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Courtney Klotz et al.
Frontiers in microbiology, 11, 345-345 (2020-04-08)
Bacterial surface-layers (S-layers) are crystalline arrays of repeating proteinaceous subunits that coat the exterior of many cell envelopes. S-layers have demonstrated diverse functions in growth and survival, maintenance of cell integrity, and mediation of host interactions. Additionally, S-layers can act...
Verónica C Martínez Allo et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6630-6639 (2020-03-13)
Aging elicits quantitative and qualitative changes in different immune components, leading to disruption of tolerogenic circuits and development of autoimmune disorders. Galectin-1 (Gal1), an endogenous glycan-binding protein, has emerged as a regulator of immune cell homeostasis by shaping the fate...
Chien-Han Yuan et al.
Biochemical pharmacology, 178, 114064-114064 (2020-06-04)
Osteosarcoma (OS) is the most common solid tumor of the bone that most often affects adolescents. The introduction of chemotherapy for the treatment of OS has largely improved the survival rates of patients with localized tumors. However, the 5-year survival...
Elizabeth Goya-Jorge et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 151, 105386-105386 (2020-05-30)
Benzothiazole is a privileged scaffold in medicinal chemistry present in diverse bioactive compounds with multiple pharmacological applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl...
A Laura Flores-Villegas et al.
Bulletin of entomological research, 110(3), 363-369 (2019-11-07)
Triatomine bugs carry the parasitic protozoa Trypanosoma cruzi, the causal agent of Chagas disease. It is known that both the parasite and entomopathogenic fungi can decrease bug survival, but the combined effect of both pathogens is not known, which is...
An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
Slezak, et al.
Protein Science, 29, 141-156 (2021)
Brenda Celeste Gutierrez et al.
Frontiers in cellular and infection microbiology, 10, 20-20 (2020-03-17)
Trypanosoma cruzi is a protozoan parasite that infects at least 7 million persons in the world (OMS, 2019). In endemic areas, infection normally occurs by vectorial transmission; however, outside, it normally happens by blood and includes congenital transmission. The persistence...
Famin Zhang et al.
Parasitology, 147(9), 940-948 (2020-02-13)
The rhoptry kinase 18 of Toxoplasma gondii (TgROP18) has been identified as a key virulence factor that allows the parasite to escape from host immune defences and promotes its proliferation in host cells. Although much research is focused on the...
Seonghan Jang et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(10) (2021-03-03)
Most animals harbor a gut microbiota that consists of potentially pathogenic, commensal, and mutualistic microorganisms. Dual oxidase (Duox) is a well described enzyme involved in gut mucosal immunity by the production of reactive oxygen species (ROS) that antagonizes pathogenic bacteria...
Timothy J Wade et al.
Scientific reports, 9(1), 19576-19576 (2019-12-22)
Norovirus is one of the most common causes of gastroenteritis. Following infection, anti-norovirus salivary immunoglobulin G (IgG) rises steeply within 2 weeks and remains elevated for several months; this immunoconversion can serve as an indicator of infection. We used a...
Ying Wang et al.
Life sciences, 253, 117726-117726 (2020-04-30)
Vascular smooth muscle cell (VSMC) proliferation plays a significant role in the development of various vascular disorders. However, the effect of cortistatin (CST) on VSMC proliferation remains unclear. Therefore, the purpose of our research aimed to study whether CST protected...
Camille N Pujol et al.
Science signaling, 13(618) (2020-02-13)
The serotonin (5-hydroxytrypatmine) receptor 5-HT6 (5-HT6R) has emerged as a promising target to alleviate the cognitive symptoms of neurodevelopmental diseases. We previously demonstrated that 5-HT6R finely controls key neurodevelopmental steps, including neuronal migration and the initiation of neurite growth, through...
Maria Markoulli et al.
Optometry and vision science : official publication of the American Academy of Optometry, 97(3), 145-153 (2020-03-14)
This study set out to explore the relationship between the ocular surface immune and nervous systems by exploring corneal nerve structure and the presence of inflammatory mediators and neuropeptides in the tear film. The purpose of this study was to...
Peng Zhou et al.
EBioMedicine, 53, 102671-102671 (2020-03-03)
The role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA) in stroke patients caused by thromboembolic occlusion of the internal carotid artery (ICA) remains unclear. Our objectives were to evaluate the critical role of NETs in the induction of...
Meichen Pan et al.
Frontiers in microbiology, 10, 3146-3146 (2020-02-11)
Lactobacillus crispatus and Lactobacillus gasseri are two of the main Lactobacillus species found in the healthy vaginal microbiome and have also previously been identified and isolated from the human gastrointestinal (GI) tract. These two ecological niches are fundamentally different, notably...
Pakjira Nanudorn et al.
Biochemical and biophysical research communications, 528(4), 691-697 (2020-06-10)
Bisphenol A (BPA) is one of the most common toxic endocrine disruptors in the environment. A fast, efficient and environmental-friendly method for BPA detoxification is urgently needed. In this study, we show that the enzymatic transformation of BPA into a...
Wioletta Lech et al.
Scientific reports, 10(1), 16946-16946 (2020-10-11)
Tuning stem cells microenvironment in vitro may influence their regenerative properties. In this study Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) were encapsulated in 3D hydrogels derived from human fibrin (FB) or platelet lysate (PL) and the oxygen level was adjusted...
Sandra N Jimenez-Garcia et al.
Molecules (Basel, Switzerland), 25(7) (2020-04-05)
Mexican spices are used in the supplementation of the human diet and as medicinal herbs for the particularly high amounts of compounds capable of deactivating free radicals. In addition, these spices can have beneficial effects on chronic, no-transmissible diseases such...
Guobao Li et al.
Microbes and infection, 22(3), 119-126 (2019-11-05)
CD4+/CD8+ T cells play a major role in conferring immune protection against tuberculosis (TB), but it remains unknown how the immune responses of CD4+/CD8+ T cells exactly correlate with the clinical variables and disease statuses during anti-TB chemotherapy. To address...
Feby Wijaya Pratiwi et al.
Biomedicines, 9(1) (2020-12-31)
Mesoporous silica nanoparticles (MSNs) have emerged as a prominent nanomedicine platform, especially for tumor-related nanocarrier systems. However, there is increasing concern about the ability of nanoparticles (NPs) to penetrate solid tumors, resulting in compromised antitumor efficacy. Because the physicochemical properties...
Simon Paris et al.
Frontiers in immunology, 11, 566893-566893 (2020-11-10)
Several observations in the world of comparative immunology in plants, insects, fish and eventually mammals lead to the discovery of trained immunity in the early 2010's. The first demonstrations provided evidence that innate immune cells were capable of developing memory...
Karmen Kapp et al.
Planta medica, 86(15), 1089-1096 (2020-05-05)
Mint flavorings are widely used in confections, beverages, and dairy products. For the first time, mint flavoring composition of mint candies and food supplements (n = 45), originating from 16 countries, as well as their antibacterial properties, was analyzed. The flavorings were...
Valery Golderman et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Neural inflammation is linked to coagulation. Low levels of thrombin have a neuroprotective effect, mediated by activated protein C (APC). We describe a sensitive novel method for the measurement of APC activity at the low concentrations found in neural tissue....
Azospirillum brasilense reduces oxidative stress in the green microalgae Chlorella sorokiniana under different stressors.
Peng, et al.
Journal of Biotechnology, 325, 179-185 (2020)
Carlos M Ramírez-Acosta et al.
Nanomaterials (Basel, Switzerland), 10(9) (2020-09-23)
Nanomedicine is entering a high maturity stage and is ready to reach full translation into the clinical practice. This is because of the ample spectrum of applications enabled by a large arsenal of nanostructured materials. In particular, bimetallic patchy core/shell...
Jaceline Gisliane Pires Sanches et al.
Frontiers in oncology, 11, 637298-637298 (2021-04-02)
Background: The incidence of colorectal cancer (CRC) has been increasing worldwide in recent years. Targeting cancer stem cells (CSCs) in CRC remains a difficult challenge. KDM2B and EZH2 play important role in the maintenance of CSCs' self-renewal capacity and tumorigenic...
Andreia Aires et al.
Antibiotics (Basel, Switzerland), 10(1) (2021-01-02)
The present investigation intended to evaluate the bacteriostatic and bactericidal abilities of clove, oregano and thyme essential oils against oral bacteria in planktonic and biofilm states. Furthermore, aiming to mimic everyday conditions, a toothbrush in vitro model was developed. Determination...
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