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Umporn Pitipakorn et al.
International journal of rheumatic diseases, 19(7), 693-699 (2015-07-23)
To determine the association between angiotensin-converting enzyme (ACE) I/D polymorphism and the presence of systemic lupus erythematosus (SLE) disease and lupus nephritis (LN), including the association with disease severity in a Thai population. In this retrospective study, 187 SLE patients
Brodie Miles et al.
Nature communications, 6, 8608-8608 (2015-10-21)
Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity. Follicular regulatory T cells (TFR) are a recently characterized subset of lymphocytes that influence the germinal centre
Qi Cheng et al.
Chemico-biological interactions, 299, 131-139 (2018-12-14)
Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential role in the pathogenesis of liver fibrosis. Methyl ferulic acid (MFA), a biologically
J Hutcheson et al.
Clinical and experimental immunology, 179(3), 435-443 (2014-10-28)
Systemic lupus erythematosus (SLE) and lupus nephritis (LN) have strong concomitance with cardiovascular disease that cannot be explained fully by typical risk factors. We examined the possibility that serum or urine expression of adipokines may act as biomarkers for LN
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Meredith K Loth et al.
Molecular neurobiology, 57(11), 4467-4487 (2020-08-04)
In the brain neuropil, translocator protein 18 kDa (TSPO) is a stress response protein that is upregulated in microglia and astrocytes in diverse central nervous system pathologies. TSPO is widely used as a biomarker of neuroinflammation in preclinical and clinical neuroimaging
Hatice Baş et al.
Environmental toxicology and pharmacology, 39(3), 1019-1026 (2015-04-12)
The adverse effects of lead nitrate (LN) and the preventive role of sodium selenite were investigated in diabetic and non-diabetic rat blood by measuring trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP), malondialdehyde (MDA) levels and activities of
Quyen A Tran et al.
Stem cells international, 2018, 4809673-4809673 (2018-05-17)
Developmental studies and 3D in vitro model systems show that the production and engagement of extracellular matrix (ECM) often precede stem cell differentiation. Yet, unclear is how the ECM triggers signaling events in sequence to accommodate multistep process characteristic of
M J O'Melia et al.
Science advances, 6(50) (2020-12-15)
Revealing the mechanisms that underlie the expansion of antitumor CD8+ T cells that are associated with improved clinical outcomes is critical to improving immunotherapeutic management of melanoma. How the lymphatic system, which orchestrates the complex sensing of antigen by lymphocytes
Caroline E Sutton et al.
Nature communications, 8(1), 1923-1923 (2017-12-14)
The transcription factor BMAL1 is a core component of the molecular clock, regulating biological pathways that drive 24 h (circadian) rhythms in behaviour and physiology. The molecular clock has a profound influence on innate immune function, and circadian disruption is linked
Haoyue Xu et al.
ACS applied materials & interfaces, 12(47), 52319-52328 (2020-11-10)
Glioma is the most prevalent type of malignant brain tumor and is usually very aggressive. Because of the high invasiveness and aggressive proliferative growth of glioma, it is difficult to resect completely or cure with surgery. Residual glioma cells are
Aneesh Thakur et al.
Frontiers in immunology, 11, 803-803 (2020-05-28)
Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and mucosally, respectively, has
Johan Westö et al.
Journal of neurophysiology, 120(2), 703-719 (2018-05-03)
Receptive field (RF) models are an important tool for deciphering neural responses to sensory stimuli. The two currently popular RF models are multifilter linear-nonlinear (LN) models and context models. Models are, however, never correct, and they rely on assumptions to
Carla Benelli et al.
Plants (Basel, Switzerland), 10(2) (2021-02-13)
Cryopreservation is a useful tool for the long-term storage of plant genetic resources, and different cryogenic procedures have recently been developed. The present study focused on the use of the Droplet-vitrification (DV) and V cryo-plate protocol for the cryopreservation of
E A Sazhina et al.
Archives of biochemistry and biophysics, 669, 32-38 (2019-05-28)
Embryos cryopreservation is a widely used technology for genetic resources storage. Cryopreservation suppresses cell respiration, but very little is known about the changes that occur with mitochondria at low temperatures. We used Raman spectroscopy to investigate photoresponse and redox state
C Chnafa et al.
Physiological measurement, 38(11), 2044-2057 (2017-10-12)
Vessel lumen calibres and flow rates are thought to be related by mathematical power laws, reflecting the optimization of cardiac versus metabolic work. While these laws have been confirmed indirectly via measurement of branch calibres, there is little data confirming
Yan Wang et al.
Plant signaling & behavior, 15(2), 1710935-1710935 (2020-01-08)
By timing many diel rhythmic events, circadian clock provides an adaptive advantage for higher plants. Meanwhile, circadian clock displays plasticity and can be entrained by the external environmental cues and internal factors. However, whether cellular energy status can regulate circadian
Wanpeng Wang et al.
Scientific reports, 5, 12644-12644 (2015-09-01)
Systemic lupus erythematosus (SLE) is a common but severe autoimmune systemic inflammatory disease. Lupus nephritis (LN) is a serious complication of SLE,affecting up to 70% of SLE patients. Circulating microRNAs (miRNA) are emerging as biomarkers for pathological conditions and play
Chien-Hui Hong et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12980-12990 (2020-05-29)
The aryl hydrocarbon receptor (AhR) represents an environmental sensor regulating immune responses. In the skin, AhR is expressed in several cell types, including keratinocytes, epidermal Langerhans cells (LC), and dermal dendritic cells (DC). The mechanisms how AhR activates or inhibits
Baodong Wang et al.
International journal of molecular medicine, 41(6), 3278-3286 (2018-03-24)
The inhibition of mesangial cell (MC) proliferation has become an important therapy in preventing glomerular proliferation diseases. Trifluoperazine (TFP) has been reported to inhibit the proliferation of several types of cancer cell, however, the effects of TFP in renal proliferation
Jun Ishizaki et al.
Rheumatology (Oxford, England), 54(3), 405-412 (2014-09-04)
The aim of this study was to clarify the clinical characteristics and predictors of silent LN (SLN), a type of LN in SLE without abnormal urinalysis or renal impairment. Of 182 patients who underwent renal biopsy, 48 did not present
Rocco Cantisani et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1717-1725 (2015-01-16)
Ag retention within lymph nodes (LNs) upon vaccination is critical for the development of adaptive immune responses, because it facilitates the encounter of the Ag with cognate lymphocytes. During a secondary exposure of the immune system to an Ag, immune
Lisa Rödling et al.
Advanced healthcare materials, 7(9), e1701403-e1701403 (2018-01-20)
There is an urgent need for 3D cell culture systems that avoid the oversimplifications and artifacts of conventional culture in 2D. However, 3D culture within the cavities of porous biomaterials or large 3D structures harboring high cell numbers is limited
Charalambos C Charalambous et al.
Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, 41, 9-18 (2018-05-02)
The investigation of the corticomotor connectivity (CMC) to leg muscles is an emerging research area, and establishing reliability of measures is critical. This study examined the measurement reliability and the differences between bilateral soleus (SOL) and tibialis anterior (TA) CMC
Interleukin-35 Level Is Elevated in Patients with Chronic Hepatitis B Virus Infection.
Sheng-Tao Cheng et al.
International journal of medical sciences, 15(2), 188-194 (2018-01-16)
Terhi Savinko et al.
Journal of immunology (Baltimore, Md. : 1950), 200(9), 3109-3116 (2018-03-28)
T cells traffic from the bloodstream into tissues to perform their functions in the immune system and are therefore subjected to a range of different mechanical forces. Integrins are essential for T cell trafficking into the tissues, as they mediate
Joan Manel Ramírez et al.
Nanotechnology, 26(8), 085203-085203 (2015-02-07)
Amorphous sub-nanometre Tb-doped SiOxNy/SiO2 superlattices were fabricated by means of alternating deposition of 0.7 nm thick Tb-doped SiOxNy layers and of 0.9 nm thick SiO2 barrier layers in an electron-cyclotron-resonance plasma enhanced chemical vapour deposition system with in situ Tb-doping
N U Patel et al.
AJNR. American journal of neuroradiology, 39(4), 756-761 (2018-02-17)
Ultrasound is a standard technique to detect lymph node metastasis in papillary thyroid cancer. Cystic changes and microcalcifications are the most specific features of metastasis, but with low sensitivity. This prospective study compared the diagnostic accuracy of a predictive model
Sunny R Shah et al.
The Journal of pharmacy and pharmacology, 72(8), 1026-1037 (2020-04-28)
The aim of this study was to develop and optimize levofloxacin loaded PLGA nanoparticles (LN) for pulmonary delivery employing screening and experimental design and evaluate their in-vitro and in-vivo performance. The objective was to achieve Mass Median Aerodynamic Diameter (MMAD)
Akihiko Murata et al.
Frontiers in immunology, 11, 775-775 (2020-06-09)
In allergic contact dermatitis (ACD) and contact hypersensitivity (CHS), the healed skin shows greater swelling than the naïve skin in the same individual upon re-exposure to the same hapten. This "local skin memory" (LSM) in healed skin was maintained for
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