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AMPD1

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Renee W Y Chan et al.
Antimicrobial agents and chemotherapy, 53(9), 3935-3941 (2009-07-15)
DAS181 is a novel candidate therapeutic agent against influenza virus which functions via the mechanism of removing the virus receptor, sialic acid (Sia), from the adjacent glycan structures. DAS181 and its analogues have previously been shown to be potently active...
Marcelo B de Jesus et al.
Journal of biomedical nanotechnology, 10(2), 355-365 (2014-04-18)
Solid lipid nanoparticles (SLNs) are a promising system for the delivery of lipophilic and hydrophilic drugs. They consist of a solid lipid core that is stabilized by a layer of surfactants. By the incorporation of cationic lipids in the formulation...
Xian-Jun Liang et al.
Molecular vision, 18, 1649-1657 (2012-07-10)
Vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen, and has been associated with angiogenesis. Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, which can induce VEGF expression. The aims of the present study were...
Dhruti Savalia et al.
Journal of molecular biology, 377(3), 774-789 (2008-02-26)
A novel bacteriophage infecting Escherichia coli was isolated during a large-scale screen for bacteriophages that may be used for therapy of mastitis in cattle. The 77,554-bp genome of the bacteriophage, named phiEco32, was sequenced and annotated, and its virions were...
Julia Simon-Areces et al.
PloS one, 6(7), e21825-e21825 (2011-08-06)
Neurogenin3, a proneural transcription factor controlled by Notch receptor, has been recently shown to regulate dendritogenesis and synaptogenesis in mouse hippocampal neurons. However, little is known about the molecular mechanisms involved in these actions of Ngn3. We have used a...
Karina Lindner et al.
Particle and fibre toxicology, 14(1), 8-8 (2017-03-23)
Carbon black nanoparticles (CBNP) are mainly composed of carbon, with a small amount of other elements (including hydrogen and oxygen). The toxicity of CBNP has been attributed to their large surface area, and through adsorbing intrinsically toxic substances, such as...
R Kaminski et al.
Gene therapy, 23(8-9), 690-695 (2016-05-20)
A CRISPR/Cas9 gene editing strategy has been remarkable in excising segments of integrated HIV-1 DNA sequences from the genome of latently infected human cell lines and by introducing InDel mutations, suppressing HIV-1 replication in patient-derived CD4+ T-cells, ex vivo. Here...
A Benard et al.
British journal of cancer, 109(12), 3073-3083 (2013-11-14)
We evaluated the clinical prognostic value of methylation of two non-coding repeat sequences, long interspersed element 1 (LINE-1) and Alu, in rectal tumour tissues. In addition to DNA methylation, expression of histone modifications H3K27me3 and H3K9Ac was studied in this...
Seth T Scanlon et al.
The Journal of experimental medicine, 208(10), 2113-2124 (2011-09-21)
Airborne exposure to microbial cell wall lipids such as lipopolysaccharide triggers innate immune responses that regulate susceptibility to allergic airway inflammation. α-Glycosylceramides represent another widespread class of microbial lipids that directly stimulate innate-like, IL-4- and IL-13-producing, CD1d-restricted NKT cells. In...
Peethambaran Divya et al.
Food research international (Ottawa, Ont.), 111, 11-19 (2018-07-17)
Coriander (Coriandrum sativum L.), a commonly used annual herb that accumulates carotenoids upon methyl jasmonate (MeJA) treatment, provides an excellent model to investigate carotenogenesis and gene regulation. To explore key mechanisms involved in enhancing carotenoids, transcriptional expression profile of ten...
Lepakshi Ranjha et al.
The Journal of biological chemistry, 289(9), 5674-5686 (2014-01-21)
MutLγ, a heterodimer of the MutL homologues Mlh1 and Mlh3, plays a critical role during meiotic homologous recombination. The meiotic function of Mlh3 is fully dependent on the integrity of a putative nuclease motif DQHAX2EX4E, inferring that the anticipated nuclease...
Laurence Colin et al.
Methods in molecular biology (Clifton, N.J.), 1087, 85-101 (2013-10-26)
Upon integration into the host cell genome, the nucleosomal organization and epigenetic control of the HIV-1 provirus play an active role in its transcriptional regulation. Therefore, characterization of the chromatin changes that occur in the viral promoter region in response...
Juan Carlos Rivera-Mulia et al.
BMC cell biology, 12, 3-3 (2011-01-20)
In the interphase nucleus of metazoan cells DNA is organized in supercoiled loops anchored to a nuclear matrix (NM). There is varied evidence indicating that DNA replication occurs in replication factories organized upon the NM and that DNA loops may...
Suneeta Tumati et al.
The Journal of pharmacology and experimental therapeutics, 330(3), 810-817 (2009-06-06)
Studies have shown that long-term (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-mediated pain sensitization are not fully understood. It was shown previously (J Neurosci 22:6747-6755, 2002) that sustained...
Oriol A Rangel-Zuñiga et al.
European journal of nutrition, 56(4), 1597-1607 (2016-03-27)
Using sunflower oil as frying oil increases postprandial oxidative stress, which is considered the main endogenous source of DNA oxidative damage. We aimed to test whether the protective effect of virgin olive oil and oil models with added antioxidants against...
Leonie Doorduin et al.
DNA research : an international journal for rapid publication of reports on genes and genomes, 18(2), 93-105 (2011-03-30)
Invasive individuals from the pest species Jacobaea vulgaris show different allocation patterns in defence and growth compared with native individuals. To examine if these changes are caused by fast evolution, it is necessary to identify native source populations and compare...
Hualin Li et al.
Journal of virology, 85(21), 11007-11015 (2011-09-16)
The induction of potent and durable cellular immune responses in both peripheral and mucosal tissues may be important for the development of effective vaccines against human immunodeficiency virus type 1 and other pathogens. In particular, effector responses at mucosal surfaces...
Kristin Robinson et al.
PloS one, 4(6), e5951-e5951 (2009-06-26)
c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown. Here, we show that c-Myc overexpression in primary human...
Brian T Edelson et al.
PloS one, 6(10), e25660-e25660 (2011-11-09)
Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors. Lymphoid-tissue resident CD8α(+) conventional DCs (cDCs) and CD11b(low/-)CD103(+) non-lymphoid DCs are developmentally related, each being dependent on FMS-like tyrosine...
Rahel D May et al.
Neurospine, 17(1), 77-87 (2020-04-07)
Spinal fusion surgery is a common treatment modality for various pathologic conditions of the spine. The bone morphogenetic protein 2 (BMP2) analogue L51P acts as a general inhibitor of BMP antagonists, whereas it shows a weak affinity for BMP type...
Masaaki Murakami et al.
The Journal of experimental medicine, 208(1), 103-114 (2011-01-12)
Cognate antigen recognition by CD4(+) T cells is thought to contribute to the tissue specificity of various autoimmune diseases, particularly those associated with class II MHC alleles. However, we show that localized class II MHC-dependent arthritis in F759 mice depends...
Wataru Fujii et al.
Biochemical and biophysical research communications, 445(4), 791-794 (2014-02-05)
The mammalian zygote-mediated CRISPR/Cas system can efficiently generate targeted genome-modified animals. However, this system is limited by the risk of off-target mutations. Here we show that offset-nicking by Cas9 nickase and paired gRNAs allows us to generate region deleted mice...
Florence Teulé et al.
Nature protocols, 4(3), 341-355 (2009-02-21)
The extreme strength and elasticity of spider silks originate from the modular nature of their repetitive proteins. To exploit such materials and mimic spider silks, comprehensive strategies to produce and spin recombinant fibrous proteins are necessary. This protocol describes silk...
Misuzu Ueki et al.
DNA and cell biology, 33(2), 79-87 (2013-12-18)
Many nonsynonymous single-nucleotide polymorphisms (SNPs) in the human deoxyribonuclease I-like 1 (DNase 1L1) gene, possibly implicated in the blocking of endocytosis-mediated foreign gene transfer, have been identified, but only limited population data are available and no studies have evaluated whether...
Liliana Íñiguez-Gutiérrez et al.
International journal of immunopathology and pharmacology, 34, 2058738420958949-2058738420958949 (2020-12-30)
Neutrophils represent the first line of host cellular defense against various pathogens. The most recently described microbicidal mechanism of these cells is the release of neutrophil extracellular traps (NET). Currently, a wide range of chemical and biological stimuli are known...
María Sumampa Coria et al.
Asian-Australasian journal of animal sciences, 33(5), 753-762 (2019-09-05)
The aim of the present study was to determine the effect of supplementing pasture-finished steers with corn silage on the expression level of the calpain system proteins and beef tenderization. Thirty Braford steers grazing on summer pasture were used for...
Francisco M Gutierrez-Mariscal et al.
Molecular nutrition & food research, 65(1), e1901290-e1901290 (2020-06-13)
It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. Patients from CORDIOPREV study, all with previous cardiovascular events, with...
Housheng Hansen He et al.
Nature methods, 11(1), 73-78 (2013-12-10)
Sequencing of DNase I hypersensitive sites (DNase-seq) is a powerful technique for identifying cis-regulatory elements across the genome. We studied the key experimental parameters to optimize performance of DNase-seq. Sequencing short fragments of 50-100 base pairs (bp) that accumulate in...
Ioanna Tzani et al.
Biotechnology and bioengineering, 117(8), 2489-2503 (2020-04-30)
RNA sequencing (RNASeq) has been widely used to associate alterations in Chinese hamster ovary (CHO) cell gene expression with bioprocess phenotypes; however, alternative messenger RNA (mRNA) splicing, has thus far, received little attention. In this study, we utilized RNASeq for...
Nian Huang et al.
Structure (London, England : 1993), 17(7), 939-951 (2009-07-17)
Besides its function as an essential redox cofactor, nicotinamide adenine dinucleotide (NAD) also serves as a consumable substrate for several reactions with broad impact on many cellular processes. NAD homeostasis appears to be tightly controlled, but the mechanism of its...
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