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Rui Zhu et al.
Cancer research, 70(18), 7264-7272 (2010-08-26)
Testicular germ cell tumors (TGCT) originate from germ cells. The 129-Ter and M19 (129.MOLF-Chr19 consomic) mouse strains have extremely high incidences of TGCTs. We found that the expression levels of Sf1-encoded splicing factor 1 (SF1) can modulate the incidence of
Adam J Lundquist et al.
Journal of neuroscience research, 97(9), 1081-1094 (2019-06-09)
Astrocytes are essential mediators of many aspects of synaptic transmission and neuroplasticity. Exercise has been demonstrated to induce neuroplasticity and synaptic remodeling, such as through mediating neurorehabilitation in animal models of neurodegeneration. However, the effects of exercise on astrocytic function
Seo-Hee Cho et al.
BMC ophthalmology, 16(1), 193-193 (2016-11-05)
Mutations of Crb1 gene cause irreversible and incurable visual impairment in humans. This study aims to use an LCA8-like mouse model to identify host-mediated responses that might interfere with survival, retinal integration and differentiation of grafted cells during neonatal cell
Jean-Christophe Larsimont et al.
Cell stem cell, 17(1), 60-73 (2015-06-23)
Sox9 is a transcription factor expressed in most solid tumors. However, the molecular mechanisms underlying Sox9 function during tumorigenesis remain unclear. Here, using a genetic mouse model of basal cell carcinoma (BCC), the most frequent cancer in humans, we show
Yoshiaki Ito et al.
Nature communications, 12(1), 4148-4148 (2021-07-08)
Osteoarthritis (OA), the most common aging-related joint disease, is caused by an imbalance between extracellular matrix synthesis and degradation. Here, we discover that both strands of microRNA-455 (miR-455), -5p and -3p, are up-regulated by Sox9, an essential transcription factor for
Anissa Elahi et al.
Cells, 10(11) (2021-11-28)
Following CNS injury, astrocytes become "reactive" and exhibit pro-regenerative or harmful properties. However, the molecular mechanisms that cause astrocytes to adopt either phenotype are not well understood. Transglutaminase 2 (TG2) plays a key role in regulating the response of astrocytes
Peiyin Yang et al.
PeerJ, 9, e11545-e11545 (2021-06-19)
The CCT complex is an important mediator of microtubule assembly and intracellular protein folding. Owing to its high expression in spermatids, CCT knockdown can disrupt spermatogenesis. In the present report, we therefore evaluated the in vivo functionality of the testis-specific
Longchang Xu et al.
Cell death & disease, 8(5), e2795-e2795 (2017-05-19)
Spermatogenesis, the process by which haploid sperm cells are produced from a diploid precursor cell, is essential for sexual reproduction. Here, we report that RING-finger protein 138 (Rnf138) is highly expressed in testes, especially in spermatogonia and spermatocytes. The role
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Attya Omer Javed et al.
Cell reports, 25(2), 368-382 (2018-10-12)
Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the phenotype remains brain specific is poorly understood. In this study, we used in vitro differentiation of human
Yue Xue et al.
Molecular cancer research : MCR, 17(1), 238-249 (2018-09-13)
The presence of cancer stem cells (CSC), which possess the ability of self-renewal and cancer initiation, is correlated with poor prognosis and drug resistance of breast cancer patients. But the molecular regulatory networks for maintenance of CSC function still remain
Katherine Martin et al.
Nature communications, 7, 12502-12502 (2016-08-19)
Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely understood, and
Xuehui Hong et al.
Nucleic acids research, 44(18), 8855-8869 (2016-08-28)
SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to
Kathleen M Capaccione et al.
Oncotarget, 5(11), 3636-3650 (2014-07-09)
Sox9 has gained increasing importance both functionally and as a prognostic factor in cancer. We demonstrate a functional role for Sox9 in inducing a mesenchymal phenotype in lung ADC. We show that Sox9 mRNA and protein are overexpressed in lung
Laura A Galvis et al.
Development (Cambridge, England), 142(8), 1458-1469 (2015-03-21)
Epigenetic mechanisms involved in the establishment of lung epithelial cell lineage identities during development are largely unknown. Here, we explored the role of the histone methyltransferase Ezh2 during lung lineage determination. Loss of Ezh2 in the lung epithelium leads to
Angel C Y Mak et al.
Gene expression patterns : GEP, 9(6), 444-453 (2009-05-12)
The development of the inner ear involves complex processes of morphological changes, patterning and cell fate specification that are under strict molecular control. SOX2 and SOX9 are SOX family transcription factors that are involved in the regulation of one or
Michael Curley et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 978-995 (2018-08-07)
Testicular Leydig cells (LCs) are the primary source of circulating androgen in men. As men age, circulating androgen levels decline. However, whether reduced LC steroidogenesis results from specific effects of aging within LCs or reflects degenerative alterations to the wider
Elizabeth Oliver et al.
BMC biology, 19(1), 212-212 (2021-09-25)
Advances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro. Despite demonstrating basic functionality, tissue organisation is often limited. We have previously detailed a three-dimensional culture model termed the three-layer gradient
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
Elvidge, GP; Glenny, L; Appelhoff, RJ; Ratcliffe, PJ; Ragoussis, J; Gleadle, JM
The Journal of Biological Chemistry null
Wei Zheng et al.
Genes, 10(12) (2019-11-30)
Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade
Elisabetta Lambertini et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 51(5), 2237-2249 (2018-12-12)
Mesenchymal stromal cells (MSCs) hold considerable promise in bone tissue engineering, but their poor survival and potency when in vivo implanted limits their therapeutic potential. For this reason, the study on culture conditions and cellular signals that can influence the
Mandayam O Nandan et al.
Developmental biology, 387(2), 191-202 (2014-01-21)
Krüppel-like factor 5 (KLF5) is a pro-proliferative transcriptional regulator primarily expressed in the intestinal crypt epithelial cells. Constitutive intestine-specific deletion of Klf5 is neonatal lethal suggesting a crucial role for KLF5 in intestinal development and homeostasis. We have previously shown
Katharina Debowski et al.
PloS one, 10(3), e0118424-e0118424 (2015-03-19)
Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS) cells, could be
Mi Chen et al.
Stem cell research & therapy, 12(1), 232-232 (2021-04-14)
Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signaling pathway network involved in CSC division remains elusive. FXR
John J Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(30), E3091-E3100 (2014-07-16)
Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical studies have suggested a therapeutic benefit of targeting the Hedgehog (Hh) signaling pathway, which is activated throughout the course
Tobias Bohnenpoll et al.
Developmental biology, 380(1), 25-36 (2013-05-21)
The mammalian urogenital system derives from multipotent progenitor cells of different germinal tissues. The contribution of individual sub-populations to specific components of the mature system, and the spatiotemporal restriction of the respective lineages have remained poorly characterized. Here, we use
Anna Kuta et al.
Development (Cambridge, England), 143(13), 2367-2375 (2016-07-07)
The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, including development of the vertebrae. Based on conservation of function between Drosophila and mammals, Fat4-Dchs1 signalling has been proposed to regulate
Diaa Massoud et al.
PloS one, 13(10), e0204851-e0204851 (2018-10-05)
Testes of seasonally breeding species experience a severe functional regression before the non-breeding period, which implies a substantial mass reduction due to massive germ-cell depletion. Two alternative mechanisms of seasonal germ-cell depletion have been described in mammals, apoptosis and desquamation
Shohei Yoshimoto et al.
Disease models & mechanisms, 13(9) (2020-08-18)
Hyposalivation and xerostomia are the cause of several morbidities, such as dental caries, painful mucositis, oral fungal infections, sialadenitis and dysphagia. For these reasons, preservation of normal saliva secretion is critical for the maintenance of functionally normal oral homeostasis and
Heather K Schofield et al.
Cellular and molecular gastroenterology and hepatology, 5(2), 169-185 (2018-04-26)
Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α. Previous studies of HIF action in the pancreas have
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