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br701330

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Mariana R Arantes et al.
Plant cell reports, 39(5), 669-682 (2020-03-04)
SBTX has defensive role against C. kikuchii, and therefore, its constituent genes SBTX17 and SBTX27 are promising candidates to engineer pathogen resistant plants. Soybean (Glycine max [L.] Merr.) is economically the most important legume crop in the world. Its productivity
G Gionchetta et al.
The Science of the total environment, 714, 136838-136838 (2020-02-06)
Microbiota inhabiting the intermittent streambeds mediates several in-stream processes that are essential for ecosystem function. Reduced stream discharge caused by the strengthened intermittency and increased duration of the dry phase is a spreading global response to changes in climate. Here
Johanna Kliche et al.
Science signaling, 14(665) (2021-01-14)
The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the host cell surface and subsequently enters host cells through receptor-mediated endocytosis. Additional cell receptors may be directly or indirectly involved, including integrins. The cytoplasmic tails of ACE2
Halil Bagci et al.
Nature cell biology, 22(1), 120-134 (2019-12-25)
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits
Merve Tomas et al.
Food research international (Ottawa, Ont.), 140, 110039-110039 (2021-03-03)
In this study, four Brassicaceae microgreens species, namely kale, red cabbage, kohlrabi, and radish, were evaluated for their phytochemical compositions using spectrophotometric assays and untargeted metabolomics before and after in vitro gastrointestinal digestion. According to the in vitro spectrophotometric results
Yogesh Vikal et al.
PloS one, 15(6), e0234335-e0234335 (2020-06-10)
Shoot fly (Atherigona naqvii) is one of the major insects affecting spring maize in North India and can cause yield loss up to 60 per cent. The genetics of insect resistance is complex as influenced by genotypic background, insect population
Edward Valencia Ayala et al.
ACS infectious diseases, 6(7), 1807-1815 (2020-05-07)
The leading animal model of experimental Chagas disease, the mouse, plays a significant role in studies for vaccine development, diagnosis, and human therapies. Humans, along with Old World primates, alone among mammals, cannot make the terminal carbohydrate linkage of the
Ewa Baranowska-Wójcik et al.
Nutrients, 12(3) (2020-03-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized, among others, by abnormally low levels of the neurotransmitter acetylcholine in the brain. Acetylcholinesterase (AChE) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. Currently, the main
Ieva Račkauskienė et al.
Journal of food science, 84(12), 3494-3503 (2019-11-19)
Thermal treatment of proteinaceous foods generates heat-induced Maillard reaction substances including toxic advanced glycation end products (AGEs) and heterocyclic amines (HAs). It is known that plant phenolic compounds may influence Maillard reaction. This study investigated the impact of lingonberry leaf
K Brennan et al.
Scientific reports, 10(1), 1039-1039 (2020-01-25)
Extracellular vesicles (EVs) are nano-sized vesicles containing nucleic acid and protein cargo that are released from a multitude of cell types and have gained significant interest as potential diagnostic biomarkers. Human serum is a rich source of readily accessible EVs;
Khanyisani Ziqubu et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-17)
The current study explored the effect of isoorientin on the metabolic activity and lipid accumulation in fully differentiated 3T3-L1 adipocytes. To achieve this, the 3T3-L1 pre-adipocytes were differentiated for eight days and treated with various concentrations of isoorientin (0.1-100 μM)
Sacnicte Ramirez-Rios et al.
Frontiers in pharmacology, 11, 543-543 (2020-05-20)
Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual
Kuan-Lin Kuo et al.
American journal of cancer research, 11(1), 171-180 (2021-02-02)
Chemotherapy with gemcitabine plus cisplatin remains the mainstay of treatment for metastatic urothelial carcinoma (UC); however, drug resistance occurs in most patients and eventually leads to treatment failure. In this study, we investigated the role of cyclin-dependent kinase 7 (CDK7)
Elisa Giacomelli et al.
Cell stem cell, 26(6), 862-879 (2020-05-28)
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered tissues or forced contraction. Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells
Shihuan Cheng et al.
OncoTargets and therapy, 13, 6651-6660 (2020-08-06)
Breast cancer is one of the most common and malignant tumors in the world. Nowadays more attention has been garnered in pristimerin anti-cancer effects. Here, we illustrate the function and regulatory mechanism of pristimerin in breast cancer therapy. Breast cancer
Wei-Ju Lee et al.
Journal of the American Geriatrics Society, 68(1), 129-136 (2019-10-07)
To investigate the summative effects of vascular risk factors (VRFs) on the progression of Alzheimer disease (AD). Longitudinal follow-up cohort study. AD patients from two teaching hospitals in Taiwan with 3-year follow-ups. A total of 330 AD patients with a mean
Karla B Neves et al.
JCI insight, 4(23) (2019-10-28)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia. Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking. CADASIL is caused by NOTCH3 mutations that influence vascular smooth muscle cell
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Lvxia Zhang et al.
Analytica chimica acta, 1148, 238174-238174 (2021-02-01)
Novel cobalt-based metal-organic frameworks (Co MOFs) were synthesized by a facile "controlled synthesis" strategy. The MOFs displayed superior catalytic performance on the chemiluminescent (CL) reaction between N-(4-aminobutyl)-N-ethylisoluminol (ABEI) and H2O2. UV-vis absorption, CL spectrum, ESR, and radical scavenger experiments were
Xi Jiang et al.
Communications biology, 4(1), 4-4 (2021-01-06)
Engineering nitrogen fixation in eukaryotes requires high expression of functional nitrogenase structural proteins, a goal that has not yet been achieved. Here we build a knowledge-based library containing 32 nitrogenase nifH sequences from prokaryotes of diverse ecological niches and metabolic
Tomasz Janek et al.
Biofouling, 36(2), 210-221 (2020-04-16)
Surfactin is a type of cyclic lipopeptide biosurfactant implicated in a wide range of applications. Although its antimicrobial activity has been characterized, its effect on Candida albicans physiology remains to be elucidated. The present study evaluated the influence of surfactin-C15
Kristin J Hung et al.
Scientific reports, 10(1), 7625-7625 (2020-05-08)
Half of postmenopausal women experience genitourinary syndrome of menopause, for which many use lubricating vaginal products. The effect of vaginal products on uropathogenic and commensal vaginal bacteria is poorly understood. We evaluated the effect of five common vaginal products (KY
Chien-Chun Liu et al.
PLoS neglected tropical diseases, 14(2), e0008054-e0008054 (2020-02-08)
Naja atra envenomation is one of the most significant clinical snakebite concerns in Taiwan. Taiwanese freeze-dried neurotoxic antivenom (FNAV) is currently used clinically for the treatment of cobra snakebite, and has been shown to limit the mortality of cobra envenomation
Yong Jin Ahn et al.
Mikrochimica acta, 188(4), 129-129 (2021-03-20)
A fast and sensitive colorimetric paper sensor has been developed using silver nanoprisms (Ag NPRs) with an edge length of ~50 nm for the detection of free H2S gas. We prepared two types of Ag NPRs-coated H2S sensing papers: a multi-zone patterned
Mehdi Tabarsa et al.
Carbohydrate polymers, 241, 116358-116358 (2020-06-09)
The polysaccharide isolated from F. gummosa (FGP) was found homogenous with a weight average molecular weight (Mw) of 50.0 × 103 g/mol and radius of gyration (Rg) of 105.3 nm. The FGP was an arabinogalactan with a backbone formed of →6)-β-Galp-1→ residues having
Daiane M O Quaresma et al.
Bioorganic chemistry, 105, 104335-104335 (2020-10-20)
Banisteriopsis argyrophylla belongs to the Malpighiaceae family, which is a species from Cerrado, also known as "cipó-prata" or "cipó-folha-de-prata." Several species of this family present biological potential. This work reports the chemical identification of the ethanol extract (EE) and its
Silvie Rimpelová et al.
Foods (Basel, Switzerland), 10(1) (2021-01-15)
Cardiac glycosides (CGs) represent a group of sundry compounds of natural origin. Most CGs are potent inhibitors of Na+/K+-ATPase, and some are routinely utilized in the treatment of various cardiac conditions. Biological activities of other lesser known CGs have not
Kaixin Guo et al.
Food & function, 11(6), 5004-5016 (2020-06-11)
Sea cucumbers have been used as food delicacies and traditional medicine for centuries, and their health benefits are partly attributed to their repertoire of proteins. Peptides prepared from the sea cucumber Apostichopus japonicus are reported to have in vitro antioxidant
Philippe Gautret et al.
Travel medicine and infectious disease, 34, 101663-101663 (2020-04-15)
We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration. We conducted an uncontrolled, non-comparative, observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over
Antje Blank et al.
NPJ vaccines, 5, 10-10 (2020-02-07)
A vaccine remains a priority in the global fight against malaria. Here, we report on a single-center, randomized, double-blind, placebo and adjuvant-controlled, dose escalation phase 1a safety and immunogenicity clinical trial of full-length Plasmodium falciparum merozoite surface protein 1 (MSP1)
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