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Rabea Dettmer et al.
Current protocols in stem cell biology, 54(1), e116-e116 (2020-07-07)
During the past decade, RNA-guided Cas9 nuclease from microbial clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has become a powerful tool for gene editing of human pluripotent stem cells (PSCs). Using paired CRISPR/Cas9 nickases (CRISPR/Cas9n) it is furthermore possible to
Cheng Ma et al.
Journal of natural products, 74(1), 32-37 (2010-12-17)
New N-hydroxypyridones, militarinones E (1) and F (2), phenylhydrazones, farylhydrazones A (3) and B (4), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (5), and the known militarinones A (6) and B (7) were isolated from cultures of the Cordyceps-colonizing fungus Isaria farinosa. The structures
Sailendharan Sudakaran et al.
The ISME journal, 9(12), 2587-2604 (2015-05-30)
Evolutionary adaptations for the exploitation of nutritionally challenging or toxic host plants represent a major force driving the diversification of phytophagous insects. Although symbiotic bacteria are known to have essential nutritional roles for insects, examples of radiations into novel ecological
Cécile Denève et al.
Antimicrobial agents and chemotherapy, 53(12), 5155-5162 (2009-10-07)
Recent outbreaks of Clostridium difficile infection have been related to the emergence of the NAP1/027 epidemic strain. This strain demonstrates increased virulence and resistance to the C-8-methoxyfluoroquinolones gatifloxacin and moxifloxacin. These antibiotics have been implicated as major C. difficile infection-inducing
Hartmut M Lode
International journal of antimicrobial agents, 32(1), 10-28 (2008-06-10)
In the current context of increasing antimicrobial resistance, it is important to use antibiotics rationally and to re-assess regularly the clinical usefulness of commonly used agents. This review focuses on the efficacy of the beta-lactam ampicillin co-administered with the beta-lactamase
Cathy C Webb et al.
International journal of food microbiology, 207, 71-76 (2015-05-23)
Freshly harvested Eastern variety cantaloupes (Cucumis melo L. var. reticulatus cv. Athena) were subjected to three different harvest and wash treatments to examine conditions under which the efficacy of the sanitizer, levulinic acid (LV) plus sodium dodecyl sulfate (SDS), could
Alejandro Beceiro et al.
Antimicrobial agents and chemotherapy, 53(3), 1177-1184 (2008-11-26)
As a part of a nationwide study in Spain, 15 clinical isolates of Acinetobacter genomic species 3 (AG3) were analyzed. The main objective of the study was to characterize the ampC genes from these isolates and to determine their involvement
Ju-Eun Jeon et al.
Journal of natural products, 73(2), 258-262 (2010-01-09)
Two new pyrroloiminoquinone alkaloids of the discorhabdin class, along with 12 compounds including one previously described synthetic derivative of the same and related skeletal classes, were isolated from the sponge Sceptrella sp., collected from Gageodo, Korea. The structures of these
Sabine Renggli et al.
Journal of bacteriology, 195(18), 4067-4073 (2013-07-10)
Bactericidal antibiotics kill by different mechanisms as a result of a specific interaction with their cellular targets. Over the past few years, alternative explanations for cidality have been proposed based on a postulated common pathway, depending on the intracellular production
Rita T Ferreira et al.
Biology open, 4(9), 1122-1131 (2015-08-16)
Adaptation of Saccharomyces cerevisiae cells to arsenic stress is mediated through the activation of arsenic detoxification machinery by the Yap8 transcription factor. Yap8 is targeted by the ubiquitin proteasome system for degradation under physiological conditions, yet it escapes proteolysis in
Oya Bozdağ-Dündar et al.
Bioorganic & medicinal chemistry, 15(18), 6012-6017 (2007-07-10)
In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives (Va-f and VIa-f) were synthesized and evaluated for their antibacterial and antifungal activities against Staphylococcus aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), methicillin resistant S. aureus (MRSA isolate)
Li-Li Li et al.
ACS nano, 8(5), 4975-4983 (2014-04-11)
The treatment of bacterial infection is one of the most challenging tasks in the biomedical field. Antibiotics were developed over 70 years and are regarded as the most efficient type of drug to treat bacterial infection. However, there is a
B F Simões et al.
Journal of evolutionary biology, 28(7), 1309-1320 (2015-05-28)
The dominant hypothesis for the evolutionary origin of snakes from 'lizards' (non-snake squamates) is that stem snakes acquired many snake features while passing through a profound burrowing (fossorial) phase. To investigate this, we examined the visual pigments and their encoding
Gro Elin Kjæreng Bjerga et al.
BMC biotechnology, 15, 78-78 (2015-08-20)
Heterologous expression of psychrophilic enzymes in E. coli is particularly challenging due to their intrinsic instability. The low stability is regarded as a consequence of adaptation that allow them to function at low temperatures. Recombinant production presents a significant barrier
Andra Teodor et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(3), 808-811 (2013-01-01)
Listeriosis is a rare food borne infection which, in the invasive form, presents as bloodstream infection, central nervous system infection, materno-fetal infection, or focal infection. Certain immunosuppressive conditions have been identified as risk factors for severe invasive disease. The invasive
Danielle L Sexton et al.
Journal of bacteriology, 197(5), 848-860 (2014-12-17)
Dormancy is a common strategy adopted by bacterial cells as a means of surviving adverse environmental conditions. For Streptomyces bacteria, this involves developing chains of dormant exospores that extend away from the colony surface. Both spore formation and subsequent spore
Woon Ju Song et al.
Science (New York, N.Y.), 346(6216), 1525-1528 (2014-12-20)
The generation of new enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds because of the challenge in designing functional, three-dimensional protein structures from first principles. Here we report an artificial metallo-β-lactamase, constructed via the self-assembly
Jitendra Keshri et al.
Microbiological research, 175, 57-66 (2015-04-12)
The Gulf of Cambay is a trumpet-shaped inlet of the Arabian Sea, located along the west coast of India and confronts a high tidal range with strong water currents. The region belongs to a semi-arid zone and saline alkaline intertidal
In Young Hwang et al.
Biomolecules & therapeutics, 23(5), 458-464 (2015-09-04)
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of HCl•EtOH-induced gastritis
Emi Hifumi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2347-2358 (2015-02-26)
Catalytic antibodies have exhibited interesting functions against some infectious viruses such as HIV, rabies virus, and influenza virus in vitro as well as in vivo. In some cases, a catalytic antibody light chain takes on several structures from the standpoint
Jinbin Zhai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(24), 9088-9105 (2015-06-19)
Mutant genes that underlie Mendelian forms of amyotrophic lateral sclerosis (ALS) and biochemical investigations of genetic disease models point to potential driver pathophysiological events involving endoplasmic reticulum (ER) stress and autophagy. Several steps in these cell biological processes are known
Leonard Chavez et al.
PLoS pathogens, 11(6), e1004955-e1004955 (2015-06-13)
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus (HIV) replication to undetectable levels but cannot fully eradicate the virus because a small reservoir of CD4+ T cells remains latently infected. Since HIV efficiently infects only activated CD4+ T cells
H F Goh et al.
Journal of dairy science, 98(8), 5080-5090 (2015-05-26)
Lactic acid bacteria are present in fermented food products and help to improve shelf life and enhance the flavor of the food. They also produce metabolites such as bacteriocins to prevent the growth of undesirable or pathogenic bacteria. In this
Junying Ma et al.
Antimicrobial agents and chemotherapy, 53(2), 519-524 (2008-10-22)
Three kinds of plasmid-mediated quinolone resistance (PMQR) determinants have been discovered and have been shown to be widely distributed among clinical isolates: qnr genes, aac(6')-Ib-cr, and qepA. Few data on the prevalence of these determinants in strains from animals are
Jason Kindrachuk et al.
Antimicrobial agents and chemotherapy, 51(12), 4374-4381 (2007-10-17)
Antimicrobial peptides (AMPs) are among the leading candidates to replace antibiotics which have been rendered ineffective by the evolution of resistant bacterial strains. Concerns do exist, however, that the therapeutic administration of AMPs may also select for resistant strains but
Wei Zhang et al.
Applied and environmental microbiology, 80(13), 3972-3981 (2014-04-22)
Pseudomonas fluorescens 2P24 is a soilborne bacterium that synthesizes and excretes multiple antimicrobial metabolites. The polyketide compound 2,4-diacetylphloroglucinol (2,4-DAPG), synthesized by the phlACBD locus, is its major biocontrol determinant. This study investigated two mutants defective in antagonistic activity against Rhizoctonia
Yan Zhang et al.
Molecules (Basel, Switzerland), 20(11), 20939-20954 (2015-11-28)
Increased transcriptional levels of genes encoding antioxidant enzymes play important protective roles in coping with excessive accumulation of reactive oxygen species (ROS) in plants exposed to various abiotic stresses. To fully elucidate different evolutions and functions of ROS-scavenging enzymatic genes
Suraj Konnath George et al.
Oncotarget, 5(14), 5750-5763 (2014-07-16)
NPM-ALK⁺ T-cell anaplastic large-cell lymphoma (ALCL) is an aggressive type of cancer. Standard treatment of NPM-ALK⁺ ALCL is CHOP polychemotherapy. Although patients initially respond favorably to CHOP, resistance, relapse, and death frequently occur. Recently, selective targeting of ALK has emerged
M J Lott et al.
Experimental parasitology, 144, 76-83 (2014-06-28)
Identifying factors which regulate temporal and regional structuring within parasite assemblages requires the development of non-invasive techniques which facilitate both the rapid discrimination of individual parasites and the capacity to monitor entire parasite communities across time and space. To this
Su-Hyun Mun et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(8-9), 714-718 (2013-03-30)
Methicillin-resistant Staphylococcus aureus (MRSA) are spread among infected patients, with infection rates increasing at an alarming rate. Furthermore, increased resistance to antibiotics has resulted in serious challenges in the treatment of infectious diseases worldwide. Under the selection pressure of exposure
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