan Liu et al.
Science translational medicine, 6(266), 266ra170-266ra170 (2014-12-17)
Doxorubicin is a highly effective anticancer chemotherapy agent, but its use is limited by its cardiotoxicity. To develop a drug that prevents this toxicity, we established a doxorubicin-induced cardiomyopathy model in zebrafish that recapitulates the cardiomyocyte apoptosis and contractility decline...
Nancy D Epsky et al.
Journal of economic entomology, 105(2), 471-479 (2012-05-23)
Tests were conducted that evaluated efficacy of wax matrix bait stations for Ceratitis capitata (Wiedemann) adults in Guatemala. Bait stations were exposed to outdoor conditions to determine effect of weathering on longevity as indicated by bait station age. Results of...
Si Mi et al.
Food research international (Ottawa, Ont.), 119, 426-435 (2019-03-20)
The primary aim of this study was to unravel key proteins for the differentiation of Tibetan (n = 15) and Duroc × (Landrace × Yorkshire) (n = 15) pork. A platform consisting of LC-MS/MS analysis and label-free quantitative proteomics was utilized. Changes in the...
Chen Qian et al.
Huan jing ke xue= Huanjing kexue, 31(10), 2417-2422 (2011-01-15)
Air-drying is always accompanied by soil moisture loss. The different influences of air-drying on soil nitrification might due to the different nitrification responses to moisture changing of acid subtropical soils. So, after applying 0 and 150 mg x kg(-1) of...
Ming-Chuan Wang et al.
Analytical and bioanalytical chemistry, 407(5), 1343-1356 (2014-12-10)
Tyrosine phosphorylation is an important regulator of signaling in cellular pathways, and dysregulated tyrosine phosphorylation causes several diseases. Mass spectrometry has revealed the importance of global phosphoproteomic characterization. Analysis of tyrosine phosphorylation by studying the mass-spectrometry (MS)-determined phosphoproteome remains difficult...
Qichen Cao et al.
Analytical chemistry, 86(14), 6804-6811 (2014-06-11)
Core fucosylation (CF) is a special glycosylation pattern of proteins that has a strong relationship with cancer. The Food and Drug Administration (FDA) has approved the core fucosylated α-fetoprotein as a biomarker for the early diagnosis of hepatocellular carcinoma (HCC)....
Esther Roselló-Lletí et al.
PloS one, 9(11), e112971-e112971 (2014-11-15)
Dilated cardiomyopathy (DCM) is a public health problem with no available curative treatment, and mitochondrial dysfunction plays a critical role in its development. The present study is the first to analyze the mitochondrial proteome in cardiac tissue of patients with...
Alba Hykollari et al.
Electrophoresis, 35(15), 2116-2129 (2014-02-28)
In this study, we have performed the first mass spectrometric analysis of N-glycans of the M31 mutant strain of the cellular slime mould Dictyostelium discoideum, previously shown to have a defect in glucosidase II. Together with glucosidase I, this enzyme...
Neelima M Bhat et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5178-5188 (2015-10-28)
B cell binding and cytotoxicity by human VH4-34-encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early response in a phase 1 trial for treatment of B cell acute lymphoblastic leukemia. Although...
Neda Saraygord-Afshari et al.
Biotechnology and applied biochemistry, 61(6), 660-667 (2014-03-01)
Patterns obtained in two-dimensional gel electrophoresis (2-DE) in the previously published articles suggest a varying number of proteins. To seek the cause of this variation, we investigated the effect of reduction power on the overall tear proteome maps. To this...
Joo-Man Park et al.
Scientific reports, 5, 17395-17395 (2015-12-02)
Glucokinase (GK), mainly expressed in the liver and pancreatic β-cells, is critical for maintaining glucose homeostasis. GK expression and kinase activity, respectively, are both modulated at the transcriptional and post-translational levels. Post-translationally, GK is regulated by binding the glucokinase regulatory...
Kavya Mohan et al.
PloS one, 9(6), e96551-e96551 (2014-06-10)
We developed a multiple light-sheet microscopy (MLSM) system capable of 3D fluorescence imaging. Employing spatial filter in the excitation arm of a SPIM system, we successfully generated multiple light-sheets. This improves upon the existing SPIM system and is capable of...
Cosima Damiana Calvano et al.
Analytical and bioanalytical chemistry, 407(3), 1015-1022 (2014-12-01)
Direct on-target plate processing of small (ca. 100 μg) fragments of paint samples for MALDI-MS identification of lipid- and protein-based binders is described. Fragments were fixed on a conventional stainless steel target plate by colloidal graphite followed by in situ fast...
Kun Peng et al.
mAbs, 6(6), 1500-1508 (2014-12-09)
RG7652 is a human immunoglobulin 1 (IgG1) monoclonal antibody (mAb) targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) and is designed for the treatment of hypercholesterolemia. A target-binding enzyme-linked immunosorbent assay (ELISA) was developed to measure RG7652 levels in human serum...
Dario Venetz et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2000-2005 (2015-02-04)
The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we...
Muhammad Shahid et al.
The journal of physical chemistry. B, 119(25), 8072-8079 (2015-06-13)
An enhanced thermal decomposition of chemical compounds in aqueous solution has been achieved at reduced solution temperatures. The technique exploits hitherto unrecognized properties of a bubble column evaporator (BCE). It offers better heat transfer efficiency than conventional heat transfer equipment....
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