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The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.

Melanie J Lewis et al.

Molecular immunology, 45(3), 818-827 (2007-08-03)

Recombinant versions of the seven equine IgG subclasses were expressed in CHO cells. All assembled into intact immunoglobulins stabilised by disulphide bridges, although, reminiscent of human IgG4, a small proportion of equine IgG4 and IgG7 were held together by non-covalent

Serological method using recombinant S2 protein to differentiate equine infectious anemia virus (EIAV)-infected and EIAV-vaccinated horses.

Sha Jin et al.

Clinical and diagnostic laboratory immunology, 11(6), 1120-1129 (2004-11-13)

We recently reported a highly protective attenuated live virus vaccine for equine infectious anemia virus (EIAV) based on a proviral construct (EIAVUKDeltaS2) with a genetically engineered mutation in the viral S2 gene that eliminates expression of this accessory protein. While

Comparative analysis of newborn and adult Bothrops jararaca snake venoms.

Thatiane C Antunes et al.

Toxicon : official journal of the International Society on Toxinology, 56(8), 1443-1458 (2010-09-08)

Different clinical manifestations have been reported to occur in patients bitten by newborn and adult Bothrops jararaca snakes. Herein, we studied the chemical composition and biological activities of B. jararaca venoms and their immunoneutralization by commercial antivenin at these ontogenetic

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.

Hyunsup Kim et al.

The Journal of biological chemistry, 297(4), 101148-101148 (2021-09-03)

The proper cellular response to DNA double-strand breaks (DSBs) is critical for maintaining the integrity of the genome. RecQL4, a DNA helicase of which mutations are associated with Rothmund-Thomson syndrome (RTS), is required for the DNA DSB response. However, the

Papain digestion of different mouse IgG subclasses as studied by electrospray mass spectrometry

Adamczyk M, et al.

Journal of Immunological Methods, 237(1-2), 95-104 (2000)

Characterization of the interferon gamma response to Lawsonia intracellularis using an equine proliferative enteropathy challenge (EPE) model.

A E Page et al.

Veterinary immunology and immunopathology, 143(1-2), 55-65 (2011-07-02)

Lawsonia intracellularis is the etiological agent of infectious intestinal hyperplasia for which several clinical diseases have been described including proliferative enteropathy (PE), intestinal adenomatosis, and ileitis. While initially recognized as the causative agent of PE in pigs, L. intracellularis is

Recombinant Protein Containing B-Cell Epitopes of Different Loxosceles Spider Toxins Generates Neutralizing Antibodies in Immunized Rabbits.

Sabrina de Almeida Lima et al.

Frontiers in immunology, 9, 653-653 (2018-04-19)

Loxoscelism is the most important form of araneism in South America. The treatment of these accidents uses heterologous antivenoms obtained from immunization of production animals with crude loxoscelic venom. Due to the scarcity of this immunogen, new alternatives for its

Unveiling toxicological aspects of venom from the Aesculapian False Coral Snake Erythrolamprus aesculapii.

Matías N Sánchez et al.

Toxicon : official journal of the International Society on Toxinology, 164, 71-81 (2019-04-19)

Most colubrid snake venoms have been poorly studied, despite the fact that they represent a great resource for biological, ecological, toxinological and pharmacological research. Herein, we explore the venom delivery system of the Aesculapian False Coral Snake Erythrolamprus aesculapii as

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