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Dongchang Xiao et al.
Frontiers in molecular neuroscience, 11, 271-271 (2018-08-22)
During mammalian retinal development, the multipotent progenitors differentiate into all classes of retinal cells under the delicate control of transcriptional factors. The deficiency of a transcription cofactor, the LIM-domain binding protein Ldb1, has been shown to cause proliferation and developmental
Rui Zhu et al.
Cancer research, 70(18), 7264-7272 (2010-08-26)
Testicular germ cell tumors (TGCT) originate from germ cells. The 129-Ter and M19 (129.MOLF-Chr19 consomic) mouse strains have extremely high incidences of TGCTs. We found that the expression levels of Sf1-encoded splicing factor 1 (SF1) can modulate the incidence of
Shohei Yoshimoto et al.
Disease models & mechanisms, 13(9) (2020-08-18)
Hyposalivation and xerostomia are the cause of several morbidities, such as dental caries, painful mucositis, oral fungal infections, sialadenitis and dysphagia. For these reasons, preservation of normal saliva secretion is critical for the maintenance of functionally normal oral homeostasis and
Adam J Lundquist et al.
Journal of neuroscience research, 97(9), 1081-1094 (2019-06-09)
Astrocytes are essential mediators of many aspects of synaptic transmission and neuroplasticity. Exercise has been demonstrated to induce neuroplasticity and synaptic remodeling, such as through mediating neurorehabilitation in animal models of neurodegeneration. However, the effects of exercise on astrocytic function
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Michael Curley et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 978-995 (2018-08-07)
Testicular Leydig cells (LCs) are the primary source of circulating androgen in men. As men age, circulating androgen levels decline. However, whether reduced LC steroidogenesis results from specific effects of aging within LCs or reflects degenerative alterations to the wider
Xuehui Hong et al.
Nucleic acids research, 44(18), 8855-8869 (2016-08-28)
SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to
Kathleen M Capaccione et al.
Oncotarget, 5(11), 3636-3650 (2014-07-09)
Sox9 has gained increasing importance both functionally and as a prognostic factor in cancer. We demonstrate a functional role for Sox9 in inducing a mesenchymal phenotype in lung ADC. We show that Sox9 mRNA and protein are overexpressed in lung
Mandayam O Nandan et al.
Developmental biology, 387(2), 191-202 (2014-01-21)
Krüppel-like factor 5 (KLF5) is a pro-proliferative transcriptional regulator primarily expressed in the intestinal crypt epithelial cells. Constitutive intestine-specific deletion of Klf5 is neonatal lethal suggesting a crucial role for KLF5 in intestinal development and homeostasis. We have previously shown
Katharina Debowski et al.
PloS one, 10(3), e0118424-e0118424 (2015-03-19)
Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS) cells, could be
Jean-Christophe Larsimont et al.
Cell stem cell, 17(1), 60-73 (2015-06-23)
Sox9 is a transcription factor expressed in most solid tumors. However, the molecular mechanisms underlying Sox9 function during tumorigenesis remain unclear. Here, using a genetic mouse model of basal cell carcinoma (BCC), the most frequent cancer in humans, we show
Tobias Bohnenpoll et al.
Developmental biology, 380(1), 25-36 (2013-05-21)
The mammalian urogenital system derives from multipotent progenitor cells of different germinal tissues. The contribution of individual sub-populations to specific components of the mature system, and the spatiotemporal restriction of the respective lineages have remained poorly characterized. Here, we use
Anna Kuta et al.
Development (Cambridge, England), 143(13), 2367-2375 (2016-07-07)
The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, including development of the vertebrae. Based on conservation of function between Drosophila and mammals, Fat4-Dchs1 signalling has been proposed to regulate
Diaa Massoud et al.
PloS one, 13(10), e0204851-e0204851 (2018-10-05)
Testes of seasonally breeding species experience a severe functional regression before the non-breeding period, which implies a substantial mass reduction due to massive germ-cell depletion. Two alternative mechanisms of seasonal germ-cell depletion have been described in mammals, apoptosis and desquamation
Anissa Elahi et al.
Cells, 10(11) (2021-11-28)
Following CNS injury, astrocytes become "reactive" and exhibit pro-regenerative or harmful properties. However, the molecular mechanisms that cause astrocytes to adopt either phenotype are not well understood. Transglutaminase 2 (TG2) plays a key role in regulating the response of astrocytes
Yoshiaki Ito et al.
Nature communications, 12(1), 4148-4148 (2021-07-08)
Osteoarthritis (OA), the most common aging-related joint disease, is caused by an imbalance between extracellular matrix synthesis and degradation. Here, we discover that both strands of microRNA-455 (miR-455), -5p and -3p, are up-regulated by Sox9, an essential transcription factor for
John J Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(30), E3091-E3100 (2014-07-16)
Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical studies have suggested a therapeutic benefit of targeting the Hedgehog (Hh) signaling pathway, which is activated throughout the course
Theodora Yung et al.
Nature communications, 10(1), 4647-4647 (2019-10-13)
Human embryonic stem cell-derived beta cells offer a promising cell-based therapy for diabetes. However, efficient stem cell to beta cell differentiation has proven difficult, possibly due to the lack of cross-talk with the appropriate mesenchymal niche. To define organ-specific niche
Zhilin Liu et al.
Molecular endocrinology (Baltimore, Md.), 29(7), 1006-1024 (2015-06-11)
The forkhead box (FOX), FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown here
Julia Eymann et al.
Frontiers in cell and developmental biology, 8, 406-406 (2020-06-18)
The retina is a complex tissue responsible for both detection and primary processing of visual stimuli. Although all vertebrate retinas share a similar, multi-layered organization, the ability to regenerate individual retinal cells varies tremendously, being extremely limited in mammals and
Jianjun Hu et al.
PloS one, 9(2), e89352-e89352 (2014-02-20)
Humans who harbor loss of function mutations in the actin-associated filamin B (FLNB) gene develop spondylocarpotarsal syndrome (SCT), a disorder characterized by dwarfism (delayed bone formation) and premature fusion of the vertebral, carpal and tarsal bones (premature differentiation). To better
Gorka Ruiz de Garibay et al.
PloS one, 10(7), e0132546-e0132546 (2015-07-15)
Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target
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Daniel R Chang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(45), 18042-18051 (2013-09-24)
Mammalian organs, including the lung and kidney, often adopt a branched structure to achieve high efficiency and capacity of their physiological functions. Formation of a functional lung requires two developmental processes: branching morphogenesis, which builds a tree-like tubular network, and
Jennifer C Jones et al.
Cellular and molecular gastroenterology and hepatology, 7(3), 533-554 (2019-03-05)
Loss of leucine-rich repeat-containing G-protein-coupled receptor 5-positive crypt base columnar cells provides permissive conditions for different facultative stem cell populations to dedifferentiate and repopulate the stem cell compartment. In this study, we used a defensin α4-Cre recombinase (Defa4Cre) line to
FSH and its second messenger cAMP stimulate the transcription of human anti-Mullerian hormone in cultured granulosa cells.
Taieb, J; Grynberg, M; Pierre, A; Arouche, N; Massart, P; Belville, C; Hesters et al.
Molecular Endocrinology null
Valérie Grandjean et al.
Development (Cambridge, England), 136(21), 3647-3655 (2009-10-13)
The size of the mammalian body is determined by genetic and environmental factors differentially modulating pre- and postnatal growth. We now report a control of growth acting in the mouse from the first cleavages to the postnatal stages. It was
Xin Wang et al.
Cell research, 30(12), 1109-1126 (2020-07-22)
During embryogenesis, the liver is the site of hepatogenesis and hematopoiesis and contains many cell lineages derived from the endoderm and mesoderm. However, the characteristics and developmental programs of many of these cell lineages remain unclear, especially in humans. Here
Katherine Martin et al.
Nature communications, 7, 12502-12502 (2016-08-19)
Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely understood, and
Diane Rebourcet et al.
Endocrinology, 157(6), 2479-2488 (2016-05-05)
The testicular vasculature forms a complex network, providing oxygenation, micronutrients, and waste clearance from the testis. The vasculature is also instrumental to testis function because it is both the route by which gonadotropins are delivered to the testis and by
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