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Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Shengdong Wang et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1068-1073 (2013-10-15)
Acetaminophen (APAP) is widely used as an antipyretic agent which is safe at therapeutic doses. However, overdose of APAP induces fatal and non-fatal hepatic necroses. The chemical reactive metabolites of APAP initiate toxicity and inflammatory response within the liver and
Cheng-Lin Fu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 867-877 (2018-09-28)
The root of Platycodon grandiflorus (Jacq.) A. DC. (P. grandiflorus), Platycodonis Radix, has been commonly applied to prevent and treat human diseases including bronchitis, asthma and excessive phlegm. Platycodin D (PD), one of the most important therapeutic components of P.
Yoko Nishimura et al.
Journal of applied toxicology : JAT, 35(2), 173-180 (2014-08-06)
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order to explore a plasma miRNA biomarker for
Patrick Scheiermann et al.
Scientific reports, 5, 8521-8521 (2015-02-18)
Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner
Antonio Martinez-Gimeno et al.
Expert review of respiratory medicine, 7(2), 113-122 (2013-04-04)
During the last few decades, a huge epidemiological effort has been made all over the world in order to cast some light on the origin of asthma (or 'wheezing disorders' as a general term) and its recent increase in prevalence.
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Richard W Friesen et al.
Journal of medicinal chemistry, 51(14), 4059-4067 (2008-05-08)
Padraick J Dornbush et al.
Bioorganic & medicinal chemistry letters, 20(17), 5299-5301 (2010-07-30)
Trichomonas vaginalis, a human-infectious protozoan, can display resistance to treatment by metronidazole. A library of 3,4-dichloroaniline amides based on propanil, an herbicide, has been synthesized and screened to test susceptibility to these analogs. From this preliminary study, the most effective
Emrah Akgun et al.
Experimental animals, 70(1), 54-62 (2020-09-24)
Folic acid (FA), is a group B vitamin, has high reactive oxygen radicals quenching ability, resulting in protection against oxidative damage in aerobic cell. Acetaminophen (N-acetyl-p-aminophenol, APAP) is a nonsteroidal anti-inflammatory drug, and can promote oxidative damage in liver and
PKCs: pernicious kinase culprits in acetaminophen pathogenesis.
Cynthia Ju et al.
Hepatology (Baltimore, Md.), 59(4), 1229-1231 (2014-03-29)
Masahiro Sugino et al.
Annals of clinical biochemistry, 52(Pt 4), 476-480 (2014-12-20)
The use of acetaminophen as a drug for pain control is expected to increase in the neonatal field. The displacement factor of acetaminophen in the reaction in the glucose oxidase peroxidase method is very high, but is also considered to
Bahar Dhowan et al.
Journal of controlled release : official journal of the Controlled Release Society, 306, 130-137 (2019-06-04)
With approximately 48,000 attributed deaths in 2017, the opioid overdose is now the leading cause of death amongst Americans under the age of 50. The overdose process can be interrupted by the administration of naloxone, a safe and effective opiate
Nabil A Khan et al.
Journal of opioid management, 9(3), 225-230 (2013-06-19)
Addiction to painkillers or other substances in pediatric and adolescent cases of noncancer chronic pain is an understudied phenomenon, even amidst documented increases in rates of prescription opioid use and misuse. Case studies can inform the training of clinicians in
Véronique Gilard et al.
Journal of pharmaceutical and biomedical analysis, 102, 476-493 (2014-12-03)
One hundred and fifty dietary supplements (DS) marketed to increase sexual performance were analyzed. All these formulations were claimed to contain only natural compounds, plant extracts and/or vitamins. (1)H NMR spectroscopy was used for detecting the presence of adulterants and
Mona Darwish et al.
Clinical therapeutics, 37(2), 390-401 (2014-12-30)
A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets
Paracetamol: mechanisms and updates
Sharma CV and Mehta V
Continuing education in anaesthesia, critical care & pain, 14(4), 153-158 (2013)
Treatment of paracetamol overdose.
Benjamin Kessler et al.
Lancet (London, England), 383(9926), 1382-1382 (2014-04-25)
[Effectiveness of analgesic combinations in the self-medication].
Eve C A Morgenstern et al.
MMW Fortschritte der Medizin, 155(9), 49-51 (2013-08-21)
Huan Yang et al.
The Journal of experimental medicine, 212(1), 5-14 (2015-01-07)
Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its
Mahmoud Mohammadi et al.
Indian pediatrics, 40(12), 1183-1186 (2004-01-15)
The present study was done to explore the relationship between the cerebrospinal fluid (CSF) glucose concentration, body temperature, seizure duration, and acetaminophen administration. Retrospective record review of 117 consecutive febrile convulsive infants aging 3 to 18 months admitted to Bahrami
F Franceschi et al.
European review for medical and pharmacological sciences, 17(16), 2129-2135 (2013-07-31)
Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and
Clinical question: are non-steroidal anti-inflammatories superior to acetaminophen for sprains/strains?
Heather Wheeler et al.
The Journal of the Oklahoma State Medical Association, 107(3), 109-110 (2014-05-08)
Chanil Jung et al.
Environmental science and pollution research international, 22(13), 10058-10069 (2015-02-15)
The combined coagulation and adsorption of targeted acetaminophen and naproxen using activated biochar and aluminum sulfate were studied under various synthetic "combined sewer overflow" (CSO) conditions. The biochar demonstrated better adsorption performance for both acetaminophen and naproxen (removal, 94.1 and
M Deutsch et al.
Cell death & disease, 6, e1759-e1759 (2015-05-08)
Necroptosis is a recently described Caspase 8-independent method of cell death that denotes organized cellular necrosis. The roles of RIP1 and RIP3 in mediating hepatocyte death from acute liver injury are incompletely defined. Effects of necroptosis blockade were studied by
Peggy Gandia et al.
Journal of clinical pharmacology, 43(11), 1235-1243 (2003-10-11)
This study evaluated the effect of simulated weightlessness on gastric emptying, using acetaminophen as a probe and -6 degrees head-down bed rest to simulate zero gravity. Eighteen volunteers were given 1 g of acetaminophen orally before the bed rest and
Claire Lewis et al.
Rapid communications in mass spectrometry : RCM, 29(12), 1107-1114 (2015-05-20)
A current challenge for analytical chemists is the development of the measurement systems and approaches required to understand dynamic processes such as tablet dissolution. The design and development of oral tablets could be improved by the availability of detailed information
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 16(15), 7424-7428 (2008-06-27)
Inhibition of 12 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC, CA I-XIV, with a series of phenols was investigated. The inhibition profile by phenols of these CAs was distinct from those of the sulfonamides and their isosteres
Sharad Mangal et al.
International journal of pharmaceutics, 479(2), 338-348 (2015-01-13)
In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive excipient. The physico-chemical and bulk properties such as particle size, surface composition, surface energy and bulk cohesion of PVP-Leu was measured and compared
Bruna Maria Manzini et al.
Cytotherapy, 17(8), 1052-1065 (2015-07-04)
End-stage liver diseases frequently require liver transplantation. Cell therapy could be an alternative. This study aimed to analyze whether undifferentiated mesenchymal stromal cells (U-MSCs) or MSC-derived hepatocyte-like cells (DHLCs) from adipose tissue (AT), umbilical cord blood (UCB) and bone marrow
Wolfgang Friebolin et al.
Journal of medicinal chemistry, 51(5), 1260-1277 (2008-02-12)
Plasmodium parasites are exposed to higher fluxes of reactive oxygen species and need high activities of intracellular antioxidant systems providing a steady glutathione flux. As a future generation of dual drugs, 18 naphthoquinones and phenols (or their reduced forms) containing
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