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Wei Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5867-5877 (2013-03-29)
Although the contribution of postsynaptic mechanisms to long-term synaptic plasticity has been studied extensively, understanding the contribution of presynaptic modifications to this process lags behind, primarily because of a lack of techniques with which to directly and quantifiably measure neurotransmitter
T I El-Hajj et al.
Neuropediatrics, 39(5), 268-271 (2009-03-19)
Biotin-responsive basal ganglia disease is a rare entity of which 10 cases have been reported in the literature. We report a case of biotin-responsive basal ganglia disease with similarities and differences compared to the previously reported cases by Ozand et
Timothy Sanchez et al.
Methods in enzymology, 524, 205-224 (2013-03-19)
From motility of simple protists to determining the handedness of complex vertebrates, highly conserved eukaryotic cilia and flagella are essential for the reproduction and survival of many biological organisms. Despite extensive studies, the exact mechanism by which individual components coordinate
Konstantina Papadia et al.
Journal of biomedical nanotechnology, 10(5), 871-876 (2014-04-17)
The biotin-Streptavidin (STREP) technique for attachment of monoclonal antibodies (mAbs) (or other ligand types) on liposome surface offers high attachment yield, however it is time consuming and expensive due to the number of steps used and the consumption of large
Pascal Loyer et al.
International journal of pharmaceutics, 454(2), 727-737 (2013-06-12)
Amphiphilic derivatives of poly(benzyl malate) were synthesized and characterized with the aim of being used as degradable and biocompatible building blocks for the design of functional nanoparticles (NPs). An anti-cancer model drug, doxorubicin, has been successfully encapsulated into the prepared
Ria M Cooke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5626-5637 (2013-03-29)
Nitric oxide (NO) is an important signaling molecule with a variety of functions in the CNS, including a potential role in modulating neuronal growth and synapse formation. In the present study, we used tractable, identified neurons in the CNS of
D Wang et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(3-4), 179-189 (2008-10-11)
Angiogenesis, or neovascularization, is known to play an important role in the neoplastic progression leading to metastasis. CD31 or Factor VIII-related antigen (F VIII RAg) immunohistochemistry is widely used in experimental studies for quantifying tumor neovascularization in immunocompromised animal models
Poorni R Adikaram et al.
Journal of molecular biology, 425(22), 4584-4594 (2013-07-31)
Protein partner exchange plays a key role in regulating many biological switches. Although widespread, the mechanisms dictating protein partner identity and, therefore, the outcome of a switch have been determined for a limited number of systems. The Escherichia coli protein
Wei Ren et al.
Biosensors & bioelectronics, 49, 380-386 (2013-06-29)
A versatile flow cytometric bead assay (CBA) is developed for sensitive DNA detection by integrating the advantages of hybridization chain reaction (HCR) for enzyme-free signal amplification, flow cytometry for robust and rapid signal readout as well as magnetic beads (MBs)
Determination of biotin levels in cerebrospinal fluid samples.
E Livaniou et al.
Journal of pharmaceutical and biomedical analysis, 21(4), 875-879 (2000-03-04)
Adam D Lietzan et al.
Archives of biochemistry and biophysics, 544, 75-86 (2013-11-05)
Biotin-dependent enzymes catalyze carboxylation, decarboxylation and transcarboxylation reactions that participate in the primary metabolism of a wide range of organisms. In all cases, the overall reaction proceeds via two half reactions that take place in physically distinct active sites. In
B Chen et al.
Journal of dairy science, 94(7), 3537-3546 (2011-06-28)
A meta-analysis of the effect of biotin on production outcomes of dairy cattle was conducted following a literature review. A total of 11 studies from 9 papers, with information on the milk production and composition data from a total number
Jun-ichi Maruyama et al.
Plant signaling & behavior, 7(12), 1589-1593 (2012-10-18)
In plants, peroxisomes are the organelles involved in various metabolic processes and physiological functions including β-oxidation, mobilization of seed storage lipids, photorespiration, and hormone biosynthesis. We have recently shown that, in fungi and plants, peroxisomes play a vital role in
Yuxi Feng et al.
PloS one, 6(2), e16865-e16865 (2011-03-08)
Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in
Chawin Ounkomol et al.
Biophysical journal, 96(3), 1218-1231 (2009-02-03)
We present a multipurpose nanomechanical force probe that combines a sideways-mounted elastic cantilever and an optical-lever detection module with automated micropipette manipulation. It allows us to apply and measure compression, stretching, adhesion, and dissociation forces in the horizontal direction while
Christoph Hirschhäuser et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(39), 13017-13029 (2013-08-13)
The synthesis and stereochemical assignment of two classes of iron-containing nucleoside analogues, both of which contain a butadiene-Fe(CO)3 substructure, is described. The first type of compounds are Fe(CO)3-complexed 3'-alkenyl-2',3'-dideoxy-2',3'-dehydro nucleosides (2,5-dihydrofuran derivatives), from which the second class of compounds is
Frédéric Bretzner et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14681-14692 (2013-09-13)
Motor behaviors result from the interplay between the brain and the spinal cord. Reticulospinal neurons, situated between the supraspinal structures that initiate motor movements and the spinal cord that executes them, play key integrative roles in these behaviors. However, the
Tuan V Bui et al.
Neuron, 78(1), 191-204 (2013-04-16)
Accurate motor performance depends on the integration in spinal microcircuits of sensory feedback information. Hand grasp is a skilled motor behavior known to require cutaneous sensory feedback, but spinal microcircuits that process and relay this feedback to the motor system
J Xue et al.
Scandinavian journal of immunology, 78(5), 419-425 (2013-09-07)
The protein biotin ligase, holocarboxylase synthetase (HLCS), is a chromatin protein that interacts physically with the DNA methyltransferase DNMT1, the methylated cytosine-binding protein MeCP2 and the histone H3 K9-methyltransferase EHMT1, all of which participate in folate-dependent gene repression. Here we tested
Steven Lin et al.
Molecular bioSystems, 7(6), 1811-1821 (2011-03-26)
Biotin is an enzyme cofactor indispensable to metabolic fixation of carbon dioxide in all three domains of life. Although the catalytic and physiological roles of biotin have been well characterized, the biosynthesis of biotin remains to be fully elucidated. Studies
Kazuki Ohno et al.
Biochemical and biophysical research communications, 456(1), 245-249 (2014-12-03)
Hydrogen sulfide (H2S) is a gaseous regulatory factor produced by several enzymes, and plays a pivotal role in processes such as proliferation or vasodilation. Recent reports demonstrated the physiological and pathophysiological functions of H2S in neurons. PTEN is a target
Christopher Eginton et al.
Biochemistry, 52(38), 6595-6600 (2013-08-30)
Solvent reorganization can contribute significantly to the energetics of protein-protein interactions. However, our knowledge of the magnitude of the energetic contribution is limited, in part, by a dearth of quantitative experimental measurements. The biotin repressor forms a homodimer as a
Elena de Juan-Franco et al.
Talanta, 114, 268-275 (2013-08-21)
We have implemented a Surface Plasmon Resonance (SPR) immunosensor based on a sandwich assay for the simultaneous detection of the two main hGH isoforms, of 22 kDa (22K) and 20 kDa (20K). An oriented-antibody sensor surface specific for both hormone
S Schenker et al.
Alcoholism, clinical and experimental research, 17(3), 566-575 (1993-06-01)
Biotin, a vitamin essential for many metabolic reactions, is supplied to the fetus exclusively from the mother. Deficiency of biotin in pregnancy leads to impaired fetal growth and development. Alcohol taken in pregnancy likewise may cause fetal growth abnormalities. Normal
Christina M Van Itallie et al.
The Journal of biological chemistry, 288(19), 13775-13788 (2013-04-05)
Biotin ligase tagging with ZO-1 was applied to identify a more complete tight junction proteome. Identical but also different proteins and functional networks were identified near the N and C ends of ZO-1. The ends of ZO-1 are embedded in
Christopher M Dundas et al.
Applied microbiology and biotechnology, 97(21), 9343-9353 (2013-09-24)
Streptavidin and its homologs (together referred to as streptavidin) are widely used in molecular science owing to their highly selective and stable interaction with biotin. Other factors also contribute to the popularity of the streptavidin-biotin system, including the stability of
Ye Yao et al.
Biochemical and biophysical research communications, 436(1), 60-65 (2013-05-28)
Tumor cell-derived exosomes (TEX) have been widely used to induce antitumor immune responses in animal models and clinical trials. However, the efficiency of the antitumor immunity that is induced by TEX is still relatively weak. In this study, we compared
P Prandoni et al.
Minerva medica, 104(2), 131-139 (2013-03-22)
In recent years, the significant limitations associated with the use of vitamin K antagonists (VKA) have encouraged the development of new agents. Based upon the central roles played by the serine proteases thrombin and Factor Xa in the blood coagulation
Jacob G Vineberg et al.
Journal of medicinal chemistry, 57(13), 5777-5791 (2014-06-06)
Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety, and 1,3,5-triazine as the tripod splitter module
Naruo Nikoh et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10257-10262 (2014-07-02)
Obligate insect-bacterium nutritional mutualism is among the most sophisticated forms of symbiosis, wherein the host and the symbiont are integrated into a coherent biological entity and unable to survive without the partnership. Originally, however, such obligate symbiotic bacteria must have
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